Bee Brood as a Food for Human Consumption: An Integrative Review of Phytochemical and Nutritional Composition.

The utilisation of edible insects for human nutrition is a long-standing practice in many parts of the globe, and is being gradually introduced into countries without an entomophagic tradition as well. These unconventional sources of protein of animal origin have arisen as a sustainable alternative to other animal protein sources, such as meat. This review intends to present the compilation of data in the scientific literature on the chemical composition and nutritional value of the bee brood of species and subspecies as edible foods.

Defining and Assessing Distress in Oncology Patients: A Systematic Review of the Literature.

Unlabelled: Psychological distress is an extremely relevant phenomenon in cancer patients due to its high prevalence, especially when cancer diagnoses are increasingly frequent. It is estimated that only one-third of patients with clinically significant levels of distress are referred to mental health services. To reinforce this point, most health centers lack the resources for distress screening.

Health-Related Physical Fitness of Romanian University Students: The European Fitness Badge Approach.

Physical fitness is a key determinant of health in university students, a population at risk of sedentary behaviors and lifestyle-related health issues. The European Fitness Badge (EFB) provides a comprehensive assessment of fitness parameters and individualized feedback. This study aimed to evaluate the physical fitness of Romanian university students using the EFB to examine the effects of activity profile, sex, age, and academic major and to associate physical fitness with body composition indices, including Body Mass Index (BMI) and A Body Shape Index (ABSI).

Benefits and Harms of Antibiotic Use in End-of-Life Patients: Retrospective Study in Palliative Care.

Many patients at the end of life receive antibiotics to alleviate symptoms and improve quality of life; however, clear guidelines supporting decision making about the use of antibiotics are still lacking. This study aimed to evaluate the benefits and harms of antibiotic use among patients under a palliative care community support team in Portugal. An observational, cross-sectional, retrospective study was conducted on 249 patients who died over a two-year period, having been followed for at least 30 days prior to their death.

Risk Factors and Prevalence of spp. in Poultry Carcasses in Slaughterhouses Under Official Veterinary Inspection Service in Brazil.

Because of the relevance of spp. in poultry, in 2016, the Brazilian Ministry of Agriculture, Livestock, and Supply updated its regulation for the control and monitoring of in the poultry meat production chain. We herein present the results of the official monitoring of sampling cycles of carcasses performed by the Brazilian official veterinary inspection service (SIF) and the Center for Epidemiology, Statistics, and Public Health of the Veterinary School of the Federal University of Minas Gerais.

Adaptation and Validation of the Compassionate Capacity Scale for Portuguese Healthcare Students (CCS-PHS).

Compassion is a critical competence for healthcare students. However, there are no tools that measure compassionate capacity during students' training. Recently, the Compassion Capacity Scale (CCS) was developed for health professionals, exhibiting good psychometric properties.

A new large hypercarnivorous crocodyliform from the Maastrichtian of Southern Patagonia, Argentina.

The first crocodyliform specimen from the Maastrichtian Chorrillo Formation (Austral Basin, Patagonia) is here described. The discovery was made about 30 km to the SW of the town of El Calafate (Province of Santa Cruz, Argentina) and consists of a beautifully preserved and articulated skull and jaws, and part of the postcranial skeleton that were preserved encased in a large concretion. This new taxon belongs to the notosuchian clade Peirosauridae, representing the latest and southernmost record for this group of crocodyliforms.

The Influence of Cone Location and Phenotype on the Risk and Rate of Keratoconus Progression.

Purpose: To assess if cone location and phenotype have an impact on the risk of keratoconus progression.

Methods: Retrospective multi-centric cohort study. The baseline visit was used to classify cases according to cone location (based on thinnest pachymetry and maximum keratometry, max) and phenotype.

Correction: Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate).

Correction for 'Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate)' by Joana S. Ferreira , , 2025, , 7000-7013, https://doi.org/10.

Model robust designs for dose-response models.

An optimal experimental design is a structured data collection plan aimed at maximizing the amount of information gathered. Determining an optimal experimental design, however, relies on the assumption that a predetermined model structure, relating the response and covariates, is known a priori. In practical scenarios, such as dose-response modeling, the form of the model representing the "true" relationship is frequently unknown, although there exists a finite set or pool of potential alternative models.

Validation and Administration of the Spanish Questionnaire 'Humanisation of Pediatric Care in Pain Management with a Non-Pharmacological Approach (HUPEDCARE-Q)'.

: The pain associated with invasive procedures is one of the most common experiences in the pediatric population. Its management remains insufficient due to gaps in healthcare training and knowledge. The aim of this study was to analyze the attitudes, beliefs, care practices, and training of healthcare professionals in relation to pediatric pain, through the development and application of the questionnaire 'Humanisation of Pediatric Care in Pain Management with a Non-Pharmacological Approach (HUPEDCARE-Q)'.

Urine Glycosaminoglycan Scores for Surveillance of Recurrence in Intermediate- and High-risk Nonmetastatic Clear Cell Renal Cell Carcinoma-An Observational Prospective Multicentre Diagnostic Test Cohort Study.

Background And Objective: Nonmetastatic (M0) clear cell renal cell carcinoma (ccRCC) recurs in ∼20% of patients within 5 yr after surgery. With no biomarkers available, recurrence detection relies on radiological imaging. Urine glycosaminoglycan profiles (GAGomes) were previously associated with M0 ccRCC recurrence.

Time-saved and time-invested with anti-amyloid treatments in early Alzheimer's disease: practical considerations.

Anti-amyloid treatments for early Alzheimer's disease very effectively remove amyloid deposits from the brain and have shown an approximately 30 % less worsening in cognitive functions compared to placebo. Some additional metrics, such as time-saved, i.e.

