HLA matching in the PTCy era: the locus still matters. Comment on: Selection of unrelated donors for allogeneic transplantation using post-transplant cyclophosphamide in acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.

Not available.

Blinatumomab restores asparaginase activity in pediatric B-cell acute lymphoblastic leukemia patients with PEG-Asparaginase hypersensitivity.

Not available.

Comparative Effectiveness of TAVI Platforms and Surgical Aortic Valve Replacement: A Network Meta-Analysis of Randomized Controlled Trials.

Background: Evidence informing clinical guidelines assumes that all transcatheter aortic valve implantation (TAVI) devices have similar effectiveness, in other words, displaying a class effect across TAVI valves. We aimed to assess the comparative effectiveness of different TAVI platforms relative to other TAVI counterparts or surgical aortic valve replacement (SAVR).

Methods: MEDLINE/Embase/CENTRAL were searched from inception until April 2025, for randomized controlled trials comparing outcomes with different commercially available TAVI devices relative to other TAVI counterparts or SAVR.

It's Hey Jude, not Hey Jade: Input Variation and the Emergence of the Infant Lexicon.

A growing literature explores the representational detail of infants' early lexical representations, but no study has investigated how exposure to real-life acoustic-phonetic variation impacts these representations. Indeed, previous experimental work with young infants has largely ignored the impact of accent exposure on lexical development. We ask how routine exposure to accent variation affects 6-month-olds' ability to detect mispronunciations.

Few-shot learning for highly accelerated 3D time-of-flight MRA reconstruction.

Purpose: To develop a deep learning-based reconstruction method for highly accelerated 3D time-of-flight MRA (TOF-MRA) that achieves high-quality reconstruction with robust generalization using extremely limited acquired raw data, addressing the challenge of time-consuming acquisition of high-resolution, whole-head angiograms.

Methods: A novel few-shot learning-based reconstruction framework is proposed, featuring a 3D variational network specifically designed for 3D TOF-MRA that is pre-trained on simulated complex-valued, multi-coil raw k-space datasets synthesized from diverse open-source magnitude images and fine-tuned using only two single-slab experimentally acquired datasets. The proposed approach was evaluated against existing methods on acquired retrospectively undersampled in vivo k-space data from five healthy volunteers and on prospectively undersampled data from two additional subjects.

Drugs Withdrawn from the Canadian Market for Safety and Effectiveness Reasons, 1990-2024: A Cross-Sectional Study.

Introduction: At times it is necessary to withdraw drugs after they have been approved because of lack of effectiveness or safety concerns. Health Canada does not keep a list of withdrawn drugs.

Objective: The aim of this study was to generate a list of all drugs approved since 1990 and subsequently withdrawn from the Canadian market for safety or effectiveness reasons until the end of 2024.

Ketamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and Tolerability.

Ketamine has emerged as a promising treatment for major depression, though its efficacy and safety remain incompletely characterized in older adults. This systematic review synthesizes current evidence for ketamine in geriatric depression. A search of PubMed, EMBASE, and PsycINFO was conducted.

Influence of titanium-base and universal abutment heights on the adaptation and fracture of screw-and-cemented-retained lithium disilicate crowns.

Purpose: This in vitro study evaluated the adaptation and fracture resistance of screw- and cement-retained implant-supported restorations using lithium disilicate crowns cemented onto titanium bases and universal abutments of different heights.

Methods: Thirty crowns were designed, milled, and divided into three groups: TBA (titanium base abutment - 4.7-mm-height and 4.

Reported use of implementation science theories, models, and frameworks in 151 implementation trials: secondary analysis of a systematic review targeting nursing practice.

Background: Theories, models, and frameworks (TMFs) are central to the development and evaluation of implementation strategies supporting evidence-based practice (EBP). However, evidence on how and to what extent TMFs are used in implementation trials remains limited.

Purpose: This study aimed to examine the nature and extent of TMF use in implementation trials, identify which TMFs are most frequently employed, and explore temporal trends in their use.

Relevance of Georg Grosz's Weimar-era drawings to promoting social justice and health equity in contemporary society.

The arts and humanities can direct attention to the health-threatening effects of adverse living and working conditions and the political and economic systems that spawn them. Most of these efforts aim to improve healthcare by promoting empathy and sensitivity among health professionals towards patients and improving clinical skills. However, less effort is devoted towards improving living and working conditions-the structural and social determinants of health-that cause illness and make managing illness difficult.

Enhancing driving safety with customized music: A simulator study using entropy weight and Bayesian Networks.

Introduction: Listening to music while driving is a common practice. Extensive research has explored its effects on driving performance, with a growing consensus suggesting that the optimal complexity of music varies depending on different driving scenarios to maintain drivers' arousal levels. However, these optimal levels can vary significantly among individuals.

The prevalence of benzodiazepines and other hypnotics and their impact on injury severity among older adults involved in motor vehicle collisions: a multicenter retrospective cohort study.

Introduction: Older adults are increasingly involved in motor vehicle collisions (MVCs). Hypnotics are known to impair driving ability. This study investigated the prevalence of hypnotics use among older adult drivers involved in MVCs and evaluated their impact on injury severity and co-prevalence with other central nervous system (CNS) depressants.

