A single blood luteinizing hormone level of triptorelin stimulation test can diagnose hypothalamic-pituitary-gonadal axis activation in girls with high body mass index.

Background: Body mass index (BMI) may influence peak luteinizing hormone (PLH) levels during gonadotropin releasing hormone (GnRH) or GnRH analogues stimulation testing. BMI effects should be considered when interpreting test results for pubertal disorders in girls with overweight/obesity, but few studies have excluded it.

Methods: This was a hospital data-based retrospective study.

Genome-wide identification of xyloglucan endotransglucosylase/hydrolase genes in almond and PdXTH2 overexpression induces cell structural disassembly and promotes programmed cell death progression.

The xyloglucan endotransglucosylase/hydrolase (XTH) gene family plays a crucial role in fruit development and texture regulation. We used the telomere-to-telomere genome of 'Wanfeng' almond to identify and analyse the XTH gene family, examining protein physicochemical properties, phylogenetic relationships, protein conserved motifs, gene structure, gene replication, and expression patterns. We identified 23 PdXTH family members through the telomere-to-telomere level genome of 'Wanfeng' almond.

Molecular detection and phylogenetic analysis of lumpy skin disease virus in Yunnan Province, China from 2019 to 2023.

The lumpy skin disease (LSD), caused by the lumpy skin disease virus (LSDV), represents an emerging infectious disease that poses substantial economic losses to the cattle industries in China. This study aimed to investigate the epidemiological characteristics of LSDV in Yunnan Province, Southwest China, from 2019 to 2023. A Taqman-probe-based real-time PCR (qPCR) assay was developed for the molecular detection of LSDV nucleotides.

Next-generation antifungal drugs: Mechanisms, efficacy, and clinical prospects.

Invasive fungal infections (IFIs) have become prominent global health threats, escalating the burden on public health systems. The increasing occurrence of invasive fungal infections is due primarily to the extensive application of chemotherapy, immunosuppressive therapies, and broad-spectrum antifungal agents. At present, therapeutic practices utilize multiple categories of antifungal agents, such as azoles, polyenes, echinocandins, and pyrimidine analogs.

In situ generation of zero-valent copper on swine manure-derived hydrochar: A waste-born catalyst for enhanced oxytetracycline degradation via peroxymonosulfate activation.

This study investigated the use of zero-valent copper (Cu) nanoparticles-loaded hydrochar (Cu-HC), derived from swine manure waste, as a sustainable catalyst for activating peroxymonosulfate (PMS) to degrade oxytetracycline (OTC). The in-situ generated Cu nanoparticles during the pyrolysis process of biomass played a pivotal role in establishing electron-transfer pathways, enabling the Cu-HC/PMS system to achieve nearly 100 % degradation within 30 min-outperforming both the HC/PMS system (77.1 %) and the bare PMS system (42.