Argonaute1-Dependent LtmilR2 Negatively Regulated Infection of Lasiodiplodia theobromae by Targeting a Guanine Nucleotide Exchange Factor in RAS Signalling.

Lasiodiplodia theobromae (L. theobromae) is the causative agent of grapevine canker disease, which is a serious threat to global grape production. Currently, no effective fungicides are available to manage this disease.

Periportal Paraganglioma: A Rare Cause of Obstructive Jaundice and Gastroesophageal Varices.

Paragangliomas are rare neuroendocrine tumors arising from extra-adrenal chromaffin cells. Biliary tropism is exceptionally rare and can mimic primary biliary tract malignancies, thus presenting a diagnostic challenge. We describe a rare case of periportal paraganglioma presenting with obstructive jaundice and gastric and duodenal varices.

Endoscopic Submucosal Dissection for Previously Attempted Colorectal Lesions: An International Multicenter Experience.

Background And Aims: Salvage endoscopic submucosal dissection (ESD) has been proposed for previously attempted colorectal lesions (PACLs), yet the extensive submucosal fibrosis impacts procedural difficulty and resection outcomes. The aim of this study was to evaluate the efficacy and safety of salvage ESD for the treatment of PACLs.

Methods: This international, multicenter study enrolled consecutive patients who underwent ESD to manage PACLs.

Diversity of Bacterial Communities in Seleniferous Soils and Their Impact on Plant Growth and Selenium Toxicity.

The present study aimed to investigate the diversity of bacterial communities in seleniferous soils using Illumina Mi-Seq Next-Generation Sequencing. This study also compared seleniferous soils (SE) with non-seleniferous (NS) soils to evaluate Selenium (Se) impact on microbial communities and soil properties. Metagenomic analysis identified Proteobacteria as the predominant phylum in both environments, with SE soils exhibiting a higher dominance (48%) than NS soils (31%).

DeepOmicsSurv: a deep learning-based model for survival prediction of oral cancer.

Objective: Oral cancer is an important health challenge worldwide and accurate survival time prediction of this disease can guide treatment decisions. This study aims to propose a deep learning-based model, DeepOmicsSurv, to predict survival in oral cancer patients using clinical and multi-omics data.

Methods: DeepOmicsSurv builds on the DeepSurv model, incorporating multi-head attention convolutional layers, dropout, pooling, and batch normalization to boost its strength and precision.

Dalbergia sissoo Ethanolic Extract: A Natural Source of Antioxidant, Antibacterial, and Anticorrosive Agents.

Medicinal plants have been extensively studied for their bioactive compounds and medicinal uses. Dalbergia sissoo, belonging to the Fabaceae family, has shown promise in traditional medicine for treating infections, cardiovascular diseases, and skin issues. However, systematic studies on its bioactive compounds and recovery efficiency using different solvents have been limited, particularly regarding potential industrial applications.

Ferroptosis: A Mechanism of Cell Death With Potential Scope in Cancer Therapy.

Ferroptosis is a type of regulated cell death caused by oxidative imbalance of the intracellular microenvironment. This causes the accumulation of toxic lipid peroxides, depicted by iron overload and lipid peroxidation, which results in disease development. The affected cell population displays unique morphological and biochemical features, which are distinct from other modes of cell death, like apoptosis, pyroptosis, and necroptosis.

Protein profiling uncovers IGF-1R inhibition potential of 3-(2-furoyl)-indole scaffolds in hepatocellular carcinoma.

Aim: This study investigates the anti-proliferative potential and possible molecular mechanisms of 3-(2-furoyl)-indole derivatives against HepG2.

Method: Identified hit compounds (4a, 4b, 4c) using MTT screening, were further investigated for their efficacy and mechanism of action through FACS studies, in-silico molecular docking, molecular dynamics (MD) simulations, and label-free quantitative proteome and ADMET prediction.

Results: Lead compound 4a, showed IC50 of 27 µM against HepG2 cells and a binding score of -8.

Structural and rheological characterization of starch-based eutecto-oleogel.

The study aimed to develop a novel eutecto-oleogel and its characterizations. Using starch, beeswax, oil, and natural deep eutectic solvents (NADES), an oleogel with low hardness and high liquid fat was developed. The addition of starch and NADES in oleogels caused the formation of new intra or intermolecular hydrogen bonding and improved the oil binding capacity, thermal behavior, and texture of the oleogels.

Endoscopic management of surgical complications.

While the endoscopic management of surgical complications like leaks, fistulas, and perforations is rapidly evolving, its core principles revolve around closure, drainage, and containment. Effectively managing these conditions relies on several factors, such as the underlying cause, chronicity of the lesion, tissue viability, co-morbidities, availability of devices, and expertise required to perform the endoscopy. In contrast to acute perforation, fistulas and leaks often demand a multimodal approach requiring more than one session to achieve the required results.

The final plug: novel use of vascular plug for management of bronchoesophageal fistula.

Video 1Successful management of a postsurgical bronchoesophageal fistula with a combination of a self-expanding vascular plug, glue containing cyanoacrylate, and a fully covered metal stent.

