Human urine-derived stem cells from different donor sources ameliorate diabetic nephropathy in mice by activating autophagy and restoring mitochondrial function of podocyte.

Background: Human urine-derived stem cells (hUSCs) are a novel type of mesenchymal stem cells (MSCs) originating from the kidney, with promising potential for personalized therapies. However, it remains unclear whether hUSCs can be successfully isolated from individuals of different ages and disease states-including healthy young individuals, healthy elderly individuals, and patients with diabetic nephropathy (DN), as well as their therapeutic potential and mechanism in DN.

Methods: hUSCs were isolated from healthy young men (hUSC-HY), healthy elderly men (hUSC-HE), and male DN patients (hUSC-DN), and their biological characteristics were systematically evaluated.

Circulating bile acid profiles characteristics and the potential predictive role in clear cell renal cell carcinoma progression.

Background: The incidence of clear cell renal cell carcinoma (ccRCC) has steadily increased over the past decade, and recent studies have linked bile acid (BA) metabolism to its development. However, the metabolic profile of BAs and their potential as biomarkers in ccRCC pathogenesis remain poorly characterized, making their evaluation crucial for advancing disease understanding and management.

Methods: A total of 68 newly diagnosed ccRCC patients and 63 healthy controls were enrolled.

Metagenomic Next-Generation Sequencing-Assisted Diagnosis of Japanese Spotted Fever: Report of One Case.

Japanese spotted fever(JSF)is an infectious disease caused by ,with nonspecific clinical symptoms and a high risk of misdiagnosis.We reported a case of JSF,in which was detected in blood cells by metagenomic next-generation sequencing.The patient recovered after treatment with doxycycline.

Global incidence trends of autoimmune diseases from 1990 to 2021 and projections to 2050: A systemic analysis of the global burden of disease study 2021.

Background: The analysis of the incidence trends of four autoimmune diseases (ADs) globally from 1990 to 2021, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS), and psoriasis, reveals significant patterns of change, which further projects the incidence of these diseases at the global, regional, and national levels up to the year 2050.

Methods: The estimates for the number of incident cases and age-standardized incidence rates (ASIR), along with the 95 % uncertainty intervals (UI) for RA, IBD, MS and psoriasis, were obtained from the Global Burden of Diseases Study 2021. The estimated annual percentage change (EAPC) was used to quantify the global incidence trends of these four ADs from 1990 to 2021.

Human amniotic mesenchymal stem cell-islet organoids enhance the efficiency of islet engraftment in a mouse diabetes model.

Aims: Despite islet transplantation has proved a great potential to become the standard therapy for type 1 diabetes mellitus (T1DM), this approach remains limited by ischemia, hypoxia, and poor revascularization in early post-transplant period as well as inflammation and life-long host immune rejection. Here, we investigate the potential and mechanism of human amniotic mesenchymal stem cells (hAMSCs)-islet organoid to improve the efficiency of islet engraftment in immunocompetent T1DM mice.

Main Methods: We generated the hAMSC-islet organoid structure through culturing the mixture of hAMSCs and islets on 3-dimensional-agarose microwells.

Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats: a potential role of the hypothalamic-pituitary-adrenal axis.

Objective: To verify the hypothesis that electroacupuncture inhibits the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis regulating the expression of glial fibrillary acidic protein (GFAP) in the hippocampus of acute myocardial ischemia (AMI) rats.

Methods: Sixty-six healthy male Sprague-Dawley rats were randomly divided into five groups: Sham, AMI (Model), electroacupuncture at Shenmen (HT7)-Tongli (HT5) segment (EA), non-acupoint electroacupuncture (Control), and Model + corticosterone (Model + CORT). AMI was induced occlusion of the left anterior descending coronary artery, followed by 3 d of electroacupuncture at Shenmen (HT7)-Tongli (HT5) segment.

Engineering of zeolitic imidazolate frameworks based on magnetic three-dimensional graphene as effective and reusable adsorbent to enhance the adsorption and removal of caffeine from tea samples.

As more and more adverse health effects of caffeine are being discovered, decaffeinated drinks are receiving increasing attention. In this work, a magnetic imidazole zeolite backbone compounded with three-dimensional graphene was successfully synthesized as a solid adsorbent using a layer-by-layer self-assembly technique, which can rapidly and effectively adsorb caffeine from tea. Meanwhile, the structure and properties of caffeine in tea were investigated by various physicochemical characterization tools.

Cancer-associated fibroblast infiltration in osteosarcoma: the discrepancy in subtypes pathways and immunosuppression.

Osteosarcoma (OS), the primary malignant bone tumor, has a low survival rate for recurrent patients. Latest reports indicated that cancer-associated fibroblasts (CAFs) were the main component of tumor microenvironment, and would generate a variable role in the progression of tumors. However, the role of CAFs is still few known in osteosarcoma.

Astragaloside IV plays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like receptor protein 3 signaling pathway.

Objective: To investigate the efficacy of Astragaloside IV (AS-IV) on radiation-induced liver inflammation in mice.

Methods: The mice were divided into normal group, dimethyl sulfoxide solvent group, irradiation group (IR), irradiation + AS-IV (20 mg/kg) group (IR+AS-20) and irradiation + AS-IV (40 mg/kg) group (IR+AS-40). One month after intraperitoneal injection of AS-IV, the mice were irradiated with 8Gry Co60γ, the blood was collected for biochemical analysis, and the liver was collected for hematoxylin-eosin staining, immunofluorescence and electron microscopic observation, oxidative stress, and Western blot analysis.

