Unveiling Targeted Approaches to Combat Drug Resistance in Cancer Chemotherapy.

Despite significant advancements in medical science, cancer continues to be a major cause of morbidity and mortality worldwide. A key factor contributing to this persistent burden is the emergence of resistance to conventional therapeutic modalities, including chemotherapy, radiation therapy, and surgery. This phenomenon of drug resistance significantly hampers the efficacy of these treatments, leading to therapeutic failure and poor clinical outcomes.

Indigenous Negative Pressure Wound Therapy: A Low-cost Equivalent Alternative to Conventional Vacuum-assisted Closure Therapy - A Prospective Randomized Open-blind Endpoint Study.

Background: Vacuum assisted closure therapy (VAC) is a noninvasive, cost-effective alternative to surgical wound management. Indigenous negative pressure wound therapy (NPWT) systems offer comparable clinical outcomes without financial constraints.

Materials And Methods: This prospective comparative study was conducted over 1 year at the Orthopedics department of RIMS, Ranchi.

Copper-Catalyzed and 1,3-Sulfonyl Migration Enabled Installation of Azaindoles in the Periphery of Aryl Rings: Synthesis of Sulfonylated Pyrrolo[2,3-]quinolines and Investigation of Antimalarial Potency.

Herein, an atom efficient and one-pot protocol, offering a series of sulfonylated pyrrolo[2,3-]quinolines via C-N, C-C, and C-S bond formation, has been developed with an inexpensive copper catalyst. Notably, the reaction proceeds via a double-annulation reaction followed by a 1,3-sulfonyl migration sequence. Moreover, the method is applicable to a broad range of 2-carbonylanilines.

Diving into Unknown Waters: Water-Soluble Clickable Au Nanoclusters Protected with N-Heterocyclic Carbenes for Bio-Medical Applications.

The use of gold nanoclusters in biomedical applications has been steadily increasing in recent years. However, water solubility is a key factor for these applications, and water-soluble gold nanoclusters are often difficult to isolate and susceptible to exchange or oxidation in vivo. Herein, we report the isolation of N-heterocyclic carbene (NHC)-protected atomically precise gold nanoclusters functionalized with triethylene glycol monomethyl ether groups.

Organo Chalcogenone-Triggered Luminescent Copper(I) Clusters for Light Emitting Applications.

A novel organo sulfur and selenium-controlled emission behavior in discrete copper(I) clusters has been demonstrated for the first time. The pentanuclear [CuBr()] (), trinuclear [CuBr()] (), dinuclear [CuI()] (), and tetranuclear [CuI()CHCN] () copper(I) discrete clusters have been synthesized from the reaction between [ = 1-isopropyl-3-(pyridin-2-yl)-imidazol-2-thione] or [ = 1-isopropyl-3-(pyridin-2-yl)-imidazol-2-selone] chelating ligands and corresponding copper(I) halide salts. These new clusters have been characterized by FT-IR, UV-visible, thermogravimetric analysis, and fluorescence spectroscopy techniques.

A gold(I) 1,2,3-triazolylidene complex featuring the interaction between gold and methine hydrogen.

A mesoionic N-heterocyclic carbene-gold(I) complex with a unique Au⋯H-C(methine) intramolecular hydrogen bonding interaction has been investigated in the solid state. The structure of this new neutral gold(I)-carbene was characterized by FT-IR and NMR spectroscopy, TGA, and X-ray diffraction techniques. Density functional theory (DFT) and atoms-in-molecule (AIM) analysis revealed that the gold-hydrogen bonding situation is more favored.