Publications by authors named "Aleksandra Gurgul"
Phenylpropanoids (PA), which are plentiful in cruciferous vegetables, have not received adequate attention for their anti-inflammatory properties. Despite their potential benefits, the bioavailability and stability of these and other natural compounds under physiological conditions remain limited. This study aims to develop a natural nanovesicular delivery system that efficiently incorporates a phenylpropanoid extract-specifically, a multi-component anti-inflammatory extract derived from broccoli-with the goal of enhancing its bioavailability.
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- Annonaceous acetogenins are natural compounds that help fight cancer and have special chemical structures.
- This study created a new method using liquid chromatography and mass spectrometry to identify these compounds in plant samples easily.
- The results showed that the method worked well, allowing scientists to tell similar compounds apart and suggesting it could be used for other types of acetogenins too.
Four new adjacent bis-tetrahydrofuran acetogenins, bullacin C (), uvarirufin (), and uvariasolins III () and IV (), along with 11 known acetogenins, were isolated from the stem of . Their structures were elucidated based on spectroscopic data analysis, including 1D and 2D NMR, HRESIMS, and MALDI-MS/MS of the lithium adducts. Absolute configurations were assigned using Mosher ester analysis and ECD measurements.
View Article and Find Full Text PDFBackground: Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-inflammatories in seedlings.
Methods: A growth method was utilized to produce a phenylpropanoid-rich broccoli sprout extract, referred to as Original Extract (OE).
Polyoxygenated cyclohexene derivatives and other constituents of Uvaria rufa stem.
Phytochemistry
December 2023
Six undescribed compounds, uvarirufols D and E, (+)-uvarigranol B, (-)-uvarigranol E, 6-acetoxy-5-hydroxy-7-methoxyflavanone and cherrevenaphthalene D, along with twelve known compounds, including polyoxygenated cyclohexenes, flavonoids, and lignans, were isolated from the methanol extract of Uvaria rufa stems. Their structures were elucidated by spectroscopic analyses and the absolute configurations were determined using electronic circular dichroism. Several isolates were evaluated for cytotoxic, antitubercular and anti-inflammatory potentials.
View Article and Find Full Text PDF(family; Dryopteridaceae) has been reported for its medicinal importance in cancer, gastrointestinal disorders, and infections. The present study aimed to investigate the detailed phytochemical profile of and its cytotoxic potential using various cancer cell lines. The phytochemical profile of methanolic extract and its fractions were established by employing UHPLC-MS/MS and Global Natural Product Social (GNPS) molecular networking.
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- - A new phenylpropanoid glycoside, named lyciumphenylpropanoid B, was isolated from the stem of a plant in the Annonaceae family, along with nine other known compounds, many of which are being reported for the first time from this genus.
- - The structure of these compounds was determined using advanced techniques like NMR spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism calculations.
- - The study evaluated the cytotoxic and anti-tubercular effects of the isolated compounds, finding that dipyrithione exhibited strong anti-mycobacterial activity and notable cytotoxicity against certain cancer cell lines, while kelampayoside A showed moderate cytotoxic effects.
Chemical constituents of Entandrophragma angolense and their anti-inflammatory activity.
Phytochemistry
September 2022
Article Synopsis
- Researchers isolated six new compounds from the stem bark of Entandrophragma angolense, including unique triterpenoids and a catechin glucoside, alongside nineteen known compounds.
- The structure of these compounds was identified using spectroscopic methods and high-resolution mass spectrometry, with their configurations confirmed through electronic circular dichroism.
- The new compounds were tested for their ability to inhibit nitric oxide production in response to lipopolysaccharides, finding moluccensin O and (-)-catechin to have effective concentrations of 81 μM and 137 μM, respectively.
L. is widely used as a traditional medicine for the management of inflammation and cancer. In the present study, phyto-chemical analysis of was carried out and its cytotoxic potential against human melanoma (MDA-MB-435) and ovarian cancer cells (OVCAR3) was evaluated.
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