Publications by authors named "Annika Belzer"

Article Synopsis
  • Cutaneous immune-related adverse events include various skin reactions like lichenoid reactions and severe conditions like Stevens-Johnson syndrome, often treated with high-dose systemic corticosteroids.
  • The use of corticosteroids can hinder antitumor responses and lead to complications, prompting the exploration of corticosteroid-sparing targeted immunomodulators as alternatives.
  • Biologic agents, effective for non-cutaneous immune-related issues, are gaining recognition for their ability to treat diverse cutaneous reactions, though more research is needed on their long-term impact on cancer treatment.
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Dermatologic adverse events resulting from oncologic therapy are common and negatively impact patients' quality of life. Dermatologic adverse events include toxicity of the skin, oral mucosa, nails, and hair and are seen with cytotoxic chemotherapy, targeted therapy, immunotherapy, and radiation therapy, with distinct patterns of dermatologic adverse events by drug class. Here, we review the literature on the impact of dermatologic adverse events on quality of life.

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Article Synopsis
  • A case report highlights a 21-year-old healthy man diagnosed with proctitis and epididymitis linked to a cytomegalovirus (CMV) infection, a condition rarely documented in immunocompetent individuals.
  • The patient experienced severe rectal and testicular pain, leading to a hospitalization where tests confirmed acute primary CMV infection.
  • This study emphasizes the need for more awareness of CMV as a potential sexually transmitted infection, even in individuals with functioning immune systems.
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Climate change has a pervasive impact on health and is of clinical relevance to every organ system. Climate change-related factors impact the skin's capacity to maintain homeostasis, leading to a variety of cutaneous diseases. Stratospheric ozone depletion has led to increased risk of melanoma and keratinocyte carcinomas due to ultraviolet radiation exposure.

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Dear Editor, Granuloma annulare (GA) is an inflammatory skin disease that has been associated with diabetes, dyslipidaemia, hypothyroidism and autoimmune disorders.1,2 The annualized incidence and prevalence of GA in the USA are approximately 0.04% and 0.

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is a Gram-negative bacillus that causes skin and soft tissue infections (SSTI), as well as bacteremia, pneumonia, and urinary tract infections. infections are typically nosocomial and are often transmitted through water sources. Although historically described in immunocompromised hosts, prevalence is increasing in both immunocompromised and immunocompetent populations.

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Background: How indices specific to respiratory compromise contribute to prognostication in patients with ARDS is not well characterized in general clinical populations. The primary objective of this study was to identify variables specific to respiratory failure that might add prognostic value to indicators of systemic illness severity in an observational cohort of subjects with ARDS.

Methods: Fifty subjects with ARDS were enrolled in a single-center, prospective, observational cohort.

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Article Synopsis
  • The study aimed to explore how plasma metabolite profiles can distinguish between different subgroups of patients with early sepsis and sepsis-associated acute respiratory distress syndrome (ARDS).
  • Three metabolically distinct subgroups were identified among critically ill patients, where one subgroup exhibited a notably higher risk of 60-day mortality along with increased organ dysfunction rates.
  • The findings suggest that while metabolomic profiling can differentiate patients in early sepsis, it does not effectively separate those with moderate-to-severe ARDS from those without, indicating limitations in its application for this specific condition.
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Background: In response to the COVID-19 pandemic, the Yale New Haven Health System began rescheduling nonurgent outpatient appointments as virtual visits in March 2020. While Yale New Haven Health expanded its telemedicine infrastructure to accommodate this shift, many appointments were delayed and patients faced considerable uncertainty.

Objective: Medical students created the Medical Student Task Force (MSTF) to help ensure continuity of care by calling patients whose appointments were delayed during this transition to telemedicine.

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With age, the epidermis becomes hypoplastic and hypoproliferative. Hypoproliferation due to aging has been associated with decreased stem cell (SC) self-renewal in multiple murine tissues. The fate of SC self-renewal divisions can be asymmetric (one SC, one committed progenitor) or symmetric (two SCs).

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