From "academic success" to "commercial success" -The model of medical device translation driven by SCI articles.

Unlabelled: For Asia-Pacific countries used to long-term medical device manufacturing, developing innovative medical devices must be rooted in our profound research strength and mature medical productivity. Here, we developed a new model for achieving efficient translation through cooperation among local hospitals, universities, and industries and introduced the project manager system and Key Opinion Leader training. This "From SCI to FDA" model is a pivot for transferring cutting-edge research into valuable medical devices.

Dumbbell-shaped hydrogel plug for annulus fibrosus repair: From material design to in vivo validation.

Background: Intervertebral disc (IVD) herniation is a degenerative spine disease, and current treatments often result in reherniation due to iatrogenic annulus fibrosus (AF) defects. Developing effective AF repair strategies is critical to preventing reherniation and improving surgical outcomes. This study aims to develop a novel hydrogel plug to repair significant AF defects, improving surgical outcomes and reducing the risk of reherniation.

Biomechanics characterization of an implantable ultrathin intracortical electrode through finite element method.

Neural electrodes are widely used in brain-computer interfaces and neuroprosthesis for the treatment of various neurological disorders. However, as components that come into direct contact with neural tissue, implanted neural electrodes could cause mechanical damage during surgical insertions or while inside the brain. Thus, accurately and timely assessing this damage was vital for chronic implantation, which posed a significant challenge.

Advances in Annulus Fibrosus Repair: Hybrid Scaffolds and Fabrication Techniques for Regeneration.

Intervertebral disc (IVD) herniation is a leading cause of lower back pain, with symptoms ranging from tingling to disability. Discectomy, as the most common treatment, relieves pain and reduces inflammation, but the unrevealed defect in annulus fibrosus (AF) inevitably increases the risk of herniation as high as 21%. Repair and regeneration of AF are crucial to prevent herniation and recreate healthy IVD.

Comprehensive Impact of Multiplanar Malalignment on Prosthetic Mechanics Under Gait Loading After Total Knee Arthroplasty-A Finite Element Analysis.

Background: Component alignment is a key factor influencing clinical outcomes after total knee arthroplasty (TKA). Previous studies have shown that single-plane alignment can significantly affect knee joint kinematics and biomechanics. However, the comprehensive impact of multiplanar malalignment has been rarely investigated.

Factors influencing the posterior tibial slope after medial opening-wedge high tibial osteotomy.

Introduction: Medial Opening-wedge High Tibial Osteotomy (HTO) is an effective treatment for medial compartment osteoarthritis and knee varus in relatively young and active patients. While it can effectively correct lower limb alignment in the coronal plane, it may also affect the posterior tibial slope (PTS) in the sagittal plane. However, the factors influencing PTS and methods for maintaining PTS stability remain controversial.

Failure analysis and design improvement of retrieved plates from revision surgery.

Background: The fracture of bone plate can cause considerable pain for the patient and increase the burden on the public finances. This study aims to explore the failure mechanism of 49 plates retrieved from revision surgery and introduce pure magnesium (Mg) block to improve the biomechanical performance of the plate via decreasing the stiffness and to stimulate the biological response of the plate potentially by the degradation of Mg block.

Methods: The morphological analysis and component analysis of the plates were conducted to determine the fracture reason of the plates combining the clinical data.

ACL reconstruction combined with anterolateral structures reconstruction for treating ACL rupture and knee injuries: a finite element analysis.

The biomechanical indication for combining anterolateral structures reconstruction (ASLR) with ACL reconstruction (ACLR) to reduce pivot shift in the knee remains unclear. This study aims to investigate knee functionality after ACL rupture with different combinations of injuries, and to compare the effectiveness of ALSR with ACLR for treating these injuries. A validated finite element model of a human cadaveric knee was used to simulate pivot shift tests on the joint in different states, including 1) an intact knee; 2) after isolated ACL rupture; 3) after ACL rupture combined with different knee injuries or defect, including a posterior tibial slope (PTS) of 20°, an injury to the anterolateral structures (ALS) and an injury to the posterior meniscotibial ligament of the lateral meniscus (LP); 4) after treating the different injuries using isolated ACLR; v.

Shape and Size of the Annulus Fibrosus Excision Alters the Biomechanics of the Intervertebral Disc.

Study DesignBiomechanical testings and finite element analysis.ObjectivesThis study aims to investigate how annulus fibrosus (AF) incision size (RIS, Ratio of incision width to AF height) and shape affect intervertebral disc (IVD) biomechanics.MethodsA validated finite element model of lumbar spines simulated various incisions in the middle-right posterior region of the AF, with different sizes and shapes.

Innovative hydrogel-patch combination for large annulus fibrosus defects: a prospective approach to address herniation recurrence.

