Inhibition of iron ion accumulation alleviates polystyrene nanoplastics-induced pulmonary fibroblast proliferation and activation.

Microplastics (MPs) and nanoplastics (NPs) are increasingly recognized as widespread environmental pollutants with significant ecological and human health implications, with particularly severe impacts on the respiratory system. This study aimed to explore the effects of polystyrene nanoplastics (PS-NPs, 80 nm) on pulmonary fibroblast proliferation and activation in NIH/3 T3 cells. Herein, we conducted a PS-NPs-induced fibroblast-to-myofibroblast transition (FMT) model and a pulmonary fibrosis mouse model.

Lysosomal Acidification: A New Perspective on the Pathogenesis and Treatment of Pulmonary Fibrosis.

Pulmonary fibrosis is a complex pathophysiological process characterized by local pulmonary inflammation and fibrosis, along with systemic inflammation and distal organ damage. The acidic environment of lysosomes, as intracellular degradation and recycling centers, is important for cellular homeostasis and function. This review summarizes the potential role of lysosomal acidification in pulmonary fibrosis pathogenesis and its implications for cross-organ effects.

Association between brominated flame retardants and obesity: a mediation analysis through markers of oxidative stress and inflammation.

Background: Recent studies have provided compelling evidence that exposure to brominated flame retardants (BFRs) can adversely affect human health. We aim to explore the potential impact of BFRs on adiposity and central obesity.

Methods: Data from the National Health and Nutrition Examination Surveys (NHANES) cycles conducted between 2009 and 2014 was used to study the connections between variables.

TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy.

Evidence suggests that ferroptosis participates in kidney injury. However, the role of ferroptosis in antimony (Sb) induced nephrotoxicity and the mechanism are unknown. Here, we demonstrated that Sb induced injury in renal tubular epithelial cells (RTECs) and ferroptosis.