Intersecting precision fermentation for global cell-based food production innovation: Challenges and opportunities.

Precision fermentation represents an innovative cell-based production approach that employs synthetic biology and metabolic engineering tools, revolutionizing global food production by utilizing "microbial cell factories" to produce added-value ingredients. However, its global implementation is hindered by technological and scalability bottlenecks, regulatory fragmentation, regional accessibility and consumer acceptance, and nutritional trade-offs challenges. This review utilizes illustrated case studies and modeling analysis to present a detailed exploration of precision fermentation intersecting with global cell-based food production, discussing actionable research gaps and insights as well as advanced bioengineering practices and analytical techniques, to address these challenges for ongoing academic research, industrial applications and policy initiatives, thus supporting the transition of fermentation-enabled food production toward efficient and sustainable manufacturing.

Coordination-inspired assembly of binary nanocrystal superlattices featuring a diamond-like sublattice.

We present a coordination-inspired strategy for assembling binary nanocrystal superlattices (BNSLs) using CdSe nanotetrapods as symmetry-encoding building blocks. Exploiting their intrinsic tetrahedral geometry, which mimics the sp hybridization of carbon atoms in a diamond lattice, we encode spatially defined binding sites that guide regioselective coassembly with spherical nanocrystals. By tuning the size ratio between components, we achieve both three-dimensional and two-dimensional BNSLs with long-range structural order.

Binding of autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion.

In eukaryotic systems, three major types of cell junctions have been well characterized. While bacterial adhesion mechanisms also exhibit remarkable diversity, the molecular processes that regulate the dynamic modulation of binding strength between elongated bacterial cells and host cells remain poorly understood. () utilizes the surface adhesin CbpF to interact with the highly expressed host receptors CEACAM1 and CEACAM5 on cancer cells to facilitate tumor colonization.

Association of MSH2, MSH6, and MLH1 polymorphisms with susceptibility and survival in lung cancer patients.

Background: Lung cancer (LC) is the leading cause of cancer-related deaths globally. Genetic variants in mismatch repair (MMR) genes, such as MutS homolog 2 (MSH2), MutS homolog 6 (MSH6) and MutL homolog 1 (MLH1), may influence individual susceptibility and clinical outcomes in LC.

Objective: This study investigated the associations of genetic polymorphisms in MSH2, MSH6, and MLH1 with susceptibility and survival outcomes in lung cancer patients in the Guangxi Zhuang population.

Tetramethylpyrazine alleviates acute kidney injury by activating the Wnt/β-catenin pathway independent of DKK1.

Acute kidney injury (AKI) is a group of common clinical syndromes characterized by a rapid decline in renal function over a short period of time. At present, the treatment methods are limited, and research is needed to identify drugs that could alleviate renal ischemia-reperfusion (I/R) injury. Tetramethylpyrazine (TMP) is a bioactive alkaloid extracted from the Chinese herbal medicine Chuanxiong.