Nano-carriers based Approaches Loaded with Herbal Bioactive Compounds for the Treatment of Cancer: Recent Updates and Future Prospects.

Introduction: Traditional cancer therapies like chemotherapy and radiotherapy frequently face challenges, such as systemic toxicity, the development of resistance, and poor tolerance among patients. Recently, there has been a growing interest in herbal bioactive compounds because of their wide-ranging anticancer properties and natural sources. Nonetheless, the clinical use of these compounds is restricted by their low solubility in water, limited bioavailability, and rapid metabolic clearance.

Exosomal peptides and proteins in wound healing and skin regeneration.

Wound healing is a highly coordinated biological process that includes inflammation, angiogenesis, proliferation, and tissue remodeling. Chronic wounds, comprising diabetic foot ulcers as well as pressure ulcers, present significant healthcare challenges due to prolonged healing and susceptibility to infections. Traditional treatments often fail to modulate the wound microenvironment, leading to suboptimal outcomes.

Elucidating the Complex Etiology of Schizophrenia: Comprehensive Insights into the Therapeutic Roles of Natural Compounds and Pharmacological Interventions.

Schizophrenia (SCZ) remains a captivating mental disorder marked by complex symptomatology. Despite the success of the current therapeutic options for psychosis, a definitive cure remains elusive. Hence, this review explores mechanisms underlying SCZ pathophysiology, examining their potential as novel therapeutic targets.

Design and evaluation of carnosic acid-loaded thermosensitive lipidic nanogels for nasal delivery: ex vivo permeation, nasal ciliotoxicity, and antioxidant assessment.

Carnosic acid (CA) is a diterpene phenolic compound derived from the leaves of , known for its neuroprotective, anti-inflammatory, and antioxidant properties. However, its effectiveness is limited due to poor solubility and a low dissolution rate. To enhance its neuroprotective potential, a thermosensitive intranasal nanogel incorporated with CA-loaded nanostructured lipid carriers (NLC) was developed using a quality-by-design approach to improve delivery and efficacy of CA.

Topical Miconazole Nanogel: In Vitro Characterization, In Vivo Skin Irritation, and Enhanced Antifungal Efficacy.

This study focused on the development of a miconazole nanogel formulation. The nanogel was prepared using the solvent diffusion method (high-speed homogenization) with Carbopol 940/chitosan/locust bean gum (Different gelling agents were used) and triethanolamine. The formulation was thoroughly evaluated for various physicochemical properties, including appearance, pH, FTIR analysis, viscosity, washability, spreadability, extrudability, drug content, entrapment efficiency, particle size, zeta potential, optical microscopy, differential scanning calorimetry (DSC), skin irritation, ex-vivo skin penetration, in-vitro diffusion, in-vitro antifungal activity, and stability.

Exploring the therapeutic potential of ligand-decorated nanostructured lipid carriers for targeted solid tumor therapy.

Solid tumors present significant therapeutic challenges due to their complex pathophysiology, including poor vascularization, dense extracellular matrix, multidrug resistance, and immune evasion. Conventional treatment strategies, such as chemotherapy, radiotherapy, and surgical interventions, are often associated with systemic toxicity, suboptimal drug accumulation at the tumor site, and chemoresistance. Nanostructured lipid carriers (NLCs) have emerged as a promising approach to enhance anticancer therapy.

Preventive effect of acemannan on DMBA-induced mouse skin tumorigenesis by modulating inflammatory cytokines and apoptosis pathways: molecular docking and molecular dynamic simulation approaches.

Skin cancers, such as melanoma and non-melanoma skin cancers, are increasingly prevalent due to environmental and lifestyle factors. Melanoma arises from the aberrant proliferation of melanocytes and is significantly influenced by UV radiation-induced oxidative stress. This study investigated the therapeutic potential of acemannan against 7,12-dimethylbenz[a]anthracene (DMBA)-evoked skin cancer in mice.

Exploring the molecular pathways of advanced rectal cancer: A focus on genetic, RNA, and biological technique.

Colorectal cancer (CRC) is the third most frequently diagnosed cancer, with rectal cancer (RC) accounting for approximately 35 % of cases, posing a significant health burden. The early phase of R progression is characterized by the accumulation of genetic and epigenetic changes that promote cell growth. These rapidly dividing cells form a benign adenoma, which can eventually transform into malignant tumors and metastasize to other organs.

Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, permeation, histopathology, and anti-inflammatory study.

Objective: Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It is poorly soluble and has various gastrointestinal side effects such as bleeding and ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery to improve therapeutic efficacy.

Transferrin-modified Gemcitabine Encapsulated Polymeric Nanoparticles Persuaded Apoptosis in U87MG Cells and Improved Drug Availability in Rat Brain: An Active Targeting Strategy for Treatment of Glioma.

Among primary brain tumors, glioma has one of the highest fatality rates. Routine chemotherapy often faces off-target drug loss and sub-optimal drug availability at brain tissue. The present study aims at the development of transferrin-conjugated gemcitabine loaded poly (lactic co glycolic acid) nanoparticles (Tf-GB-PLGA-NPs) targeted strategy for brain cancer cell.

Luliconazole-niacinamide lipid nanocarrier laden gel for enhanced treatment of vaginal candidiasis: , , and preclinical insights.

