One-Pot Asymmetric Assembly of Hierarchical Triple-Layer Nickel Foam/Titanium Carbonitride MXene Aerogels for Superior Microwave Absorption and Tailored Thermal Management.

Rapid strides in portable electronics and telecommunication technologies have sharply escalated the demand for high-performance electromagnetic interference (EMI) shielding materials that effectively suppress secondary electromagnetic pollution while simultaneously integrating thermal management. Here an innovative, lightweight, hierarchical triple-layer aerogel structure comprising nickel (Ni) foam (NiF), titanium carbonitride (TiCNT) MXene, and poly(vinyl alcohol) (PVA), fabricated via a facile, one-step bidirectional freeze-casting process is presented. This asymmetric aerogel architecture strategically employs an impedance-matching MXene/PVA top layer for optimized microwave entry, a NiF/MXene/PVA interlayer introducing magnetic loss and enhancing heat conduction, and a reflective, thermally foamed MXene bottom layer promoting internal reflection for superior energy absorption.

Satisfaction with a daily supportive text messaging program aimed at promoting psychological well-being of educators: Outcomes from implementation of the Wellness4Teachers.

Background: The Wellness4Teachers program, a daily supportive text messaging program, was launched in Canada to mitigate psychological problems among teachers.

Objective: This study assessed subscribers' experiences and satisfaction with the Wellness4Teachers supportive text messaging program.

Methods: This cross-sectional study was conducted during the 2022/2023 academic year and employed a mixed-methods approach.

The lab-field continuum in conservation physiology research: leveraging multiple approaches to inform policy and practice.

In the field of conservation physiology, there is often a trade off between conducting research in controlled laboratory settings or in inherently variable field environments. However, this belief sets up a false dichotomy where laboratory experiments are perceived as providing precise, mechanistic understanding with low variability at the cost of environmental realism while field studies are ecologically relevant but criticized for generating inconsistent evidence that is difficult to interpret and replicate. Despite the perceived binary view, these approaches are not in opposition to one another, but rather form a continuum along increasing ecological complexity.

Renal oncocytoma mimicking chromophobe renal cell carcinoma: Management using proposed diagnostic algorithm with emphasis on 99mTc-sestamibi SPECT/CT.

Renal oncocytomas are benign renal tumours characterized by a central stellate scar that are indistinguishable on CT/MR imaging from malignant chromophobe renal cell carcinomas (ChrRCCs). Renal oncocytomas and ChrRCCs can be separate entities but can also co-exist on a spectrum in hybrid oncocytic/ chromophobe tumours. In the past, invasive biopsy and pathologic diagnosis has been relied on to differentiate these lesion and direct management.

Production of Methylmercury in Peatlands Following Permafrost Thaw Increases along a Trophic Gradient.

Permafrost thaw in peatlands risks increasing the production and mobilization of methylmercury (MeHg), a bioaccumulative neurotoxin that poses a health hazard to humans. We studied 12 peatlands on a trophic gradient in northwestern Canada, including permafrost peat plateaus and thawed bogs and fens, to determine the effects of thaw on MeHg production from measures of soil and porewater MeHg and in situ methylation assays. The production of MeHg was greater in thawed peatlands, especially rich fens, as indicated by higher potential rates of microbial methylation of inorganic mercury (Hg) to MeHg and higher soil %MeHg (MeHg:total Hg).

Ethnic and Gender Disparities in Access to Deep Brain Stimulation Surgery for Parkinson's Disease.

Background: Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD) in appropriately selected patients. DBS may be underused in certain patient populations, especially women and racialized groups. Barriers and biases to receiving DBS that could account for underuse among these groups are not well studied in Canada.

Tubulointerstitial Nephritis Post-Microsporidium Infection in a Combined Liver-Kidney Transplanted Patient: A Case Report.

