Chemical Constituents, In Silico Studies and In Vitro Antioxidant, Enzyme Inhibitory and Antibacterial Activities of the Algerian Essential Oil and Extracts.

The objective of this study is to evaluate, for the first time, the chemical composition and the antioxidant, enzyme inhibitory, photoprotective and antibacterial properties of the essential oil (EO) as well as its organic extracts. The analysis of the EO obtained from the aerial parts of was carried out employing the technique of gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC-MS). Forty-four constituents were identified, constituting 91.

Physiochemical Characterization and Antioxidant Potential of Sorghum and Cork Oak as Valuable Additives to Traditional Pasta.

This study aimed to valorize underutilized local ingredients by developing nutritionally enhanced pasta products enriched with sorghum and cork oak flours. The resulting pasta samples were characterized by their chemical composition, color attributes, functional properties, texture, microstructure, and antioxidant capacity. Semolina-based pasta showed higher protein content, while cork oak flour contributed significantly to lipid content, and sorghum flour was notably rich in fiber and minerals.

Cream Formulated with Lemon Essential Oil-Loaded Pectin Capsules: Effects on Microbiological Quality and Sensory Properties.

This study aimed to develop a novel cream formulation incorporating pectin-based microcapsules loaded with lemon essential oil (LEO), with the goal of enhancing both sensory attributes and microbiological quality. The capsules were added at increasing concentrations (0%, 0.25%, 0.

Synthesis, biological evaluation, and molecular docking of novel quinazoline derivatives as multifunctional bioactive agents.

In this study, a new series of 1,2-dihydroquinazoline and quinazoline derivatives was synthesized via an efficient one-pot multicomponent reaction between 2-aminobenzophenone, various aromatic or heteroaromatic aldehydes, and ammonium acetate, using DABCO as an organocatalyst in ethanol under mild conditions. The structures of the synthesized compounds were confirmed by spectroscopic techniques including H NMR, C NMR, HRMS, and, in selected cases, X-ray crystallography. The antioxidant potential of the compounds was evaluated using four complementary in vitro assays: DPPH, ABTS, ferric-phenanthroline, and reducing power methods.

Investigating risk factors for hypospadias: insights from a study in Eastern Algeria.

Background: Hypospadias is among the most common congenital anomalies of the male genitalia, with a multifactorial cause involving genetic, environmental, and maternal factors. In Algeria, the condition remains under-studied, with limited data on its epidemiology and risk factors.

Objective: To analyze the clinical characteristics, associated anomalies and key risk factors for hypospadias in Eastern Algeria over a 16-year period.

Optimization of Cassava Starch/Onion Peel Powder-Based Bioplastics: Influence of Composition on Mechanical Properties and Biodegradability Using Central Composite Design.

Synthetic plastic pollution represents a major global concern, driving the search for sustainable and biodegradable packaging alternatives. However, many biodegradable plastics suffer from inadequate mechanical performance. This study aimed to develop a biodegradable film based on cassava starch, incorporating onion peel powder (OPP), a byproduct rich in quercetin derivatives, as a reinforcing agent and plasticized with crude glycerol.

The effect of CYP3A4, CYP3A5 and MDR1 (ABCB1) single nucleotide polymorphisms on the pharmacokinetics of cyclosporine in Algerian stable renal transplant recipients.

Background: Cyclosporine (CsA) is a calcineurin inhibitor (CNI) commonly prescribed after organ transplantation to reduce the risk of graft rejection and prolong both graft and patient survival. However, its clinical use is often limited by a narrow therapeutic index and highly variable, unpredictable pharmacokinetics. Consequently, close therapeutic monitoring is essential to ensure effective immunosuppression.

LC-HRESIMS-Guided Phytochemical Characterization and Bioactivity Evaluation of Filipendula hexapetala Gilib. From Algeria: Antioxidant and Anticholinesterase Potential Supported by In Silico Analysis.

Filipendula hexapetala Gilib., a medicinal plant native to Sétif, Northeastern Algeria, holds therapeutic potential, though its bioactive constituents remain underexplored. This study provides the first comprehensive analysis of its chemical composition and biological activities.

Antimicrobial resistance in : One Health perspective on global food safety challenges.

