"Weekend warrior" physical activity pattern and risk of incident cancer.

Purpose: To investigate the associations between different physical activity patterns, including "weekend warrior" (WW) (i.e. most weekly moderate-vigorous physical activity (MVPA) achieved over 1-2 days)) and regular (MVPA spread more evenly) patterns with the risk of incident cancers.

The role of intrinsic capacity in predicting cancer mortality - Evidence from the UK Biobank.

Aim: To examine the association between intrinsic capacity and cancer mortality in middle-aged and older adults.

Methods: We analysed a prospective cohort of 443,130 participants from the UK Biobank, with seven biomarkers reflecting the level of functioning in five domains of intrinsic capacity to calculate an overall score (ranging from 0 [better] to +4 [poor]). Associations between intrinsic capacity scores and mortality from any type of cancer (censored as of December 31, 2022) were estimated using Cox proportional hazard models adjusted for multiple potential confounders.

The central dorsal component of the dorsoradial ligament of the trapeziometacarpal joint: Cadaveric and sonographic validation.

Purpose: Osteoarthritis of the trapeziometacarpal joint is very common, especially in females, and is closely associated with ligamentous laxity and joint subluxation. The dorsoradial ligament (DRL) remains largely unexplored in ultrasound studies despite its clinical relevance. This study aimed to identify the central fascicle of the DRL anatomically and ultrasonographically and to establish a standardized ultrasound examination protocol.

Unravelling the cell death mechanism triggered by catalytic copper-iron nanoparticles and .

Nanomedicine has developed an impressive array of anticancer devices, from drug delivery vectors to hyperthermia-enabling nanoparticles. Lately, emphasis has been shifted to the tumour microenvironment (TME) and to active nanomaterials adapted to the prevailing conditions. Among them, catalytic nanomaterials (also called nanocatalysts) represent a highly interesting alternative, especially when they are able to target metabolites that are present to a greater extent in tumoral cells, opening a window for a catalytically selective action.

Three-Step One-Pot Photocatalytic Oxidation of Feedstocks and Organocatalytic Sequential Cascade to Access Enantioenriched α-Aminonitriles.

A three-step, one-pot, sequential cascade starting from simple feedstocks to increase complexity toward value-added chiral synthetic building blocks is reported. This is achieved by precisely integrating organic photocatalysis and noncovalent organocatalysis, often operating at dissimilar conditions and reaction media. In particular, this strategy is used to enable the direct transformation of readily available benzylic substrates, such as methylbenzenes, benzyl alcohols, or amines, into enantioenriched α-aminonitriles by benzylic CH photooxidation to their corresponding aldehydes, followed by in situ imine formation and final asymmetric organocatalytic Strecker reaction.

Characterizing grazing and terrain use patterns of Hispano-Breton mares in the Spanish Pyrenees using GPS devices and remote sensing data.

Geotechnologies, such as Global Navigation Satellite Systems (GNSS) and remote sensing, are essential for documenting topographic features and analyzing land use. Among them, the GPS (Global Position System)-based sensors have proven highly effective in monitoring livestock, providing high-resolution data on movement patterns. This study tracked two Hispano-Breton mares in the Spanish Pyrenees during summer 2023 using GPS collars.

Association between maternal circulating total triiodothyronine and subsequent risk of preeclampsia.

Introduction: To clarify the uncertain association between maternal total triiodothyronine (TT3) levels and preeclampsia risk.

Methods: In a hospital-based cohort of pregnant women with universal thyroid testing, we assessed the association between TT3 and preeclampsia using directed acyclic graphs (DAG) to control confounders.

Results: Maternal TT3 levels were associated with preeclampsia risk, with an adjusted odd ratio (OR) of 2.

Explosive adoption of corrupt behaviors in social systems with higher-order interactions.

