Comparison of efficacy and accuracy of tooth movements in optimized and conventional attachments of clear aligners - A systematic review and meta-analysis.

Aim: This systematic review and meta-analysis aimed to compare the efficacy and accuracy of optimized versus conventional attachments in clear aligner treatment using Invisalign.

Materials And Methods: Adhering to the 'Preferred Reporting Items for Systematic Review and Meta-analysis' (PRISMA) 2020 guidelines, the review obtained 6 retrospective cohort studies and one randomized controlled trial, sourced from databases such as PubMed, SCOPUS, Web of Science, Cochrane Library, Google Scholar, and clinical trial registries. Four studies were included for meta-analysis.

Role of the rs6184 growth hormone receptor gene polymorphism in mandibular morphogenesis.

Background: Polymorphisms in the growth hormone receptor (GHR) gene influence the craniofacial system by affecting the growth of the mandibular body length and ramal height, with significant variations observed across different ethnic populations. This study investigated the relationship between a single nucleotide polymorphism (rs6184) in the GHR gene and its effects on mandibular morphogenesis in a Dravidian population.

Methods: A total of 250 subjects were divided into three groups.

Role of ACTN3 Gene rs1815739 Polymorphism and Its Effects on Mandibular Morphogenesis.

Objectives: Genetic polymorphism of the α-actinin-3 (ACTN3) gene has an influence on the facial skeletal profile, with the activity of the α-actinins protein influencing the contractile properties of the masseteric muscles. This study examines the association between the ACTN3 rs1815739 polymorphism through a Stop Codon (changing 577RR to 577XX) resulting in variations in mandibular morphogenesis.

Materials And Methods: Two hundred and fifty subjects were categorised into three groups.

Differential impact of CD34+ cell dose for different age groups in allogeneic hematopoietic cell transplantation for acute leukemia: a machine learning-based discovery.

Allogeneic hematopoietic cell transplantation (allo-HCT) presents a potentially curative treatment for hematologic malignancies yet carries associated risks and complications. Continuous research focuses on predicting outcomes and identifying risk factors. Notably, the influence of CD34+ cell dose on overall survival (OS) has been the subject of numerous studies yielding contradictory results.

Mechanism of Action of Green-Synthesized Silver Nanoparticle-Incorporated Dental Varnish Against Candida albicans.

Introduction:  , a common fungal pathogen, is often associated with oral infections such as denture stomatitis. Dental varnishes, especially those incorporating antimicrobial agents, have shown promise in preventing colonization. This study investigates the antifungal efficacy of a dental varnish incorporating green-synthesized silver nanoparticles (AgNPs) using and extracts.

Evaluation of Antimicrobial Efficiency, Shear Bond Strength, and Adhesive Remnant Index of TiO Infiltrated Orthodontic Adhesive - An Study.

Background: Enamel demineralization is an unavoidable adverse effect encountered with bonding brackets in orthodontic therapy. Introducing nanoparticles into the composite adhesive paste can prevent enamel demineralization. Titanium dioxide (TiO) is known to exhibit direct antimicrobial efficiency.

Evaluation of Antibacterial Effects of an Oral Rinse Containing Ocimum tenuiflorum and Ocimum gratissimum on Streptococcus mutans and Lactobacillus Species.

Background And Aim: Dental caries, primarily caused by and Lactobacillus spp., is a major global health issue. There is a growing need for effective, natural antimicrobial treatments.

Evaluating the Remineralizing Effects of Calcium Sucrose Phosphate and Casein Phosphopeptide-Amorphous Calcium Phosphate Toothpastes on Artificial Carious Lesions Using Micro-computed Tomography: An In Vitro Investigation.

Background White spot lesions (WSLs) are common early indicators of enamel demineralization, particularly in pediatric orthodontic patients. Effective remineralization of these lesions is crucial for preventing further dental decay. This study aimed to evaluate the three-dimensional remineralization efficacy of two commercial toothpastes, calcium sucrose phosphate (CaSP) and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), using micro-computed tomography (micro-CT).

Three-dimensional analysis of the potency of Cocos nucifera in demineralizing the artificial enamel carious lesion: a micro-CT study.

Background: Herbal based ingredients form a more sustainable and effective means for management of ailments related to the human body. Previously plant-based extracts of Cocos nucifera had effective remineralization potential. Hence to identify the changes in enamel mineral density and volume during the remineralization procedure, this study was done with an aim of three-dimensional micro-CT analysis to identify the potency of Cocos nucifera in remineralizing the artificial enamel carious lesion.

Remineralization potential of varying concentrations of two plant-based extracts of on white spot lesions using SEM and EDAX analysis: An study.

Aim: To evaluate the remineralization potential of varying concentrations of two plant-based extracts of on white spot lesions using SEM and EDAX testing methods.

Materials And Methods: The pulp was freshly obtained from coconut and divided into two. Then, coconut milk was obtained by blending, while the next portion was freeze-dried and lyophilized.

