Highly stretchable, self-healing and conductive silk fibroin-based double network gels a sonication-induced and self-emulsifying green procedure.

Regenerated silk fibroin (RSF)-based hydrogels are promising biomedical materials due to their biocompatibility and biodegradability. However, the weak mechanical properties and lack of functionality limit their practical applications. Here, we developed a tough and conductive RSF-based double network (DN) gel, consisting of a sonication-induced β-sheet physically crosslinked RSF/S gel as the first network and a hydrophobically associated polyacrylamide/stearyl methacrylate (PAAm/C18) gel as the second network.

Aqueous-based electrospun P(NIPAAm--AAc)/RSF medicated fibrous mats for dual temperature- and pH-responsive drug controlled release.

This paper presents a green method for fabricating dual temperature- and pH-responsive electrospun fibrous mats from an aqueous-based blend poly(-isopropylacrylamide--acrylic acid) (P(NIPAAm--AAc)) and regenerated silk fibroin (RSF) by employing electrospinning technique. P(NIPAAm--AAc) was synthesized by free radical solution polymerization and its low critical solution temperature (LCST) was in the physiological range (38.8 °C).