In Vitro Assessment of Apoptotic and Cell Cycle Arrest Analysis on HepG2 Cells by Polyethylene Glycol-Coupled Selenium Nanocomposite Fabricated From Flowers.

Polymer-encapsulated nanocomposite has been proven to have ameliorative effects in the treatment of cancer. The focused objective of the present research is to fabricate polyethylene glycol (PEG)-based flower selenium nanocomposite (CFF-SeNC). The fabricated CFF-SeNC was characterised using a UV-visible spectrophotometer, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM)-energy dispersive x-ray (EDX), and x-ray diffractometer (XRD) analysis.

Inducing agents and PCOS - A comprehensive analysis.

Polycystic Ovary Syndrome (PCOS) is a severe and heterogeneous endocrine disorder affecting 6-20 % of women of reproductive age globally. Despite its high prevalence, the underlying etiology and pathophysiology remain unclear, necessitating the use of animal models to study disease mechanisms and therapeutic targets. This review critically evaluates various induction agents used in PCOS animal models and their ability to mimic the clinical, metabolic, and reproductive manifestations of the human condition.

An Innovative Phyto-mediated Nanocomposite-modified Glass Ionomer Cement: A Detailed Study on Synthesis, Cytotoxicity, Anti-inflammatory Effects, Antimicrobial Activity, Mechanical Performance, and Solubility.

Background: Glass ionomer cement (GIC), or polyalkenoate cement, is popular for esthetic restorations due to its tooth-bonding ability but suffers from low mechanical strength, abrasion resistance, and moisture sensitivity, leading to the search for better alternatives.

Aim: To evaluate the cytotoxicity, anti-inflammatory, antimicrobial, mechanical properties, and solubility of phyto-mediated nanocomposite-modified GIC.

Materials And Methods: Chitosan-titanium-zirconia-hydroxyapatite (Ch-Ti-Zr-HA) nanocomposites were synthesized using a single-step phyto-mediated process and added to GIC at 3, 5, and 10% concentrations (groups I, II, and III), with conventional GIC as the control (group IV).

: An overview of its magical properties.

, native to the Indian subcontinent, is renowned for its cardioprotective benefits, owing to bioactive compounds like antioxidants and anti-inflammatory agents. Beyond heart health, it is gaining attention for applications in oral health, particularly periodontal therapy, due to its anti-inflammatory and wound-healing properties. Its flavonoids and tannins have demonstrated effectiveness in managing bacteria and inflammation in periodontal pockets.

Antibacterial Properties of Lemon Juice-Mediated Zinc Oxide Nanoparticle and Titanium Dioxide Nanoparticle.

Introduction: The emergence of antibiotic-resistant pathogenic bacteria has become a major global health concern, with the increasing prevalence of infections that are difficult to treat with conventional antibiotics. As a result, there is a critical need for alternative antimicrobial agents that can effectively control bacterial infections and combat the growing problem of antibiotic resistance.

Materials And Methods: In this study, the antibacterial properties of lemon juice mediated zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO2 NPs) was evaluated against oral pathogens.

Assessment of Antimicrobial Activity Against Candida albicans, Streptococcus mutans, Enterococcus faecalis and Staphylococcus aureus and Cytotoxic Effect of the Mouthwash Prepared Using Persea americana and Clove - An In Vitro Study.

Context: A natural mouthwash with minimal side effects is essential for obviating the disadvantages of chemically based mouthwashes. Research has been carried out worldwide using herbal extracts from leaves, stems, seeds, fruits, etc., for various dental purposes.

Green synthesis of silver nanoparticles using neem and turmeric extract and its antimicrobial activity of plant mediated silver nanoparticles.

Introduction: The green synthesis of silver nanoparticles has gained attention for being environmentally friendly and cost-effective. This study investigates the synthesis of silver nanoparticles using neem and turmeric extracts, which serve as natural reducing and capping agents, with a focus on characterizing these nanoparticles and assessing their antimicrobial properties against oral pathogens.

Materials And Methods: Neem and turmeric extracts were prepared by heating their powdered forms in distilled water, followed by filtration.

Enhancing Wear Resistance in Glass Ionomer Cement through Green-mediated Chitosan-, Titanium-, Zirconium-, and Hydroxyapatite-based Nanocomposites: An Analysis before and after Chewing Simulator Endurance.

