Metabolic responses to energetic stimuli in female athletes using or not hormonal contraceptives during a high training load period.

Background: Despite growing interest in women's physiology in exercise sciences, the understanding of female athletes' energy metabolism remains limited. This study aimed to analyze substrate oxidation in response to energetic stimuli in female athletes using or not hormonal contraceptives, and to determine the influence of the estradiol-to-progesterone ratio fluctuations on energy metabolism.

Methods: Body composition (dual-energy X-ray absorptiometry), energy expenditure and substrate oxidation rates (resting, low-intensity walking exercise (4 km/h), and postprandial conditions; indirect calorimetry) were assessed among 32 athletes (23±3 years) during a high-training load period, in athletes using or not hormonal contraceptives (nine and 23, respectively).

Initial and evolutionary profile of adverse responders to an intensive weight loss intervention: the RESOLVE Study.

Background: There is a need to better identify adverse responders to weight-loss interventions. The aim of this study was to: 1) identify potential predictive factors of adverse responders to weight loss; and 2) follow their long-term evolution.

Methods: One-hundred participants (56 females) with overweight (59.

Male and female workers suffering from chronic low back pain display different interrelationships between the biopsychosocial variables.

Objective: To study the biopsychosocial model of chronic low back pain in the workplace and the role of sex in it.

Design: Cross-sectional nationwide survey in a service company.

Patients: 256 workers (women 64.

The Hyperkinetic Circulatory Response during Exercise in Metabolic Myopathies: A Peculiar Model of Integrated Biology.

Introduction: A hyperkinetic circulatory response has been described in some metabolic myopathies, a heterogeneous group of inborn errors of intermediary metabolism that interfere with the generation of ATP in skeletal muscle. However, an accurate picture of the cardiovascular response to exercise in the various metabolic myopathies remains elusive.

Material And Methods: We therefore sought to systematically review the literature by searching the PubMed/MEDLINE and Embase databases.

Is systematic deltoid ligament repair necessary in bimalleolar equivalent ankle fractures? A bi-centric case-control study.

Background: Bimalleolar equivalent fractures (BEF) represent a particularly challenging subset of ankle fractures, with ongoing debate among ankle surgeons about the necessity of systematic deltoid ligament repair. The present study aims to address this controversy by investigating the radiological and clinical outcomes of deltoid ligament repair in BEF compared to conservative management.

Hypothesis: Systematic deltoid ligament repair in BEF is not necessary.

Efficacy of different modalities of faecal microbiota transplantation in ulcerative colitis: systematic review and network meta-analysis.

Background: While several small sample size randomized controlled trials suggested the superiority of faecal microbiota transplantation (FMT) over placebo in ulcerative colitis (UC), the most effective modality to perform FMT remains unknown.

Objectives: To compare the efficacy of different modalities of FMT to induce clinical remission in patients with UC.

Data Sources And Methods: We performed a systematic review and network analysis (sources: MEDLINE, Embase, Cochrane CENTRAL; random effects model) of randomized controlled trials including at least one arm of FMT in adult patients with active UC.

Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial.

Purpose: Airway driving pressure has garnered considerable attention for lung-protective ventilation. We evaluated the clinical effectiveness of airway driving pressure as a target to individualize positive-end-expiratory pressure (PEEP) setting in mechanically ventilated patients at risk for postoperative respiratory failure.

Methods: We conducted a multicenter, pragmatic, assessor-masked, randomized trial among adult patients undergoing emergency abdominal surgery in 22 hospitals in France.

Real-world comparison of the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis: the TORUS study.

Background And Aims: We compared the effectiveness of tofacitinib and ustekinumab in patients with ulcerative colitis (UC) previously exposed to at least one anti-TNF agent.

Methods: In this multicenter real-world evidence study, we consecutively included UC patients ≥18 years-old, previously exposed to anti-TNF therapy, with partial Mayo score >2 and, starting tofacitinib or ustekinumab. All the comparisons were performed using propensity score analyses.

Surgical Management of Gastric Cancer in Elderly Patients: Results of a Multicenter Cohort of the French Surgical Association.

