Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury.

Background: Sepsis is a critical condition triggered by infection and characterized by systemic inflammation and subsequent multiorgan failure. Chaihuang Qingfu Pill (CHQF), an in-hospital formulation developed by Hunan Provincial People's Hospital, is derived from the traditional Chinese medicine compound Qingyi Decoction through optimized herbal compatibility. It possesses pharmacological activities including heat-clearing and purgation, choleretic and anti-jaundice effects, as well as Qi-regulation and mass-resolving properties.

SAM-DTA: a sequence-agnostic model for drug-target binding affinity prediction.

Drug-target binding affinity prediction is a fundamental task for drug discovery and has been studied for decades. Most methods follow the canonical paradigm that processes the inputs of the protein (target) and the ligand (drug) separately and then combines them together. In this study we demonstrate, surprisingly, that a model is able to achieve even superior performance without access to any protein-sequence-related information.

DigestPath: A benchmark dataset with challenge review for the pathological detection and segmentation of digestive-system.

Examination of pathological images is the golden standard for diagnosing and screening many kinds of cancers. Multiple datasets, benchmarks, and challenges have been released in recent years, resulting in significant improvements in computer-aided diagnosis (CAD) of related diseases. However, few existing works focus on the digestive system.

High-extinction-ratio low-voltage dual-racetrack modulator for low-power DAC-less PAM-4 modulation.

In a parallel-coupled dual-racetrack modulator, resonant light in two resonators can interfere with each other. In lieu of critical coupling, such interference is capable of producing high extinction ratios (ERs) for high-speed modulation. Experiments demonstrate ERs of over 9 dB at 50 Gb/s and 40-50% modulation depth enhancement compared with a single-resonator modulator at 50-56 Gb/s with a peak-to-peak driving voltage of 2.

Study on landscape ecological risk assessment of Hooded Crane breeding and overwintering habitat.

Xinqing Wetland and Shengjin Lake Wetland are the main habitats of Hooded Crane in China. However, in recent years, the irrational land use situation of occupied wetlands has occurred frequently, resulting in the destruction of the breeding of the Hooded Crane population and the destruction of the wintering habitat. The paper takes Xinqing Wetland and Shengjin Lake Wetland as the research area, and uses landscape ecology and geostatistics as the theoretical basis to reveal the changes of land landscape in the study area, and analyze the main breeding and wintering habitat types of Hooded Crane.

Incoherent control of locally controllable quantum systems.

An incoherent control scheme for state control of locally controllable quantum systems is proposed. This scheme includes three steps: (1) amplitude amplification of the initial state by a suitable unitary transformation, (2) projective measurement of the amplified state, and (3) final optimization by a unitary controlled transformation. The first step increases the amplitudes of some desired eigenstates and the corresponding probability of observing these eigenstates, the second step projects, with high probability, the amplified state into a desired eigenstate, and the last step steers this eigenstate into the target state.