Fetal heart quantification ultrasound technology for the quantitative analysis of fetal cardiac morphology and function in hypertensive disorders of pregnancy.

Background: Hypertensive disorders of pregnancy (HDP) are associated with adverse outcomes for both the mother and fetus, including impaired fetal cardiac development and function. Accurate assessment of fetal heart morphology and function is essential for the early detection and management of potential complications. This study investigated the clinical application value of fetal heart quantification (Fetal HQ) technology in evaluating the cardiac morphology and function in fetuses from pregnancies affected by HDP.

Quantitative analysis of fetal cardiac structure and function in gestational diabetes mellitus using fetal HQ technology.

Background: Gestational diabetes mellitus (GDM) can contribute to changes in fetal cardiac structure and function, with potential implications for long-term cardiovascular health. This study focuses on assessing these cardiac adaptations in fetuses from GDM pregnancies by using the innovative Fetal Heart Quantification (Fetal HQ) technology to provide a detailed evaluation of structural and functional parameters.

Methods: A prospective study was conducted from March 2023 to October 2024 at Xiangyang No.

Innovative cardiovascular casting technique features the complex malformation of berry syndrome.

Background: Prenatal diagnosis of Berry syndrome, a rare combination of cardiac anomalies including aortopulmonary window (APW), aortic origin of the right pulmonary artery (RPA), interrupted aortic arch (IAA), hypoplastic aortic arch, or coarctation of the aorta (COA), poses a significant challenge. Due to the rarity of the disease, and the limited case reports available to features the complex malformation of Berry syndrome postpartum, this article introduces an innovative approach to visually showcase this unusual disease. The proposed method provides a comprehensive display of the structural deformities, offering valuable insights for clinical practitioners seeking to comprehend this condition.

[Feasibility of bone marrow mesenchymal stem cells differentiation in diabetic pancreatic microenvironment].

Objective: The bone marrow mesenchymal stem cells (BMSCs) have the capacity to differentiate into insulin-producing cells (IPCs) in vitro. However, low differentiation efficiency and poor maturity are the main obstacles. To investigate the feasibility of BMSCs differentiation into IPCs in diabetic pancreatic microenvironment of pigs.

Mesenchymal stem cells adopt beta-cell fate upon diabetic pancreatic microenvironment.

Objectives: : This study observed whether mesenchymal stem cells (MSCs) adopt beta-cell fate upon diabetic microenvironment.

Methods: : We transplanted male porcine MSCs to diabetic female pigs by directly injecting into pancreas. Recipients' sera and pancreatic tissue were analyzed to assess the therapeutic effect.

Analysis of TAP1 and TAP2 polymorphism of mother-infant in Chinese patients with pre-eclampsia.

To analyze the polymorphism of TAP gene and the shared rates of alleles between mothers and their infants in Chinese patients with pre-eclampsia, TAP1 and TAP2 genotyping was performed by the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in 42 patients, 106 normal pregnant women, and their neonates. The allelic frequency of TAP and the alleles shared in maternal-fetus were compared and analyzed in the two groups. Our results showed that, with totally eight alleles of TAP1 and TAP2 examined in the samples, no significant difference was found in allelic frequencies between pre-eclampsia group and control group, as well as between mothers and their neonates.

Studies on activity of NK cells in preeclampsia patients.

The activity of the NK cells in patients with preeclampsia was studied to investigate the pathogenesis of preeclampsia. By using MTT and 51Cr releasing technique, the proliferation and killing ability of the NK cells in maternal and umbilical blood from preeclampsia patients (n = 18) and normal third trimester pregnant women (n = 18) were detected. The NK-92 cell line was as the positive control.