Preschool Hearing Screening: Nineteen Years of the Coração Delta Project in Campo Maior, Portugal.

: Preschool hearing screening is justified by the risk of late onset hearing loss, the high prevalence of otitis media with effusion in school-aged children, and the critical timing just before children begin formal reading and learn to write. This study describes the results of the annual preschool hearing screening program in Campo Maior from 2007 to 2025 (nineteen years) and correlates the audiological referral to the otoscopy findings by the otolaryngologists. : Retrospective study using clinical records from nineteen years of preschool hearing screening.

Enzyme-Free Monitoring of Glucose Using Molecularly Imprinted Polymers and Gold Nanoparticles.

This work describes a non-enzymatic electrochemical glucose biosensor combining for the first time molecularly imprinted polymers (MIPs) for glucose concentration and gold nanoparticles (AuNPs) on screen-printed carbon electrodes (SPEs), where both MIPs and AuNPs were assembled in situ. Electrochemical impedance spectroscopy (EIS) was used to evaluate the analytical performance of the sensor, which has a linear range between 1.0 µM and 1.

A Review on the Management of Symptoms in Patients with Incurable Cancer.

Palliative care aims to alleviate suffering and prioritize the quality of life of patients facing serious and fatal diseases, such as cancer. Cancer patients, especially in advanced stages, often have many difficult-to-control symptoms, such as pain, fatigue, dyspnea, anxiety, and depression, requiring the attention of a multidisciplinary team highly trained in palliative care and end-of-life management. Pain, dyspnea, nausea, and vomiting are the focus of symptomatic assessment in palliative care, but patients experience other equally important symptoms that do not receive as much attention and are often overlooked, which negatively impacts the quality of life of these patients.

Movement behaviours, air pollution and health in school-aged children: a cross-sectional study to guide the co-creation of healthier environments - the MOVE-AIR project.

Introduction: The MOVE-AIR study was designed to explore the moderating role of movement behaviours on the association between air pollutants and health outcomes in Portuguese children. Secondarily, it aims to characterise the settings (both indoor and outdoor) where children are exposed to air pollutants and to co-create solutions with participants to mitigate the exposure to air pollutants in children's daily life. This study aims to describe the MOVE-AIR study protocol in detail.

CD4 differentiated T regulatory cells is modified by physical fitness and visceral adipose tissue in young adults-A cross-sectional study.

Central adiposity and poor cardiorespiratory fitness are modifiable risk factors for various diseases. This study investigated their impact on CD4 differentiated T regulatory (Treg) cell responses. Thirty-eight young adults were classified into high cardiorespiratory fitness/low visceral adipose tissue (High V̇O-Low VAT, n = 20) and low cardiorespiratory fitness/high VAT (Low V̇O-High VAT, n = 18).

Luminescence and energy transfer processes in GdErAlCrO.

GdErAlO and GdErAlCrO samples were synthesized using a solid-state reaction method. Structural analysis revealed that the samples crystallized in an orthorhombic structure phase with a space group. The average crystallite sizes were around 283 nm and 574 nm for GdErAlO and GdErAlCrO, respectively.

Plant traits and associated ecological data from global change experiments and climate gradients in Norway.

Plant functional trait-based approaches are powerful tools to assess the consequences of global environmental changes for plant ecophysiology, population and community ecology, ecosystem functioning, and landscape ecology. Here, we present data capturing these ecological dimensions from grazing, nitrogen addition, and warming experiments conducted along a 821 m a.s.

Disagreement between self- and informant-reported memory complaints and progression of mild cognitive impairment to dementia.

Objectives: To evaluate whether discrepancy between patient and informant reports of memory deficits can be used as a proxy of impaired awareness of memory function in Mild Cognitive Impairment (MCI) and to determine its prognostic value in conversion to dementia.

Method: We conducted a longitudinal study including 128 older adults with memory complaints, diagnosed with MCI. At baseline, participants were assessed for central Alzheimer's Disease biomarkers, memory complaints (Subjective Memory Complaints scale, SMC) and cognition (MMSE).

Biopsychological Effects of Ashwagandha () in Athletes and Healthy Individuals: A Systematic Review.

Unlabelled: Ergogenic supplements are becoming increasingly popular in the diet of trained individuals, due to their potential benefits. Ashwagandha () is one of the supplements that has recently grown in popularity. Despite growing interest, its scientific background remains limited and sometimes inconsistent.

Bone marrow adipocytes: key players in vascular niches, aging, and disease.

Bone marrow adipocytes (BMAs) are emerging as metabolically active endocrine organs within the bone marrow microenvironment, engaging in extensive crosstalk with vascular niches, osteogenic cells, and hematopoietic compartments. In aging and metabolic disorders, mesenchymal and adipocyte progenitors undergo significant quantitative and qualitative transformations that shift from osteogenesis toward adipogenesis. This enhanced adipogenic profile alters the secretion of key adipokines and cytokines, thereby impairing endothelial function, destabilizing the vascular niche, and reducing hematopoietic stem cell support-culminating in bone fragility and disrupted blood cell production.

Studies on the toxic effects of three regioisomeric methoxylated xanthones against Trypanosoma cruzi amastigotes and their binding with human serum albumin.

The synthetic 1-methoxyxanthone, 2-methoxyxanthone, and 4-methoxyxanthone (compounds 1, 2, and 3, respectively) were tested against amastigotes of Trypanosoma cruzi (C2C4, LacZ), showing an activity profile that depends on the position of the methoxy group in the xanthone ring, targeting pteridine reductase 1 of T. cruzi (TcPTR1). The initial pharmacokinetic assessment involved biophysical characterization of the interaction between the xanthones and human serum albumin (HSA, the main globular protein responsible for drug distribution), using circular dichroism (CD), steady-state and time-resolved fluorescence measurements, combined with in silico calculations.