Tralokinumab as a Therapeutic Alternative for Dupilumab-associated Arthralgia in Atopic Dermatitis: A Multi-center Case Series.

Atopic dermatitis (AD) is a chronic inflammatory skin condition that often requires systemic treatment to achieve optimal clinical outcomes. The clinical and immunological heterogeneity of AD necessitates the use of various therapies to maximize efficacy while minimizing adverse events (AEs). Dupilumab, the first biologic agent approved by the United States Food and Drug Administration (FDA) for moderate-to-severe AD, targets interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling pathways.

Uncovering shared genetic features between inflammatory bowel disease and systemic lupus erythematosus.

Inflammatory bowel disease (IBD) is an autoimmune disease (AD) characterized by chronic, relapsing intestinal inflammation. Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement and overactivation of both innate and adaptive immunity. The extra intestinal manifestations (EIMs) that commonly occur in IBD include many of the organ sites that are affected by SLE.

Psoriasis: Perspectives from Irwin M. Braverman, MD.

Dr Irwin M. Braverman is recognized as an expert on many skin diseases, including psoriasis, an immune-mediated disorder that presents with scaly erythematous plaques. The most common clinical subtype is plaque psoriasis, with scalp, inverse, guttate, pustular, and nail psoriasis representing additional subtypes.

The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program.

We sought to examine the association between hidradenitis suppurativa, and cigarette smoking and cannabis use with a cross-sectional study using , a National Institutes of Health research programme that focuses on traditionally underrepresented populations in research. Using electronic health record and survey data, we found that the odds of cigarette smoking and cannabis use are increased by 75% and 54%, respectively, in patients with hidradenitis suppurativa.

Association between fine particulate matter and eczema: A cross-sectional study of the All of Us Research Program and the Center for Air, Climate, and Energy Solutions.

Background: The prevalence of eczema has increased with industrialization. Industrial practices generate ambient air pollution, including fine particulate matter of diameter ≤ 2.5μm (PM2.

Impact of Atopic Dermatitis (Eczema) and Its Treatment on the Risk of Adverse Events Following Total Knee Arthroplasty.

Background: Atopic dermatitis (AD), also known as eczema, is a highly prevalent, chronic inflammatory skin condition. The perioperative outcomes of patients with AD after total knee arthroplasty (TKA) have not been characterized.

Methods: Adult patients who underwent TKA were identified in the PearlDiver administrative database.

Bipolar disorder among individuals with atopic dermatitis: a case-control study in the All of Us Research Program.

Background: Atopic dermatitis (AD) has been associated with psychiatric comorbidities.

Objectives: To characterize the association between AD and bipolar disorder (BPD) with a case-control study of the National Institutes of Health All of Us Research Program.

Methods: We used Systematized Nomenclature of Medicine diagnostic codes to identify cases of AD.

Non-invasive epidermal proteome assessment-based diagnosis and molecular subclassification of psoriasis and eczematous dermatitis.

Background: Immunologic heterogeneity is known to exist within both eczematous dermatitis and psoriasis; however, selection of molecularly targeted therapies for individual patients generally does assess for or incorporate such information about patient-specific immune changes.

Objective: We sought to develop a rapid, non-invasive method for obtaining and analyzing epidermal protein biomarkers from skin and utilize this methodology to dissect immunologic heterogeneity in both psoriasis and eczematous dermatitis.

Methods: We optimize and evaluate detergent-based immune profiling system (DIPS) which utilizes a combination of two detergents to solubilize full-thickness epidermis when applied to the skin with an applicator.