Introduction: Gastric cancer primarily affects the elderly, but surgical management varies with age. This multicenter, retrospective cohort study assessed treatment approaches and outcomes in gastric cancer patients based on age.

Methods: Between 2007 and 2017, 2,131 patients treated in French Surgical Association centers were identified.

Evaluating a predictive model of tyrosine kinase inhibitor therapy failure in a European-type cohort: a step towards population-specific tools.

Predicting therapeutic failure in patients with chronic phase-chronic myeloid leukemia (CP-CML) treated with tyrosine kinase inhibitors (TKI) remains a major challenge for personalized care management. The Sokal and EUTOS long-term survival scores were designed to predict CML-related mortality, but are also used to guide therapeutic choices, despite their poor performance for this purpose. A recent study proposed a refined predictive model of therapy failure specifically tailored for patients treated with imatinib and second-generation TKIs that showed promising results in a Chinese cohort.

Effects of face-to-face and remote Tai Chi in stable axial spondyloarthritis: a pilot randomised controlled trial.

To investigate the effects of a Tai Chi (TC) programme (hospital-based or remote) on total physical activity (PA) time in patients with axial spondyloarthritis (axSpA ). Between January 2019 and July 2021, patients with stable AS (BASDAI ≤ 40/100 or symptoms at an acceptable level, within the last six months) were enrolled in a four-month parallel, two-arm pilot study. Participants were randomised to either the immediate Tai Chi group (ITG), starting face-to-face TC immediately after enrolment for a duration of 4 months, or to the waiting list control group (WLCG), which started a 2 month face-to-face TC programme 2 months after enrolment.

Impact of Visitation Restrictions in ICU on Psychological Symptoms in Family Members: Experience of the COVID-19 Pandemic.

Rationale: The COVID-19 pandemic required unprecedented measures including visitation restrictions.

Objectives: To assess their impact on psychological symptoms (anxiety-depression, posttraumatic stress disorder (PTSD)) among ICU family members.

Methods: In this prospective multicentre quasi-experimental study, family members of patients with invasive mechanical ventilation with or without COVID-19, were enrolled during one of three periods (March 15 - June 5) subject to visitation restriction policies mandated by French health authorities: forbidden (2020, n= 304), restricted (2021, n= 294) and unrestricted (2022, n= 213).

Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for a stepped-wedge cluster-randomised controlled trial.

Introduction: In the intensive care unit (ICU), brain-injured patients are frequently exposed to mechanical ventilation to protect the brain and preserve physiology. After intracranial pressure control and sedation withdrawal, this population is prone to residual disorder of consciousness and altered neurological control of respiratory drive, cough and airway protection. Consequently, extubation failure is more frequent than in general ICU patients, and there is no clear evidence-based clinical trigger for extubation.

Chronic Lateral Ankle Instability Repair Technique Using All-Inside and All-Knotless Soft-Tissue Anchors.

Chronic lateral ankle instability (CLAI) is common in sports. Whereas traditional open Broström-Gould surgery remains the gold standard for anterior talofibular ligament repair, advances in arthroscopic techniques with knotless suture anchors offer promising alternatives, reducing recovery time and complications. This article presents a minimally invasive arthroscopic technique for anterior talofibular ligament reconstruction with knotless anchors, reattaching the ligament to the fibula and minimizing risks of knot irritation and impingement.

Modulatory roles of bone morphogenetic protein 2 and asporin in osteo/cementoblast differentiation potential of human periodontal ligament stem cells: a multivariate model analysis.

Unlabelled: Understanding the molecular mechanisms regulating osteo/cementogenic differentiation is critical for optimizing cell-based strategies in periodontal regeneration. This study employed multivariate statistical modeling to investigate, in vitro, the interaction between bone morphogenetic protein 2 (BMP2) and asporin (ASPN) in human periodontal ligament stem cells (hPDLSCs) and its impact on mineralization potential. Four primary hPDLSC populations-two with high osteo/cementogenic potential (HOP) and two with low potential (LOP)-were cultured under standard (SDM) and osteo/cementogenic (OM) conditions.

Post-hoc mediation analysis of two biomarkers, and survival in acute respiratory distress syndrome.

