OCT-PAM dual-mode imaging to evaluate early ischemic stroke in rats.

Early diagnosis of ischemic stroke is crucial for timely intervention and saving brain function. The mechanisms of stroke are complex, involving multiple parameters such as blood flow perfusion, tissue status, and oxygenation levels. These parameters interact with each other, necessitating multiple systems to evaluate.

Non-contact all-optic OCT-PAM imaging with shared detection light.

We proposed a non-contact all-optic OCT-PAM dual-modal system based on a single detection light source. A homodyne low-coherence interferometer was adopted to detect the vibration induced by photoacoustic excitation. The optical coherence tomography (OCT) and photoacoustic microscopy (PAM) shared the same broadband light source for signal detection, thus simplifying the dual-modal system and making it compact.

Optical attenuation coefficient decorrelation-based optical coherence tomography angiography for microvascular evaluation of Alzheimer's disease on mice.

Significance: The deep cortical microvasculature is closely linked to the pathogenesis of Alzheimer's disease (AD). However, tail artifacts from superficial cortical vessels often interfere with detecting deep vessels in optical coherence tomography angiography (OCTA) imaging. A more accurate method to assess deep cortical vasculature is crucial for understanding its relationship with AD onset.

Internal Secondary Structural Conformational States of Silk Fibroin Studied by Raman Spectroscopy with Band Deconvolution Analysis.

Silk fibroin (SF) is an extensively utilized biofiber recognized for its excellent mechanical properties across various applications. However, the relationship between its internal structure and mechanical behavior remains inadequately understood. In this work, we employed polarized Raman spectra to investigate how SF's secondary structures respond to external tensile loads.

Probe fusion all-optic OCT-PAM dual-mode imaging system for biomedical imaging.

We proposed a non-contact photoacoustic (PA) detection method using spectral domain optical coherence tomography (SDOCT). Two interference spectrums (A-lines) were acquired before and after the PA excitation with SDOCT. PA signal propagated within the sample causing the vibration.

Scalable synthesis of ant-nest-like bulk porous silicon for high-performance lithium-ion battery anodes.

Although silicon is a promising anode material for lithium-ion batteries, scalable synthesis of silicon anodes with good cyclability and low electrode swelling remains a significant challenge. Herein, we report a scalable top-down technique to produce ant-nest-like porous silicon from magnesium-silicon alloy. The ant-nest-like porous silicon comprising three-dimensional interconnected silicon nanoligaments and bicontinuous nanopores can prevent pulverization and accommodate volume expansion during cycling resulting in negligible particle-level outward expansion.

The role of loop 7 in mediating calcineurin regulation.

Calcineurin (CN) is a heterodimer protein consisting of a 61 kDa catalytic subunit A and a 19 kDa regulatory subunit B. It plays a critical role in T-cell activation and is involved in many cellular processes. Regulation of CN is rather complex, including a number of factors such as divalent metal ions (primarily Ca(2+) and Mn(2+)), calmodulin (CaM) and autoinhibition (AI) segment.