Effectiveness of Local Mother's Kitchen Recipe Talks in Reducing the Burden of Anemia Among Children Under Five, Adolescents, Pregnant Women, and Lactating Mothers in Guntur District, India: A Community-Based Intervention Trial.

Background Iron deficiency anemia remains a significant public health concern, particularly among vulnerable groups such as children under five, adolescents, pregnant women, and lactating mothers in low- and middle-income countries. Sustainable, community-driven dietary interventions leveraging locally available foods could provide a culturally acceptable alternative. Objective This study assesses the effectiveness of a community-based intervention that incorporates local mother's kitchen recipes and nutrition education talks in enhancing hemoglobin and dietary iron intake levels among targeted groups in the Guntur District, India.

Burden and predictors of peripheral neuropathy among cultivators and laborers using biothesiometer at primary healthcare setting: A cross-sectional study from Nutakkhi, Guntur, Andhra Pradesh.

Background: Peripheral neuropathy has a wide range of causes and subtle symptoms, making it difficult to diagnose. This study aimed to determine the prevalence of peripheral neuropathy among cultivators and laborers in a Center for Rural Health AIIMS (CRHA) primary healthcare center in Nutakki, Guntur District, Andhra Pradesh. The study-associated risk factors, early detection, and prevention strategies can be implemented to improve their health outcomes.

Profiling of outpatients attending Centre for Rural Health, Nutakkhi, Andhra Pradesh, South India.

Background: Primary healthcare services are the first contact point for a person to seek preventive promotive and curative healthcare. The present study aimed to assess the morbidity profile of outpatients at a Centre for Rural Health AIIMS, Nutakkhi, Andhra Pradesh, South India.

Materials And Methods: This record-based study analyzed morbidity data from outpatients at the Centre for Rural Health AIIMS (CRHA), located in Nutakkhi, Andhra Pradesh, South India, serving a population of about 15,000.

A review on targeting tunable nanocarrier interaction, physiochemical properties, and futuristic nanocarrier.

Targeting nanotechnology has emerged as a promising approach in drug delivery systems, offering enhanced therapeutic efficacy and reduced side effects. The physicochemical properties of nanocarriers largely influence the interaction of the nanocarrier within the body and its intended targets. Factors such as size, shape, surface charge, and elasticity play crucial roles in determining the nanocarrier's ability to navigate biological barriers, evade the immune system, and selectively accumulate at the target site.

Unmasking the Long-Term Effects of COVID-19 With a Focus on Chronic Fatigue Syndrome: A Community-Based Study From India.

Background The COVID-19 pandemic has highlighted the enduring health burden of long COVID, scientifically termed the postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or PASC. Long COVID manifests as diverse symptoms affecting multiple organ systems, significantly impacting individuals globally, and especially underrepresented rural populations. Objective This study aimed to evaluate the prevalence of chronic fatigue syndrome (CFS) among laboratory-confirmed COVID-19 patients in rural India, focusing on identifying its predictors and the implications for healthcare systems in resource-limited settings.

Pluronics® F68 and D-α-tocopheryl polyethylene glycol succinate 1000 tailored self-assembled mixed micelles to improve oral bioavailability of oleanolic acid: in vitro and in vivo characterization.

Oleanolic acid (OA) ischaracterized by its low water solubility, poor permeability and majorly metabolized by cytochrome P450 (CYP) isozymes in the intestinal tract, particularly CYP3A, which contribute to the low oral bioavailability. OA has multiple pharmacological actions including hepatoprotective, anti-inflammatory, antidiabetic and antiviral effects. OA classified as a BCS IV drug which have restricted its potential clinical application.

Phytochemical baicalin potentially inhibits Bcl-2 and VEGF: an approach.

Background: The rising prevalence of cancer cells exhibits uncontrolled growth and invasive and aggressive properties, leading to metastasis, which poses a significant challenge for global health. Central to cancer development are proteins such as NF-kB, p53, VEGF, and BAX/Bcl-2, which play important roles in angiogenesis, cell apoptosis regulation, and tumor growth.

Methodology: This study evaluates the activity of six different natural as well as novel therapeutic strategies against cancer.

