Publications by authors named "Azucena Gonzalez-Coloma"

Endophytic fungi produce a diverse range of bioactive secondary metabolites with potential applications in biopesticide development. This study investigates the nematicidal and antifeedant properties of ethyl acetate extracts from endophytic fungi isolated from wild Arabidopsis thaliana populations in Spain. The extracts were tested against the plant-parasitic nematode Meloidogyne javanica, and two common insect pests, Myzus persicae and Spodoptera littoralis.

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is a destructive phytopathogen responsible for crown rot, trunk canker, and root rot in over 5,000 plant species worldwide. Despite its significant impact, the molecular interactions between this oomycete and host plants are not well understood. This study aimed to investigate the physiological and molecular responses of (tomato) to infection.

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In the current work, the production of dioxolanone and meroterpene type secondary metabolites under different fermentation conditions by the endophytic fungus Phyllosticta capitalensis (isolate YCC4) isolated from the leaves of the endemic plant Persea indica has been evaluated. Different techniques, such as microparticle-enhanced culture (MPEC: bentonite, talcum powder) and surface adhesion fermentation (SAF: metallic mesh and glass wool) were applied to the culture medium. Ethyl acetate extracts from different fermentations of the isolate YCC4 were analyzed for their content and revealed the following dioxolanone derivatives: metguignardic acid (1), guignardianone C (2), ethyl guignardate (3), guignardianone D (4) and phenguignardic acid methyl ester (5), and meroterpenes: guignardone A (6) and B (7), guignarenone C (8), guignarenone B (9) and guignardone I (10).

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Endolichenic fungi represent an important ecological group of microorganisms that form associations with photobionts in the lichen thallus. These endofungi that live in and coevolve with lichens are known for synthesizing secondary metabolites with novel structures and diverse chemical skeletons making them an unexplored microbial community of great interest. As part of our search for new phytoprotectants, in this work, we studied the endolichenic fungus sp.

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The search for natural product-based biopesticides from endophytic fungi is an effective tool to find new solutions. In this study, we studied a pre-selected fungal endophyte, isolate YCC4, from the paleoendemism , along with compounds present in the extract and the identification of the insect antifeedant and nematicidal ones. The endophyte YCC4 was identified as sp.

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Article Synopsis
  • * Various reactions led to the development of new structures, including isomerization and rearrangement into longibornane and himachalane derivatives, with the molecular characterization performed using advanced techniques like NMR and mass spectrometry.
  • * The resulting longipinene derivatives displayed moderate to high insecticidal activity against certain insects and showed significant root growth inhibition in certain plants, along with notable ixocidal and nematicidal effects.
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  • The text addresses corrections made to the article referenced by DOI: 10.3389/fpls.2022.804104.* -
  • These corrections likely involve updates or clarifications to the research findings or data presented in the original article.* -
  • This ensures the integrity and accuracy of the published scientific work in the field of plant sciences.*
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The continuous search for natural product-based biopesticides from fungi isolated from untapped sources is an effective tool. In this study, we studied a pre-selected fungal endophyte, isolate Aa22, from the medicinal plant Artemisia absinthium, along with the antifungal, insect antifeedant and nematicidal compounds present in the extract. The endophyte Aa22 was identified as Stemphylium solani by molecular analysis.

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This work presents the biocidal effects and chemical compositions of two essential oils (EOs) obtained by hydrodistillation of subsp and subsp. . The two subspecies studied had different chemical composition, when analysed by gas chromatography coupled to mass spectrometry with 1,8-cineole (56.

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  • The essential oil (EO) from an African medicinal plant was analyzed and found to mainly contain benzyl isothiocyanate (96.23%), which exhibited significant insect antifeedant and nematicidal activities against various pests and root-knot nematodes.
  • The oil effectively impacted insect feeding patterns, with specific efficient doses noted, while it showed potent activity against nematode juveniles and inhibited egg hatching significantly.
  • While the EO suppressed germination and growth of ryegrass and reduced tomato root growth, it demonstrated selective effects on crops, indicating its potential use for sustainable pest control in agriculture.
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  • Cannabis has been historically used to alleviate pain and nausea in cancer patients undergoing chemotherapy and radiotherapy, mainly due to compounds like THC and CBD.
  • Research indicates that cannabinoids may have an antitumor effect, but conflicting results have limited their clinical application.
  • A study analyzing extracts high in CBD showed that these extracts can increase cell mortality by inhibiting cytochrome c oxidase activity, suggesting oxidative stress may play a crucial role in their potential benefits against cancer.
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Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as that cause disease in humans and animals, and that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments.

