A novel zeolitic imidazolate MOF-on-MOF homostructure for the rapid and sensitive quantification of enrofloxacin in complex food and water matrices.

Enrofloxacin (ENR), a broad-spectrum fluoroquinolone antibiotic, is widely used in both human and veterinary medicine. However, residual ENR in food and water can pose significant health risks. In this study, a novel bimetallic zeolitic imidazolate framework (ZIF-67@ZIF-8) a type of metal-organic framework (MOF), was synthesized at room temperature, and employed as an effective sorbent in a dispersive micro-solid phase extraction (Dμ-SPE) procedure for the rapid and sensitive detection of ENR.

Deep Learning-Based Nuclei Segmentation and Melanoma Detection in Skin Histopathological Image Using Test Image Augmentation and Ensemble Model.

Histopathological images play a crucial role in diagnosing skin cancer. However, due to the very large size of digital histopathological images (typically in the order of billion pixels), manual image analysis is tedious and time-consuming. Therefore, there has been significant interest in developing Artificial Intelligence (AI)-enabled computer-aided diagnosis (CAD) techniques for skin cancer detection.

Muscle Synergies of the Lower Extremities During Gait Initiation in Individuals With and Without Chronic Ankle Instability.

Background: Chronic ankle instability (CAI) disrupts postural stability after ankle sprains and inadequate treatment. Gait initiation (GI), governed by central nervous system (CNS) patterns, is used to evaluate stability. Muscle synergy, which reflects coordinated activations, reveals neuromuscular control.

Synthesis and photocatalytic degradation of azithromycin by iron/zinc oxide nanoparticle-reinforced carbon nanofibers.

Water pollution caused by persistent pharmaceutical contaminants, such as azithromycin, presents serious public health and environmental challenges. This study introduces iron/zinc oxide-reinforced carbon nanofibers (Fe/Zn-CNFs) synthesized via a scalable electrospinning process as a novel solution for treating pharmaceutical waste streams. The synthesized nanofibers showed a crystalline structure (confirmed by XRD and Raman analyses), an optimized bandgap energy of 2.

Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds.

In the first part of this study, magnetic nanoparticles were decorated with folic acid (Vitamin B9) under ultrasonic agitation in water, resulting in heterogeneous nano-biocatalysts (FA@γ-FeO), which were characterized using different techniques, such as VSM, FT-IR, and FESEM. The efficiency of the as-prepared magnetic nanocatalyst was assessed in the synthesis of quinoxaline derivatives. In the second part, a Cu (II) folic acid complex was used for modifying the surface of γ-FeO (FA-Cu@γ-FeO).

Polymer-Modified Carbon Nanotubes as Smart Carriers for Anticancer Drug Delivery: Insights from MD and DFT Calculations.

Carbon nanotubes (CNTs) have emerged as promising nanocarriers in targeted drug delivery, leveraging their unique physicochemical properties. Polymer modification of single-walled carbon nanotubes (SWCNTs) enhances their solubility and biocompatibility, improving the delivery of anticancer drugs such as thalidomide (Thal), 5-fluorouracil (5-FU), and Temozolomide (TMZ) to target cells. In this context, hybridization refers to the noncovalent interactions between the polyfluorene binop (PFOB) polymer and the CNT surface, enhancing drug adsorption properties.

Dietary Application of Grape (Vitis Vinifera L.) Pomace for Fattening Lambs: Implications on Growth Performance, Rumen Fermentation, and Meat Fatty Acid Composition.

Dietary inclusion of grape pomace (GP) for finishing lambs is expected to improve performance and product quality, thanks to its rich polyphenolic content and favourable fatty acid (FA) profile. This study determines the implications of feeding varying levels of GP (Vitis vinifera L. cultivar SiahGohar) on production performance, rumen fermentation, blood parameters, and meat FA composition in finishing lambs.

A new electrochemical sensor for the detection of uric acid and xanthine based on a carbon paste electrode coated with a metal organic framework.

This study presents a simple strategy for developing a new electrochemical sensor based on a carbon paste electrode (CPE) coated with a copper nanotube-based MOF (NT Cu-MOF/CPE) using electrochemical/chemical approaches. This enzyme-free sensor was employed for the selective determination of uric acid (UA) and xanthine (XA) biomolecules in Britton-Robinson buffer (pH 3) individually and simultaneously by differential pulse voltammetry. The electrode surface was characterized using XRD, FE-SEM, EDX, and AFM techniques.