Antimicrobial resistance (AMR) in is a major concern in terms of human health, environmental sustainability, and global food security. , the world's most prevalent foodborne pathogen, has gradually gained resistance to important drugs, complicating treatment efforts and leading to rising morbidity, mortality, and economic costs. Overuse of antibiotics in human medicine and agriculture, inadequate regulatory compliance, and environmental pollution from agricultural runoff and treated sewage all contribute to the growth and spread of AMR in .

Association between C677T variant of methylene tetrahydrofolate reductase and hypospadias risk in Algeria.

Background: Hypospadias, a congenital condition characterized by the urethral opening being on the underside of the penis, has received limited attention in its association with the MTHFR C677T variant. Given the crucial role of folate metabolism in embryonic development, and the involvement of the MTHFR C677T polymorphism in folate metabolism, this study aims to investigate whether this variant contributes to the risk of hypospadias in an Algerian population.

Methods: This case-control study included 105 patients with hypospadias and 125 controls.

Molecular detection of virulence genes and antimicrobial resistance in Salmonella isolates from avian and human sources in northeastern Algeria.

Products of avian origin are one of the major Salmonella reservoirs, responsible for serious public health concerns. Transmission and pathogenicity are mainly caused by molecular mechanisms, including chromosomal and plasmid-encoded virulence factors. This study aimed to perform phenotypic identification, antibiotic resistance profiling against 15 antibiotics, and characterization of virulence factors of 80 Salmonella strains (30 from human and 50 from poultry), collected in Annaba and Constantine regions in Algeria.

Insights into the antioxidant activity and metal chelation capacity of natural marine bromophenols: role of C-O-C and C-C linkages and the catechol group.

Marine algae are an important source of phenolic compounds with multiple biological applications. Among them, bromophenols (BPs) show remarkable antioxidant activity , although their mechanisms of action remain poorly elucidated. In this study, we used density functional theory (DFT) calculations to explore in detail the antioxidant mechanism of two natural BPs (BP-I and BP-II), differing only in the bond linking their phenolic groups (C-O-C C-C).

Ultrasound-Enhanced Ionotropic Gelation of Pectin for Lemon Essential Oil Encapsulation: Morphological Characterization and Application in Fresh-Cut Apple Preservation.

The growing demand for natural preservatives in the food industry has highlighted the importance of essential oils (EOs), despite their limitations related to volatility and oxidative instability. This study addresses these challenges by developing pectin-based microcapsules for encapsulating lemon essential oil (LEO) using ultrasound-assisted ionotropic gelation. The EO, extracted from Citrus limon (Eureka variety), exhibited a high limonene content (56.

Antioxidant and antibacterial properties of Pituranthos scoparius extracts in alginate/gelatin matrix for pumpkin preservation.

Recent research efforts have increasingly focused on the development of environmentally sustainable, bio-based antimicrobial and antioxidant films as alternatives to conventional plastics, which pose significant environmental and biological hazards. In this study, gelatin derived from chicken feet was combined with essential oils, ethanolic extracts from the plant Pituranthos scoparius (PS), and alginate to fabricate films with enhanced antimicrobial and antioxidant properties. A total of six film formulations, including controls, were produced, and their physicochemical and mechanical characteristics, as well as antimicrobial and antioxidant activities, were systematically evaluated.

Design, synthesis and evaluation of anticancer and antioxidant properties of phenolic derivatives incorporating 4H-pyran/1,4-dihydropyridine/1,3-dihydropyrimidinone scaffolds.

Twenty-four heterocyclic derivatives bearing a phenolic moiety were prepared with good to excellent yields. Their antioxidant properties were examined using various in vitro methods, including DPPH, FRAP, metal chelation, and PRAP assays. The vanillin derivatives 6, 9, 12, and 15 showed the most pronounced antioxidant effects, with derivative 15 exhibiting the highest activity in multiple tests, indicating its antioxidant potential.

Comprehensive In Vitro and In Silico Analysis of Antimicrobial and Insecticidal Properties of Essential Oil of L. from Algeria.

This study investigated the phytochemical composition and biological activities of essential oil (EO) from Algeria, focusing on its antimicrobial, antifungal, and insecticidal properties using in vitro and in silico approaches. Gas chromatography-mass spectrometry (GC-MS) analysis identified myrtenyl acetate (57.58%), 1,8-cineole (17.

