Exosome as a stable carrier for anti-inflammatory phenylpropanoid metabolites: a proof-of-concept study.

Phenylpropanoids (PA), which are plentiful in cruciferous vegetables, have not received adequate attention for their anti-inflammatory properties. Despite their potential benefits, the bioavailability and stability of these and other natural compounds under physiological conditions remain limited. This study aims to develop a natural nanovesicular delivery system that efficiently incorporates a phenylpropanoid extract-specifically, a multi-component anti-inflammatory extract derived from broccoli-with the goal of enhancing its bioavailability.

Chemical constituents of the aerial parts of (L.) DC (Rubiaceae).

A phytochemical investigation of the aerial parts of afforded thirteen compounds, including a new naphthoquinone di-glycoside (), three isopentenyl isoflavones (-), four flavonoids (-), three iridoid glycosides (-) and two coumarins ( and ). Their structures were elucidated based on extensive spectroscopic analyses, chemical methods, and the comparison with the literature. Among them, compound possesses a 2-(3-methylnaphthalen-2-yl)acetic acid core with two glucosyl groups, compounds - are the first three representatives from the Rubiaceae family, and compounds - and were isolated from genus for the first time.

Acetogenins from the Stem of and Their Cytotoxic Activity.

Four new adjacent bis-tetrahydrofuran acetogenins, bullacin C (), uvarirufin (), and uvariasolins III () and IV (), along with 11 known acetogenins, were isolated from the stem of . Their structures were elucidated based on spectroscopic data analysis, including 1D and 2D NMR, HRESIMS, and MALDI-MS/MS of the lithium adducts. Absolute configurations were assigned using Mosher ester analysis and ECD measurements.

Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior.

Background: Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-inflammatories in seedlings.

Methods: A growth method was utilized to produce a phenylpropanoid-rich broccoli sprout extract, referred to as Original Extract (OE).

Polyoxygenated cyclohexene derivatives and other constituents of Uvaria rufa stem.

Six undescribed compounds, uvarirufols D and E, (+)-uvarigranol B, (-)-uvarigranol E, 6-acetoxy-5-hydroxy-7-methoxyflavanone and cherrevenaphthalene D, along with twelve known compounds, including polyoxygenated cyclohexenes, flavonoids, and lignans, were isolated from the methanol extract of Uvaria rufa stems. Their structures were elucidated by spectroscopic analyses and the absolute configurations were determined using electronic circular dichroism. Several isolates were evaluated for cytotoxic, antitubercular and anti-inflammatory potentials.

Structurally diverse (9β-H)-pimarane derivatives with six frameworks from the leaves of Icacina oliviformis and their cytotoxic activities.

Thirteen previously undescribed (9β-H)-pimarane derivatives, icacinolides A-G (1-7) and oliviformislactones C-H (8-13), together with four known analogs (14-17), were isolated from the leaves of Icacina oliviformis. Their structures were constructed by extensive spectroscopic analysis, C NMR-DP4+ analysis, ECD calculation, single-crystal X-ray diffraction, and chemical methods. These structurally diverse isolates were classified into six framework types: rearranged 3-epi-17-nor-(9β-H)-pimarane, rearranged 17-nor-(9β-H)-pimarane, 16-nor-(9β-H)-pimarane, 17-nor-(9β-H)-pimarane, 17,19-di-nor-(9β-H)-pimarane, and (9β-H)-pimarane.

Identification of small molecule inhibitors against MMP-14 via High-Throughput screening.

Matrix metalloproteinases (MMPs) are involved in various cellular events in physiology and pathophysiology through endopeptidases activity. The expression levels and activities of most MMPs remain minimal in the normal conditions, whereas some MMPs are significantly activated in pathological conditions such as cancer and neovascularization. Hence, MMPs are considered as both diagnostic markers and potential targets for therapeutic agents.

Oxalactam A, a Novel Macrolactam with Potent Anti- Activity from the Endophytic Fungus .

A novel macrolactam named oxalactam A (), three known dipeptides (-) as well as other known alkaloids (-) were obtained from the endophytic fungus , which was derived from the tuber of (Icacinaceae). All chemical structures were established based on spectroscopic data, chemical methods, ECD calculations, and C-DP4+ analysis. Among them, oxalactam A () is a 16-membered polyenic macrolactam bearing a new skeleton of 2,9-dimethyl-azacyclohexadecane core and exhibited potent anti- activity with a MIC value of 10 μg/mL in vitro.

UHPLC-MS/MS-GNPS based phytochemical investigation of (Hope) C. Chr. and evaluation of cytotoxicity against liver and prostate cancer cell lines.

(family; Dryopteridaceae) has been reported for its medicinal importance in cancer, gastrointestinal disorders, and infections. The present study aimed to investigate the detailed phytochemical profile of and its cytotoxic potential using various cancer cell lines. The phytochemical profile of methanolic extract and its fractions were established by employing UHPLC-MS/MS and Global Natural Product Social (GNPS) molecular networking.

Pinostrobin: An Adipogenic Suppressor from Fingerroot () and Its Possible Mechanisms.

Obesity is a critical factor for chronic metabolic syndromes. The culinary plant fingerroot () has been reported for its anti-obesity activity. The anti-adipogenic effects of pandurantin A, a main component of fingerroot cultivated in Indonesia, have been studied.

A New C22-Quassinoid with Anti-Pancreatic Adenocarcinoma Activity from Seeds of Brucea javanica.