Prediction model of colorectal cancer (CRC) lymph node metastasis based on intestinal bacteria.

Background: Lymph node metastasis is the main metastatic mode of CRC. Lymph node metastasis affects patient prognosis.

Objective: To screen differential intestinal bacteria for CRC lymph node metastasis and construct a prediction model.

Adsorption performance of GO-doped activated ATP composites towards tetracycline.

Antibiotic-related environmental contamination directly threatens ecosystems and human health. Adsorption is an efficient and simple treatment process for removing antibiotics from water environments. Attapulgite (ATP) is a natural clay mineral extensively researched as a promising adsorbent material in the food industry, pharmaceutical sanitation, and organic wastewater treatment.

Study on Intrinsic Influence Law of Specimen Size and Loading Speed on Charpy Impact Test.

Charpy impact energy/impact toughness is closely related to external factors such as specimen size. However, when the sample size is small, the linear conversion relationship between the Charpy impact energy of the sub-size and full-size Charpy specimens does not hold; the Charpy impact toughness varies with the size of the specimen and other factors. This indicates that studying the internal influence of external factors on impact energy or impact toughness is the key to accurately understanding and evaluating the toughness and brittleness of materials.

The complete chloroplast genome of a solid type of (Bambusoideae: Poaceae), a species endemic to China.

(Bambusoideae: Poaceae), widely distributed in the Yangtze River Basin and various provinces (regions) in southern China, is one of the most important small and medium-sized bamboo species used in both bamboo shoots and timber. In the present study, we assembled a complete chloroplast genome of the economically important bamboo form f. H.

The complete chloroplast genome of var. (Bambusoideae: Poaceae).

var. (T.H.

A meta-analysis of Watson for Oncology in clinical application.

Using the method of meta-analysis to systematically evaluate the consistency of treatment schemes between Watson for Oncology (WFO) and Multidisciplinary Team (MDT), and to provide references for the practical application of artificial intelligence clinical decision-support system in cancer treatment. We systematically searched articles about the clinical applications of Watson for Oncology in the databases and conducted meta-analysis using RevMan 5.3 software.

The complete chloroplast genome of f. (Poaceae).

f. is a precious wood-use bamboo resource, with almost solid stem. The complete chloroplast genome of the f.

The Efficacy and Safety of Radiofrequency Catheter Ablation for Cardiac Arrhythmias in Pediatric Patients.

Background: We aimed to evaluate the acute and long-term efficacy and safety of radiofrequency catheter ablation (RFCA) in Chinese pediatric patients with arrhythmias.

Methods: We gathered clinical data from pediatric patients who underwent RFCA in several large medical centers in China between 2000 and 2019.

Results: A total of 4,622 different substrates in 4,622 patients were ablated, with the majority consisting of supraventricular tachycardia (N = 3,831, 82.

Molecular regulatory network of PD-1/PD-L1 in non-small cell lung cancer.

Lung cancer remains the most common cancer and the leading cause of cancer death worldwide. Despite effective chemotherapy and molecular-based therapies, the median and overall survival remains poor. Immune checkpoint inhibitors have changed the treatment landscape for patients with non-small cell lung cancer (NSCLC) by inhibiting negative T cell regulators, including programmed death 1 (PD-1, CD279) and programmed death ligand 1 (PD-L1, also known as B-H1, CD274) inhibitors.

Citric acid enhances the physical properties, cytocompatibility and osteogenesis of magnesium calcium phosphate cement.

In recent years, the magnesium phosphate cements showed impressive advantages for their setting property, mechanical strength, and resorption rate in laboratory investigation. While it remained a big challenge to develop the magnesium phosphate cements with ideal self-setting properties, sufficient mechanical strength, excellent biocompatibility, and osteoinductivity for clinical application. In our work, we prepared the magnesium calcium phosphate cement (MCPC) using the MgO, KHPO, and Ca(HPO) particles with the citric acid added.

Zhen-wu-tang attenuates Adriamycin-induced nephropathy via regulating AQP2 and miR-92b.

Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia and edema. The disorder of sodium and water metabolism is a critical mechanism regulating the origination and progression of NS. Zhen-wu-tang (ZWT) has been traditionally used to treat edema disease in China and Japan.

Identification and characterization of a pyridoxal 5'-phosphate phosphatase in tobacco plants.

Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B, is an important cofactor for many biochemical transformations. PLP is also a very reactive molecule, and the most well-established mechanism for maintaining low levels of free PLP is its dephosphorylation by phosphatases. In our previous study, the crude enzyme extract from tobacco leaves rapidly hydrolyzed PLP at a pH optimum of 5.

Unsupervised Deep Learning of Compact Binary Descriptors.

Binary descriptors have been widely used for efficient image matching and retrieval. However, most existing binary descriptors are designed with hand-craft sampling patterns or learned with label annotation provided by datasets. In this paper, we propose a new unsupervised deep learning approach, called DeepBit, to learn compact binary descriptor for efficient visual object matching.

[Strategy and effect of snail control in inside-embankment areas in Junshan District, Hunan Province from 1998 to 2017].

Objective: To explore the strategy and countermeasures of snail control and evaluate the effect in inside-embankment areas of lake-type schistosomiasis endemic area, for providing the effective method for controlling and interrupting the schistosomiasis transmission.

Methods: The data of schistosomiasis epidemic and its control and prevention were collected in Junshan District, Hunan Province, and the effect of snail control countermeasures were evaluated and the trend of indexes of snails was drafted in the inside-embankment areas of Junshan District, Hunan Province from 1998 to 2007.

Results: The area with snails in the inside embankment areas of Junshan District decreased by 98.