Implementing Social Media Strategies in Community-Partnered HIV Research: Practical Considerations From 3 Ongoing Studies.

Background: In recent years, social media has emerged as a pivotal tool in implementation science efforts to address the HIV epidemic. Engaging community partners is essential to ensure the successful and equitable implementation of social media strategies. There is a notable lack of scholarship addressing the operational considerations for studies using social media strategies in community-partnered HIV research.

Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multi-site, Double-blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).

Rationale: There are insufficient data to inform the management of central sleep apnea (CSA) in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Nocturnal oxygen therapy (NOT) has been postulated to benefit CSA patients with HFrEF, but has not been rigorously studied. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.

PASS-01: Randomized Phase II Trial of Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel and Molecular Correlatives for Previously Untreated Metastatic Pancreatic Cancer.

Purpose: To assess modified folinic acid/leucovorin, fluorouracil, irinotecan, oxaliplatin (FOLFIRINOX; mFFX) versus gemcitabine/nab-paclitaxel (GnP) in de novo metastatic pancreatic ductal adenocarcinoma (PDAC) and explore predictive biomarkers.

Patients And Methods: Patients were randomly assigned 1:1 to mFFX or GnP with exclusion of germline pathogenic variants in or . The primary end point was progression-free survival (PFS) between arms with 0.

Building MHealth technology for Health Promotion in Reproductive Planning: innovations in primary care.

Reproductive Planning is a recognized basic human right and is essential to guaranteeing the quality of health providers' work processes in Primary Health Care (PHC). This study aimed to build a prototype of a mobile application on reproductive planning to aid the ongoing education of nurses in PHC. This methodological study is based on four stages: modeling, navigation design, abstract interface design, and implementation, and was built based on the thematic categorization of article contents stemming from an integrative review, totaling 24 moblets.

Febrile temperature augments ring-stage Plasmodium falciparum adhesion to brain endothelial cells.

Sequestration of Plasmodium falciparum-infected erythrocytes (IE) in the microvasculature is a major virulence determinant. While the sequestration of mature stage parasites (trophozoite and schizonts) to vascular endothelium is well established, the conditions that promote ring-stage IE sequestration is less understood. Here, we observed in ring-stage parasites that febrile exposure increased transcript levels of several exported parasite genes involved in the trafficking of the P.

Distinct Evolutionary Signatures of Human Parainfluenza Viruses 2 and 4 Reveal Host Antagonism Divergence and Phylogenetic Discordance.

Human parainfluenza virus 2 (HPIV-2) and human parainfluenza virus 4 (HPIV-4) are significant but underappreciated respiratory pathogens, particularly among high-risk populations including children, the elderly, and immunocompromised individuals. In this study, we sequenced 101 HPIV-2 and HPIV-4 genomes from respiratory samples collected in western Washington State and performed comprehensive evolutionary analyses using both new and publicly available sequences. Phylogenetic and phylodynamic analyses revealed that both HPIV-2 and HPIV-4 evolve at significantly faster rates compared to mumps virus, a reference human orthorubulavirus.

Surface-Morphology-Assisted Trapping of Strongly Coupled Electron-on-Neon Charge States.

Single electrons confined to a free neon surface and manipulated through the circuit quantum electrodynamics architecture is a promising novel quantum computing platform. Understanding the exact physical nature of the electron-on-neon (eNe) charge states is important for realizing this platform's potential for quantum technologies. We investigate how resonator trench depth and substrate surface properties influence the formation of eNe charge states and their coupling to microwave resonators.

Molecular exaptation by the integrin αI domain.

Integrins bind ligands between their alpha (α) and beta (β) subunits and transmit signals through conformational changes. Early in chordate evolution, some α subunits acquired an "inserted" (I) domain that expanded integrin's ligand-binding repertoire but obstructed the ancestral ligand pocket, seemingly blocking conventional integrin activation. Here, we compare cryo-electron microscopy structures of apo and ligand-bound states of the I domain-containing αEβ integrin and the I domain-lacking αβ integrin to illuminate how the I domain intrinsically mimics an extrinsic ligand to preserve integrin function.

Intermodal microwave-to-optical transduction using silicon-on-sapphire optomechanical ring resonator.

Optomechanical and electro-optomechanical systems have emerged as one of the most promising approaches for quantum microwave-to-optical transduction to interconnect distributed quantum modalities for scaling the quantum systems. These systems use suspended structures to increase mode overlap and mitigate loss to achieve high efficiency. However, the suspended design's poor heat dissipation under strong drive limits the ultimate efficiency.

Evaluating the effect of interactive two-way texting on 6-month antiretroviral therapy outcomes: Findings from a randomized controlled trial in Lilongwe, Malawi.

Retention on antiretroviral therapy (ART) is critical for achieving viral load suppression (VLS) among people living with HIV (PLHIV). Retention remains challenging in high-prevalence settings like Malawi. Short messaging service (SMS) interventions, particularly hybrid two-way texting (2wT), show promise in improving ART retention.

Universal Effective Charges in the sd and fp Shells.

The 247-keV state in ^{54}Sc, populated in the β decay of ^{54}Ca, is reported here as a nanosecond isomer with a half-life of 26.0(22) ns. The state is interpreted as the 1^{+} member of the πf_{7/2}⊗νf_{5/2} spin-coupled multiplet, which decays to the 3^{+},πf_{7/2}⊗νp_{1/2} ground state.

Evidence for Similar Collectivity of High Transverse-Momentum Particles in p-Pb and Pb-Pb Collisions.