Previous studies have shown that plasma soluble receptor for advanced glycation end-products (sRAGE) and the radiographic assessment of lung edema (RALE) are associated with the severity of acute respiratory distress syndrome (ARDS) both at baseline and over time. This study aims to explore the causal relationships among sRAGE, the RALE score, their fluctuations, and 90-day survival. Causal mediation analysis was conducted as a secondary analysis of the randomized controlled lung imaging for ventilator setting in ARDS (LIVE) trial, which assessed a mechanical ventilation strategy based on lung morphology.

New three-dimensional nuclear morphometry tool quantifies impact of slow freezing on sperm hypercondensed chromatin.

Background: Perm freezing compromises nuclear integrity. Standardized tools to assess three-dimensional (3D) chromatin alterations are lacking.

Objectives: This study aimed to present a novel protocol for 3D nuclear morphometric analysis of human spermatozoa to measure slow freezing and thawing-induced alterations.

High prevalence of primary headaches among patients with post-traumatic stress disorder: an observational study of consecutive patients.

Background: Primary headaches affect between 40% and 50% of people worldwide and are linked to a range of medical and mental health conditions, including post-traumatic stress disorder (PTSD). Our objective is to assess the prevalence of primary headaches in individuals with PTSD, identify the types, timing, and impact of traumatic experiences, and compare this prevalence to that of the general population.

Methods: This descriptive, retrospective observational study included 302 patients.

Sex and Age Differences in Ketamine Efficacy and Safety in Chronic Pain Alleviation.

Ketamine use for chronic pain and depression has increased worldwide, but sex differences in its efficacy and safety have been little studied; this study examines existing evidence to address this gap. A prospective, multicenter, one-year observational study in 585 chronic pain patients was performed; 256 patients had one administration of ketamine and 329 had two or more. The primary outcome looked at was mean pain intensity (0-10), assessed every month for 1 year by telephone.

A comparison of minimally invasive plate osteosynthesis (MIPO) versus open reduction and internal fixation (ORIF) in the management of tibial pilon fractures: A prospective randomized study.

Introduction: The aim of this study was to compare two surgical procedures for the treatment of tibial pilon fractures, i.e. minimally invasive plate osteosynthesis (MIPO) vs.

What is the optimal approach to analyse ventilator-free days? A simulation study.

Background: Ventilator-free days (VFDs) are a composite outcome in critical care research, reflecting both survival and mechanical ventilation duration. However, analysis methods for VFDs are inconsistent, with some focusing on counts and others on time-to-event outcomes, while other approaches such as the multistate model and the win ratio have emerged. We aimed to evaluate various statistical models through simulations to identify the optimal approach for analysing VFDs.

Efficacy and safety of thalidomide for oncology-related uses approved in Brazil: An overview of systematic reviews.

The aim of this overview was to summarize evidence of the efficacy and safety of thalidomide in the treatment of oncology-related diseases approved in Brazil, and to assess the quality of the available data. A literature search was performed in the Cochrane Library, PubMed, Embase, Lilacs, and SciELO databases. Studies must contain evidence of efficacy and/or safety of thalidomide use for multiple myeloma - MM, graft-versus-host disease - GVHD, and myelodysplastic syndrome - MDS.

Investigating the effectiveness of an intraoperative decision support guided fluid therapy intervention on postoperative outcome of high-risk patients undergoing high-risk abdominal surgery: protocol for an international multicentre stepped-wedge cluster-randomised implementation trial.

Background: Inappropriate fluid administration can impact patient outcome. Intraoperative advanced haemodynamic monitoring coupled with a treatment protocol based on stroke volume optimisation can help determine the appropriate timing for fluid boluses. Although recommended by several anaesthesia societies, this strategy is rarely implemented because protocols are complex and compliance is often poor.

Does food reward predict changes in weight and body composition during multidisciplinary interventions in adolescents with obesity? Bayesian and frequentist meta-analyses.

Background: A predisposition to elevated food reward may hinder weight loss success during multidisciplinary interventions. However, this has not been consistently demonstrated in adults, nor at all in children.

Objective: To test the associations between explicit and implicit food reward and preference at baseline and prospective changes in weight and body composition in adolescents with obesity.