Efficacy of platelet-rich albumin and fibrin gel in two-stage lateral sinus lift: a prospective study.

Background: Maxillary sinus lift procedures require biomaterials that combine osteogenic potential with structural stability. This study evaluates Albumin-Platelet-Rich Fibrin (Alb-PRF), a novel autologous material, as a standalone graft alternative in two-stage lateral sinus lifts, addressing limitations of rapid resorption in traditional platelet concentrates.

Methods: A prospective study was conducted on nine patients (mean age: 48.

Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK and ROS1 in oral squamous cell carcinoma.

Oral Squamous Cell Carcinoma (OSCC) is the sixth most aggressive type of oral cancer. Mutations in cancer-driving genes such as protein kinase are well known in cancer progression. We selected candidate genes (PIK3CA, BRAF, EGFR, ALK, and ROS1) for mutations exploration in the OSCC patients belonging to Khyber Pakhtunkhwa (KP) through Next Generation-Whole Exome Sequencing (NG-WES) using Formalin Fixed Paraffin Embedded (FFPE) tissue blocks (27 tumor and 7 paired normal) for the 1st time followed by in-silico characterization.

Rehabilitation of Vertical Gaze Palsy and Impaired Eye Proprioception Following Bilateral Thalamic Infarcts: A Case Report.

IntroductionThalamic infarctions, which account for .6% of all ischemic strokes, are characterized by altered mental status, vertical gaze palsy, and memory impairment. There is only one other case report on the rehabilitation of a vertical gaze palsy due to thalamic lesions.

Withania coagulans-mediated green synthesis of silver nanoparticles: characterization and assessment of their phytochemical, antioxidant, toxicity, and antimicrobial activities.

Background: In this study, we report the biofabrication of silver nanoparticles (Ag-NPs) using aqueous leaf extracts of Withania coagulans, which act as both reducing and capping agents. The goal was to synthesize and characterize the silver nanoparticles and evaluate their biological properties.

Results: The silver nanoparticles were characterized by multiple techniques including UV-visible spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), high-resolution transmission electron microscopy (HRTEM), zeta potential, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC).

Antibiotic resistance and bacterial spectrum in cerebrospial fluid cultures: Initial insights from Pakistan.

Antimicrobial resistance (AMR) is a rising global health concern, especially in resource-limited countries like Pakistan, where indiscriminate and unregulated use of antibiotics has significantly worsened this problem. The study aimed to analyze the bacterial spectrum and antimicrobial resistance patterns in cerebrospinal fluid (CSF) cultures from patients with suspected bacterial meningitis, providing crucial insights for better infection control and treatment strategies.This retrospective study analyzed 1107CSF cultures were between 2019 and 2024 at the Lady Reading Hospital, MTI, Khyber Pakhtunkhwa, Pakistan, to assess bacterial profiles in patients with suspected bacterial meningitis and investigate the AMR patterns.

Comparative evaluation of modified frenectomy with papilla preservation flap versus conventional technique in upper labial frenectomy: a randomized controlled trial.

Introduction: Cosmetic concerns among patients have led to an increased demand for dental treatments aimed at achieving a perfect smile. One of the main cosmetic issues in adults is the gap between the upper incisors, known as diastema, and the upper lip frenulum is often a contributing factor to this condition. Therefore, it is imaportant to focus on this aspect.

Bilateral mandibular osteomyelitis following chemo-radiotherapy: Critical rare case report and review of literature.

Introduction And Importance: Osteomyelitis, an inflammatory condition of the bone, poses significant challenges in clinical management due to its multifactorial etiology and variable presentation. Understanding the underlying mechanisms, risk factors, and biological processes is essential for improving treatment outcomes. Through this paper, we present an exceptionally rare case of "bilateral" aggressive osteomyelitis affecting the mandible, resulting in significant bone loss on both sides.

Endoscopic Sleeve Gastroplasty Versus Laparoscopic Sleeve Gastrectomy: A Comparison in Effectiveness and Safety Profile.

