Cross-cultural adaptation, validity and reliability of the Dutch version of the Lymphedema Symptom Intensity and Distress Survey-Head and Neck version 2.0 (LSIDS-H&N v2.0) in head and neck cancer patients.

Purpose: This study aims to cross-culturally validate the Dutch version of the Lymphedema Symptom Intensity and Distress Survey-Head and Neck version 2.0 (LSIDS-H&N v2.0).

Management of a first time anterior shoulder dislocation: the decision-making process of a surgeon.

Background: Management of a first-time anterior shoulder dislocation in young and active patients remains a topic of ongoing debate. This study aims to use choice-based conjoint analysis to identify the factors influencing a surgeon's decision-making process and explore potential heterogeneity in the identified decision patterns.

Methods: A discrete choice experiment was conducted among all 94 members of the Belgian Elbow and Shoulder Society.

A (P56S) mutation in a Dutch patient with familial motor neuron disease: a case report.

The c.166C > T p.(Pro56Ser) or P56S mutation in the gene was initially identified as a cause of motor neuron disease in Brazil in a large extended pedigree comprising >1,500 individuals including more than 200 cases.

Call for founding members of the European Organization For University Physical and Rehabilitation Medicine (UniPRM).

Rehabilitation is increasingly recognized as a key component of health systems worldwide. To meet the growing demand for rehabilitation services, it is essential to strengthen academic capacity in Physical and Rehabilitation Medicine within universities. Academic structures are critical for training future physicians and professionals, and for advancing research and innovation in rehabilitation.

Men's Self and Identity and Their Relations to Others in a Changing World.

As masculinities are changing, taking a social identity perspective on men and their relations with others helps to understand how men navigate their social world. Combining this with other common approaches in the psychology of gender, men, and masculinities, we review how such a perspective helps to understand men's differing health and well-being outcomes, work/family choices, and their responses to changing gender relations and other social developments (privilege, threat, allyship). In so doing, we emphasize that men's audiences (i.

Clinical care of family members of patients with dilated cardiomyopathy.

Genetic family screening following the detection of a pathogenic or likely pathogenic variant in a proband with dilated cardiomyopathy (DCM) remains one of the main applications of genetic testing. While cardiac screening is recommended for all first-degree relatives, the a priori risk among family members varies. Consequently, screening regimens should be tailored according to both genetic and clinical information at the individual and familial level.

Recommendations for disclosure of artificial intelligence in scientific writing and publishing: a regional anesthesia and pain medicine modified Delphi study.

Introduction: The use of artificial intelligence (AI) in the scientific process is advancing at a remarkable speed, thanks to continued innovations in large language models. While AI provides widespread benefits, including editing for fluency and clarity, it also has drawbacks, including fabricated content, perpetuation of bias, and lack of accountability. The editorial board of (RAPM) therefore sought to develop best practices for AI usage and disclosure.

Renal Outcomes After Lung or Combined Heart-Lung Transplantation in Pulmonary Hypertension.

Renal impairment is considered a contra-indication for lung (LTX) or combined heart-lung (HLTX) transplantation due to increased mortality. We hypothesized that renal impairment in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) is the result of reduced cardiac output and should be partly reversible after LTX. We performed a retrospective analysis in 67 consecutive PAH and CTEPH patients who underwent (H)LTX, to investigate the postoperative evolution of renal function in function of baseline renal function using a mixed model effect test.

Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: Technical challenges and controversies.

Chronic thromboembolic pulmonary hypertension requires referral to an expert center for final diagnosis and assessment of treatment possibilities by a multidisciplinary team. Pulmonary endarterectomy is the only potentially curative therapy and therefore remains the treatment of choice. However, many practices and minor technical aspects of this procedure may still provoke controversy.

The Indispensable Value of Small-Molecule Antivirals in Epidemic and Pandemic Preparedness.

Harbingers of infectious viral pandemics, such as the H1N1 influenza, SARS, Zika, Ebola, MERS, and SARS-CoV-2, caused major outbreaks in the first two decades of the 21st century. Despite warnings, therapeutic tools that could be rapidly and sustainably scaled at a global level when SARS-CoV-2 emerged were lacking. Small-molecule antivirals can play a crucial role in both individual patient care and broader public health strategies for controlling and mitigating the impact of viral diseases.

Development and validation of the Revised Epistemic Trust, Mistrust and Credulity Questionnaire (ETMCQ-R).

Background: It has been argued that disruptions to epistemic trust are implicated in psychopathology; however, this requires empirical testing, and an existing scale evaluating epistemic trust, the Epistemic Trust, Mistrust and Credulity Questionnaire (ETMCQ), requires improvement.

Aims: This study tested a revised version of the Epistemic Trust, Mistrust and Credulity Questionnaire (the ETMCQ-R), examining the strength of associations between the updated scale and mental health symptoms, epistemic vice, psychological resilience, perceived social support, attachment style, history of childhood adversity and an experimental measure of trust, and epistemic stance as a mediator between adversity and psychopathology.

Method: Using an online survey design, 525 participants completed the ETMCQ-R alongside other measures.

Real-life evaluation of novel forced expiratory ratios with asthma exacerbations and symptoms.

