Publications by authors named "Akhilesh Singh"

Membrane transporters (MTs) are pivotal for maintaining cellular homeostasis and facilitating the movement of ions, water, and nutrients across cellular membranes, ensuring plant growth and development. These proteins are central in regulating the source-to-sink relationship, enabling efficient sugar and nutrient transport, and ensuring resilience against abiotic stresses such as salinity, drought, heat, cold, and heavy metal toxicity. Key transporters, including Na/H antiporters and K channels, maintain ionic balance by mediating ion compartmentalization and efflux critical for plant survival, improving nutrient use efficiency.

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Emerging research has highlighted the significant role of microorganisms in the initiation and progression of colorectal cancer (CRC). However, further investigation is required to elucidate the precise mechanisms by which the microbial community or specific bacteria contribute to carcinogenesis. The present work deals with the isolation and identification of bacteria from nine CRC biopsy samples and nine adjacent normal biopsy samples.

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The method proposed explores the integration of Internet of Things (IoT) technologies and sensor fusion techniques into modern transportation systems to enhance efficiency, safety, and road quality assessment. The study not only emphasizes the importance of V2V communication using DSRC Dedicated Short Range Communication, Threshold Based Algorithms (TBA) and Dynamic Time Warping (DTW) but also proposes a novel approach of IoT multi-sensor fusion hardware model that is designed to identify clean and rough surface road conditions. By deploying multi sensor module into proposed model, real-time road surface data is collected and processed to classify them into flat clean or bumpy rough categories based on their smoothness index.

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Human colon hosts a highly organized protective microbial ecosystem in the form of biofilms, increasingly recognized as key contributors to colorectal cancer (CRC) progression through microbial dysbiosis and complex host-microbiota interactions. In India, CRC ranks among the top ten cancers, with an age-standardized incidence rate of approximately 6.3 per 100,000 in males and 3.

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In a perovskite oxide of [Formula: see text], the [Formula: see text] octahedral rotation and tilting are known to result in a structural distortion and transform the crystalline structure to a lower symmetry phase, such as the tetragonal phase (T-phase) and distorted orthorhombic phase (O-phase). Here, we present the observation of such structural transformation in 6 unit cell (uc) ultrathin films of [Formula: see text] (SRO) driven by an additional [Formula: see text] (STO) capping layer. A series of nominal STO (x uc)/SRO (6 uc) films with x ranging from 0 to 8 were grown on STO (001) substrates using an oxide molecular beam system with adsorption-controlled growth technique for SRO and layer-by-layer growth technique for STO.

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Background: Hypertension is among the most complex global public health concerns. Hypertension and kidney diseases share a strong correlation. The existence of microalbuminuria signifies early renal impairment.

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Aim: Reconstruction of tongue defects has always been a challenging aspect of onco-surgery. Although a variety of locoregional and free flaps have been advocated, it still poses a challenge due to its complex function in deglutition and speech articulation. Hence, this study aims at reducing the dilemma of flap selection for better patient outcome.

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Unlabelled: Earlobe clefts have been the major concern for aesthetic repair in the present situation. The advent of platelet-rich plasma (PRP) for enhancement of healing has never been treated for cleft earlobe repair. This study aims to compare and evaluate the efficacy of wound healing with and without platelet-rich plasma injection in bilateral earlobe cleft lobe repair.

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Salt stress is a major abiotic stressor that limits plant growth, development, and agricultural productivity, especially in regions with high soil salinity. With the increasing salinization of soils due to climate change, developing salt-tolerant crops has become essential for ensuring food security. This review consolidates recent advances in plant genetics, transcription factors (TFs), and next-generation sequencing (NGS) technologies that are pivotal for enhancing salt stress tolerance in crops.

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Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide despite advances in medical research and therapeutics. Emerging evidence suggests a significant role of the gut-brain axis, a complex communication network involving the gut microbiota, central nervous system, and cardiovascular system, in modulating cardiovascular health. The gut microbiota influences systemic inflammation, neurohumoral pathways, and metabolic processes, which are critical in the pathogenesis of CVD.

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Article Synopsis
  • Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease primarily affecting small bile ducts, with limited treatment options and a reliance on liver transplants in severe cases.
  • Researchers studied T cell responses to a specific protein (PDC-E2) linked to PBC, focusing on a common genetic marker (HLA Class II DRB4∗01:01) found in many patients.
  • They discovered unique T cell receptors (TCRs) that can target a new PDC-E2 epitope, leading to the development of engineered regulatory T cells (EngTreg) that could help suppress harmful immune responses in PBC patients, offering potential for new therapies.
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Effective pain management in Emergency Departments (EDs) is vital for improving patient comfort and clinical outcomes. This review provides a comprehensive analysis of current pain management practices in ED settings, focusing on the challenges and opportunities for optimization. The review examines pharmacologic and non-pharmacologic pain management strategies, evaluating their effectiveness and identifying inconsistencies and gaps in current practices.