Baseline Clinical Factors Are Associated With Risk of Complications in Crohn's Disease: Appraisal of the American Gastroenterological Association Clinical Care Pathway.

Introduction: The American Gastroenterological Association (AGA) has compiled risk factors that may be predictive of disease complications in Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study was to evaluate the performance of the AGA risk factors for risk stratification in UC and CD.

Methods: We included participants of 2 cohorts: the Ocean State Crohn's and Colitis Area Registry cohort and the Mayo Clinic cohort.

Thermally stable and color-tunable bi-activated (Dy/Eu) alkaline earth metasilicate phosphor for luminescent devices.

A solid-state reaction methodology has been adopted to synthesize Dy (dysprosium)/Eu (europium) co-activated NaCaSiO (NCMS) phosphors. The structural, morphological, and luminescence characteristics of the prepared materials have been investigated. The phase purity of the material was confirmed by X-ray diffraction (XRD) by comparing the diffraction peaks with the JCPDS standard pattern (JCPDS card no.

Challenging clinical presentation of Zinner syndrome.

Zinner syndrome is a rare congenital malformation of the mesonephric duct comprising of seminal vesicle cyst, ipsilateral renal agenesis, and ejaculatory duct obstruction. Clinical presentation varies with perineal pain, painful ejaculation, hematospermia and infertility common presenting complaints. Here, we present a case of Zinner syndrome in a 35-year-old male with a rare clinical presentation of only abdominal discomfort.

UV-excited blue- to green-emitting Tb -activated sodium calcium metasilicate colour tunable phosphor for luminescence devices.

Tb -doped Na Ca Si O (NCMS:Tb ) phosphors were synthesized using a solid-state reaction route with increasing dopant concentration. The phase identification studies for NCMS:Tb phosphors were carried out using an X-ray diffraction (XRD) technique. The XRD patterns for the as-synthesized phosphors showed satisfactory agreement with the standard pattern (JCPDS card no.

Groundwater Pollution and Human Health Risks in an Industrialized Region of Southern India: Impacts of the COVID-19 Lockdown and the Monsoon Seasonal Cycles.

Samples of groundwater were collected during a post-monsoon period (January) and a pre-monsoon period (May) in 2020 from 30 locations in the rapidly developing industrial and residential area of the Coimbatore region in southern India. These sampling periods coincided with times before and during the lockdown in industrial activity and reduced agricultural activity that occurred in the region due to the COVID-19 pandemic. This provided a unique opportunity to evaluate the effects of reduced anthropogenic activity on groundwater quality.

Natural Plus Synthetic Hydrotropic Solubilization using Response Surface Methodology to Optimize the Solid Dispersion of Hydrochlorothiazide.

Background: Solubility/dissolution is said to be the key factor that influences the oral bioavailability of drug and is also the rate limiting step in formulation development.

Objective: Hydrochlorothiazide (HCZ) is a BCS Class IV drug with low solubility and low permeability. The present work aimed to increase the solubility of hydrochlorothiazide using blends of natural and synthetic hydrotropes.

Groundwater quality evolution based on geochemical modeling and aptness testing for ingestion using entropy water quality and total hazard indexes in an urban-industrial area (Tiruppur) of Southern India.

This study used geochemical modeling to understand the chemical evolution of groundwater, entropy water quality index to assess the aptness of groundwater for human consumption, and total hazard index to determine the possible non-carcinogenic risks among children, women, and men in an urban-industrial area (Tiruppur region) of southern India. For the above purposes, 40 groundwater samples were collected from tube and dug wells, and they were tested for various physicochemical parameters. Fluoride and nitrate levels ranged from 0.

Appraisal of subsurface hydrogeochemical processes in a geologically heterogeneous semi-arid region of south India based on mass transfer and fuzzy comprehensive modeling.

The main aim of the present study was to examine the quality of the groundwater and decipher the sources of groundwater fluoride through mass balance modeling based on fluoride exposure in a geologically heterogeneous semi-arid region of southern India. This was achieved by hydrogeochemical analysis, graphical methods, and mass transfer modeling approaches. Fuzzy comprehensive technique was applied to evaluate the quality of groundwater for groundwater management.

The effects of geochemical processes on groundwater chemistry and the health risks associated with fluoride intake in a semi-arid region of South India.

This study attempts to establish the effects of subsurface geochemical processes based on the hydrogeochemical attributes of 61 well samples collected in a semi-arid region of South India. The study also provides the health risks associated with the consumption of fluoride-enriched groundwater by the rural people since groundwater is the major source of water supply in the Shanmuganadhi River basin. In this work, water-rock interaction diagrams, an entropy-weighted water quality index (EWQI), and health risk models as per the United States Environmental Protection Agency (USEPA) were prepared to understand the geochemical mechanism behind the groundwater chemistry and its role in impacting health.

Correction: Evaluation of 19,460 Wheat Accessions Conserved in the Indian National Genebank to Identify New Sources of Resistance to Rust and Spot Blotch Diseases.

[This corrects the article DOI: 10.1371/journal.pone.