Human behaviors in social systems are often shaped by group pressure and collective norms, especially since the rise of social media platforms. However, in the context of adopting misbehaviors, most existing contagion models rely on pairwise interactions and thus fail to capture group-level dynamics. To fill this gap, we introduce a higher-order extension of the honesty-corruption-ostracism model to study the emergence of systemic corruption in populations where individuals interact through group structures.

Cutaneous AL-Type Amyloidomas as a Variant of Primary Cutaneous Marginal Zone Lymphoma: A Series of 30 Patients.

AL-amyloidomas, particularly those primarily localized to the skin, present diagnostic and clinical challenges. They predominantly arise from immunoglobulin light chains, often due to plasma cell proliferation. The relationship between this entity, AL-amyloidomas, and primary cutaneous marginal zone lymphoma remains a subject of scientific debate.

Uncertainty Propagation and Input Sensitivity in Life Cycle Assessment: An Application to Phase Change Materials.

Global and local sensitivity analyses are essential for identifying key parameters in life cycle assessment models. However, due to limited information on parameter uncertainty, they are often overlooked. This paper's objective is to address this gap by proposing a methodological framework for defining input sensitivity, for midpoint and end point indicators, and a quantitative approach for determining input uncertainties.

Flow Reactor Study of NH/DEE Oxidation Chemistry.

The pursuit of environmentally sustainable alternatives to conventional fuels is essential today. Ammonia emerges as a promising candidate, though its inherent disadvantages must be addressed. Co-firing ammonia with fuels exhibiting superior thermochemical properties is one of the most widely accepted solutions.

What is the status of (Ixodidae)?

The original description of is predominantly based on morphological and ecological characteristics. It was postulated that is a cryptic species of the complex, mainly found in the Mediterranean region of Spain, Portugal, Morocco, Algeria, and Tunisia. Although definitive proof is lacking, genetic insights support that is a distinct species, but that the morphological characteristics, particularly from the adult stages, as well as molecular features, might not be distinctive enough for identification.

How the Global South is reshaping scholarly communication.

The Global South has emerged as a beacon of innovation in scholarly publishing, championing equitable and community-driven models of knowledge dissemination. Here we explore various initiatives originating from Latin America, Africa, and Asia, highlighting platforms that are free for both readers and authors. These initiatives also promote multilingualism, public funding, and non-profit, scholarly-led governance structures.

Towards consensus: The need for standardised definitions in Long (post) COVID care in 34 European countries.

Background: The COVID-19 pandemic has significantly impacted global healthcare systems, leading to challenges in managing Long COVID. Variations in definitions and diagnostic criteria across Europe hinder recognition and treatment efforts. This study aims to analyse and compare the definitions of Long COVID used in 34 European countries.

Granular cell tumour of the breast: An uncommon benign lesion with suspicious radiological features. Case report and literature review.

Granular cell tumour is an uncommon benign lesion of neural lineage, associated with ATP6AP1 and ATP6AP2 inactivating mutations (endosomal pH regulators). These tumours typically develop in the head and neck region, particularly in the tongue, and are rarely found in the mammary gland, with an estimated incidence of 1:1000 of all breast tumours. They have similar clinical and radiological features, that usually mimic malignant lesions with spiculated margins.

Stronger prooxidative effects of chromium(VI) comparing to chromium(III) in endocrine and non-endocrine tissues with the thyroid being completely resistant to antioxidant protection.

Chromium (Cr) is a harmful heavy metal pollutant. Cr(VI) is a group 1 carcinogen (carcinogenic to humans), whereas Cr(III) is a group 3 carcinogen (not classifiable as to its carcinogenicity to humans). Cr is also documented to be an endocrine disrupting chemical.

Improving transport efficiency for large human cells for enabling accurate determination of cellular nanoparticle uptake via SC-ICP-TOF-MS.

