[Career development in gynaecology and obstetrics: retrospective study of practitioners trained in Tours (2000-2021)].

Objective - To describe the proportion of obstetrician-gynecologists trained in the Centre-Val de Loire region still practicing obstetrics, particularly on-call duties, after completion of training, and to identify practice patterns and factors associated with discontinuation. Methods - A cross-sectional observational study was conducted among physicians who completed obstetrics and gynecology training between 2000 and 2021. A 69-item online questionnaire collected sociodemographic, professional, and satisfaction data from professionals.

[Cervical cancer: Guidelines for clinical practice].

Objectives: To establish clinical practice guidelines for the management of women with cervical cancer.

Methods: An organizing committee composed of a chair, two coordinators, and a methodologist defined the questions to be addressed and appointed a working group of 36 experts. Questions were formulated using the PICO format (Patients, Intervention, Comparison, Outcome).

Intensity of perinatal care for extreme preterm births and neurodevelopmental outcomes at age 5½: the EPIPAGE-2 cohort study.

Objective: To explore the impact of intensity of perinatal ('survival-focused') care on outcomes at 5½ years for two groups of survivors: those born at 24-26 and at 27-28 weeks of gestation.

Design: Prospective, population-based national cohort.

Setting: France, 2011.

Incidence, Risk Factors and Outcomes of SARS-CoV-2 Infection in Pregnant Women: The COROPREG Population-Based Study.

Background: Population-based data are needed to reliably assess the impact of SARS-CoV-2 infection during pregnancy.

Objectives: To estimate the population-based incidence of SARS-CoV-2 infection and its severe forms in the obstetric population, identify risk factors of severe SARS-CoV-2 infection (severe COVID-19) and describe delivery, maternal and neonatal outcomes by disease severity, using a definition of severity based on organ dysfunction.

Methods: A prospective population-based study conducted over the three first pandemic waves between March 2020 and April 2021 in 281 maternity hospitals in six French regions included all women with SARS-CoV-2 infection during pregnancy or within 7 days post-partum, whether symptomatic or not, hospitalised or not.

Prevalence of term prelabor rupture of membranes and factors associated with a longer interval of rupture: data from the 2021 French national perinatal survey.

Objectives: Term prelabor rupture of membranes (term PROM) increases maternal and neonatal morbidity, but its current prevalence is unknown. This study aimed to estimate the prevalence of term PROM and to identify factors associated with a longer interval of rupture of membranes using recent national population-based data.

Study Design: Women with singleton pregnancies and term deliveries from the 2021 French National Perinatal Survey were selected.

[Prostaglandins or cervical balloon for the induction of labor for cervical ripening: A literature review].

Objective: Induction of labor in France concerns one birth out of four with 70% of induction starting by cervical ripening, either with a pharmacological (prostaglandins) or a mechanical (balloon) method. This review aims to compare these two methods within current knowledge, using the PRISMA methodology.

Methods: Trials comparing these two methods, published or unpublished up to July 2023, in French or English were searched for in the PubMed, Cochrane Library and ClinicalTrial.

Five-year outcomes for extremely preterm babies with active perinatal management: A clinical prediction model.

Objective: To develop and validate a clinical prediction model for outcomes at 5 years of age for children born extremely preterm and receiving active perinatal management.

Design: The EPIPAGE-2 national prospective cohort.

Setting: France, 2011.

Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study.

Aim: To describe the circumstances, causes and timing of death in extremely preterm infants.

Methods: We included from the EPIPAGE-2 study infants born at 24-26 weeks in 2011 admitted to neonatal intensive care units (NICU). Vital status and circumstances of death were used to define three groups of infants: alive at discharge, death with or without withholding or withdrawing life-sustaining treatment (WWLST).

Timing and Preventability of Cardiovascular-Related Maternal Death.

Objective: To describe the clinical profile, management, and potential preventability of maternal cardiovascular deaths.

Methods: We conducted a retrospective, descriptive study of all maternal deaths resulting from a cardiovascular disease during pregnancy or up to 1 year after the end of pregnancy in France from 2007 to 2015. Deaths were identified through the nationwide permanent enhanced maternal mortality surveillance system (ENCMM [Enquête Nationale Confidentielle sur les Morts Maternelles]).