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  • The coronoid process of the mandible is rarely fractured in maxillofacial trauma, but complications can arise from these fractures, prompting a need for better classification and analysis of cases.
  • A study at a level 1 trauma center analyzed patients with coronoid fractures, using a new 'tripartite' classification system to organize their findings based on age, causes, and types of fractures.
  • Results indicated that most fractures occurred in individuals aged 21-40 years, primarily due to road traffic accidents, and the new classification helps streamline communication and treatment strategies for these injuries.
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The growing challenge of food waste management presents a critical opportunity for advancing the circular bioeconomy, aiming to transform waste into valuable resources. This paper explores innovative strategies for converting food wastes into renewable food resources, emphasizing the integration of sustainable technologies and zero-waste principles. The main objective is to demonstrate how these approaches can contribute to a more sustainable food system by reducing environmental impacts and enhancing resource efficiency.

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Cardiac arrhythmias encompass a range of conditions characterized by abnormal heart rhythms, affecting millions globally and significantly contributing to morbidity and mortality. This review provides a comprehensive analysis of the current practices and emerging therapies in managing cardiac arrhythmias, covering their definition, classification, epidemiology, and the critical importance of effective management. It explores the pathophysiology underlying various arrhythmias, including the mechanisms of arrhythmogenesis, such as re-entry, automaticity, and triggered activity.

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Objectives: To determine age- and sex-related changes in mastoid air cells volume in orthodontic malocclusions (class 1, class 2, class 3) in cone beam computed tomography (CBCT), morphometric analysis, and age prediction on the basis of mastoid air cells.

Methods: In total, 150 3D CBCT scans of study subjects having class 1, class 2, and class 3 malocclusions have been analyzed retrospectively for the estimation of volume of mastoid air cells by Dolphin imaging software V11.9, and measurement data of volumes have been recorded and analyzed using SPSS software 24.

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Introduction: Cosmesis is the primary concern for the patient undergoing facial surgery and there are numbers of well proven materials that are available such as adhesive tapes, subcuticular suture, skin adhesive or glue to achieve better cosmesis. The objective of our study was to assess the surgical outcome of sutureless skin closures using Octyl-2-cyanoacrylate (Dermabond™) versus Steri-Strip™.

Method: The present prospective study was conducted in 20 patients.

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  • The systematic review investigates how mandibular advancement therapy (MAT) impacts inflammatory biomarkers in patients with obstructive sleep apnea (OSA), aiming to provide clarity on MAT’s effectiveness.
  • The study included fifty-four relevant articles from a search of major medical databases, ultimately narrowing down to three randomized clinical trials involving 148 patients with an average age of 53.11 years.
  • Findings suggest that while MAT significantly decreased the apnea-hypopnea index in patients with moderate to severe OSA, its effect on inflammatory and metabolic biomarkers was minimal.
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  • * A case study of a 45-year-old man shows ongoing issues with chronic lymphatic obstruction and recurrent cellulitis in his leg, despite antibiotic treatment.
  • * Effective management requires a combination of therapies including compression stockings, surgery, and a multidisciplinary approach to prevent complications from lymphedema and elephantiasis.
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Present study is a comparative evaluation of the financial impact on choice of flap, clinical results as well as post resection quality of life assessment of cancer patients reconstructed with anterolateral thigh(ALT) flap and pectoralis major myo-cutaneous(PMMC) flap. Ethical clearance was obtained from institutional ethical committee. In this non-randomised, prospective study design among 49 oral squamous cell carcinoma cases, 39 cases were reconstructed using PMMC flap and 10 using ALT flap from year 2020 to 2022.

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The growing population and waste biomass accumulation are leading to increased environmental pollution and climate change. Waste biomass comprising of nutrient rich components has promising potential to produce value-added products for sustainable environmental solutions. This review explores the critical role of bio-based heterogeneous catalysts in enabling sustainable waste biomass utilization.

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Cesium lead halide perovskite (CsPbX; X = Cl, Br, I) nanocrystals showing intense band-edge emission and high photoluminescence quantum yield are known to be a potential candidate for application in optoelectronic devices. However, controlling toxicity due to the presence of Pbin lead-based halide perovskites is a major challenge for the environment that needs to be tackled cautiously. In this work, we have partially replaced Pbwith Mnions in the CsPb(Cl/Br)nanocrystals and investigated their impact on the structural and optical properties.

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FOXP3+ regulatory T cells (Treg) are required for maintaining immune tolerance and preventing systemic autoimmunity. PI3Kδ is required for normal Treg development and function. However, the impacts of dysregulated PI3Kδ signaling on Treg function remain incompletely understood.

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