A national atlas to improve the study of Canadians living with long COVID (post-COVID-19 condition).

Objectives: To develop a national atlas of (1) Canadian cohorts studying or with the potential to study adults living with long COVID (LC) and (2) harmonize provincial and territorial administrative datasets to facilitate the creation of validated case-ascertainment algorithms and foster national collaboration on LC research.

Methods: We conducted a multifaceted environmental scan that included a comprehensive literature search and a survey of members of Canada's national LC research network between August 21, 2023, and November 10, 2023. We identified provincial and territorial cohorts, including those that were linkable to administrative data and common data elements among administrative datasets.

Atypical Presentation of Anti-NMDAR Encephalitis in an Elderly Male With Dominated Memory Impairment From Damascus Hospital.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare but serious autoimmune disorder that is typically characterized by a broad spectrum of psychiatric and neurological symptoms. In the academic literature, memory deficits often occur alongside psychiatric symptoms, seizures, motor dysfunctions, and other cognitive issues; it is rare to find it dominated by memory impairment with only one previous seizure. We present a unique presentation of anti-NMDAR encephalitis in a 70-year-old Middle Eastern male patient who primarily exhibited memory impairment along with one unrepeated recent seizure.

Salmonella spp. Inactivation During Hot Air Drying of Apples: Influence of Temperature, Bed Depth, and Air Velocity.

Dried fruit has been linked to recalls and outbreaks due to microbiological hazards. While most drying processes are optimized for product quality, microbiological safety may not always be prioritized. The food industry is required to validate process preventive controls to ensure they significantly minimize or prevent microbial hazards.

Impact of an Enhanced Disinfection Protocol on the Incidence of Infections and Antibiotic Consumption in a Hospital Setting: A Retrospective Intervention Study.

: infection (CDI) is a major concern in hospital-acquired infections. spores can survive on surfaces for months and require sporicidal disinfection for elimination. The use of disinfectants should be based on laboratory-confirmed sporicidal activity, tested according to current standards in suspension and carrier tests.

Associations between Parental Social Support and Early Childhood Screen-time in US Children.

Excessive childhood screen-time is associated with adverse lifestyle and mental health outcomes. Studies suggest that social support, perceived assistance from others, can empower parents to manage screen-time; however, it is unclear which sources of support are relevant and whether income influences these associations. We examined whether individual, family, and neighborhood social support are associated with optimal early childhood screen-time.

Treatment of Ochronotic Osteoarthropathy and the Evaluation of Selected Lower Limb Muscle Properties, Including the Patellar Tendon: A Case Report and Mini Literature Review.

Alkaptonuria (AKU) is a rare genetic disorder characterized by elevated levels of circulating homogentisic acid (HGA), which accumulates in connective tissues. The musculoskeletal system is particularly susceptible to HGA deposition, often resulting in severe ochronotic osteoarthropathy, especially in the hips, shoulders, knees, and spine. However, little is known about the effects of AKU on skeletal muscle tissue.

Perforated meckel's diverticulum misdiagnosed as a urinary tract infection in an 11-year-old adolescent: case report of a rare differential diagnosis.

Background: Meckel's diverticulum, a congenital anomaly of the gastrointestinal tract, is often asymptomatic but can present with complications such as inflammation, perforation, or obstruction. Misdiagnosis is common owing to its varied presentations, particularly when symptoms mimic other conditions such as urinary tract infections (UTI).

Case Presentation: An 11-year-old boy presented with persistent suprapubic pain and dysuria for one week.

Deep learning-based contour propagation in magnetic resonance imaging-guided radiotherapy of lung cancer patients.

Fast and accurate organ-at-risk (OAR) and gross tumor volume (GTV) contour propagation methods are needed to improve the efficiency of magnetic resonance (MR) imaging-guided radiotherapy. We trained deformable image registration networks to accurately propagate contours from planning to fraction MR images.Data from 140 stage 1-2 lung cancer patients treated at a 0.

The impact of communication skills training on patient-centered attitude and patient satisfaction: A longitudinal study of Egyptian physicians.

