Multiresponsive luminescent sensors for antibiotics and Cr with two luminescent Zn/Cd coordination complexes.

Two new Zn/Cd luminescent coordination polymers (CPs) based on the V-shaped bis(imidazole) ligand 3,6-bis (1H-benzo[d]imidazol-1-yl)-9-methyl-9H-carbazole (bbimc) with [1,1'-biphenyl]-4,4'-dicarboxylic acid ligand (Hbpdc) have been synthesized under solvothermal conditions: {[Zn(bbimc)(bpdc)]·DMF·2.5HO} (CP 1), {[Cd(bbimc)(bpdc)]·2DMF} (CP 2). CP 1 and CP 2 both display a uninodal 4-c unimodal sql topology 2D framework with vertex symbols of {4·6}.

Jiangu granules ameliorate postmenopausal osteoporosis via rectifying bone homeostasis imbalance: A network pharmacology analysis based on multi-omics validation.

Background: Postmenopausal osteoporosis (PMOP) is a series of reactions to bone homeostasis dysregulation mediated by estrogen deficiency in elderly women. Jiangu granules, a traditional Chinese medicine formula, has been proven as an effective treatment approach for PMOP, which still needs more research iin its complex regulatory mechanisms.

Purpose: Our study aimed to identify the putative targets and regulatory mechanisms of Jiangu granules in PMOP treating.

Nucleus Pulposus-Targeting Nanocarriers Facilitate Mirna-Based Therapeutics for Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IDD) is a common cause of low back pain. Understanding its molecular mechanisms is the basis for developing specific treatment. To demonstrate that miR-22-3p is critical in the regulation of IDD, miRNA microarray analyses are conducted in conjunction with in vivo and in vitro experiments.

A water stable and highly fluorescent Zn(II) based metal-organic framework for fast detection of Hg, Cr, and antibiotics.

The development of luminescent metal-organic frameworks for effective sensing and monitoring of environmental pollutants is of great significance for human health and environmental protection. In this work, a novel water-stable Zn-based luminescent coordination polymer, namely {[Zn(BBDF)(ATP)]·2DMF·3HO} ((BBDF = 2,7-bis(1-benzimidazol-1-yl)-9,9-dimethyl-9-fluorene) and HATP = 2-aminoterephthalic acid), was designed and obtained using the mixed-ligand method. Structural analysis indicated that 1 presents a two-fold interpenetrated two-dimensional layer structure with one dimensional (1D) channels along the axis.

4D label-free quantitative proteomics analysis to screen potential drug targets of Jiangu Granules treatment for postmenopausal osteoporotic rats.

Postmenopausal osteoporosis (PMOP) is a disease with a high prevalence in postmenopausal women and is characterized by an imbalance in bone metabolism, reduced bone mass, and increased risk of fracture due to estrogen deficiency. Jiangu granules (JG) is a compound prescription used in traditional Chinese medicine to treat PMOP. However, its definitive mechanism in PMOP is unclear.

Self-Motion of Water Droplets along a Spacing Gradient of Micropillar Arrays on Copper.

Self-driven droplet transport along an open gradient surface is increasingly becoming popular for various microfluidics applications. In this work, a gradient copper oxide layer is formed on a copper sheet (as a bipolar electrode, BPE) in a KOH solution by bipolar electrochemistry. The deposits at different positions present a rich variety of colors, compositions, and microstructures along the longitudinal axis of the BPE.

High-Performance Bifunctional Ni-Fe-S Catalyst in situ Synthesized within Graphite Intergranular Nanopores for Overall Water Splitting.

Low-cost and efficient bifunctional catalysts are urgently needed for overall water splitting used in large-scale energy storage. In this study, we develop a nickel and iron (di)sulfide (Ni-Fe-S) composite catalyst that is in situ synthesized and fixed within the intergranular nanopores inside high pure polycrystalline graphite. Two precursor solutions (reactants) may permeate the graphite intergranular pores to a depth of more than 3.

Survivals of the Intraoperative Motor-evoked Potentials Response in Pediatric Patients Undergoing Spinal Deformity Correction Surgery: What Are the Neurologic Outcomes of Surgery?

Study Design: This is a retrospective cases study from a prospective patient register.

Objective: To clarify the clinical implication regard to the survivals of motor-evoked potential (MEP) response.

Summary Of Background Data: Intraoperative neurophysiological monitoring has become an essential component for decreasing the incidence of neurological deficits during spine surgeries.

Intraoperative neuromonitoring loss in abnormal magnetic resonance imaging signal intensity from patients with cervical compressive myelopathy.

Purpose: Our objective of this study was to evaluate if cervical compressive myelopathy (CCM) patients with preoperative abnormal magnetic resonance imaging (MRI) might easily lead to intraoperative neuromonitoring (IONM) loss.

Method: A consecutive series of 152 CCM patients who underwent cervical cord decompression were enrolled in this study between December 2013 and February 2017. All patients with abnormal MRI signal intensity were divided into 2 groups (group 1: T2-WIs hyperintensity; group 2: both T2-WIs hyperintensity and T1-WIs hypointensity).