Survival and neurodevelopmental impairment of outborn preterm infants at 5.5 years of age: an EPIPAGE-2 prospective, matched study using multiple imputation.

Objective: To determine whether birth outside a level-3 centre (outborn) is associated with a difference in the combined outcome of mortality or moderate-to-severe neurological impairment at 5.5 years of age compared with birth in a level-3 centre (inborn) when antenatal steroids and gestational age (GA) are accounted for.

Design: Individual matched study nested within a prospective cohort.

Balloon catheters versus vaginal prostaglandins for labour induction (CPI Collaborative): an individual participant data meta-analysis of randomised controlled trials.

Background: Induction of labour is one of the most common obstetric interventions globally. Balloon catheters and vaginal prostaglandins are widely used to ripen the cervix in labour induction. We aimed to compare the effectiveness and safety profiles of these two induction methods.

A study of diabetic ketoacidosis in the pregnant population in the United Kingdom: Investigating the incidence, aetiology, management and outcomes.

Aim: To estimate the incidence of diabetic ketoacidosis (DKA) among pregnant women, describe its clinical features, management and outcomes and identify the risk factors for the condition.

Methods: A national population-based case-control study was conducted in the UK using the UK Obstetric Surveillance System between April 2019 and September 2020 including all pregnant women with DKA irrespective of the level of blood glucose. The incidence rate of DKA in pregnancy was estimated.

Contribution of ultrasonography to the prediction of the induction-delivery interval: The ECOLDIA prospective multicenter cohort study.

Introduction: To evaluate the ability of preinduction ultrasonographic cervical length to predict the interval between induction and delivery in women at term with a Bishop score of 4 to 6 at induction.

Study Design: This multicenter prospective observational cohort recruited 334 women from April 2010 to March 2014. Inclusion criteria were women with singleton pregnancies at a gestational age ≥37 weeks, with no previous caesarean, a medical indication for induction of labor, and a Bishop score of 4, 5, or 6.

[Health consequences of tobacco exposure during pregnancy and childhood].

Health consequences of tobacco exposure during pregnancy and childhood.In France, about 15% of fetuses are exposed to maternal smoking during pregnancy and about 30% of children are exposed to second-hand tobacco smoke. Furthermore, 20 to 25% of young adults are active smokers.

Risk factors for very preterm delivery out of a level III maternity unit: The EPIPAGE-2 cohort study.

Background: Regionalisation programmes aim to ensure that very preterm infants are born in level III units (inborn) through antenatal referral or transfer. Despite widespread knowledge about better survival without disability for inborn babies, 10%-30% of women deliver outside these units (outborn).

Objective: To investigate risk factors associated with outborn deliveries and to estimate the proportion that were probably or possibly avoidable.

Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial.

Background: Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2).

Term prelabor rupture of membranes: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF).

Objective: To determine the management of patients with term prelabor rupture of membranes.

Methods: Synthesis of the literature from the PubMed and Cochrane databases and the recommendations of French and foreign societies and colleges.

Results: Term prelabor rupture of membranes is considered a physiological process until 12 h have passed since rupture (professional consensus).

Impact of antenatal corticosteroids on head circumference of full-term newborns: A French multicenter cohort study.

Introduction: Our main objective was to evaluate whether antenatal corticosteroids increase the risk of small head circumference in children born at term. Secondary objectives were to evaluate whether they increase the risk of small birthweight and birth length among those children.

Material And Methods: A historical cohort included 275 270 live term born children between 2000 and 2013 in 175 French maternity units.

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.

Introduction: Previous studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained amniotic fluid, neonatal intensive care unit admission, and stillbirth. The objective was to compare the neonatal and maternal consequences in pregnancies affected by intrahepatic cholestasis and normal pregnancies.

Material And Methods: This case-control study compares pregnancies affected by intrahepatic cholestasis (pruritus and bile acid ≥ 10 μmol/L) with low-risk pregnancies managed between December 2006 and December 2014 at a French university hospital center.