Virtual perspectives of sanguinarine on cancer prevention and treatment through molecular dynamic study.

Cancer prevention involves resisting cancer development at initial stages, retarding angiogenesis and initiating cancer cell apoptosis. Through the use of virtual screening, binding free energy calculations, and molecular dynamics simulations, we were able to identify compounds with potential anticancer activity."During the virtual screening process, compounds with promising drug-like properties were chosen using the Lipinski rule of five, and their binding affinities were evaluated by docking studies.

Anemia Across Lifespans in Rural South India: A Comprehensive Study of Age and Gender Dynamics From the Field Practice Area of Centre for Rural Health (CRHA), Nutakki, Andhra Pradesh.

Background: Anemia is a significant public health issue in rural India, with a very big impact on health and productivity. This study investigates the prevalence and severity of anemia stratified by age and gender in a village in Southern India, using different guidelines.

Methods:  Retrospective data (n=3523) from a 2023 anemia survey done in the field area at Chirravuru under the Centre for Rural Health AIIMS (CRHA), Primary Health Centre (PHC), Nutakki (a peripheral unit of All India Institute of Medical Sciences {AIIMS}, Mangalagiri) covering 90% of the estimated population of the village was taken for the study.

Modular Architecture of Retinal Layers in Diabetic Patients Without Retinopathy.

Purpose Diagnosing diabetic retinopathy (DR) in the pre-clinical stage is crucial to reversing DR. This study aimed to compare the retinal thickness changes between healthy controls (HCs) and diabetics without retinopathy (DWORs). For the first time, we would like to introduce the concept of network modularity analysis in studying retinal networks to demonstrate disrupted retinal layer organization as evidence of subclinical retinopathy.

Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study.

Hair follicle growth process through several well-organized stages with specific input by several signaling pathways including Wnt/β-catenin and Sonic Hedgehog with GSK3β in this process. As such, this research focus on investigating the efficacy of molecules that are able to inhibit GSK3β action in inducing hair regrowth. Applying computational techniques, three compounds NMN, Resveratrol and EGCG were analyzed for their GSK3β inhibition.

Enhancing adolescent health awareness: impact of online training on medical and community health officers in Andhra Pradesh, India.

Objectives: The present study was done to study the knowledge change among Medical Officers (MO) and Community health officers (CHO) regarding menstrual hygiene, early marriages, and HIV/STI with emphasis on adolescents after online training.

Methods: This is a retrospective record-based analysis conducted in the State Adolescent Health Centre, AIIMS Mangalagiri, Andhra Pradesh in 2023-2024 over 10 months. Participants were selected based on their attendance at online training sessions involving MOs and CHOs on menstrual cups, menstrual hygiene, early marriages, and HIV/STI.

PSMA-RADS to improve evaluation and management of prostate cancer.

Prostate-Specific Membrane Antigen (PSMA) positron emission tomography (PET) / computed tomography (CT) has become essential in managing prostate cancer, offering superior diagnostic accuracy. The introduction of the U.S.

A retrospective study to assess adolescent nutritional deficiencies and the association with post-COVID-19 status.

Introduction: Adolescents represent 16% of the world's population and around 21% of the Indian population. A study was done to assess the double burden of malnutrition, the proportion of inadequate intake of some important macronutrients and micronutrients, and the impact of COVID-19 pandemic on nutrient intakes among adolescents.

Methodology: Retrospective data analysis of the adolescents presented at the Adolescent Health Clinic at a teaching hospital (tertiary care level) in Andhra Pradesh, India, between September 2022 and December 2022 was done in the current study.

A Retrospective Study of the Profiles of Outpatients Attending the State Adolescent Friendly Health Resource Center, Andhra Pradesh, South India.

Background: Adolescents compose a significantly large age group, and attention to their health needs is lacking due to insufficient data and policy implementation globally and in India. India, having 268 million adolescents, faces the world's largest adolescent population, which highlights the importance of addressing their health requirements. The aim of this study was to describe the morbidity profiles of adolescent patients attending the State Adolescent Friendly Health Resource Centre at a tertiary-level healthcare institution in South India.

Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management.

Cancer prevention is currently envisioned as a molecular-based approach to prevent carcinogenesis in pre-cancerous stages, i.e., dysplasia and carcinoma .