Background And Objectives: Current treatment options for obesity typically involve a combination of lifestyle changes, medications, and bariatric surgeries. This study aimed to assess the safety profile of the endoscopic sleeve gastroplasty (ESG), which is a novel non-invasive approach, as compared to laparoscopic sleeve gastrectomy (LSG) and to correlate their weight loss effectiveness and complication risk in Lebanese patients.

Subjects And Methods: This is a retrospective study, including 70 patients who underwent ESG at Fouad Khoury Hospital and 70 patients who underwent LSG at Trad Hospital, between September 2021 and March 2023.

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved in OSCC using NG-WES and their analysis using bioinformatics tools.

Predictive factors for insertion torque values in transalveolar sinus lift procedures.

Objectives: The objective of this retrospective study was to investigate the impact of bone-related factors such as initial bone height (IBH), imaginary pixel unit (IPU), bone diameter (BD), crestal cortical thickness (CCT), and sinus floor thickness (SFT) in transalveolar sinus lift procedures using threaded bone expanders without bone graft materials.

Materials And Methods: This retrospective cohort study was carried out on patients who had reported to the department of oral and maxillofacial surgery at Tishreen University between January 2018 and June 2024. The sample consisted of patients who had transalveolar sinus lift using motorized threaded bone expanders with simultaneous hybrid dental implants placement without bone graft materials.

Phytochemical-Mediated Green Synthesis of Silver, Copper, and Ag-Cu Bimetallic Nanoparticles Using Peganum harmala Demonstrating Advanced Catalytic, Antioxidant, and Biomedical Applications.

This study explores the green synthesis of silver (Ag-NPs), copper (Cu-NPs), and silver-copper bimetallic nanoparticles (Ag-Cu Bimetallic NPs) using the leaf extract of Peganum harmala, a sustainable and renewable plant source. This eco-friendly synthesis method avoids hazardous chemicals and minimizes waste, advancing the principles of green nanotechnology. Characterization demonstrated distinct properties; Ag-NPs, Cu-NPs, and Ag-Cu bimetallic NPs exhibited surface plasmon resonance peaks at 425 nm, 555 nm, and 525 nm, respectively, and crystallite sizes of 21.

Novel Azo dyes containing a hydrazide-hydrazone moiety for dyeing polyester fabric.

Novel azo dyes containing a hydrazide-hydrazone moiety linked to the benzothiazole nucleus are synthesized effectively in this study. The primary purpose of the study was to identify the best dyeing parameters, such as shade, temperature, pH, and time, in order to better understand the behaviour of dispersed dyes during polyester dyeing. To achieve excellent colour strength in value (K/S = 26), the ideal dyeing conditions for disperse dye 4 were 30 min, pH of 8, and 110 °C at shade 3%.

Autogenous bone ring augmentation and simultaneous implant placement in the atrophic posterior maxilla: A case report.

Introduction And Importance: Restoring lost teeth in the posterior atrophic maxilla presents a significant challenge due to insufficient bone volume for implant placement. Simultaneous implant placement during lateral sinus lift is often considered, but the decision is typically based on the amount of existing bone. The aim of this study was to investigate the feasibility of simultaneous implant placement and maxillary sinus floor augmentation in the atrophic posterior maxilla using autogenous bone ring.

Simulating the Morphological Changes of Facial Deformities after Using 3D-printed Polyether Ether Ketone Facial Implants.

Background: Patient-specific implants (PSIs) have been presented as an effective solution for diseases that require reconstruction. PSIs are designed to precisely fit anatomical defects or deformities in terms of shape and size. In addition to the possibility of predicting the results of surgery regarding soft tissue changes.

Potential nanomedicinal applications and physicochemical nature of Hyphaene thebaica-reduced nano-samaria.

Herein we described the biofabrication of samarium oxide nanoparticles (HT-SmO NPs) by applying the aqueous fruit extract of Hyphaene thebaica was utilized as an eco-friendly chelating agent. The prepared NPs were subjected to various physicochemical properties and potential in biomedical applications. X-ray Diffraction (XRD) pattern revealed sharp peaks that corroborated with the Joint Committee on Powder Diffraction Standards (JCPDS) card no.