Assessment of Toxicity of Green Synthesized Silver Nanoparticle-coated Titanium Mini-implants with Uncoated Mini-implants: Comparison in an Animal Model Study.

Aim: To assess the potential for systemic toxicity when silver nanoparticle-coated mini-implants were implanted in Wistar albino rats conducted as a comparative study in the animal model by assessing the blood biochemistry, liver and kidney function, and histology of the implanted site.

Materials And Methods: The surface of the mini-implant was coated with a green-mediated silver nanoparticle. Uncoated mini-implants were placed in two groups of eight Wistar albino rats, and silver nanoparticle-coated mini-implants were placed in another eight rats.

Enamel Remineralization Efficacy of Coconut Milk and Lyophilized Coconut Extract in Different Concentrations on Demineralized Enamel Surfaces: An In-Vitro Study.

Aim The current study's objective is to determine the remineralizing efficacy of freeze-dried lyophilized coconut extract and coconut milk made from freshly grated coconut on artificial carious lesions produced by pH cycling. Materials and methods Freshly extracted coconut pulp was split into two parts. The first half was blended to obtain coconut milk, and the second part was freeze-dried and lyophilized.

Comparison of treatment effects during en-masse retraction of upper anterior teeth placed using mini-implants placed at infrazygomatic crest and interradicular sites: A randomized controlled trial.

Introduction: The objective of this prospective study was to examine the efficacy of posterior interradicular and infrazygomatic crest mini-implants for en-masse anterior retraction.

Methods: The 22 patients were divided into two groups. In group 1 (IZC n = 11), mini-implants were placed in the infrazygomatic crests and in group 2 (IR, n = 11), mini-implants were placed in the molar-premolar interradicular sites.

Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.

In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C4), recently associated with an increased risk of schizophrenia. To design a disease-relevant assay, we first developed a rapid and robust 3D protocol capable of producing large numbers of astrocytes from pluripotent cells.

Morphology and gene expression profiling provide complementary information for mapping cell state.

Morphological and gene expression profiling can cost-effectively capture thousands of features in thousands of samples across perturbations by disease, mutation, or drug treatments, but it is unclear to what extent the two modalities capture overlapping versus complementary information. Here, using both the L1000 and Cell Painting assays to profile gene expression and cell morphology, respectively, we perturb human A549 lung cancer cells with 1,327 small molecules from the Drug Repurposing Hub across six doses, providing a data resource including dose-response data from both assays. The two assays capture both shared and complementary information for mapping cell state.

A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses.

The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic changes, we generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2.

Cephalometric Analysis in Orthodontics Using Artificial Intelligence-A Comprehensive Review.

Artificial intelligence (AI) is a branch of science concerned with developing programs and computers that can gather data, reason about it, and then translate it into intelligent actions. AI is a broad area that includes reasoning, typical linguistic dispensation, machine learning, and planning. In the area of medicine and dentistry, machine learning is currently the most widely used AI application.

Comparative Assessment of pH and Degree of Surface Roughness of Enamel When Etched with Five Commercially Available Etchants: An Study.

Aim: To evaluate the pH and degree of surface roughness caused by five commercially and readily available etchants on tooth enamel.

Materials And Methods: Five different etchants were chosen. An electric pH meter was utilized to test the pH of the etchants employed.

The World Wide Web of orthodontics- A comprehensive narrative on teledentistry pertaining to the orthodontics of the 21 century.

Teledentistry has proven effective in practically all dental fields. It also allows access to inaccessible and underdeveloped locations. Better treatment outcomes were documented in patients treated by an orthodontist supervised by teledentistry than by a general dentist with minimal orthodontic experience alone.

anti-inflammatory activity of silymarin/hydroxyapatite/chitosan nanocomposites and its cytotoxic effect using brine shrimp lethality assay.

Silymarin, a bioactive compound, is one of the most prominent drugs used in liver diseases. Chitosan and hydroxyapatite (HAP) are the major materials used employed in many biomedical processes like drug delivery, osteointegration, etc. The nanoparticles and nanocomposites are advanced materials with many biomedical applications in diagnosis and therapeutics.

Concerns with oral health care services for adults with cognitive and intellectual disabilities.

It is of interest to document data on oral health care services for adults with cognitive and intellectual disabilities. Hence, a study protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO) with registration number: CRD42020150759. We used PubMed, Science Direct, LILACS and SCIELO to collect data from known literature using keywords containing MESH (Medical Subject Headings) terms.

Pain Perception Associated with Mini-Implants and Interventions for Pain Management: A Cross-Sectional Questionnaire-Based Survey.

Background: Orthodontists use mini-implants temporarily as an effective mode of skeletal anchorage devices. The placement of mini-implants can cause pain and discomfort to the patients. Patients often develop swelling, and the pain could interfere with their daily activities.

Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network-based Cellular Signatures drug discovery platform.

Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The common ΔF508-CFTR mutation results in protein misfolding and proteasomal degradation. If ΔF508-CFTR trafficks to the cell surface, its anion channel function may be partially restored.