Effect of selective COX-2 inhibitors and non-selective non-steroidal anti-inflammatory drugs on severity of acute pancreatitis: A systematic review and meta-analysis.

Background: It's been suggested that non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the inflammatory response and severity of acute pancreatitis (AP). In this systematic review and meta-analysis, we aimed to explore the impact of selective COX-2 and non-selective NSAIDs compared to non-NSAID options on the severity of AP.

Methods: We searched MEDLINE, EMBASE, and Cochrane Central, from database inception through September 2023.

Breaking Grounds: A Comprehensive Analysis of Cutting-Edge Treatments for Primary Biliary Cirrhosis/Primary Biliary Cholangitis With Futuristic Treatments.

Primary biliary cholangitis (PBC) is an autoimmune disorder characterized by biliary destruction leading to intrahepatic biliary cholestasis. It predominantly affects women during the fifth and sixth decades. Treatment options have progressed from ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) to liver and stem cell transplant.

Socioeconomic and demographic disparities in the impact of digestive diseases in the middle East and North Africa (MENA) region.

Introduction: Digestive diseases (DD) pose a significant global health burden, with the Middle East and North Africa (MENA) region providing a unique landscape to study the impact of socioeconomic disparities on DD incidence and outcomes. This study examines the burden of DD in the MENA region, focusing on socioeconomic influences.

Methods: We utilized data from the Global Burden of Disease (GBD) dataset from 1990 to 2021, analyzing trends in incidence, mortality, and disability-adjusted life years (DALYs) for DD.

Personality Traits and Burnout in Emergency Medicine Residents.

Background: Burnout is prevalent in medical training, and some data indicates certain personality types are more susceptible. The criterion reference for measurement of burnout is the Maslach Burnout Inventory (MBI), which scores three factors: emotional exhaustion (EE); depersonalization (DP); and personal accomplishment (PA). Emotional exhaustion most closely correlates with burnout.

Incidental Gastrointestinal Stromal Tumor in a Patient Undergoing Robotic Sleeve Gastrectomy.

Bariatric surgery is the most effective treatment option for patients with refractory morbid obesity to help facilitate weight-loss and reduce long-term metabolic morbidity and mortality. Over 200,000 procedures are performed annually in the United States with sleeve gastrectomy being the most common surgical approach. However, the growing popularity of surgical bariatric interventions has led to an increase in incidental findings of gastrointestinal neoplasms in intraoperative specimens.

Treating a Non-mixed Neuroendocrine Colorectal Tumor Under Mixed Neuroendocrine Neoplasm (MiNEN) Protocols: A Case Report of Successful Outlier Management.

A 65-year-old male presented after a positive Cologuard testing. He was asymptomatic at presentation, with no reported complaints of fever, chills, abdominal pain, diarrhea, constipation, hematochezia, or unexpected weight loss. CT imaging of the abdomen and pelvis revealed a 2 cm mass at the rectosigmoid junction with a single enlarged lymph node nearby measuring 2.

Forty-five-year trends in intra- and extrahepatic cholangiocarcinoma: sex- and race-based insights.

Background: A comprehensive review of 45-year trends in intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) in the United States has not been published. Given their rising incidence, our study aimed to analyze trends in incidence and survival, comparing ICC and ECC.

Methods: We extracted a 45-year dataset (1975-2020) from the Surveillance, Epidemiology, and End Results database.

Racial disparities in cardiovascular manifestations among patients with sickle cell trait: analysis of national inpatient sample data (2016-2020).

Sickle cell trait (SCT) is a condition that affects up to 3 million individuals and 10% of African Americans (AA) in the United States (U.S.).

Prescription of pregabalin for prevention of acute post-mastectomy pain syndrome (APMPS): a systematic review and meta-analysis of randomized controlled trials.

Background: Mastectomy is generally considered the most effective treatment option for breast cancer. However, it is linked to a variety of complications that contribute to an elevated morbidity. Acute Post Mastectomy Pain Syndrome (APMPS) is 2 months or more of neuropathic pain after mastectomy.

Cancer-Associated Venous Thromboembolism Among Hospitalized Patients with Solid and Hematological Malignancies: A Comprehensive National Study.

Introduction: Venous thromboembolism (VTE) is a major cause of non-cancer-related mortality in cancer patients. Understanding how demographic factors and cancer types influence VTE risk is critical for developing prevention strategies. This study investigates the incidence of VTE in a large cancer patient population, focusing on gender, race, and differences between solid and hematological malignancies.

Ethical Considerations of Percutaneous Endoscopic Gastrostomy Tube Placement in a Patient With Creutzfeldt-Jakob Disease and Advanced Dementia.

Background: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive neurodegenerative condition that is not easily diagnosed and has no curative treatments available, essentially requiring palliative measures, including tube feeding. Nonetheless, data shows that the endoscope used for percutaneous endoscopic gastrostomy (PEG) tube insertion can be a vector for CJD transmission.