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In this work, we have studied the benzofurans of (aerial parts and transformed roots), (aerial parts and transformed roots), (aerial parts), and (aerial parts and roots). This work has permitted the isolation of the new benzofurans 10-ethoxy-11-hydroxy-10,11-dihydroeuparin (), (-)-eupachinin A ethyl ether (), 11,15-didehydro-eupachinin A (), 10,12-dihydroxy-11-angelyloxy-10,11-dihydroeuparin (), 2,4-dihydroxy-5-formyl-acetophenone () isolated for the first time as a natural product, 11-angelyloxy-10,11-dihydroeuparin (), and 12-angelyloxyeuparone (), along with several known ones (-). In addition, the incubation of the abundant component, 6-hydroxytremetone (), with the fungus has been studied.

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The development of strains with high cannabidiol (CBD) and low tetrahydrocannabinol (THC) content is a growing field of research, both for medical and recreational use. However, the mechanisms behind clinical actions of cannabinoids are still under investigation, although there is growing evidence that mitochondria play an important role in many of them. Numerous studies have described that cannabinoids modulate mitochondrial activity both through activation of mitochondrial cannabinoid receptors and through direct action on other proteins such as mitochondrial complexes involved in cellular respiration.

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  • A flagellated protozoan causes avian trichomonosis in birds, and resistant strains to the common treatment highlight the need for new therapies.
  • The study tested 36 essential oils (EOs) from Lamiaceae and Asteraceae against the protozoan, finding some Lamiaceae EOs to be particularly effective.
  • Key compounds like α and β-thujones and linalyl acetate showed promise in treating the infection with limited cytotoxicity, suggesting Lamiaceae plant products could serve as viable alternative treatments.
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  • Plant essential oils (EOs) are becoming popular as biopesticides for protecting crops, offering insecticidal, acaricidal, fungicidal, and nematicidal properties.
  • The cultivation of Medicinal and Aromatic Plants (MAPs) for EOs supports conservation and sustainability, while also ensuring consistent active ingredients.
  • EOs not only target pests directly but can also enhance plant defenses, aligning with the EU's goal of promoting sustainable agricultural practices by prohibiting harmful plant protection products.
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Active metabolites from plants are considered safer than synthetic chemicals for the control of plant-parasitic nematodes of the genus . In the present work, 75 aqueous extracts (AEs) from different vegetative parts of 34 native plant species of the Yucatan Peninsula were evaluated against second-stage juveniles (J2s) of and in microdilution assays. The highest mortality (M) against both species was produced by the foliar AE from (M ≥ 94%) and (M ≥ 77%) at 3% / after 72 h.

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The chemical composition of essential oils (EOs) from ten Peruvian Piper species (Piper coruscans, Pc; P. tuberculatum, Pt; P. casapiense, Pcs; P.

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The hydrolate byproduct resulting from the industrial essential oil extraction of Spanish purple garlic has been studied against the root-knot nematode by in vitro and in vivo bioassays. The essential oil, the hydrolate and its organic fraction caused high mortality of juveniles, suppressed egg hatch, and reduced nematode infection and reproduction on tomato plants. The nematicidal compounds of garlic oil, diallyl disulfide and diallyl trisulfide, were the major components of the hydrolate organic fraction.

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In this work, we studied the direct and indirect plant protection effects of an essential oil (AEO) on tomato seedlings against sp. (). AEO exhibited a toxic effect against .

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In the present work, 27 triterpene derivatives have been subjected to 3D-QSAR, ADME-Tox, and molecular docking for their insecticidal activity. The selected derivatives are previously semi-synthesized based on compounds obtained from and latex. The in silico studies were used to predict and to evaluate the antibacterial and insecticidal properties of the 3D structure of triterpene derivatives.

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  • * The analysis revealed that the wild tree's leaves had greater chemical diversity than stems, while the aeroponic plants showed less variation, with roots having the least diversity; however, ryanoids were present in all parts.
  • * Our findings indicated that while stem extracts were particularly effective against insects, leaf extracts contributed to antifeedant activity as well; selecting specific seedlings before cultivation could enhance the production of potent extracts.
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  • The production of reactive oxygen species (ROS) increases during cellular stress, leading to damage in lipids, proteins, and nucleic acids, with varying sensitivity across different tissues.
  • Antimalarial drugs, like atovaquone and quinidine, were tested for their effects on superoxide production in human tissues, revealing significant differences in their safety profiles based on tissue type.
  • The study utilized cell membrane microarrays to assess superoxide production influenced by mitochondrial activity and specific inhibitors, helping to characterize the potential oxidative toxicity of these drugs.
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Tick control is a priority in order to prevent the transmission of vector-borne diseases. Industrial chemical acaricides and repellents have been the most efficient tools against hard ticks for a long time. However, the appearance of resistances has meant the declining effectiveness of the chemicals available on the market.

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