Electrospinning Enables Opportunity for Green and Effective Antibacterial Coatings of Medical Devices.

The growing antimicrobial resistance and the increasing environmental concerns associated with conventional antibacterial agents have prompted a search for more effective and sustainable alternatives. Biopolymer-based nanofibers are promising candidates to produce environment-friendly antibacterial coatings, owing to their high surface-to-volume ratio, structural adaptability, and tunable porosity. These features make them particularly well-suited for delivering antimicrobial agents in a controlled manner and for physically modifying the surface of medical devices.

The role of microplastics as vectors of antibiotic contaminants via a molecular simulation approach.

Microplastics (MPs) and nanoplastics (NPs) have emerged as major environmental pollutants due to their persistence, widespread distribution, and ability to interact with organic contaminants, including antibiotics. This study employs molecular dynamics (MD) simulations to investigate the adsorption mechanisms of three commonly used antibiotics-ciprofloxacin, amoxicillin, and tetracycline-on two types of non-biodegradable microplastics: polypropylene (PP) and polystyrene (PS). Furthermore, the impact of microplastic aging, simulated by introducing oxidized and hydrophilic functional groups, on adsorption efficiency and interaction mechanisms has been explored.

Effect of Water Salinity, Dietary Potassium Carbonate, Vitamin D Levels, and Vitamin D Form (1α-Hydroxycholecalciferol) on Calcium and Phosphorus Digestibility and Tibia Bone Properties in Broilers.

This study aimed to assess the joint impact of water salinity, KCO, vitamin D levels, and inclusion of 1α-hydroxycholecalciferol (1αOHD3) on broiler tibiae. A total of 1200 one-day-old male Ross broiler chickens were given four different levels of vitamin D (2000, 5000, 7000, and 5000 IU + 20 µg/kg 1αOHD), three levels of water salinity (WS) (low, moderate, high), and two concentrations of KCO (0 and 2.5 g/kg).

Synthesis and swelling studies of modified chitosan smart hydrogels containing alkyl sulfonate anionic pendant groups as microparticles for insulin release.

The hydrogel system effectively delivered insulin, demonstrating its potential to overcome challenges associated with conventional injectable insulin therapies. This pioneering platform leverages smart hydrogels, known for their responsiveness to environmental cues such as temperature, pH, ionic strength, and concentration. Among the fabricated hydrogels, the M5 microparticle, characterized by the lowest cross-linking agent concentration (14%) and the highest propane sultone content used during its preparation, exhibited the greatest water uptake and swelling capacity.

Digitally Designed Bone; A 3D-patient-specific Allograft Shelf for Severe Adolescent Hip Dysplasia: From Digital Design to Clinical Reality-A Conceptual Case Report.

Background: Adolescents with severe dysplasia of the hip regularly undergo a periacetabular osteotomy to prevent pain and early osteoarthritis. Unfortunately, this procedure is not suited for severe dysplasia with a non-congruent-deformed hip joint. The optimal treatment might be a tailor-made biologic optimization of femoral coverage with a shape matching the aberrant anatomy.

Inclusion of Sub-Antarctic Macroalgae () as Feed Ingredient for Grazing Sheep.

Two experiments were carried out to evaluate the inclusion impacts of macroalgae (Gs) for grazing sheep. Experiment (Exp.) 1 studied the effect of Gs on in vitro gas production (IVGP), dry matter (DM) digestibility (IVDMD), and methane (CH) emission using three fistulated sheep and 96 h incubation of samples.

An innovative in-body adjustable triple-band Notch UWB monopole antenna with improved bandwidth performance.

This study introduces a compact ultra-wideband (UWB) monopole antenna featuring adjustable multi-band rejection capabilities while considering the influence of a human body model on stop bands to optimize bandwidth performance. By incorporating two L-shaped slots into the ground plane, the antenna achieves an extensive bandwidth of up to 140% (3-17 GHz). The adjustable triple-band rejection at 4.

Exploring a green and precise approach based on graphene oxide-cobalt ferrite nanocomposite for detection and quantification of vitamin B9 and antibacterial assessment.