Effects of the Decrease in Blood Lead Levels on Renal and Neurological Functions Among Occupationally Exposed and Unexposed Populations of South India: A Cohort Study.

Introduction: Exposure to lead in excess of the permissible limit is a known risk factor leading to preventable morbidity. The present study aimed to assess whether there is a change in the neurological and renal parameters among adults with blood lead levels (BLLs) higher than recommended at baseline and after prevention among differently exposed adults.

Methodology: In the Guntur District of Andhra Pradesh, India, a cohort study was carried out in 2022-2023 among 180 adult males and females aged 20 to 60 years in three groups: direct occupational exposure, indirect occupational exposure, and no occupational exposure.

Alarming levels of inadequate intake of B group vitamins in tribal lactating women from South India.

Background: Micronutrients are necessary for proper growth and development of the human body, though required in small amounts. Dietary intake of these micronutrients by lactating women is essential for their own health as well as children's overall growth and development. objective of present study is to assess the adequacy of dietary B-group vitamins intake during lactation and to find out the factors associated with their inadequate intake.

"Prevalence, Predictors, and Impact of Hepatic Steatosis in Patients With Ulcerative Colitis: A Prospective Observational Cohort Study".

Background And Aims: There are no prospective studies evaluating effect of non-alcoholic fatty liver disease (NAFLD) in patients with ulcerative colitis (UC). This prospective observational study assessed the prevalence of NAFLD, its predictors, and its effect on long-term outcomes in UC.

Methods: Consecutive UC patients underwent transient elastography, body composition analysis, bone densitometry, anthropometry, and baseline demographic and subjective global assessment.

Prevalence of Undernutrition Among Tribal Lactating Mothers in Andhra Pradesh, India.

Background In Andhra Pradesh, India, tribal communities face unique nutritional challenges due to limited access to healthcare and a predominantly plant-based diet. Maternal undernutrition is a significant concern, impacting the well-being of both mothers and their offspring. This study focuses on assessing the prevalence of undernutrition among tribal mothers in Andhra Pradesh using the BMI-for-age criterion.

Study on knowledge of front-of-pack labeling and food group-based dietary intake among chronic gastritis patients.

Introduction: Chronic gastritis is one of the most prevalent disorders affecting individuals, which affects hundreds of millions of people in different ways around the world. The significant incidence of poor dietary quality and diet-related illnesses may be addressed by orienting customers toward healthier food options. The objective of the study was to estimate the knowledge of front-of-package labels (FoPLs) and food group-based dietary intake of nutrients among patients with chronic gastritis.

Menstrual cup webinar series: A developing model of modified pre- and post-tests in the online teaching-learning of primary health care workers.

Menstrual hygiene management, especially in resource-limited settings, is challenging. The acceptability of the menstrual cup is increasing recently in western countries whereas, in developing countries like India, the awareness, acceptability, and use of menstrual cups are very limited. We assessed the effectiveness of modified pre-post-test teaching-learning methodology in an online webinar series on menstrual cups using Moore's outcome assessment.

Gum-based Nanoparticles Targeting for Colon Rectal Cancer: Latest Research and Patents.

Colorectal disease is the third most prevelant cancer in both men and women, with an expected 106,180 new cases of colon cancer and 44,850 new cases of rectal cancer as per American Cancer Society. Targeted medicine delivery is vital in the treatment of colon disorders because it delivers long-term therapeutic results with little side effects. Natural polymer is biocompatible and biodegradable, which enables safety, improves storage, and physiological stability, it is utilized as drug delivery vehicles and has made great strides in recent years.

Inhibition of resuscitation-promoting factor B (RpfB) by microbially derived natural compounds: a computational study.

The majority of the world population (around 25%) has latent Mycobacterium tuberculosis (Mtb) infection, among which only 5-10% of individuals develop active tuberculosis (TB), and 90-95% continue to have latent tuberculosis infection. This makes it the biggest global health concern. It has been reported that the resuscitation-promoting factor B (RpfB) is an exciting potential target for tuberculosis drug discovery due to its significant role in the reactivation of latent TB infection to an active infection.