Objective: Patient-centered care (PCC) provides recognized global benefits but remains underexplored in the Middle East and North Africa (MENA) region, particularly in Egypt. This study assesses the impact of communication skills training on doctor-patient relationships, patient-centered attitudes, and patient satisfaction in healthcare centers across Giza governorate.

Methods: From November 2022 to January 2024, a multi-center longitudinal study was carried out in healthcare centers across the Giza governorate in Egypt, involving 102 physicians and 257 patients.

Dapagliflozin enhances systolic and diastolic function in concordance with clinical response in patients with left ventricular dysfunction.

Unlabelled: OBJECTIVE: Sodium-glucose co-transporter-2 (SGLT2) inhibitors have reshaped heart failure (HF) management. However, evidence regarding their effects on cardiac structure, particularly for dapagliflozin, remains inconsistent. This study evaluates dapagliflozin's impact on echocardiographic parameters and its concordance with clinical response.

The effects of melatonin on oxidative stress, inflammation, apoptosis and Nrf2/HO-1 in acrylamide-induced lung injury in rats.

This study is to investigate the effects of melatonin on lung inflammation, oxidative stress, apoptosis, tissue damage, and MT1 and MT2 receptors in acrylamide-induced lung toxicity. Fifty male rats were randomly divided into five groups. The control group received distilled water orally for 11 days, while the acrylamide group received acrylamide (50 mg/kg, i.

Genetic polymorphisms in are associated with clinical outcomes and dapagliflozin response in heart failure patients.

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have emerged as promising therapeutics for heart failure (HF). Nevertheless, evidence supporting the mechanism of SGLT2i efficacy in HF patients is currently limited. Genetic variation in (encoding SGLT2) may influence HF progression and SGLT2i response, as well as inform potential SGLT2i mechanisms.

Two rare complications of cerebrospinal fluid shunting: A rare case report from Syria.

Introduction: Hydrocephalus, characterized by an abnormal accumulation of cerebrospinal fluid in the brain's ventricles, is commonly treated with ventriculoperitoneal (VP) shunts. A rare complication of VP shunts is the formation of abdominal pseudocysts (APCs). Ventriculoatrial (VA) shunts are used when VP shunts are not feasible, but they can lead to rare complications, including catheter migration.

Evaluation of a Fruit and Vegetable Voucher Program in a Prenatal and Pediatric Primary Care-Based Obesity Prevention Program.

Maternal consumption of fruits and vegetables can reduce future childhood obesity risk. , a fruit and vegetable voucher program redeemable at New York City (NYC) farmers' markets, supports access to fresh produce. In a cross-sectional analysis within a cohort study, we evaluated the integration of into the prenatal expansion of a primary care-based obesity prevention program.

Bacteroides maternus sp. nov., a novel species isolated from human faeces.

A novel bacterial strain, MSB163, was isolated from the stool sample of a healthy mother, 4 weeks after giving birth via vaginal delivery. Taxonomic identification tools revealed that MSB163 belongs to the genus Bacteroides, but it is distinct from any currently known species. The closest related species is Bacteroides cellulosilyticus strain BFG- 250, with an average nucleotide identity (fastANI) of 94.

Burnout syndrome and healthy lifestyle among Egyptian physicians: A cross-sectional study.

Introduction: The phenomenon of burnout and the lifestyle of physicians significantly influence the delivery of healthcare. Over time, burnout intensifies, negatively impacting professional performance, which in turn leads to decreased quality of treatment, patient satisfaction, and productivity. Additionally, it increases the occurrence of medical mistakes and turnover among physicians.

Lipid rafts: novel therapeutic targets for metabolic, neurodegenerative, oncological, and cardiovascular diseases.

Lipid rafts are specialized microdomains within cellular membranes enriched with cholesterol and sphingolipids that play key roles in cellular organization, signaling, and homeostasis. This review highlights their involvement in protein clustering, energy metabolism, oxidative stress responses, inflammation, autophagy, and apoptosis. These findings clarify their influence on signaling, trafficking, and adhesion while interacting with the extracellular matrix, cytoskeleton, and ion channels, making them pivotal in the progression of various diseases.

