The impact of hormonal intrauterine device use on health-related quality of life in women with a history of venous thromboembolism: a systematic review.

Objective: To systematically review the available evidence on changes in health-related quality of life (HRQoL) associated with the levonorgestrel-releasing intrauterine system (LNG-IUS) for contraception or menstrual bleeding management in women with a history of venous thromboembolism (VTE), regardless of anticoagulant use.

Methods: This systematic review was conducted following Cochrane Collaboration guidelines and the PRISMA statement. A comprehensive search was carried out in PubMed, Embase, Cochrane Central, Scopus, Web of Science, and the Virtual Health Library (VHL), without language or date restrictions.

A Review on the Management of Symptoms in Patients with Incurable Cancer.

Palliative care aims to alleviate suffering and prioritize the quality of life of patients facing serious and fatal diseases, such as cancer. Cancer patients, especially in advanced stages, often have many difficult-to-control symptoms, such as pain, fatigue, dyspnea, anxiety, and depression, requiring the attention of a multidisciplinary team highly trained in palliative care and end-of-life management. Pain, dyspnea, nausea, and vomiting are the focus of symptomatic assessment in palliative care, but patients experience other equally important symptoms that do not receive as much attention and are often overlooked, which negatively impacts the quality of life of these patients.

Bioactive Compounds, Technological Advances, and Sustainable Applications of Avocado ( Mill.): A Critical Review.

Avocado (), originally from Mesoamerica, has emerged as a focus of intense scientific and industrial interest due to its unique combination of nutritional richness, bioactive potential, and technological versatility. Its pulp, widely consumed across the globe, is notably abundant in monounsaturated fatty acids, especially oleic acid, which can comprise over two-thirds of its lipid content. In addition, it provides significant levels of dietary fiber, fat-soluble vitamins such as A, D, E and K, carotenoids, tocopherols, and phytosterols like β-sitosterol.

Disorder of Glucose Metabolism and Therapy: Implications on the Natural History of Advanced Chronic Liver Disease.

Introduction: Hepatogenous diabetes (HD) is a disorder of glucose metabolism (DGM) that develops as a complication of advanced chronic liver disease (ACLD) with an estimated prevalence of 20-70%. It appears to be associated with a larger number of decompensations, but its impact on the natural history of the disease is unclear. The treatment of DGM is hampered by the fact that some therapeutic agents are associated with a risk of complications in ACLD.

Corrigendum: Management of Cancer-Associated Thrombosis: Unmet Needs and Future Perspectives.

[This corrects the article DOI: 10.1055/s-0041-1736037.].

Burnout protective patterns among oncology nurses: a cross-sectional study using machine learning analysis.

Background: Oncology nurses face unique and intense demands due to the nature of their work, caring for patients with life-threatening illnesses. The emergence of professional burnout among these nurses is influenced by several factors, highlighting the importance of identifying protective and risk factors to mitigate its impact. This study aims to identify burnout profiles and protective socio-demographic and work-related patterns associated with reduced burnout among oncology nurses.

Microaneurysm Counting as a Biomarker for the Hyperperfusion Stage of Nonproliferative Diabetic Retinopathy.

Introduction: This study aimed to investigate the utility of microaneurysm (MA) counting as a tool for characterizing the hyperperfusion stage of nonproliferative diabetic retinopathy (NPDR) and to examine the hypothesis that MAs can serve as a surrogate biomarker for the presence of intraretinal microvascular abnormalities (IRMAs).

Methods: Forty-nine (n = 49) eyes with type 2 diabetes mellitus with NPDR were included in this analysis: 12 with Early Treatment Diabetic Retinopathy Study (ETDRS) levels 43 and 37 with levels 47-53. Automated MA detection was performed using the RetmarkerDR software (Retmarker SA, Meteda Group, Italy), alongside manual detection, both done in the central retina (field 2).

Dissociation of plasma oxyntomodulin levels from anthropometric measures and metabolic markers in women with polycystic ovary syndrome.