Aim And Background: Glass ionomer cement (GIC) serves as a widely used restorative dental material, known for its direct bonding to tooth structures and fluoride-releasing properties. This study aims to investigate the enhancement of GIC through the incorporation of a green-mediated nanocomposite comprising chitosan, titanium, zirconium, and hydroxyapatite, with a focus on evaluating the wear resistance of the modified GIC.

Materials And Methods: A one-pot synthesis technique was utilized to prepare a green-mediated nanocomposite incorporating chitosan, titanium, zirconium, and hydroxyapatite nanoparticles.

The Antifungal Activity of Chitosan Nanoparticle-Incorporated Probiotics Against Oral Candidiasis.

Background: Candida species, especially , cause oral candidiasis, also known as oral thrush. It affects the elderly, newborns, patients under antibiotics, chemotherapeutic agents, and patients with weaker immune systems. Although successful, traditional antifungal medications are available, they may have negative effects and do not prevent recurrence.

Formulation and evaluation of Phaseolus lunatus seed coat mediated silver nanoparticles mouthwash: A comprehensive study on biomedical properties and toxicological assessment.

Silver nanoparticles have promising therapeutic potential in the field of dentistry, as newly emerging oral therapeutics, in the form of mouthwashes based on silver nanoparticles, demonstrate significant potential for enhancing oral management thus the present investigation aims to formulate silver nanoparticles-based mouthwash from an aqueous extract of Phaseolus lunatus seed coat (PLSC) and evaluate its biomedical properties. The green synthesized AgNPs in the mouthwash were characterized using UV-visible spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and x-ray diffraction (XRD). The formulated mouthwash was assessed for its anti-microbial activity using the agar well diffusion technique and time-kill curve assay.

Mechanism of Action of Green-Synthesized Silver Nanoparticle-Incorporated Dental Varnish Against Candida albicans.

Introduction:  , a common fungal pathogen, is often associated with oral infections such as denture stomatitis. Dental varnishes, especially those incorporating antimicrobial agents, have shown promise in preventing colonization. This study investigates the antifungal efficacy of a dental varnish incorporating green-synthesized silver nanoparticles (AgNPs) using and extracts.

Evaluation of Antibacterial Effects of an Oral Rinse Containing Ocimum tenuiflorum and Ocimum gratissimum on Streptococcus mutans and Lactobacillus Species.

Background And Aim: Dental caries, primarily caused by and Lactobacillus spp., is a major global health issue. There is a growing need for effective, natural antimicrobial treatments.

Emerging therapeutic and diagnostic strategies for coronary artery disease: Current trends and future perspectives.

Coronary vascular disease (CVD) is the general term used to cover conditions like narrowed blood vessels that may cause stroke or heart attack. Coronary artery disease (CAD) is one of the CVD and it is the most severe disease worldwide. The traditional treatment for CAD includes Coronary Artery Bypass Graft Surgery (CABG) and Percutaneous Coronary Intervention (PCI).

Antifungal Activity of Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulation-Based Oral Rinse Against Candida albicans.

Background Candida albicans is a common fungal pathogen responsible for oral infections, posing significant health challenges. Traditional antifungal treatments often come with side effects and resistance issues, highlighting the need for effective natural alternatives. O.

Comparative Evaluation of Antioxidative and Anti-inflammatory Properties of Acerola-Mediated Silver Nanogel and Copper Oxide Nanogel.

Background: The tropical plant acerola of the genus includes shrubs and trees with fruit that is high in nutrients and bioactive chemicals. Acerola stands out due to its exceptionally high ascorbic acid content, ranging from 1500 to 4500 mg/100 g. Vitamin C intake greatly influences gingival health.

Synthesis of Silver Nanoparticles Using Azadirachta indica and Syzygium aromaticum Extract and Its Antibacterial Action Against Enterococcus faecalis: An In Vitro Study.

Introduction Nanotechnology is the study of manipulating matter at the atomic scale involving particles smaller than 100 nm. Silver nanoparticles (AgNPs) are gaining popularity across diverse sectors including medical, food, healthcare, consumer goods, and industrial fields due to their distinctive physical and chemical characteristics. The eco-friendly synthesis of AgNPs offers a straightforward, cost-effective, and environmentally benign method devoid of hazardous chemicals.