Microsporidia are emerging opportunistic pathogens in immunosuppressed individuals, including solid organ transplant recipients. We present a case of tubulointerstitial nephritis (TIN) caused by Microsporidia infection in a 55-year-old male who underwent combined liver-kidney transplantation (CLKT) for metabolic-associated fatty liver disease and end-stage kidney disease. The patient developed diarrhoea, abdominal bloating and acute kidney injury (AKI) 1 month post-transplant.

Clubroot Disease: 145 Years Post-Discovery, Challenges, and Opportunities.

Clubroot, a destructive disease of Brassicaceae, is caused by the soilborne, biotrophic protist . The pathogen was first identified by Mikhail Woronin in 1875 and named turnip disease in England. This pathogen has a unique, multiphase life cycle that takes place largely within a living host; however, it can also persist as resting spores in the soil for several years.

Can Step-Based Metrics Predict Current and Future Health-Related Fitness and Patient-Reported Outcomes among Women Diagnosed with Breast Cancer?

Purpose: Wearable sensors that track physical activity in daily life may offer insights that help healthcare providers optimize care plans for individuals with cancer. Therefore, we examined the links between lower health-related fitness and worse patient-reported health and various step-based metrics.

Methods: The Alberta Moving Beyond Breast Cancer Study enrolled 1,528 women recently diagnosed with breast cancer and measured health-related fitness and patient-reported health outcomes near diagnosis, and one year later.

Association of Anti-VEGF Therapy with Reported Ocular Adverse Events: A Global Pharmacovigilance Analysis.

Objective: Anti-vascular endothelial growth factor (VEGF) therapies have transformed the management of neovascular age-related macular degeneration, diabetic macular edema, and macular edema secondary to retinal vein occlusion (RVO). This class-wide pharmacovigilance study evaluated the disproportionality of reported ocular adverse events (AEs) among anti-VEGF agents using real-world data.

Design: A population-based, observational pharmacovigilance study.

Analyzing Mobility Indicators Using Machine Learning to Detect Mild Cognitive Impairment: A Systematic Scoping Review.

The global aging population is rapidly increasing, and the prevalence of age-related cognitive conditions, such as mild cognitive impairment (MCI), is becoming more common. This condition, which represents intermediate stages between normal aging and dementia, underscores the importance of early detection and timely intervention to address the growing demand for health services. Traditional cognitive assessments have limitations, such as the consistency of results, prompting the need for innovative technology-based solutions.

Adsorption and interaction mechanisms of asphaltene subfractions on silica surfaces.

Adsorption of asphaltenes onto mineral solids contributes to fouling, scaling, and plugging issues in the oil industry. Among asphaltene subfractions, those with strong oil/water interfacial activity are expected to possess superior adsorption abilities on mineral surfaces. In this study, interfacially non-active (INAA) and active (IAA) fractions were separated from whole asphaltenes.

The extracts of Ardisia elliptica fruit attenuate inflammation in LPS-activated BV2 microglia via JNK, ERK1/2, p38, and NF-κB signaling inhibition.

Background: Neuroinflammation is a pivotal defense mechanism against brain infections and injury; the dysregulation contributes to neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease, and multiple sclerosis. Ardisia elliptica Thunb. (Primulaceae), known as Ram Yai or Pilangkasa in Thai traditional medicine, has been used to treat diarrhea with fever.

Trawling the archives: Long-term trends in fish taxonomic and functional diversity in UK coastal community.

Effective marine conservation and fisheries management require long-term monitoring. Traditional metrics, such as species richness, abundance and diversity indices, are typically used to describe changes in community structure; however, these do not account for species' functional roles and their contribution to ecosystem processes. In this study, we investigated changes in functional diversity (FD) of fish species in a UK temperate coastal ecosystem at both the community and species levels from 1988 to 2023, using scientific trawl surveys.

Integrative hepatology: Enhancing overall health to manage liver disease.