Single-cell inductively coupled plasma-mass spectrometry (SC-ICP-MS) provides high-throughput, quantitative information on nanoparticle (NP)-cell interaction, but its application to larger mammalian cells remains limited due to the low transport efficiency (TE) provided by commercially available introduction systems. In this study, we have addressed this challenge by working at a higher spray chamber temperature (150 °C), which led to a 81-fold increase in TE for A549 human lung carcinoma cells (measured size of ∼20 μm). This observation was also validated using other cell types with different sizes and morphologies, such as red blood cells (∼6 μm) and Raji cells (∼11 μm), for which respective TE improvements of 2.

Alternatives Integrating Omics Approaches for the Advancement of Human Skin Models: A Focus on Metagenomics, Metatranscriptomics, and Metaproteomics.

The human skin microbiota, a complex community of bacterial, fungal, and viral organisms, plays a crucial role in maintaining skin homeostasis and regulating host-pathogen interactions. Dysbiosis within this microbial ecosystem has been implicated in various dermatological conditions, including acne vulgaris, psoriasis, seborrheic dermatitis, and atopic dermatitis. This review, for the first time, provides recent advancements in all four layers of omic technologies-metagenomics, metatranscriptomics, metaproteomics, and metabolomics-offering comprehensive insights into microbial diversity, in the context of functional skin modeling.

Emulsion-Coated Active Papers Extend the Storage Life of Tomato Fruit.

This study focused on developing emulsion-coated active papers with antifungal properties to extend the shelf life of tomatoes during home storage, thereby reducing food waste in households. First, a mixture of essential oils (EO)-composed of 33.3% oregano and 66.

AI-Based Facial Phenotyping Supports a Shared Molecular Axis in -, -, and -Related Syndromes.

Despite significant advances in gene discovery, the molecular basis of many rare genetic disorders remains poorly understood. The concept of disease modules, clusters of functionally related genes whose disruption leads to overlapping phenotypes, offers a valuable framework for interpreting these conditions. However, identifying such relationships remains particularly challenging in ultra-rare syndromes due to the limited number of documented cases.

Genomic insights from a final Bronze Age community buried in a collective tumulus in an Urnfield settlement in Northeastern Iberia.

The transition from the Bronze Age (BA) to the Iron Age (IA) on the Northeastern Iberian Peninsula is characterized by the emergence of cremation as the main funerary practice. Cultural attributes of a group, known as the Urnfield Culture, expanded from Central Europe to Northeastern Iberia during the Final Bronze Age (FBA), from ~1300 to ~850 cal BCE. Various hypotheses on the group's emergence exist, but cremations hinder DNA preservation.

Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials.

Adolescence represents a critical period of neurodevelopment during which brain-derived neurotrophic factor (BDNF) plays a fundamental role in neuronal survival and synaptic plasticity. While exercise-BDNF relationships are well-documented in adults, evidence in adolescents remains limited and inconsistent. This systematic review examined the effects of exercise modalities on circulating BDNF concentrations in adolescent populations.

Table Tennis as a Tool for Physical Education and Health Promotion in Primary Schools: A Systematic Review.

Racket sports are very popular not only in professional sports but also among recreational players. As a result, their impact on the field of education has grown significantly in recent years. Table tennis (TT) offers significant advantages in terms of skill acquisition and health improvement.

Bacteria-Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy.

Bacteria exhibit adaptive phenotypic traits that confer resistance to host defenses and antimicrobial therapies. In response to the global threat of antimicrobial resistance, bacteria-responsive nanostructured drug delivery systems have emerged as a promising alternative to conventional broad-spectrum antimicrobials. These systems release therapeutics selectively in response to bacterial presence or to their secreted enzymes, toxins, antigens, or extracellular biomarkers, enabling precise activation at infection sites while minimizing off-target effects.

and spp.: From Food Spoilage to Beneficial Food Applications.

The genera and comprise thermophilic, spore-forming bacteria. The extraordinary heat resistance of their spores, together with their ability to form biofilms and produce thermostable enzymes, makes them a relevant cause of spoilage in shelf-stable, heat-treated products like dairy and canned foods. However, these same biological traits offer valuable opportunities for the food industry.