Synthesis, characterization, and application of a poly(acrylic acid-co-acrylamide) cation exchanger (ACX) for camel lactoferrin purification.

The goal of this study is to develop an optimized poly(acrylic acid-co-acrylamide) cation exchanger (ACX) for protein purification. Cation exchange chromatography is a widely used technique in protein purification. ACX was synthesized and tailored to purify positively charged proteins using batch chromatography.

Mechanistic insights into the P-coumaric acid protection against bisphenol A-induced hepatotoxicity in in vivo and in silico models.

Bisphenol A (BPA), commonly found in plastic containers and epoxy resins used for food products, presents substantial health risks, particularly in relation to hepatic toxicity. This study investigates BPA-induced liver damage and explores the mechanistic dose-dependent protective effects of P-coumaric acid (PCA). 50 male rats were divided into control, BPA-treated, BPA + PCA50, BPA + PCA100, and PCA100 groups.

Gallic acid's protective mechanisms against acrylamide-induced pulmonary injury: in vivo and in silico insights into the Nrf-2/HO-1/NFκB pathway modulation.

Acrylamide (ACR) is a toxic compound formed during the heating of tobacco and starchy foods, contributing to increased reactive oxygen species (ROS) levels and significant health risks. This study evaluates the protective effects of gallic acid (GA), a natural polyphenol with potent antioxidant and anti-inflammatory properties, against ACR-induced lung injury. Fifty male rats were divided into five groups: Control, ACR, GA50 + ACR, GA100 + ACR, and GA100.

Mosaic Darier's Disease: A Case of Unilateral Localized Type I Segmental Darier's Disease.

Darier's disease (DD), also known as Darier-White disease, is a rare autosomal dominant genodermatosis resulting from mutations in the ATP2A2 gene. It commonly manifests as keratotic papules or plaques in seborrheic areas and is often triggered by heat, sweating, and trauma. A rare mosaic variant, segmental Darier's disease, occurs due to post-zygotic mutations and presents along Blaschko's lines.

D-allulose enhances lipid oxidation in HepG2 cells via peroxisome proliferator-activated receptor α (PPARα).

Lipid accumulation in hepatocytes in non-alcoholic steatohepatitis (NASH) is attributed partly to loss of insulin-responsiveness and/or an increased pro-inflammatory state. Since the rare sugar D-allulose has insulin mimetic and anti-inflammatory properties, its effects on lipid accumulation in liver-derived cells was tested. In HepG2 cells exposed to 200 μM oleic acid for 72 h, D-allulose treatment decreased intracellular lipid accumulation with an IC = 0.

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A-menin to bivalent promoters.

Members of the KMT2C/D-KDM6A complex are recurrently mutated in urothelial carcinoma and in histologically normal urothelium. Here, using genetically engineered mouse models, we demonstrate that Kmt2c/d knockout in the urothelium led to impaired differentiation, augmented responses to growth and inflammatory stimuli and sensitization to oncogenic transformation by carcinogen and oncogenes. Mechanistically, KMT2D localized to active enhancers and CpG-poor promoters that preferentially regulate the urothelial lineage program and Kmt2c/d knockout led to diminished H3K4me1, H3K27ac and nascent RNA transcription at these sites, which leads to impaired differentiation.

Exploring Cannabis-Associated Presentations to Canadian Pediatric Emergency Departments: A Cross-Sectional Study.

Objective: Recent studies found that recreational legalization of cannabis consumption for Canadian adults has increased presentation to the emergency department (ED) among children. In this descriptive study, our objectives were to (1) understand Canadian pediatric emergency medicine (PEM) providers' training and knowledge of clinical presentations associated with cannabis exposure in children and (2) describe pediatric ED presentations related to cannabis exposure across Canada following legalization in 2018.

Method: In 2021, following ethics board approval, 230 Pediatric Emergency Research Canada (PERC) network pediatric emergency medicine (PEM) physicians were invited to share about their knowledge, training, and experience with patients presenting with cannabis-associated emergencies using an anonymized survey administered through REDCap.