Comparative phenolic profiling and antioxidant activity of Boiss. & Reut. and Viv. from Algeria.

L. plants are used in phytotherapy and as food. (CT) and (CD) are endemic of Algeria and have been scarcely studied up to now.

Metoprolol removal and mineralization by TiO and iron pillared clay nanocomposite: Impact of operating parameters, water matrices, and solar light.

This study investigates the photocatalytic degradation of metoprolol tartrate (MET) using TiO nanostructures supported on Fe pillared activated bentonite (FeAB) under UV, visible, and solar irradiation. The TiO/FeAB nanocomposite was synthesized via sol-gel and hydrothermal methods, and was characterized using techniques such as XRD, EDS, FTIR, SEM, BET and UV-Vis spectroscopy. The TiO nanoparticles were uniformly distributed on the clay surface, with a red shift observed in UV-visible spectroscopy.

Hydroperoxyl Radical Scavenging Activity of Bromophenols from Marine Red Alga : Mechanistic Insights, Kinetic Analysis, and Influence of Physiological Media.

Bromophenols (BPs), particularly those derived from marine sources, are known for their potent radical scavenging activity, effectively neutralizing reactive oxygen species (ROS). However, their exact mechanism of action remains largely unexplored, limiting our understanding of their potential as natural antioxidants. In this study, the antiradical mechanisms of two BP derivatives ( and ), previously isolated from the marine red alga , were systematically investigated using thermodynamic and kinetic calculations.

Effect of blast furnace slag on the fresh and hardened properties of volcanic tuff-based geopolymer mortars.

Volcanic tuffs are abundant in several regions of the world, and their use has emerged as an economically viable alternative for geopolymer production. This study investigates the effects of incorporating 0 to 30% blast furnace slag (BFS) into volcanic tuff (VT)-based geopolymer mortars cured at room temperature and 80 °C on various properties, including setting time, mechanical strength (compressive and flexural), workability, water absorption and microstructure. Infrared spectroscopy (FTIR) was used to characterize the geopolymer mortars.

Recent advances in chemistry, biochemistry, and nutrition of dates palm fruit (Phoenix dactylifera L.) cultivars.

Date palm trees, fruits and leaves have historic life changes with human beings, and their utilizations started by using them as foods and remedy, especially against the resulting bruises of consecutive wars involving wounds, burnes and invasive diseases such as Malaria, Cholera and recently against the emergence of Covid-19 disease symptoms. The richness of palm date- fruits with reducing sugars, polyphenolic acids, flavonoid compounds, hydrosoluble and liposoluble vitamins makes them as versatile food and feed products. In part, minerals remain as the catalyst elements for these golden fruits.

Evaluating the multifaceted bioactivity of essential oil: the central role of eugenol.

Background/aim: L. is a versatile plant traditionally used to treat digestive and respiratory issues, improve oral health, and relieve pain, particularly in regions such as Southeast Asia, South Asia, and parts of the Middle East. Its essential oil (EO), predominantly composed of eugenol, is rich in bioactive compounds.

Nutritional Composition, Physicochemical Properties, Antioxidant Activity, and Sensory Quality of -Enriched Wheat Bread.

This study evaluates the effects of fortifying bread with different concentrations (3%, 10%, and 30%) of L. (MC) infusion and powder, derived from the plant's aerial parts (stem, leaf, and flower). UPLC/MS-MS analysis of MC infusion and powder ethanolic extract confirmed the presence of polyphenolic compounds, including flavonoids, contributing to enhanced antioxidant and enzyme inhibitory properties.

Corrigendum: Antioxidant, Anti-Alzheimer's, anticancer, and cytotoxic properties of peanut oil: , , and GC-MS analysis.

[This corrects the article DOI: 10.3389/fchem.2024.

Novel 2-Alkoxy-3-Cyanopyridine Derivatives as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, and In Silico Investigations.

Alzheimer's disease remains a major challenge in neuroscience and medicine. Cholinesterase inhibitors provide symptomatic relief but do not alter disease progression. While significant progress has been made in understanding its biology, there is an urgent need for effective therapies.