Background Context: Large annulus fibrosus (AF) defects often lead to a high rate of reherniation, particularly in the medial AF region, which has limited self-healing capabilities. The increasing prevalence of herniated discs underscores the need for effective repair strategies.

Purpose: The objectives of this study were to design an AF repair technique to reduce solve the current problems of insufficient mechanical properties and poor sealing capacity.

Risk Factors for Periprosthetic Femoral Fractures After Cementless Total Hip Arthroplasty.

Background: The present study aimed to identify the risk factors of periprosthetic femoral fracture (PFF) after cementless total hip arthroplasty and rank them based on importance.

Methods: The age, sex, body mass index (BMI), osteoporosis, canal flare index (CFI), canal bone ratio (CBR), canal calcar ratio (CCR), stem design, and stem canal fill ratio (P1, P2, P3, and P4) of the proximal femoral medullary cavity of 111 total hip arthroplasty patients who had PFF and 388 who did not have PFF were analyzed. Independent-samples student t-tests were used for continuous variables, and Chi-square tests were used for categorical variables.

Automatic planning and geometric analysis of the drilling path in core decompression surgery for osteonecrosis of the femoral head.

Background And Objective: Core decompression surgery is an effective treatment method for patients with pre-collapse osteonecrosis of the femoral head (ONFH). The treatment relies on accurately predrilling the wire into the necrotic lesion. However, the surgical planning of this drilling path remains unclear.

Mechanical alignment tolerance of a cruciate-retaining knee prosthesis under gait loading-A finite element analysis.

Component alignment is one of the most crucial factors affecting total knee arthroplasty's clinical outcome and survival. This study aimed to investigate how coronal, sagittal, and transverse malalignment affects the mechanical behavior of the tibial insert and to determine a suitable alignment tolerance on the coronal, sagittal, and transverse planes. A finite element model of a cruciate-retaining knee prosthesis was assembled with different joint alignments (-10°, -7°, -5°, -3°, 0°, 3°, 5°, 7°, 10°) to assess the effect of malalignment under gait loading.

Correlation between morphological features of the anterior cruciate ligament: A quantitative study using a porcine model.

Introduction: Knowledge of the morphological features of the anterior cruciate ligament (ACL) is critical for accurate reconstruction of it. This study aimed to explore the quantitative correlations among different morphological features of the ACL, thus to provide useful information for improving anatomical reconstruction techniques and designing artificial ligaments.

Methods: 19 porcine knees were fixed at full extension using 10% formalin and were dissected to expose the ACL.

Biomechanical evaluation of a novel intervertebral disc repair technique for large box-shaped ruptures.

The purpose of this study was to analyze the feasibility of repairing a ruptured intervertebral disc using a patch secured to the inner surface of the annulus fibrosus (AF). Different material properties and geometries for the patch were evaluated. Using finite element analysis, this study created a large box-shaped rupture in the posterior-lateral region of the AF and then repaired it with a circular and square inner patch.

Failure analysis of a locking compression plate with asymmetric holes and polyaxial screws.

Locking compression plates (LCP) with asymmetrical holes and polyaxial screws are effective for treating mid-femoral fractures, but are prone to failure in cases of bone nonunion. To understand the failure mechanism of the LCP, this study assessed the material composition, microhardness, metallography, fractography and biomechanical performance of a retrieved LCP used for treating a bone fracture of AO type 32-A1. For the biomechanical assessment, a finite element surgical model implanted with the intact fixation-plate system was constructed to understand the stresses and structural stiffness on the construct.

Hourglass-shaped grafts are superior to conventional grafts for restoring knee stability and graft force at knee flexion angle of 30° following anterior cruciate ligament reconstruction: A finite element analysis.

Anterior cruciate ligament reconstruction (ACLR) using a generally columnar graft is considered the gold standard for treating anterior cruciate ligament ruptures, but such grafts cannot replicate the geometry and mechanical properties of the native anterior cruciate ligament. To evaluate the effectiveness of an innovative hourglass-shaped graft versus a traditional columnar graft for restoring joint stability and graft force, while avoiding notch impingement following anterior cruciate ligament reconstruction. Finite element models of a human knee were developed to simulate ① An intact state, ② anterior cruciate ligament reconstruction using columnar grafts with different diameters (7.

Wear Analysis of Tibial Inserts Made of Highly Cross-Linked Polyethylene Supplemented with Dodecyl Gallate before and after Accelerated Aging.

The wear of the tibial insert is one of the primary factors leading to the failure of total knee arthroplasty. As materials age, their wear performance often degrades. Supplementing highly cross-linked polyethylene (HXLPE) with dodecyl gallate (DG) can improve the oxidation stability of tibial inserts for use in total knee arthroplasty (TKA).