Investigation of the impact of sulfur on the properties of CZTS nanomaterials for enhanced supercapacitor performance.

CuZnSnS (CZTS) has been synthesised using ethylene glycol as a solvent by the solvothermal method. Preliminary characterisation, like X-ray diffraction, Raman spectroscopy, and FTIR, confirmed the tetragonal structure of CZTS with kesterite phase. In the synthesis, a series of samples with different concentrations of sulfur were produced, accompanied by an in-depth analysis of structural parameters such as crystallite size and strain, utilising both the Scherrer equation and the Williamson-Hall method.

Harmonized Immune Recovery Monitoring after HCT: Evidence & Practical Guidance from the Westhafen Intercontinental Group.

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative option for patients with high-risk malignancies and non-malignant disorders. Long-term survival depends on robust immune reconstitution (IR), which governs overall immune homeostasis and risks of infection, graft-versus-host disease, and relapse. However, despite its centrality to post-transplant outcomes, IR is not consistently monitored across transplant centers, limiting ability to generate meaningful, comparable, and translatable data.

Adapting the Grog survey app for alcohol screening and feedback in aboriginal and Torres Strait Islander health services: a mixed methods study protocol.

Background: Routine use of brief, structured screening tools is essential to detect and provide support for Australians who drink above recommended levels. However, detecting drinking above recommended levels in Aboriginal and Torres Strait Islander Australian primary care settings is complex. Inaccuracies in completing a screening tool such as Alcohol Use Disorders Identification Test - Consumption, can lead to errors in estimating drinking in First Nations contexts where group sharing and episodic drinking make it difficult to accurately estimate alcohol consumption with tools that assume regular drinking patterns.

Right Hepatic Artery Pseudoaneurysm Following Laparoscopic Cholecystectomy: A Rare Complication Treated With Coil Embolization.

Hepatic artery pseudoaneurysm (HAPA) is an uncommon but potentially life-threatening vascular complication following laparoscopic cholecystectomy, often presenting days to weeks postoperatively. We describe the case of a 34-year-old female patient who presented 45 days following surgery with recurring hematemesis, melena, abdominal pain, and jaundice. Ultrasonography with colour Doppler suggested a vascular lesion near the porta hepatis, and triple-phase CT angiography confirmed a right hepatic artery (RHA) pseudoaneurysm leading to intrahepatic biliary radical dilatation (IHBRD).

Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder: A Randomized Clinical Trial.

Importance: Measurement-based care (MBC) guides clinical decisions through structured monitoring of symptoms and adverse effects. Although MBC has been associated with improved outcomes in major depressive disorder (MDD), its effectiveness in low- and middle-income countries (LMICs) remains understudied.

Objective: To assess whether MBC accelerates the resolution of depressive symptoms compared with standard care among adults with MDD in Pakistan.

Automated drug design for druggable target identification using integrated stacked autoencoder and hierarchically self-adaptive optimization.

Drug classification and target identification are crucial yet challenging steps in drug discovery. Existing methods often suffer from inefficiencies, overfitting, and limited scalability. Traditional approaches like support vector machines and XGBoost struggle to handle large, complex pharmaceutical datasets effectively.

Neurofilament light chain in Alzheimer's disease.

Neurofilament light chain (NfL) is a sensitive marker of neuroaxonal injury with growing clinical relevance in Alzheimer's disease (AD). Across cohorts, blood and CSF NfL concentrations are higher in AD than controls, with reported 1.7-1.

Surgical management of biventricular hydrocephalus caused by tuberculosis-induced bilateral obstruction of the foramen of Monro: illustrative case.

Background: Occlusion of the foramen of Monro is an exceedingly rare condition in adults and can lead to obstructive hydrocephalus. The authors present the first reported case of biventricular hydrocephalus caused by tuberculosis-induced bilateral obstruction of the foramen of Monro. They also discuss the technical nuances and surgical challenges associated with this condition.

The PPAR-β/δ agonist GW0742 alleviates DNA damage and lupus nephritis in an animal model of systemic lupus erythematosus via restoring DNA repair gene expression.