In this study, magnetic cobalt ferrite/graphene oxide (CoFeO/GO) sorbent was synthesized and used in magnetic dispersive micro-solid phase extraction (MD-µ-SPE) combined to spectrofluorometric as a green, precise, and effective method to separate and detect of vitamin B9 in food and biological samples. The structure, morphology and magnetic properties of CoFeO/GO nanocomposite was characterized by Fourier transform infrared (FT-IR) spectroscopy, X-Ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), and vibrating sample magnetometer (VSM). Four parameters of pH, sorbent dose, temperature, and sonication time were selected as effective variables on the process and optimized by central composite design (CCD).

Effect of High-Intensity Interval Training on Mitigating High-Fat Diet-Induced Damage in Rat Testicular Tissue.

A high-fat diet (HFD) is a risk factor for infertility, and regular exercise has been considered as a nonpharmacological intervention in the treatment of infertility. This study examined how high-intensity interval training (HIIT) affects testicular levels of malondialdehyde, total antioxidant capacity, glutathione (GSH), GSH peroxidase, catalase (CAT), superoxide dismutase, glucose, lactate, total cholesterol (TC), and testicular and serum testosterone (TES) levels in rats fed with a HFD or normal diet (ND). Forty-four male Wistar rats were assigned to the ND control (NDC), HFD control (HFDC), HIIT+ND, and HIIT+HFD groups.

Highly accurate anomaly based intrusion detection through integration of the local outlier factor and convolutional neural network.

Intrusion detection systems (IDS) are critical for safeguarding computer networks by identifying malicious activities. However, distinguishing attacks in IDSs with high accuracy is challenging. This research proposes a novel approach to enhance the accuracy of anomaly-based intrusion detection systems (IDS).

g-CN-Vitamin B5-Cu@γ-FeO as a magnetic nano biocomplex photocatalyzed efficient one pot tandem synthesis of benzimidazoles and imines.

This work introduces a natural-based nanostructured catalyst involving copper complexed with g-CN-Vitamin B5 hybrid supported on magnetic nanoparticles as an efficient photocatalytic system. Structural, morphological, optical, thermal, and magnetic assessments of the as-prepared catalyst are carried out. The one-pot aerobic oxidation of benzylic alcohols into aldehydes followed by their condensation with various aromatic amines or diamines was successfully performed under visible-light in the presence of the photocatalyst to yield imines and benzimidazoles.

Predicting radial dose function of LDR brachytherapy sources in the calcified soft tissues through Monte Carlo simulation.

This study aimed to investigate the effect of tissue calcification on the dose distribution of low-energy brachytherapy seeds used in the treatment of prostate and breast tumors. To achieve this, simulations of the IR-I andCs-1 seeds were conducted using the MCNPX Monte Carlo (MC) code. Brachytherapy dosimetric parameters, such as the dose rate constant (Λ) and radial dose function (g (r)), were calculated in water following the TG-43U1 protocol and validated by comparing the results with data reported in other literature.

A study of current and future distribution modeling of scorpion sting of deadly scorpion, Hemiscorpius acanthocercus (Scorpiones: Hemiscorpiidae) in southern Iran under climate change.

Scorpion stings represent a major public health issue, especially in tropical and subtropical regions like Iran, scorpion stings are commonly ignored and under-reported. Hemiscorpius is medically important genus in the family Hemiscorpiidae, comprising approximately 19 described species. This study aims to estimate the potential distribution of Hemiscorpius acanthocercus, identify suitable habitats, examine environmental constraints on its range, and provide insights into the species' ecology and areas at increased risk of scorpion stings.

Comparative effects of sensory motor and virtual reality interventions to improve gait, balance and quality of life MS patients.

Multiple sclerosis (MS) is a neurological disorder that affects the central nervous system, causing inflammation and damage to the myelin sheath, leading to balance and gait impairments. Sensory-motor (SN) and virtual reality (VR) interventions have shown promise in addressing these balance issues by engaging all three components of the balance control systems. This study aimed to compare the effectiveness of sensory-motor and virtual reality training on the functional status and quality of life of MS patients.

The Relationship Between Adherence to the MIND Diet and Maternal Anxiety and Sleep Disorders.

Objectives: Maternal diet is essential for the mother's and infant's health. Our Study aimed to evaluate the relationship between breastfeeding mothers' psychological distress and the Mediterranean diet and Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet.

Methods: The data were collected in a cross-sectional survey conducted by the authors in 2021.