Despite remarkable advances in diagnostics, pharmacotherapy, and transplantation, conventional hepatology often falls short in addressing the persistent symptoms, impaired quality of life, and broader health needs of people living with chronic liver disease. Integrative Hepatology-rooted in the principles of integrative medicine-offers a holistic, evidence-informed approach that combines conventional hepatology with complementary modalities to address the biological, nutritional, physical, psychosocial, behavioral, and environmental determinants of liver health. This framework emphasizes multimodal, patient-centered care aimed at improving both liver-specific and overall health outcomes.

The role of pharmacists in the management of patients with atrial fibrillation: A systematic review and meta-analysis.

Background: Pharmacist-led interventions have demonstrated benefits across various medical conditions; however, their impact on atrial fibrillation (AF) remains unexplored. This study aims to synthesize the available evidence regarding the pharmacist's role in AF management.

Methods: A systematic review with searches in PubMed, Scopus, and Web of Science was performed (PROSPERO: CRD42025647848).

Metabolic Control and Frequency of Clinical Monitoring Among Canadian Children With Phenylalanine Hydroxylase Deficiency: A Retrospective Cohort Study.

Achieving and maintaining metabolic control is critical for children with phenylalanine hydroxylase (PAH) deficiency. This retrospective longitudinal cohort study investigated metabolic control and monitoring frequency of children with PAH deficiency (≤ 12 years) treated at one of 12 pediatric metabolic centres across Canada. We abstracted data from medical charts and analyzed outcomes by age and diagnostic classification, using mixed effects regression.

Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.

The therapeutic value of antiviral nucleoside analogs was highlighted during the coronavirus disease 2019 (COVID-19) pandemic, with remdesivir and molnupiravir repurposed for their broad-spectrum antiviral activity. The cytidine analog azvudine (FNC) has recently gained attention as a potential treatment for human immunodeficiency virus type 1 (HIV-1) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Considering the distinct substrate specificities of HIV-1 reverse transcriptase (RT) and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), a unifying mechanism of inhibition remains elusive.

Assessing the socioeconomic burden in pediatric inflammatory bowel disease-a survey of families and national providers.

Objectives: Despite rapidly rising rates of pediatric inflammatory bowel disease (IBD), literature exploring the financial burden on families of children with IBD remains limited. This study sought to better understand the socioeconomic burden of pediatric IBD on families at our institution and compare IBD provider practices and perceptions across the country.

Methods: Two separate electronic surveys exploring demographics, financial impacts of an IBD diagnosis, and perceptions around IBD care were developed for patient families and IBD providers respectively.

Diagnostic Yield of Various Serum Creatinine Testing Frequencies in People At Risk for CKD.

Background: Guidelines recommend regular serum creatinine testing to detect chronic kidney disease (CKD) among people with diabetes or hypertension, but the ideal frequency of testing is unknown. We determined the diagnostic yield for incident CKD as defined by ≥2 measures of eGFR <60 mL/min/1.73m2, based on testing frequencies of every 2, 3, 4 or 5 years as compared to annually.

Care Delivery Strategies for Anxiety, Depression, Obsessive Compulsive Disorder, and Tourette Syndrome to Improve Health Outcomes in Children and Youth.

The purpose of this rapid review was to identify effective care delivery strategies for children and youth with anxiety, depression, obsessive compulsive disorder (OCD) and Tourette syndrome (TS) to inform the development of Canadian standards for mental health care provision. The review was developed using the Cochrane organization's minimum standards for Rapid Reviews.The eligible population was children and youth with anxiety disorders, depressive disorder, OCD, or TS.

A national atlas to improve the study of Canadians living with long COVID (post-COVID-19 condition).

Objectives: To develop a national atlas of (1) Canadian cohorts studying or with the potential to study adults living with long COVID (LC) and (2) harmonize provincial and territorial administrative datasets to facilitate the creation of validated case-ascertainment algorithms and foster national collaboration on LC research.

Methods: We conducted a multifaceted environmental scan that included a comprehensive literature search and a survey of members of Canada's national LC research network between August 21, 2023, and November 10, 2023. We identified provincial and territorial cohorts, including those that were linkable to administrative data and common data elements among administrative datasets.