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively.

Probing Benchmark Models of Hidden-Sector Dark Matter with DAMIC-M.

We report on a search for sub-GeV dark matter (DM) particles interacting with electrons using the DAMIC-M prototype detector at the Modane Underground Laboratory. The data feature a significantly lower detector single e^{-} rate (factor 50) compared to our previous search, while also accumulating a 10 times larger exposure of ∼1.3  kg-day.

Epithelial competition determines gene therapy potential to suppress Fanconi Anemia oral cancer risk.

Fanconi Anemia (FA) is a heritable syndrome characterized by DNA damage repair deficits, frequent malformations and a significantly elevated risk of bone marrow failure, leukemia, and mucosal head and neck squamous cell carcinomas (HNSCC). Hematopoietic stem cell gene therapy can prevent marrow failure and lower leukemia risk, but mucosal gene therapy to lower HNSCC risk remains untested. Major knowledge gaps include an incomplete understanding of how rapidly gene-corrected cellular lineages could spread through the oral epithelium, and which delivery parameters are critical for ensuring efficient gene correction.

A protocol to develop a Quality Assessment Tool for Realist Synthesis (QUATRES).

A realist synthesis or review is a theory-driven, realist-informed interpretive approach to synthesizing secondary data, informing evidence-based practice, and explaining social phenomena. Realist syntheses use flexible and iterative methods to achieve this goal, including drawing on stakeholders' knowledge. Thus, realist syntheses require robust planning to be conducted and reported.

Gaps in care across the cancer screening continuum for cervical, colorectal and lung cancer.

Background: While screening for cervical, colorectal, and lung cancers reduce cancer-specific mortality, the full benefits of screening are only realized when coupled with timely care across the subsequent "screening continuum" steps, including surveillance (results warranting frequent monitoring), diagnostic evaluation (results that require additional testing), and treatment (detected cancers). Our goal was to describe the proportion of individuals receiving timely cervical, colorectal, and lung cancer care at each step in the screening continuum.

Methods: This retrospective cohort study used data from the 10 health care settings that participate in the Population-based Research to Optimize the Screening Process (PROSPR II) consortium and included individuals who were eligible for a step along the cancer screening continuum in 2018.

An analysis of behavioral characteristics and enrollment year variability in 47,444 dogs entering the Dog Aging Project from 2020 to 2023.

Understanding dog behavior, especially in the context of the human social environment, is critical to maintaining positive human-dog interactions and relationships. Furthermore, behavior can be an important indicator of health and welfare in companion dogs. Behavioral change can signal transitions in life stages, alert caretakers to potential illnesses or injuries, and is an important factor in understanding and measuring stress.

Influence of Carrier Oil, Sex, and Age on Pharmacokinetic and Acute Behavioral Effects of Vaporized Cannabis Extract in Mice.

The legalization of cannabis in several states across the United States has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Previous rodent studies have revealed age and sex differences in response to injected Δ-tetrahydrocannabinol (THC). However, the pharmacokinetic and pharmacodynamic properties of THC administered through more translationally relevant routes of administration are less well known.

Long-Term Outcomes of Liver Pathology Following a Sleeve Gastrectomy.

The rising prevalence of obesity in the United States is paralleled by an increase in type II diabetes (T2D) and metabolic-associated steatotic liver disease. While lifestyle changes often do not afford sustainable weight loss, bariatric surgery, particularly sleeve gastrectomy (SG), offers a durable solution. This study investigates long-term outcomes in Veterans who underwent SG with concurrent liver biopsy.

Top Ten Tips Palliative Care Clinicians Should Know About Intentionally Interprofessional Collaboration.

Although high-quality and holistic specialty palliative care is delivered by an interprofessional team, little guidance is available to optimize approaches to and sustainment of such teamwork. This article supports individuals to practice at the top of their education, clinical training, and scope of practice while maximizing the functionality of the palliative care team as a whole. We intentionally use the term rather than to clarify that we are focused on collaboration of team members who represent multiple professions or occupations that require specialized training and meet ethical standards (e.

Ignoble Gas: The Questionable Role of Xenon in Rapid Ascents of Mount Everest.

Manferdelli, Giorgio, Marc M Berger, and Andrew M Luks.Ignoble Gas: The Questionable Role of Xenon in Rapid Ascents of Mount Everest. 00:00-00, 2025.

The "Secret of Seven Stones": Short-Term Efficacy of an Online Intergenerational Sexual Health Education Game for Early Adolescents and Their Parents.

Intergenerational games offer a potential channel to impact parent-youth sexual health communication. The "Secret of Seven Stones" (SSS) is an 18-level online adventure game and parent website designed to engage parents and youth (11-14 years) in conversations about healthy dating relationships and sexual behavior and to provide sexual health skills training to youth. Study hypotheses were that SSS exposure would increase sexual health parent-child communication, increase youth intentions to delay sexual debut, and reduce youth exposure to situations that promote sexual activity.

Volitional Control of Frequency and Intensity in Speakers With and Without Hyperfunctional Voice Disorders.

Purpose: Prior studies of vocal auditory-motor control in people with hyperfunctional voice disorders (HVDs) have found evidence of unusually large responses to auditory feedback perturbations of fundamental frequency (0) and more variable voice onset times in unperturbed speech. However, it is unknown whether people with HVDs perform similarly to people with typical voices when asked to make small changes in vocal parameters in volitional tasks. The purpose of this study was to compare performance on minimal movement tasks for 0 and intensity in people with and without HVDs.