How often did syphilis tests have corresponding HIV tests in Ontario, Canada? A retrospective analysis of comprehensive laboratory data.

Objectives: Canadian guidelines recommend HIV testing for individuals being evaluated for syphilis. Our objective was to examine three aspects of HIV testing (ie, if an HIV test occurred, the timing of the HIV test in relation to the syphilis test and the proportion with a positive HIV test result) among syphilis tests between 2017 and 2022 from individuals with no evidence of a previous HIV diagnosis.

Design And Setting: This study is a retrospective analysis of comprehensive laboratory testing data from Ontario's provincial public health laboratory.

Validation of a standardised approach to collect sociodemographic and social needs data in Canadian primary care: cross-sectional study of the SPARK tool.

Objective: This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources ('SPARK Tool') against comparison questions from well-established national surveys (Post Survey Questionnaire (PSQ)) to inform the development of a standardised tool to collect patients' demographic and social needs data in healthcare.

Design: Cross-sectional study.

Setting: Pan-Canadian study of participants from four Canadian provinces (SK, MB, ON and NL).

Beta- and gamma-band neuromagnetic oscillations in chronic stroke rehabilitation using music-supported therapy and manual training.

Neural oscillations in beta (13-30 Hz) and gamma (>30 Hz) frequency bands index a variety of sensorimotor and cognitive processes. To compare two rehabilitation regimens for chronic stroke patients with a hemiparetic hand, we randomly assigned them to either music-supported therapy or physiotherapy for 10 weeks. Previously, we reported the music group's improved motor speed, mood, well-being, and rhythm perception.

Development and Initial Results from the Canadian Cardiac Amyloidosis PyrophosphatE Imaging Registry (CAPER).

Background: Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure in older adults. Technetium-99m pyrophosphate (PYP) imaging has emerged as a highly effective tool for diagnosing ATTR-CM. We established a multi-center Canadian registry to provide a platform for research regarding the prevalence of ATTR-CM and accuracy of methods for screening or diagnosis.

The molecular electrometer at 40.

In 1987 Seelig and colleagues proposed that the phosphocholine headgroup of phosphatidylcholine behaved as a universal sensor of surface electrostatic charge, both cationic and anionic, in lipid bilayers (J. Seelig, P.M.

Heart DHA turnover is faster in female compared to male ALA- and EPA-fed mice.

Young females have higher circulating docosahexaenoic acid (DHA) levels than males, though the metabolic basis remains incompletely understood. Building on previous findings demonstrating higher hepatic synthesis of the DHA precursor, docosapentaenoic acid (DPAn-3) in males, this study extends the investigation to n-3 PUFA turnover in extrahepatic tissues of male and female C57BL/6N mice using compound-specific isotope analysis (CSIA). Animals were fed a 12-week diet enriched in either α-linolenic acid (ALA), eicosapentaenoic acid (EPA), or DHA, starting with a 4-week phase containing low carbon-13 (δC)-n-3 PUFA, followed by an 8-week phase with high δC-n-3 PUFA (n = 4 per diet, time point, sex).

Sex-specific Outcomes Following Thoracic Aortic Surgery.

Introduction: The impact of sex on quality of life (QoL) and long-term mortality after thoracic aortic surgery is incompletely understood. We investigated whether sex-related differences in these outcomes exist following surgery.

Methods: Patients undergoing thoracic aortic surgery between 2004-2023 were identified using the Manitoba Thoracic Aortic Database, which was linked to population-level registries in the Manitoba Centre for Health Policy.

RNA in plasma extracellular vesicles of adolescent rhesus macaques reveal immune, bioenergetic and microbial imprints of early life adversity - an exploratory analysis.

Background: Exposure to early life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for the emergence of psychosomatic disorders in adolescence and adulthood. Most investigations into biological processes that have been perturbed by ELA have profiled DNA methylation in whole blood and coalesced around perturbations of immunobiology being centrally insulted by ELA.

Methods: To identify novel molecular signatures that are enduringly perturbed by childhood maltreatment, we isolated circulating extracellular vesicles (EVs) from plasma collected from adolescent rhesus macaques that had either experienced nurturing maternal care (CONT, n = 7, 4M 3F) or maltreatment in infancy (MALT, n = 6, 3M 3F).

Real-world use of terlipressin in cirrhosis and acute kidney injury: frequent use beyond hepatorenal syndrome.

Background & Aims: Terlipressin is indicated to treat hepatorenal syndrome (HRS)-acute kidney injury (AKI), but is likely used outside this primary indication in clinical practice. We aimed to investigate real-world practice patterns on the use of terlipressin in AKI in cirrhosis.

Methods: International prospective study including patients hospitalized for decompensated cirrhosis.

A randomized Phase II trial of High Dose-Rate (HDR) and Low Dose-Rate (LDR) brachytherapy as monotherapy in localized prostate cancer: analysis of initial arms of Canadian cancer trials group PR19 (NCT02960087).

Purpose/objectives: Low Dose-Rate Brachytherapy (LDR) and High Dose-Rate Brachytherapy (HDR) are options for favorable risk prostate cancer. We hypothesized that HDR provides comparable disease control with less urinary toxicity. Primary objective was to determine prostate cancer control at 48 months, defined as a PSA < 0.