A lipid-based nanocarrier system is a novel technique for the delivery of poorly soluble drugs through topical delivery. This study developed a dual-drug (luliconazole: LZ, and niacinamide: NM) loaded lipid nanocarrier (LN)-laden gel for the treatment of vaginal candidiasis. The LNs were prepared using cholesterol and soya-α-lecithin through a thin-film hydration technique.

Virtual reality modulating dynamics of neuroplasticity: Innovations in neuro-motor rehabilitation.

Virtual reality (VR) technology has emerged as a ground-breaking tool in neuroscience, revolutionizing our understanding of neuroplasticity and its implications for neurological rehabilitation. By immersing individuals in simulated environments, VR induces profound neurobiological transformations, affecting neuronal connectivity, sensory feedback mechanisms, motor learning processes, and cognitive functions. These changes highlight the dynamic interplay between molecular events, synaptic adaptations, and neural reorganization, emphasizing the potential of VR as a therapeutic intervention in various neurological disorders.

Depression unveiled: Insights into etiology and animal models for behavioral assessment, exploring the multifactorial nature and treatment of depression.

Over the past century, significant shifts in daily living have led to an increased prevalence of mental disorders, often linked to hormonal imbalances. Among these, anxiety and depression stand out as prevalent diagnoses, particularly in industrialized nations. Depression, according to the DSM-5, is a heterogeneous condition that affects emotional, cognitive, and physical functioning, with symptoms including insomnia, sexual dysfunction, and weight changes.

Preparation and characterization of a ciprofloxacin-loaded nanoparticles incorporated polymeric film dressing.

In an effort to prepare a modern polysaccharide-based dressing for sustained/prolonged delivery of the antibacterial agent to prevent and control skin wound infection, ciprofloxacin (CP)-loaded sodium alginate (SA)-chitosan (CS) nanoparticles (NPs) were incorporated into novel arabinoxylan (AX)-pectin (PC) blended polymeric films by solvent casting. The CP-NPs were prepared by a two-step ionic interaction method with < 300 nm size, about 25 mV zeta potential, 74% CP-loading efficiency, and approximately round shape. The CP-NPs were incorporated in optimized AX-PC polymeric film prepared by using 2% AX and 2% PC with a plasticizer (2% glycerol) and then these films were characterized for suitability as a film dressing.

Luteolin-loaded Invasomes Gel for Transdermal Delivery: Development, Optimization, in-vitro, and Preclinical Evaluation.

Luteolin (LN), is an herbal bioactive flavone and exhibits many pharmacological activities. However, the bioavailability of LN is limited due to its inadequate solubility and significant first-pass metabolism. The present study developed transdermal LN-loaded invasomes (IVM) gel to improve the therapeutic efficacy.

Development of Lipid Polymer Hybrid Nanoparticles of Abietic Acid: Optimization, In-Vitro and Preclinical Evaluation.

The objective of the current research was to develop abietic acid (AA)-loaded hybrid polymeric nanoparticles (HNPs) for anti-inflammatory and antioxidant activity after oral administration. AAHNPs were developed by microinjection technique and optimized by 3-factor 3-level Box-Behnken design. The AAHNPs were evaluated for morphology, FTIR, X-ray diffraction, in-vitro release, ex-vivo permeation, in-vitro antioxidant, and in-vivo anti-inflammatory activity.

Syrupy herbal formulation of green bean pod extract of L.: Formulation optimization by central composite design, and evaluation for anti-urolithiatic activity.

The green bean pods of L. are traditionally used as a folk remedy for treating calcium oxalate kidney stones. The current research aimed to develop a syrup formulation containing green bean pod extract for anti-urolithiatic activity.

Novel Products as Promising Therapeutic Agents for Angiogenesis Inhibition.

Objective: Angiogenesis is the process of forming new blood vessels from pre-existing vessels and occurs during development, wound healing, and tumor growth. In this review, we aimed to present a comprehensive view of various factors contributing to angiogenesis during carcinogenesis. Anti-angiogenesis agents prevent or slow down cancer growth by interrupting the nutrients and blood supply to the tumor cells, and thus can prove beneficial for treatment.

Niosomes gel of apigenin to improve the topical delivery: development, optimization, permeation, antioxidant study, and evaluation.

Niosomes (NS) are the promising and novel carrier of the drug for effective transdermal delivery. Apigenin (AN) is a natural bioactive compound and has various pharmacological activities. AN is poorly water soluble which directly affects therapeutic efficacy.

Development of Soft Luliconazole Invasomes Gel for Effective Transdermal Delivery: Optimization to In-Vivo Antifungal Activity.

Luliconazole (LZ) is a good candidate for the treatment of fungal infection topically but has limitations, i.e., poor solubility and poor permeability to skin.

Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation.

The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal administration. AXT-NLC was prepared by the melt emulsification ultrasonication method and optimized using the Box-Behnken design (BBD). The optimized formulation (AXT-NLC) exhibited particle size PDI, zeta potential, and entrapment efficiency (EE) of 108 nm, 0.

Intranasal Nanotransferosomal Gel for Quercetin Brain Targeting: I. Optimization, Characterization, Brain Localization, and Cytotoxic Studies.

Numerous neurological disorders have a pathophysiology that involves an increase in free radical production in the brain. Quercetin (QER) is a nutraceutical compound that shields the brain against oxidative stress-induced neurodegeneration. Nonetheless, its low oral bioavailability diminishes brain delivery.