Background: Small airways dysfunction (SAD) is an important treatable trait in persistent asthma but remains poorly captured by conventional spirometry. The (FEV3-FEV1)/FVC and FEV3/FEV6 ratios have been proposed as novel markers of peripheral airflow limitation.

Objective: We investigated the relationship between (FEV3-FEV1)/FVC and FEV3/FEV6 with symptom control and severe exacerbation frequency in patients with moderate-to-severe asthma.

Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits.

Synaptic dysfunction is a hallmark of neurodevelopmental disorders (NDDs), often linked to genes involved in cytoskeletal regulation. While the role of these genes has been extensively studied in neurons, microglial functions such as phagocytosis are also dependent on cytoskeletal dynamics. We demonstrate that disturbance of actin cytoskeletal regulation in microglia, modeled by genetically impairing the scaffold protein Disrupted-in-Schizophrenia 1 (DISC1), which integrates actin-binding proteins, causes a shift in actin regulatory balance favoring filopodial versus lamellipodial actin organization.

Automated DWI-FLAIR mismatch assessment in stroke using DWI only.

Introduction: In Acute Ischemic Stroke (AIS), mismatch between Diffusion-Weighted Imaging (DWI) and Fluid-Attenuated Inversion-Recovery (FLAIR) helps identify patients who can benefit from thrombolysis when stroke onset time is unknown (15% of AIS). However, visual assessment has suboptimal observer agreement. Our study aims to develop and validate a Deep-Learning model for predicting DWI-FLAIR mismatch using solely DWI data.

Music as Fluidum: A Rheological Approach to the Materiality of Sound as Movement Through Time.

Music is an elusive phenomenon with sounds that disappear while sounding. This challenges the description of the music and its processing by the listener or performer. A possible answer to this problem lies in the definition of music as flowing sound energy that continuously modifies its substance and shape.

Diagnostic accuracy of CT venography compared to ultrasonography for detection of peripherally inserted central venous catheter-related thrombosis in patients with cancer: the DETECT study.

Background: Ultrasonography is the primary diagnostic imaging modality for upper extremity deep-vein thrombosis (DVT) related to peripherally inserted central venous catheters (PICCs). Computed tomography (CT) venography may offer higher sensitivity, while additionally providing information about the superior vena cava and central pulmonary arteries.

Purpose: We compared the diagnostic accuracy of CT venography with ultrasonography for screen-detected PICC-related venous thromboembolism (VTE).

Consistency in treatment effects and statistical significance between early-stage pregnancy endpoints and live birth in randomized controlled trials of infertility: a systematic meta-epidemiological study.

Importance: Live births are the 'gold standard' for assessing infertility treatments but are less frequently reported than clinical pregnancy. Identifying approaches to interpret randomized controlled trials (RCTs) without live birth data is essential.

Objective: To evaluate the correlation between treatment effects and the consistency of statistical significance in conclusions drawn from live birth versus early-stage pregnancy endpoints (an umbrella term defined as biochemical, clinical, or ongoing pregnancy) in RCTs reporting both outcomes.

LaIT6: A Novel Insect-Selective K-Channel Toxin from Scorpion Venom.

Scorpion venom contains various insecticidal peptides. Previously, through transcriptome analysis of the venom gland of , we identified precursor sequences of several peptides that share sequences similar to those acting on K channels. In this study, we chemically synthesized five of the peptides which were found in the venom and evaluated their insecticidal activity against crickets.

The association between respiratory physiology and self-reported respiratory symptoms in patients with persistent somatic symptoms.

Background: Persistent somatic symptoms (PSS) comprise a spectrum of physical complaints arising from complex interactions between various biomedical and psychosocial factors. This study aimed to investigate both physiological and self-reported respiratory measures in individuals with PSS compared to healthy controls, and examine factors associated with dyspnea and functional respiratory complaints in patients with PSS.

Materials/methods: 38 patients meeting DSM-5 criteria for Somatic Symptom Disorder and 38 matched healthy controls completed respiratory assessments, including spirometry, capnography (etCO₂), and manual evaluation of thoracic versus diaphragmatic breathing patterns.

Sex differences in venous thromboembolism outcomes: findings from the GARFIELD-VTE registry.

Background: The association of sex with clinical outcome risk in venous thromboembolism (VTE) is unclear.

Objective: To investigate sex differences in clinical outcomes and anticoagulation effectiveness in VTE in the GARFIELD-VTE registry.

Methods: Outcomes included all-cause mortality, VTE recurrence, major and any bleeding, myocardial infarction (MI)/acute coronary syndrome (ACS), and stroke/transient ischaemic attack (TIA) over 3 years of follow-up.

Potential Allergens in Medical Adhesives in Tapes, Wound Dressings, and Ostomy Care: A Scoping Review.

Background: Medical adhesives are increasingly reported, although still underestimated as causes of allergic contact dermatitis, for which identification of the sensitising culprits is often impossible, mainly because of non-declaration of components on medical device packaging and lack of cooperation from manufacturers.

Objectives: To report on the allergens identified in medical adhesives in tapes, wound dressings, and ostomy care.

Methods: The relevant literature (1980-2024) on sensitization sources and allergens was analysed and the results reported.