Effectiveness of white tea-mediated silver nanoparticles as an intracanal irrigant against Enterococcus faecalis: An in vitro study.

Background: The probability of a positive outcome of root canal therapy is substantially higher if the infection is eradicated successfully before the obturation of the root canal system. Irrigation is an essential aspect of root canal debridement, as it enables more thorough cleaning than is possible with root canal instrumentation alone. To overcome the side effects of chemical irrigants, there has been a search for herbal medicines as substitutes.

A Novel Gum Paint Formulation Derived From Licorice and Triphala: Characteristics and Clinical Significance for Improved Oral Health.

Background: The clinical use of antimicrobial agents for managing aphthous ulcers and periodontal diseases has long been a subject of intensive research by numerous investigators. As concerns over the side effects and antibiotic resistance associated with conventional therapies persist, there has been a concerted effort to explore alternative medicinal approaches. In line with this objective, our study introduces a novel herbal gum paint designed specifically to address the therapeutic needs of individuals suffering from oral ulcers and periodontal diseases.

Anticariogenic, Antidiabetic, and Toxicology Evaluation of the Ethanolic Extract of Croton bonplandianum: An In Vitro Study.

Background Herbal medicine has gathered increasing attention in contemporary healthcare practices, offering natural remedies for a wide range of ailments such as skin diseases, liver disorders, bronchitis, and asthma. Among the plethora of medicinal plants, , commonly known as "Ban Tulsi," holds significant medicinal value owing to its diverse pharmacological properties. This study investigated the cytotoxicity, embryotoxicity, antidiabetic, and anticariogenic effects of an ethanolic extract derived from .

Characterization and Biomedical Applications of Green-Synthesized Selenium Nanoparticles Using Tridax procumbens Stem Extract.

Background Selenium nanoparticles (SeNPs) are one of the metal nanoparticles that have been widely utilized for their anti-microbial, anti-oxidant, anti-inflammatory activities, and other biomedical applications. (TP) stem extract is a promising herb species rich in flavonoids, tannins, alkaloids, phytosterols, and hydroxycinnamates, which play a major role in wound healing applications.  Aim The study aims to synthesize SeNPs using TP stem extract characterizations, and its biomedical applications.

Unlocking estrogen receptor: Structural insights into agonists and antagonists for glioblastoma therapy.

Glioblastoma (GBM), a malignant brain tumor originating in glial cells, is one of the most common primary brain malignancies, affecting one in 100,000 people, typically in the frontal lobe. Estrogens, like estradiol-17 (E2), significantly influence GBM progression, metastasis, and angiogenesis. Estrogen receptors (ERs) are crucial in signal transduction and physiology, making them potential therapeutic targets.

Biomedical Applications of Lauric Acid: A Narrative Review.

Lauric acid, a major component of coconut oil, has been studied for its various health benefits over the years. Lauric acid is a medium-chained fatty acid with several potential biomedical applications based on its antimicrobial action, capacity for drug delivery, tissue engineering scaffolds, and cleansing capabilities. Various studies are carried out in vitro and in vivo using experimental animals, such as rats, shedding light on the efficacy of lauric acid.

Green Synthesis and Investigation of Antimicrobial Activity and Compressive Resilience of Glass Ionomer Cement Modified With Zirconia Nanoparticles: An In Vitro Study.

Background Glass ionomer cement (GIC) serves as a crucial biomaterial in dental restoration, offering applications in filling, lining, and adhesive procedures. Nevertheless, its mechanical properties often fall short, particularly in regions subjected to considerable stress. To address this issue, zirconia nanoparticles are incorporated at specific levels.

Comparative Anti-inflammatory Activity of a Nanocomposite-Based Herbal Oral Rinse and a Commercial Oral Rinse.

Introduction: The present study aimed to evaluate and compare the anti-inflammatory effects of two oral rinse formulations, a commercial oral rinse and an  and  (nanocomposites, NCs) oral rinse, using in vitro assays commonly employed to assess anti-inflammatory activity.

Materials And Methods: The anti-inflammatory potential of the oral rinse formulations was assessed using bovine serum albumin (BSA) denaturation, egg albumin denaturation, and membrane stabilization assays. Diclofenac sodium was used as a reference standard in all assays.