An undescribed C22-quassinoid named sergeolide A (1) and fifteen known quassinoids (2-16) were obtained from the seeds of Brucea javanica (Simaroubaceae). All chemical structures were established based on spectroscopic data and X-ray diffraction analysis. Sergeolide A (1) is the first example of a naturally occurring C22-quassinoid bearing a butenolide group fused the A ring of the bruceolide skeleton from Brucea genus.

Isolation and elucidation of two isoflavonoids from an American Indian plant, Pursh, using Magnetic Microbead Affinity Selection Screening (MagMASS) for estrogen receptor alpha ligands.

A new isoflavonoid, xanthocerin J, along with previously described xanthocerin A, were isolated from a methanol extract of aerial parts of a traditional American Indian herb, Pursh (Asteraceae). The structures of these compounds were characterized using mass spectrometry and NMR based on an isolation protocol using magnetic microbead affinity selection screening (MagMASS) for ligands to the estrogen receptor alpha (ERα). These compounds bound to ERα from an active fraction that exhibited dose-dependent antiestrogenic activity in the Ishikawa assay.

Quinone Derivatives as Promising Anti- Agents from Aerial Parts of .

Seven new naphthoquinone diglycosides (-), three new anthraquinones (-), and eight known analogues were obtained from the aerial parts of collected from West Africa in a bioassay-guided phytochemical investigation. All isolated compounds were elucidated by comparison with the literature and interpretation of spectroscopic data, and the absolute configurations of the new naphthoquinone diglycosides (-) were confirmed by chemical methods and ECD calculations. Notably, compound was found to be the first naphthoquinone diglycoside containing carboxylic acid and isopentenyl side chains isolated from a species in the genus .

UHPLC-MS/MS-GNPS based phytochemical investigation of L. And evaluation of cytotoxicity against human melanoma and ovarian cancer cells.

 L. is widely used as a traditional medicine for the management of inflammation and cancer. In the present study, phyto-chemical analysis of was carried out and its cytotoxic potential against human melanoma (MDA-MB-435) and ovarian cancer cells (OVCAR3) was evaluated.

Angiogenesis-Inhibitory Piperidine Alkaloids from the Leaves of .

Eight new 2,6-disubstituted piperidin-3-ol alkaloids (-), featuring a C unsaturated alkyl side chain, together with three previously reported analogues (-) were isolated from the leaves of medicinal plant . Their structures and absolute configurations were elucidated unambiguously by means of 1D and 2D NMR spectroscopic data analysis, modified Mosher's method, Snatzke's method, and quantum chemical electronic circular dichroism (ECD) calculations, as well as single-crystal X-ray crystallography. The isolates were evaluated for their antiangiogenic effects on human umbilical vein endothelial cells (HUVECs).

Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways.

Ethnopharmacological Relevance: Ervatamia coronaria, a popular garden plant in India and some other parts of the world is known traditionally for its anti-inflammatory and anti-cancer properties. The molecular bases of these functions remain poorly understood.

Aim Of The Study: Efficacies of the existing therapies for colorectal cancer (CRC) are limited by their life-threatening side effects and unaffordability.

Identification of Small Molecule Inhibitors against Dihydroorotase via HTS.

Drug-resistant is an imminent threat to public health, increasing the importance of drug discovery utilizing unexplored bacterial pathways and enzyme targets. pyrimidine biosynthesis is a specialized, highly conserved pathway implicated in both the survival and virulence of several clinically relevant pathogens. Class I dihydroorotase (DHOase) is a separate and distinct enzyme present in gram positive bacteria (i.

A novel P38α MAPK activator Bruceine A exhibits potent anti-pancreatic cancer activity.

Pancreatic cancer remains one of the cancers with the poorest prognosis bearing an overall 5-year survival rate of about 5%. Efficient new chemotherapic drugs are still highly desired. Here, bruceine A, a quassinoid identified from the dried fruits of (L.

(9βH)- and 17-Nor-Pimaranes from .

Eleven pimarane-type diterpenoids were isolated from the tubers of , including three new compounds, icacinlactone M (), icacinlactone H 2--β-d-glucopyranoside (), and icacinlactone N 3--β-d-glucopyranoside (), together with an artifact of acrenol (). Among the known structures, icacinlactone A (), icacinlactone B (), icacinlactone H (), 12-hydroxyicacinlactone A (), 14α-methoxyhumirianthol (), and annonalide () are reported from for the first time, whereas icacinol () has previously been found in this plant. Icacinol, 14α-methoxyhumirianthol, and annonalide displayed moderate cytotoxic activity in a panel of human cancer cell lines.

Further prenylated anthranoids from Harungana madagascariensis.

Ten undescribed anthranoids, including three anthraquinone acetals as racemic mixtures, (±)-kenganthranol G-I, and seven prenylated anthranols, (±)-kenganthranol J-M and harunganol G-I, together with thirteen known compounds, were isolated from the stem bark of Harungana madagascariensis. The structures of (±)-kenganthranol G and (±)-kenganthranol J were confirmed by X-ray crystallography. (±)-Kenganthranol G was separated into (+)-kenganthranol G and (-)-kenganthranol G by chiral HPLC and their absolute configurations were established by electronic circular dichroism.

Limonoids and other triterpenoids from Entandrophragma angolense.

Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). The chemical structures were elucidated on the basis of spectroscopic and HRMS data, and the absolute configuration was established with the aid of electronic circular dichroism. Compound 5 displayed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC values ranging from 2.