Recurrent Malignant Phyllodes Tumor of the Breast: A Case Report.

Malignant phyllodes tumors of the breast are rare fibroepithelial neoplasms with aggressive behavior and high recurrence rates. They pose significant diagnostic and therapeutic challenges due to their overlap with other malignancies, necessitating accurate diagnosis and a tailored treatment approach to improve patient outcomes. A 29-year-old Asian female initially underwent a lumpectomy for a right breast mass diagnosed as a phyllodes tumor on histopathology.

AI-augmented prediction of high-risk PINK1 variants associated with Parkinson's disease: integrating multilayered bioinformatics, MD simulation, and deep learning.

Parkinson's disease is a prevalent neurodegenerative disease, in which genetic mutations in many genes play an important role in its pathogenesis. Among these, a mutation in the PINK1 gene, a mitochondrial-targeted serine/threonine putative kinase 1 that protects cells from stress-induced mitochondrial dysfunction, is implicated in autosomal recessive Parkinsonism. However, the exact etiology is not well understood.

Prevalence of White Coat Hypertension Among Surgical Patients at a Tertiary Care Hospital: A Cross-Sectional Observational Study.

Background The prevalence of white coat hypertension (WCH) among surgical patients is a significant concern. WCH refers to a condition where individuals with normal blood pressure at home exhibit elevated readings when measured at a medical facility, affecting clinical decision-making processes. The aim is to determine the prevalence of WCH among patients undergoing elective surgery at a tertiary care hospital and to evaluate its association with demographic factors, surgical type, and perioperative waiting time.

Exon 11 Mutations in Breast Cancer: A Study From Pakistan.

Breast cancer ranks among the top causes of cancer-related deaths in women around the globe, with genetic mutations in the gene being a frequent cause of breast or ovarian cancer. This study investigates hotspot mutations in exon 11 of the gene among Pakistani women diagnosed with breast cancer. Thirty clinically diagnosed breast cancer patients, all women, were enrolled in the current study, and high-quality DNA was extracted from peripheral blood samples.

The synergistic potential of camrelizumab and rivoceranib in advanced hepatocellular carcinoma: a review of current evidence.

Camrelizumab, a PD-1 inhibitor, and rivoceranib, a VEGFR tyrosine kinase inhibitor, have emerged as a promising combination therapy for advanced or unresectable hepatocellular carcinoma (HCC). This review explores the clinical efficacy and therapeutic potential of this dual treatment approach. A comprehensive literature search was conducted using PubMed/MEDLINE and Google Scholar to evaluate key clinical trials, including the pivotal CARES-310 trial.