Systemic lupus erythematosus (SLE) is a persistent autoimmune inflammatory disease associated with an elevated risk of kidney damage. The etiology of SLE remains unclear; nevertheless, current investigations increasingly indicate that increased DNA damage and deficiencies in the mechanisms of its repair might contribute to its pathogenesis, necessitating the identification and management of the disease. Therapies for SLE have improved considerably over recent decades.

Guardians of Sensation: Evaluating Metformin's Power Against Chemotherapy-Induced Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating complication of cancer treatment, particularly with agents like paclitaxel. Effective preventive measures for CIPN are limited. Metformin, an antihyperglycemic agent with neuroprotective properties, has shown promise in preclinical studies; however, its clinical utility in preventing CIPN remains underexplored.

Molecular Crosstalk between Artificial Sweetener Aspartame and Diabetes-Linked Insulin Hormone Unveils Possible Amyloidosis Risks.

An important adaptation for diabetes patients is the consumption of artificial sweetener aspartame, which is present in more than thousands of food products and medicines. Several studies have shown diverse side effects of aspartame, and it is also known to form amyloid-like cytotoxic and cross-seeding-competent nanostructures. Here, we reveal a direct crosstalk between aspartame and insulin that induces their cross-seeding and coaggregation events.

Rare phenotype of juxtaepiphyseal osteochondroma of the proximal phalanx and its management: A case report.

Background: Osteochondroma of the hand and phalanges is rare. Although rare, solitary phalangeal osteochondromas can result in pain, cosmetic deformity, compression of nearby neurovascular structures and tendons, or functional limitation of adjacent joints that warrant surgical correction when symptomatic. At times, involvement of the growth plate by juxtaepiphyseal exostosis can cause angulation deformity, necessitating corrective osteotomy.

Nanoengineered-based delivery systems to modulate CD4 T cell responses in cancer: emerging paradigms in cancer immunotherapy.

Background: CD4 T-cells play a pivotal role in cancer immunology, functioning as both tumor-suppressing and tumor-promoting agents depending on their differentiation and cytokine profiles. Targeting CD4 T-cells with novel drug delivery systems, particularly nanoparticle-based formulations, offers a promising approach to enhancing antitumor immune responses while minimizing systemic toxicity.

Objective: This review aims to explore the immunological significance of CD4 T-cells in cancer and their modulation using novel drug delivery systems.

Comparing efficacy and safety of direct aspiration versus stent retriever thrombectomy in acute basilar artery occlusion: A systematic review and meta-analysis.

Acute basilar artery occlusion (BAO) can lead to severe stroke and is linked to significant disability or death if not treated. This meta-analysis evaluated the effectiveness and safety of first-line thrombectomy options: Direct Aspiration (DA) and Stent Retriever Thrombectomy (SRT) for acute BAO. Electronic databases, including PubMed, Cochrane Central, ScienceDirect, Embase, and Web of Science were searched from inception until July 2025.

C1 lateral mass reconstruction using a titanium cage following total resection of the aneurysmal bone cyst: illustrative cases and literature insights.

Introduction: There are limited reports of C1 lateral mass reconstruction using a titanium mesh cage following the surgical removal of an aneurysmal bone cyst (ABC). We describe two uncommon and challenging cases of C1 ABC, highlighting the obstacles and complexities involved in selecting the appropriate approach for tumor resection, C1 stabilization, and reconstruction.

Case Discussion: A 12-year-old boy presented with 3 months of progressive upper cervical and occipital pain with no history of trauma.

Transforming pulmonary embolism care: advanced catheter techniques in Pakistan: a case report.

Although post-operative acute pulmonary embolism (PE) is relatively rare, it poses a substantial risk of morbidity and mortality. We report the case of a 45-year-old hypertensive woman who presented with acute chest pain and dyspnoea eight days following a hysterectomy. On admission, she was tachycardic, hypotensive, and hypoxic.

Evaluation of Hepatitis B core-related antigen (HBcrAg) as a biomarker in cohorts from the United Kingdom and South Africa.

Objectives: We set out to evaluate Hepatitis B core-related antigen (HBcrAg) as a proxy for hepatitis B (HBV) viral load (VL) and liver disease in two different population settings.

