Recent Advancement in Drug Designing as Small Molecules in Targeted Cancer Therapy: Challenges and Future Directions.

The adverse outcome that patients experience as a result of anti-cancer therapy failure is primarily caused by metastasis. Making cancer a chronic disease with regular but controlled relapses is the real issue in increasing cancer patient lifespans. This can only be achieved by developing efficient therapeutic techniques that target critical targets in the metastatic process.

Recent Advances and Clinical Approach to Cancer Treatment with Nanotechnology Derived Biomolecule.

Cancer nanomedicine has the potential to take advantage of the multifunctionality and diverse biological activity of nanostructures based on biomolecules. Novel drug delivery vehicles can be designed by programming the supramolecular features of biomolecules to achieve multiple therapeutic goals at once, including efficient in vivo transport and targeted drug administration. Proteins, peptides, nucleic acids, and polysaccharides can all be engineered into multipurpose nanomedicines.

Transformation of PMMA from sunlight-blocking to sunlight-activated coupled with DNH photocatalytic platform for oxidative coupling of amines and generation/regeneration of LDC/NADH.

The photocatalytic oxidation and generation/regeneration of amines to imines and leucodopaminechrome (LDC)/NADH are subjects of intense interest in contemporary research. Imines serve as crucial intermediates for the synthesis of solar fuels, fine chemicals, agricultural chemicals, and pharmaceuticals. While significant progress has been made in developing efficient processes for the oxidation and generation/regeneration of secondary amines, the oxidation of primary amines has received comparatively less attention until recently.

Therapeutic approaches in COVID-19 followed before arrival of any vaccine.

In present times covid-19 is spreading and is showing very destructive effects. It does not only affected the physical health but mental health as well as the economy of the major affected countries. orona viruses are group of related RNA viruses.

Complexation of an Azo Dye by Cyclodextrins: A Potential Strategy for Water Purification.

The chemistry of the host-guest complex formation has received much attention as a highly efficient approach for use to develop economical adsorbents for water purification. In the present study, the synthesis of three β-cyclodextrin (β-CD) inclusion complexes with the oil orange SS (OOSS) azo dye as a guest molecule and their potential applications in water purification are described. The complexes were synthesized by the coprecipitation method and characterized by Fourier transform infrared (FTIR) spectroscopy, UV-vis spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC).

Facile synthesis of novel two- and three-dimensional coordination polymers containing dialkyltin phosphonate-based tri/tetra-nuclear clusters with appended sulfonate groups.

The coordination-driven self-assemblies of mixed-ligand dialkyltin derivatives, [(Et(2)Sn)(4) (O(2)P(OH)Me)(2)(O(3)PMe)(2)(OSO(2)Et)(2) x 2 H(2)O](n) 1, [(Et(2)Sn)(3)(O(3)PMe)(2)(OSO(2)Me)(2) x CHCl(3)](n) 2, and [(Me(2)Sn)(3)(O(3)PBu(t))(2)(OSO(2)Me)(2) x 2 CHCl(3)](n) 3 have been achieved by reacting the tin precursors, [R(2)Sn(OR(1))(OSO(2)R(1))](n) (R = Et, R(1) = Et (1a), Me (2a); R = Me, R(1) = Me (3a)) with an equimolar amount of methylphosphonic/t-butylphosphonic acid under mild conditions (rt, 8 h, CH(2)Cl(2)). These have been characterized by IR and multinuclear ((1)H, (13)C, (31)P, and (119)Sn) NMR spectroscopy as well as single crystal X-ray diffraction. The asymmetric unit of 1 is composed of a tetranuclear, Sn(4)(mu(2)-PO(2))(2)(mu(3)-PO(3))(2) core bearing an appended ethanesulfonate group on each terminal tin (Sn2) atom and two P(OH).

Synthesis, characterization, and structural studies of mixed-ligand diorganotin esters, [R2Sn(OP(O)(OH)Ph)(OS(O)2R1)]n [R = n-Bu, R1 = Me (1), n-Pr(2); R = Et, R1 = Me (3)] with 1D and 3D coordination polymeric motifs.

Mixed-ligand diorganotin esters, [R 2Sn(OP(O)(OH)Ph)(OS(O) 2R (1))] n [R = n-Bu, R (1) = Me ( 1), n-Pr ( 2); R = Et, R (1) = Me ( 3)], have been synthesized by reacting the tin precursors, R 2Sn(OR (1))OS(O) 2R with an equimolar amount of phenylphosphonic acid under mild conditions (room temperature, 6-8 h, CH 2Cl 2). These have been characterized by IR, multinuclear ( (1)H, (13)C{ (1)H}, (31)P, and (119)Sn) NMR, and single crystal X-ray diffraction studies. The asymmetric unit of 1 is comprised of a tetramer with four crystallographically unique tin atoms.

Recipe for new diorganostannates, [R2Sn(OS(O)2R1)4]2-, bearing alkanesulfonate groups using dialkyl sulfite as the reagent.

A one-pot reaction between di-n-propyl/di-n-butyltin oxide, dialkyl sulfite, and triethylamine or tetra-n-alkylammonium iodide proceeds under ambient conditions (110-120 degrees C, 20 h) via sulfur-centered Arbuzov rearrangement to afford the corresponding dianionic tetraalkanesulfonato diorganostannates [R2Sn(OSO2Me)4].2Et3NMe [R = n-Pr (1), n-Bu (2)] as well as [n-Bu(2)Sn(OSO(2)R(1))(4)].(2)R(2)(4)N [R(1) = Me, Et, n-Pr; R(2) = Et (3, 5, and 7), n-Bu (4, 6, and 8)].

Expanding the scope of sulfur-centered Arbuzov rearrangement in diethyl/di-n-propyl sulfite for the synthesis of mixed-ligand di-n-butyltin alkanesulfonates.

A one-pot reaction between di-n-butyltin oxide and diethyl/di-n-propyl sulfite in the presence of an equimolar amount of alkyl iodide proceeds via sulfur-centered Arbuzov rearrangement to afford the corresponding di-n-butyltin (alkoxy)alkanesulfonates n-Bu2Sn(OR')OS(O)2R [R = R' = Et (1), n-Pr (2); R = Me, R' = Et (3), n-Pr (4)]. The compounds 1 and 3 react with methylphosphonic acid under mild conditions to give [n-Bu2Sn(OS(O)2R)OP(O)(OH)Me]n [R = Et (5), Me (6), respectively].