Introduction: Oxyntomodulin (OXM) is a polypeptide hormone of the incretin family, which binds to the glucagon-like peptide 1 receptor, contributing to a reduction in caloric intake, an increase in energy expenditure, and weight loss in obese individuals. Polycystic ovary syndrome (PCOS) is a multifactorial condition characterized by reproductive and metabolic dysfunctions, with a high prevalence among overweight and obese women. This study aimed to investigate the correlation between clinical, anthropometric, endocrine, and metabolic variables and plasma OXM levels in women diagnosed with PCOS.

Brazilian guidelines for the pharmacological treatment of pulmonary embolism. Official document of the Brazilian Thoracic Association based on the GRADE methodology.

Venous thromboembolism (VTE) is the third most common acute cardiovascular syndrome after acute myocardial infarction and stroke. In recent years, there has been an increase in the incidence of VTE, related to population aging and common comorbidities in the elderly, including chronic cardiorespiratory disease and cancer. On the other hand, disease-related mortality, particularly for pulmonary embolism (PE), shows a decreasing trend, which can be explained by improvements in diagnostic imaging, advances in available therapies, and greater adherence to patient management protocols.

Efficacy of continuous positive airway pressure on atrial fibrillation recurrence after catheter ablation in patients with obstructive sleep apnea: a systematic review and meta-analysis.

Background: Obstructive sleep apnea (OSA) is associated with an increased risk of atrial fibrillation (AF). However, the impact of continuous positive airway pressure (CPAP) on the recurrence of AF after catheter ablation (CA) in patients with OSA remains unclear.

Methods: We systematically searched PubMed, Embase, and Cochrane databases for randomized controlled trials (RCTs) and observational studies comparing CPAP vs.

Molecular and morphological data support the synonymy of Gmelin, 1791 and Reeve, 1845 (Gastropoda, Muricidae).

The // complex includes species with a great diversity of shell shapes and shared habitats in various regions, which has raised questions and doubts about the current taxonomic classification of these species. , , and are three similar-looking black and white murex found commonly on the west coast of North and South America. The wide variety of morphological patterns within and between these species makes the classification of specimens difficult by visual observation.

HIV prevalence and factors associated with HIV positivity among Black people in primary care in Porto Alegre, Brazil, 2020-2022: a cross-sectional study.

Objective: To examine HIV prevalence among primary care service users and to investigate factors associated with positive HIV test results among Black people.

Methods: This was a cross-sectional study with data from rapid HIV testing performed in health centers in Porto Alegre-RS, Brazil. Sociodemographic differences according to race/skin color and HIV test result were analyzed using the Chi-square test and Poisson regression with robust variance.

The role of cardiovascular response as a predictor of neurologic disability in children with brain injury - a pilot study.

Objective: We aimed to assess medium-to long-term neurological outcomes in children with severe acute brain injury (ABI) and to identify cardiovascular predictors associated with unfavorable outcomes, such as heart rate (HR), blood pressure (BP), and heart rate variability (HRV). HRV refers to the oscillations in the intervals between consecutive heartbeats, reflecting the dynamic interplay between sympathetic and parasympathetic impulses to the heart. It provides a non-invasive indicator of autonomic nervous system (ANS) activity.

Ozone Aeration Enhance Flowability, Structure, and Antioxidant Activity in Blueberry Pulp Powder.

Spray drying (SD) is widely used for fruit powder production, but hygroscopic compounds can affect flowability and cause stickiness. This study evaluated rice protein and rice starch as encapsulating agents during SD of blueberry pulp (BPP and BPS, respectively), combined with ozone aeration (BPP-O3 and BPS-O3), focusing on physical, morphological, structural, and bioactive properties, as well as 56-day stability. The process yield was 55.

Effects of jazz dance and concurrent training on physical variables in postmenopausal women.

Objective: This study aimed to analyze the effects of jazz dance or concurrent training on the cardiorespiratory fitness (CRF), muscle strength and sleep quality of postmenopausal women.

Method: A randomized clinical trial with 6-month and 12-month follow-up was conducted including 70 postmenopausal women (mean age 53.19 ± 3.

ErgoReport: A Holistic Posture Assessment Framework Based on Inertial Data and Deep Learning.

Awkward postures are a significant contributor to work-related musculoskeletal disorders (WRMSDs), which represent great social and economic burdens. Various posture assessment tools assess WRMSD risk but fall short in providing an elucidating risk breakdown to expedite the typical time-consuming ergonomic assessments. Quantifying, automating, but also complementing posture risk assessment become crucial.

Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil.

Objectives: To evaluate the incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19 who underwent diagnostic tests for suspected VTE, and to correlate the IMPROVE-DD score with the incidence of VTE in this cohort.

Methods: This retrospective study included consecutive patients with COVID-19 and suspected VTE, admitted between March 2020 and September 2021 at a private hospital in Salvador (BA), Brazil, who underwent lower or upper limb venous Doppler ultrasound or chest angiotomography. Descriptive analyses and comparisons using the chi-square test were performed to identify factors potentially associated with the risk of VTE.

Anomalous intraosseous venous drainage of pretibial varices: case report.

Anomalous intraosseous venous drainage causing pretibial varices is a rare and little-known cause of varicose veins in the lower limbs (LL). We report the case of a 49-year-old male patient with chronic pain associated with large pretibial varicose veins and mild edema of the left lower limb, with no skin changes or history of previous treatment. Vascular ultrasound identified a dilatated intraosseous vein of the tibia with reflux draining to an incompetent bone perforating vein and subcutaneous varicose veins.

Evaluation of sapodilla pulp as a matrix for probiotic fermentation: Physicochemical changes, antioxidant potential, and in vitro digestibility during storage.

This study investigated the influence of three probiotic strains (Lacticaseibacillus paracasei subsp. paracasei, Bifidobacterium animalis subsp. lactis, and Lacticaseibacillus rhamnosus) on the fermentation of sapodilla pulp, assessing its bioactive and antioxidant potential, in vitro digestibility, and stability during 28 days of storage.

Pain and Suffering: The Experience of Patients With Terminal Cancer.

Purpose/objectives: Analyze the meaning of pain and suffering experienced by patients with end-stage cancer from a systemic perspective.

Design: Qualitative study based on General Systems Theory.

Sample/participants: Ten patients with terminal stage cancer were interviewed.

Bartonellosis in a Renal Transplant Recipient: Scratching More Than the Surface.

Fever of unknown origin (FUO) presents a significant diagnostic challenge in renal transplant recipients due to their immunosuppressed state, which predisposes them to a broad spectrum of potential non-infectious and infectious causes, including atypical pathogens. Among these, , the agent of bartonellosis or cat scratch disease (CSD), is a rare but significant pathogen in this population, capable of causing several systemic manifestations, including hepatosplenic involvement. We describe the case of a 60-year-old male renal transplant recipient who presented with FUO, diarrhea, and hepatosplenomegaly six months post transplantation.

Examining the connection between position-based power and social status across 70 cultures.

Even in the most egalitarian societies, hierarchies of power and status shape social life. However, power and received status are not synonymous-individuals in positions of power may or may not be accorded the respect corresponding to their role. Using a cooperatively collected dataset from 18,096 participants across 70 cultures, we investigate, through a survey-based correlational design, when perceived position-based power (operationalized as influence and control) of various powerholders is associated with their elevated social status (operationalized as perceived respect and instrumental social value).

Accuracy of machine learning and traditional statistical models in the prediction of postpartum haemorrhage: a systematic review.

Objectives: To evaluate whether postpartum haemorrhage (PPH) can be predicted using both machine learning (ML) and traditional statistical models.

Design: Diagnostic systematic review and meta-analysis of observational and clinical studies, prospectively registered on PROSPERO, performed accordingly to the Preferred Reporting Items for Systematic Reviews and Meta-analysis and Prediction model risk of bias assessment tool for studies developing, validating or updating prediction models, with the use of an independent analysis by a large language model (GPT-4 Open AI).

Data Sources: MEDLINE/PubMed, LILACS-BVS, Cochrane Library, Scopus-Elsevier, Embase-Elsevier and Web of Science.

Accuracy of capillary blood sampling for diagnosing syphilis infection.

Capillary blood collection presents advantages such as reduced invasiveness over venous serum for syphilis diagnosing. This study aimed to compare diagnostic accuracy between capillary and venous blood samples for syphilis diagnosis. Individuals aged ≥ 18 years were included in a cross-sectional study.