Methods: We undertook a cross-sectional retrospective observational study using samples and data from adults living with chronic HBV infection from the United Kingdom (UK, n=142) and South Africa (SA, n=211). We assessed HBcrAg distribution, relationship with other biomarkers, and risk stratification performance, applying point of care test (POCT) thresholds.

Reverse transcriptase inhibitors induce autophagy in a LINE-1 ORF1p-dependent manner.

Human L ong Interspersed N uclear E lement-1 (LINE-1) retrotransposons propagate throughout the genome via reverse-transcribed RNA intermediates. LINE-1 expression is pervasive in cancer. Functional LINE-1s encode two proteins: ORF1p, an RNA-binding protein, and ORF2p, harboring reverse transcriptase and endonuclease activities.

Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource.

Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the community-generated population genomics resource Drosophila Evolution over Space and Time (DEST 2.0; https://dest.

Impact of minimal residual disease on the outcome of hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia within the FORUM Trial.

In the randomized cohort of the international phase-III FORUM trial, which showed the superiority of total-body irradiation (TBI) over chemotherapy-based conditioning prior to hematopoietic stem cell transplantation (HSCT) for pediatric acute lymphoblastic leukemia (ALL), type of conditioning and remission phase, but not pre-HSCT minimal residual disease (MRD), were associated with outcome. We report the impact of MRD within the extended FORUM cohort. Patients (n=1014), 4-21 years old, transplanted from a matched donor who had ≥1 MRD measurement prior to and/or 100 days and/or 1 year after HSCT were eligible.

Electrochemical detection of agomelatine using a high-performance FeZn LDH/graphene/polyaniline nanocomposite sensor for clinical and pharmaceutical analysis.

Therapeutic monitoring of agomelatine (AG), an antidepressant with significant pharmacokinetic variability, is hindered by the complexity and cost of conventional methods. This work presents a novel electrochemical sensor employing a ternary FeZn-layered double hydroxide (LDH)/graphene/polyaniline nanocomposite for sensitive AG detection in biological and pharmaceutical samples. The synergistic properties of the nanocomposite-combining catalytic activity, high conductivity, and electrochemical stability-were confirmed through XRD, FESEM-EDS, and XPS characterization.

Exercise-induced symptoms in young childhood cancer survivors.

Purpose: Exercise-induced symptoms (EIS) are common in children and understudied in childhood cancer survivors (CCS). We assessed the prevalence of EIS in CCS and identified associated risk factors.

Methods: We included CCS aged 6-21 years who were diagnosed with cancer ≥ 1 year before study entry, were treated with systemic anticancer treatment, chest surgery, radiotherapy, or hematopoietic stem cell transplantation, completed cancer treatment, and received pediatric oncology follow-up care.

Cognitive recovery assessment in patients after desflurane versus sevoflurane-based general anaesthesia: A randomised, comparative, double-blinded study.

Background And Aims: Recovery after general anaesthesia (GA) may vary depending on personal factors and the type of anaesthetic agent used. The primary objective of this study was to compare the recovery profiles of cognitive functions following desflurane- and sevoflurane-based GA in terms of the time required for cognitive functions to return to their baseline values.

Methods: This randomised comparative trial was conducted in 60 patients aged 18-50 years, scheduled for laparoscopic cholecystectomy under GA.

Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer.

Ferroptosis-inducing agents are an emerging class of nonapoptotic, iron-dependent compounds for anticancer chemotherapy. We describe the synthesis of new aroyl diheterocyclyl pyrrole derivatives . Compound exhibited the most potent in vitro anticancer activity against breast cancer (BC), triple-negative breast cancer (TNBC), and colorectal cancer (CRC) cell lines, as well as significant efficacy in an HCT116 CRC xenograft model.

Contrasting roles of autophagy in cellular prion infection.

Autophagy is a cellular degradation program that can exert both beneficial and adverse effects in various neurodegenerative diseases. We tested the role of macroautophagy/autophagy in prion infection and how this machinery affects the life cycle of prions. In mouse embryonic fibroblasts, we found a pronounced dependence of prion replication on autophagy competence, suggesting that autophagy provides functions needed for prion propagation.