Real-world outcome of crizotinib for anaplastic lymphoma kinase-positive lung cancer: Multicenter retrospective analysis in South Korea.

Background: About 3%-5% of non-small cell lung cancer (NSCLC) presents positive anaplastic lymphoma kinase (ALK). Recently, several target agents have been approved as a treatment for ALK-positive NSCLC. This study aimed to analyze the real-world efficacy and outcome when administered crizotinib, the first approved target agent for ALK-positive NSCLC, according to first- or late-line treatment.

Conditional diagnostic accuracy according to inflammation status and age for diagnosing tuberculous effusion.

Background: Tuberculous effusion varies from lymphocyte-dominant to neutrophilic effusion according to inflammation status. The criteria of adenosine deaminase (ADA) and lymphocyte/neutrophil (L/N) ratio have yet not been evaluated across different disease conditions.

Methods: Patients who conducted pleural fluid analysis from 2009 to 2019 at Asan Medical Center were included.

Trend of asthma prevalence and risk factors in the 20s age band in South Korea.

Background: The prevalence of asthma has increased in many countries. However, whether asthma prevalence may only be true in a specific age band is not well known. Thus, we analyzed the increase in asthma prevalence according to age band and analyzed the related factors.

Type 2 Diabetes Mellitus- and Complication-Related Risk of Nontuberculous Mycobacterial Disease in a South Korean Cohort.

We aimed to investigate whether type 2 diabetes mellitus (T2DM) and diabetes-related complications constitute significant risk factors for nontuberculous mycobacterial (NTM) disease. Data from the National Health Insurance Service-National Sample Cohort (which represents 2.2% of the total South Korean population) recorded between 2007 and 2019 were extracted to establish the NTM-naive T2DM cohort ( = 191,218) and the 1:1 age- and sex-matched NTM-naive matched cohort ( = 191,218).

The antiaging effects of a product containing collagen and ascorbic acid: In vitro, ex vivo, and pre-post intervention clinical trial.

Various substances, including collagen (Naticol®) and ascorbic acid, that inhibit and prevent skin aging have been studied. Collagen prevents skin aging, has anti-inflammatory effects, and assists in normal wound healing. Ascorbic acid is a representative antioxidant that plays a role in collagen synthesis.

Sex differences in the characteristics and survival of patients with non-small-cell lung cancer: A retrospective analytical study based on real-world clinical data of the Korean population.

Purpose: This study aimed to investigate the differences in characteristics, clinical stages, treatment modalities, and survival outcomes in patients with non-small-cell lung cancer (NSCLC) based on sex differences using Korean nationwide registry data.

Methods: We analyzed the data of 8650 patients diagnosed with NSCLC between 2014 and 2017, obtained from the Korean Association for Lung Cancer Registry (KALC-R). The Cox proportional hazard model was used to define the differences in survival based on sex.

Five-Year Overall Survival and Prognostic Factors in Patients with Lung Cancer: Results from the Korean Association of Lung Cancer Registry (KALC-R) 2015.

Purpose: This study aimed to provide the clinical characteristics, prognostic factors, and 5-year relative survival rates of lung cancer diagnosed in 2015.

Materials And Methods: The demographic risk factors of lung cancer were calculated using the KALC-R (Korean Association of Lung Cancer Registry) cohort in 2015, with survival follow-up until December 31, 2020. The 5-year relative survival rates were estimated using Ederer II methods, and the general population data used the death rate adjusted for sex and age published by the Korea Statistical Information Service from 2015 to 2020.

Finite Element Plastic Limit Loads of Complex Cracks in Pipes With Two-Layered Materials.

Based on the detailed three-dimensional (3D) finite element (FE) limit analyses, the present study investigates the plastic limit loads of complex-cracked pipes with two-layered materials for determining maximum load-carrying capacity or critical crack length of pipes with two-layered materials. The complex cracks in pipes with two-layered materials consist of a partial through-wall crack and 360-deg circumferential surface crack in the inner side of pipe in the same plane in pipe, which could be developed in the preemptive weld overlay region on the dissimilar metal weld (DMW) of nuclear pipe. In terms of FE limit analyses for complex-cracked pipes with two-layered materials, total thickness of pipe, depth of 360-deg internal surface crack, length of partial through-wall crack and the effect of strength mismatch between two materials are systematically considered in the present study.