Case Presentation: We discuss the case of an elderly patient diagnosed with CJD, requiring tube feeding.

Examining the burden of mental disorders in Jordan: an ecological study over three decades.

Background: Mental disorders are a major public health issue, causing 4.9% of global disability-adjusted life years (DALYs). In Jordan, factors like regional conflicts, economic changes, and population growth contribute to this burden.

Comparing the safety and efficacy of over-the-scope suturing, through-the-scope suturing, and endoscopic hand suturing for closure of GI defects after endoscopic resection: systematic review and meta-analysis.

Background And Aims: Data comparing the efficacy and safety of OverStitch (Apollo Endosurgery, Marlborough, Mass, USA), X-Tack (Apollo Endosurgery), and endoscopic hand suturing (EHS) for closure of GI defects after endoscopic resection are limited. We conducted a meta-analysis of the available data.

Methods: Online databases were searched for studies evaluating different closure systems for GI defects.

Unraveling an Uncommon Encounter: Hypokalemic Periodic Paralysis with Brugada Phenocopy Amidst Hypokalemia.

Introduction: Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the setting of hypokalemia. A review of the literature showed that it is the seventh documented example of BrP induced by hypokalemia alongside HPP.

Unexpected Discovery at Resection Site: Plasmablastic Lymphoma After Polypectomy.

Plasmablastic lymphoma (PBL) is a rare, aggressive subtype of diffuse large B-cell lymphoma that has usually been associated with human immunodeficiency virus and Ebstein-Barr virus infections. Commonly seen in the oral cavity, it can affect any part of the gastrointestinal tract. This report describes a unique case of PBL that appeared in an 81-year-old immunocompetent patient.

Estrogen receptor subtypes and survival outcomes in non-small cell lung cancer.

Aim: Estrogen receptors (ERs), ERα and ERβ, are frequently detected in lung cancers, yet their prognostic impact on non-small cell lung cancer (NSCLC) outcomes remains uncertain. This study aims to assess the pooled prevalence and prognostic significance of ERα and ERβ in NSCLC, with a focus on gender differences.

Methods: We performed a systematic review and meta-analysis, identifying studies from major databases, including PubMed, Cochrane Library, and Embase, that reported ERα and ERβ expression and survival outcomes in NSCLC.

Overall Survival Following Interval Complete Gross Resection of Advanced Ovarian Cancer via Laparoscopy Versus Open Surgery: An Analysis of the National Cancer Database.

Advanced epithelial ovarian cancer (EOC) has traditionally been treated with primary debulking surgery; however, recent phase III trials have demonstrated similar survival outcomes for patients who were randomized to neoadjuvant chemotherapy followed by interval debulking (IDS) when compared to patients who underwent PDS. We sought to evaluate a cohort of patients with EOC diagnosed between 2010 and 2019 who underwent complete cytoreduction (R0-no gross residual disease) during IDS. We compared the outcomes after R0 resection via MIS versus laparotomy in IDS.

Is There an Association Between Emergency Department Overcrowding and Emergency Medical Services Redirection?

Background: Emergency Medical Systems (EMS) has developed policies to manage patient flow. In New York City, these practices include both diversion and redirection. Currently, gaps in the literature exist regarding the correlation between emergency department (ED) operational metrics and EMS redirection triggers.

Predictors of complications and extended length of stay following percutaneous transluminal renal artery angioplasty.

Patients with renal artery stenosis (RAS) who fail medical management may be evaluated for Percutaneous transluminal renal artery angioplasty/stenting (PTRA/S). Comorbidities increasing the risk of complications following PTRA have not been explored well. Patients undergoing PTRA/S for RAS were sampled using National Inpatient Sample (NIS) Database.

A novel case of inflammatory pseudotumor of the spleen with concurrent invasive lepidic pulmonary adenocarcinoma: a case report.

Background: Inflammatory pseudotumor of the spleen and lepidic adenocarcinoma of the lung are uncommon slow-growing malignancies that have not been previously reported to occur concurrently.

Case Presentation: We present the case of a 63-year-old Caucasian man who presented with a splenic inflammatory pseudotumor-like dendritic cell sarcoma and was found to have a concomitant invasive lepidic adenocarcinoma of the lung. The patient underwent laparoscopic splenectomy to address the splenic mass.

Effect of Cholecystectomy on Bubble Formation and Endoscopic Visualization: A Retrospective Cohort Study.

Purpose: This study aimed to evaluate the association between cholecystectomy and colonic bubble formation during colonoscopy, METHODS: A single-center retrospective cohort study was conducted at Staten Island University Hospital. Researchers reviewed 348 colonoscopy reports, comparing patients with (n = 56) and without (n = 292) a history of cholecystectomy. Colonic bubble formation was assessed using a 0-3 scale (0 = no bubbles, 3 = severe bubbles).