Cardiac myosin inhibitors - a cutting-edge solution for the management of hypertrophic cardiomyopathy: a narrative review.

Background: Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder characterized by unexplained left ventricular hypertrophy, affecting approximately 0.2% of the global population. Around 40% of HCM cases are linked to mutations in sarcomeric protein genes such as β-myosin heavy chain and myosin-binding protein C, which impair calcium signaling and myocardial contractility.

The relationship between autism spectrum disorder and screen time in children: a literature review.

Background: Autism spectrum disorder (ASD) affects millions of children globally, significantly impacting their quality of life. Understanding factors that contribute to symptoms, is essential for improving outcomes. This review aims to explore the relationship between screen time and ASD and provide insights for targeted interventions.

Tethered cord syndrome (TCS) and constipation in children: a multifaceted approach (literature review).

Tethered cord syndrome (TCS) is estimated to affect approximately 25 per 100 000 live births. Despite advancements in medical knowledge and technology, the persistence of this issue is attributed to challenges in early detection and limited awareness, often resulting in undiagnosed cases until adulthood. Constipation serves as a noteworthy symptom in children with TCS, yet it frequently goes unnoticed or is ascribed to other causes, leading to delayed diagnosis and negatively impacting a child's quality of life.

The impact of intraosseous vs intravenous vascular access during resuscitation in out-of-hospital cardiac arrest: A comprehensive systematic review and meta-analysis.

Background: Out-of-hospital cardiac arrest (OHCA) is a known cause of mortality worldwide, especially in Western countries. One of the various treatment strategies includes vascular access for the administration of life-saving drugs such as epinephrine and lidocaine. While intravenous (IV) access is traditionally performed, recent studies have evaluated the use of intraosseous (IO) access as an alternative.

Role of Artificial Intelligence in Drug Discovery to Revolutionize the Pharmaceutical Industry: Resources, Methods and Applications.

Traditional drug discovery methods such as wet-lab testing, validations, and synthetic techniques are time-consuming and expensive. Artificial Intelligence (AI) approaches have progressed to the point where they can have a significant impact on the drug discovery process. Using massive volumes of open data, artificial intelligence methods are revolutionizing the pharmaceutical industry.

Traditional Herbal Medications Utilized in the Indian Medical System forthe Management of Diabetes: An Updated Review and Clinical Implications.

Phytomedicine, also called botanical medicine, is the practice of using plants to treat disease. Diabetes, for example, has been treated and prevented with herbal medication for a lot longer than Western medicine. Worldwide, diabetes has become a major health concern.

Cubosomes: An Emerging and Promising Drug Delivery System for Enhancing Cancer Therapy.

Cancer and other diseases can be treated with cubosomes, which are lyotropic nonlamellar liquid crystalline nanoparticles (LCNs). These cubosomes can potentially be a highly versatile carrier with theranostic efficacy, as they can be ingested, applied topically, or injected intravenously. Recent years have seen substantial progress in the synthesis, characterization, regulation of drug release patterns, and target selectivity of loaded anticancer bioactive compounds.

Automation of Drug Discovery through Cutting-edge Research in Pharmaceuticals: Challenges and Future Scope.

The rapidity and high-throughput nature of technologies make them advantageous for predicting the properties of a large array of substances. approaches can be used for compounds intended for synthesis at the beginning of drug development when there is either no or very little compound available. approaches can be used for impurities or degradation products.

Recent Progress and Challenges in the Development of Edible Vaccines Produced by Genetically Modified Plants.

Biotechnologists have pioneered the idea of an edible vaccination in recent years. Subunit vaccines, such as those used to create edible vaccines, involve the introduction of certain genes into transgenic plants, which are subsequently coaxed into producing the corresponding protein. Bananas, potatoes, legumes, lettuce, soybeans, corn, and rice are all examples of foods that fall under this category.