Elsberg Syndrome With Albuminocytologic Dissociation - A Guillain-Barré Syndrome Mimic or Guillain-Barré Syndrome Variant?

Introduction: Elsberg Syndrome is a presumed infectious lumbosacral radiculitis, with or without accompanying lumbar myelitis, that is often attributed to herpes simplex virus type 2 (HSV-2).

Case: A 58-year-old man presented with lower extremity anesthesia, ataxic gait, radiological evidence of radiculitis, and CSF albuminocytologic dissociation. Polymerase chain reaction testing of CSF confirmed HSV-2 infection.

Clinico-genomic findings, molecular docking, and mutational spectrum in an understudied population with breast cancer patients from KP, Pakistan.

In this study, we report the mutational profiles, pathogenicity, and their association with different clinicopathologic and sociogenetic factors in patients with Pashtun ethnicity for the first time. A total of 19 FFPE blocks of invasive ductal carcinoma (IDC) from the Breast Cancer (BC) tissue and 6 normal FFPE blocks were analyzed by whole-exome sequencing (WES). Various somatic and germline mutations were identified in cancer-related genes, i.

Split doses versus whole dose bowel preparation using polyethylene glycol for colonoscopy: A multicentric prospective Lebanese randomized trial between 2021 and 2023.

Background And Aims: Bowel preparation is considered as major obstacle before colonoscopy, and it is often reported as the most feared part of the procedure. The aim of this study is to determine the difference in efficacy between a split dose of PEG and the previous day regimen in cleaning the colon, using Boston bowel preparation scale. In addition, also to evaluate patient satisfaction regarding the modality of preparation.

Prevalence of crimean Congo hemorrhagic fever in Khyber Pakhtunkhwa, Pakistan.

Background: CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented.

Methods: We used a gold-standard PCR-based diagnostic assay for confirmation of CCHFV among suspected patients. A total of 150 patients were enrolled from June 2022 to September 2022 and their blood samples were collected for PCR confirmation.

Exploiting the immune system in hepatic tumor targeting: Unleashing the potential of drugs, natural products, and nanoparticles.

Hepatic tumors present a formidable challenge in cancer therapeutics, necessitating the exploration of novel treatment strategies. In recent years, targeting the immune system has attracted interest to augment existing therapeutic efficacy. The immune system in hepatic tumors includes numerous cells with diverse actions.

Dental implant placement with simultaneous localized ridge augmentation using L-shaped titanium mesh in the esthetic zone: a case report.

The aim of this case report is to illustrate a successful technique for dental implant placement in the esthetic zone using simultaneous localized ridge augmentation with L-shaped titanium mesh. A 35-year-old patient presented with a single missing tooth in the esthetic zone requiring dental implant placement. The treatment plan was made to place a dental implant in conjunction with a guided bone regeneration procedure using a prefabricated L-shaped titanium mesh.

Pseudohalide Ions as Ligands to Tune Architecture and Luminescence of Polymetallic CU(I) Assemblies.

The reaction of preassembled Cu(I) bimetallic units {Cu(dppm)} and {Cu(dppa)} (dppm: bis(diphenylphosphino)methane and dppa: bis(diphenylphosphino)amine) with pseudohalide linkers (azido, dicyanamide, and tricyanomethanide) allows for the quantitative and selective preparation of three discrete tetrametallic metallacycles of formula [Cu(μ-dppm)(N)](PF), [Cu(μ-dppm)(N(CN))](PF), and [Cu(μ-dppm)(C(CN))]. To explore further the impact of the linker on the architecture and dimensionality of the molecular edifice, the study was extended to more sophisticated tetradentate cyanocarbanion ligands (tcnsMe: 2-(methylthio)-1,1,3,3-propanetetracarbonitrile and tcnsEt: 2-(ethylthio)-1,1,3,3-propanetetracarbonitrile). Three ladder-like one-dimensional coordination polymers and an octametallic metallacycle have been obtained.

Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan.

Gene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa.