Pandemic planning for primary care in Southwestern Ontario: protocol for a sequential multiple-methods design.

Introduction: During the COVID-19 pandemic, primary care providers rapidly adapted their practice in response to emerging knowledge of infection risk, resource availability and evolving patient and system needs. Given the previous lack of guidance specific to primary care settings, there is a need to formalise and integrate lessons learnt from these successful adaptations into future pandemic plans. Our project will develop a model for pandemic planning in primary care designed for replication in other Canadian regions and internationally to facilitate the scale and spread of effective primary care pandemic response strategies.

Adversity is Differentially Related to Anger and Sadness Regulation in Newcomer Refugee Children.

This study employed developmental niche frameworks to examine how adversity at the child- and parent-levels, as well as at the relational level through parental discipline strategies, was associated with refugee newcomer children's emotion regulation. Participants were 128 Syrian newcomer children (52% girls; ages 5-15 years) and their mothers who have been resettling in Canada. Mothers and children reported adverse life experiences in an interview, and mothers reported parental discipline strategies and their children's emotion regulation via a questionnaire.

Laminin is uniformly expressed in basement membranes surrounding longitudinal axon tracts in the ventral and dorsal nerve cords in .

Laminin is a core basement membrane (BM) component. Mutations in laminin subunits cause a variety of defects including axon navigation defects. We examined the localization of the laminin subunits LAM-3 (laminin αA), EPI-1 (laminin αB) and LAM-2 (laminin γ) in basement membranes surrounding the ventral nerve cord (VNC) and the dorsal nerve cord (DNC) in .

Learning from failure: Simulating pandemic agreement negotiations in a global health classroom.

Serious games, including simulations, are increasingly used in university teaching, including in medical and humanitarian fields, as well as in political science and international relations. There is less evidence of application in global health pedagogy. This article reports and reflects on the use of a simulation of global pandemic treaty negotiations in a Master of Public Health class on Global Health and International Affairs.

The impact of lifestyle factors on trajectories of cognitive subtypes in the older adult population.

Cognitive aging is a complex process influenced by diverse life experiences and environmental factors. However, some traditional studies have oversimplified this process by assuming that cognitive aging trajectories follow a uniform process and that all individuals will experience similar declines. This framework minimizes the impact of external factors, neglecting the diversity observed in the aging population.

Eyewitness suspect identification: six claims regarding the state of the science.

Psychological science on eyewitness suspect identification has a long and rich history. A few decades ago, modal expert opinion emphasised eyewitnesses' fallibility, and it was widely held that identifications made with high confidence are only slightly more likely to be accurate than those made with low confidence. The authors of this invited Contemporary Discussion agree that current science compels a more nuanced perspective in which the relationship between eyewitnesses' confidence and their accuracy varies predictably depending on specifics of how the suspect was selected, how the identification test was designed, when and how it was administered, and when confidence was assessed.

Validation of automated computed tomography segmentation software to assess body composition among cancer patients.

Background & Aims: Assessing body composition using computed tomography (CT) can help predict the clinical outcomes of cancer patients, including surgical complications, chemotherapy toxicity, and survival. However, manual segmentation of CT images is labor-intensive and can lead to significant inter-observer variability. In this study, we validate the accuracy and reliability of automatic CT-based segmentation using the Data Analysis Facilitation Suite (DAFS) Express software package, which rapidly segments single CT slices.

Barriers and Enablers to Engaging with Long-Term Follow-Up Care Among Canadian Survivors of Pediatric Cancer: A COM-B Analysis.

Survivors of pediatric cancer are at risk for late effects and require risk-adapted long-term follow-up (LTFU) care. Yet less than 50% of survivors attend LTFU care. This study aimed to identify barriers and enablers of engaging with LTFU care as perceived by Canadian survivors of pediatric cancer and healthcare providers (HCPs).

Flotillin-1 is Hijacked by Listeria monocytogenes to Drive Cell-to-Cell Spreading.

Listeria monocytogenes spreads intercellularly by creating actin-rich projections that are endocytosed into recipient cells. Caveolin-mediated endocytosis has been implicated in this process, accounting for ∼70% in cell-to-cell spread in cells depleted of caveolin-1. Thus, additional mechanisms may contribute for the remaining spread and we examined the role of flotillin-based endocytosis.

The cost and cost trajectory of genome sequencing and bioinformatics analysis for Indigenous children with suspected rare diseases.

Purpose: Indigenous peoples are underrepresented in reference genome libraries. Consequently, rare disease diagnosis may require bespoke bioinformatics analyses of genome sequences. Establishing diagnostic cost is crucial to support policy development for equitable rare disease diagnosis.

Using confidence, decision time, and confidence entropy to predict accuracy for online and real eyewitnesses.

It is important to identify factors that police can use to distinguish accurate from inaccurate eyewitnesses (i.e., reflector variables).

Neuromuscular fatigue reduces force responsiveness when controlling leg external forces.

Agile movement requires precise control of ground reaction forces, yet the impact of neuromuscular fatigue on this control remains incompletely understood. We investigated how leg muscle fatigue affects the nervous system's ability to modulate vertical ground reaction forces, hypothesizing that fatigue would impair responsiveness, and accuracy. Eighteen healthy participants (11 W, 7 M; age: 26 ± 3.

Spatial Distribution, Seasonal Variation, and Ecological Risk Assessment of Benzotriazole UV Stabilizers in Waters from Canadian Tributaries and Coastal Systems.

Benzotriazole UV stabilizers (BZT-UVs) are industrial additives of emerging environmental concern, with UV-328 recently listed under the Stockholm Convention on Persistent Organic Pollutants and several congeners listed as Substances of Very High Concern in Europe. However, their distribution and fate in coastal environments remain poorly understood. This study investigated the spatial and seasonal variations of dissolved and suspended particulate matter (SPM)-bound BZT-UVs in surface water from the St.

Concurrent stimulation of diflufenican biodegradation and changes in the active microbiome in gravel revealed by Total RNA.

The use of slowly degraded pesticides poses a particular problem when these are applied to urban areas such as gravel paths. The urban gravel provides an environment very different from agricultural soils; i.e.

Simulation Modeling of Oral Cancer Development with Risk Stratification: How Potential Screening Programs Can Be Evaluated.

Unlabelled: A barrier to early-stage oral cavity cancer detection is the lack of a defined population and screening regimen satisfying risk-benefit considerations. We constructed a microsimulation model, Simulation of Cancers of the Oral cavity and Risk Exposures (SCORE), that incorporates risk profiles defined by smoking and alcohol exposure. SCORE simulates the development and progression of oral potentially malignant disorders (OPMD) representing benign, dysplastic, or malignant lesions in the US population starting at age 40 y.

Digital Health Interventions for Depression and Anxiety in Low- and Middle-Income Countries: Rapid Scoping Review.

Background: Low- and middle-income countries (LMICs), which bear a larger proportion of the global mental illness burden, have been disproportionately impacted by the COVID-19 pandemic due to preexisting mental health care system deficiencies. The pandemic has also led to a considerable increase in care delivered through digital mental health interventions (DMHIs), many of which have been adapted from in-person formats. Thus, there is a need to examine their fidelity to the original format along with issues regarding usability and other challenges to and facilitators of their uptake in LMICs.

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies.

Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability. Over 140 proteins localized to primary cilia, which are sensory organelles essential for vertebrate development, are implicated. TMEM17 encodes a transmembrane protein at the ciliary transition zone and was previously proposed as a potential ciliopathy gene, based on reports of individuals from two families with orofaciodigital syndrome type 6 (OFD6) and Joubert syndrome (JS).

Contrasting historical trends of atmospheric rivers in the Northern Hemisphere.

Previous modeling studies have indicated that Atmospheric rivers (ARs) will become more frequent in the warming climate. However, whether we have experienced more ARs during historical period is less studied. Here, we show that winter AR frequency has significantly increased over the mid-latitude Northern Hemisphere from 1950-2022.

Facilitators and barriers to codesigning social robots with older adults living with dementia: A scoping review.

Background: Social robots are increasingly used to support older adults living with dementia by providing not only reminders and companionship but also emotional support, engagement through conversation, and a sense of comfort. Engaging older adults living with dementia in the codesign process ensures that their unique needs and challenges are met, thereby enhancing the relevance and usability of these technologies. However, limited evidence exists on effective engagement strategies for codesigning with older adults living with dementia.

BiasPruner: Mitigating bias transfer in continual learning for fair medical image analysis.

Continual Learning (CL) enables neural networks to learn new tasks while retaining previous knowledge. However, most CL methods fail to address bias transfer, where spurious correlations propagate to future tasks or influence past knowledge. This bidirectional bias transfer negatively impacts model performance and fairness, especially in medical imaging, where it can lead to misdiagnoses and unequal treatment.

Physician-in-the-Loop Active Learning in Radiology Artificial Intelligence Workflows: Opportunities, Challenges, and Future Directions.

Artificial intelligence (AI) is being explored for a growing range of applications in radiology, including image reconstruction, image segmentation, synthetic image generation, disease classification, worklist triage, and examination scheduling. However, training accurate AI models typically requires substantial amounts of expert-labeled data, which can be time-consuming and expensive to obtain. Active learning offers a potential strategy for mitigating the impacts of such labeling requirements.

Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders.

We conducted the largest genome-wide meta-analysis of borderline personality disorder (BPD) to date, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 cases and 107,750 controls (all participants of European ancestry). We identified 11 independent associated genomic loci, and nine risk genes in the gene-based analysis. We observed a single-nucleotide polymorphism (SNP) heritability of 17.

Error rates for high confidence eyewitness identifications.

Eyewitness identification of strangers is vulnerable to error, even if the eyewitness reports high confidence at the initial police identification procedure. In support of this claim, we report a new meta-analysis of data from actual criminal investigations. This analysis shows that when eyewitnesses were tested in the field by a blind lineup administrator, 1/8 of the high confidence identifications were known errors, i.

Channelized metasomatism in Archean cratonic roots as a mechanism of lithospheric refertilization.

Archean cratons represent stable continental domains which form the nuclei of the Earth's continents due to their thick ( >200 km), mechanically resistant keels. Cratons and their stable roots form through melt and fluid depletion processes. However, metasomatic refertilization may occur due to processes coeval with craton construction and/or overprinting episodes.

Contribution of trunk swing to the performance of fixed-seat rowing.

Introduction: This study aimed to test the contribution of trunk swing to the performance during fixed-seat rowing in eligible and non-eligible (NE) para rowers. Assessment of trunk swing is used to classify para rowers with physical disability in Para Rowing (PR) 1 and PR2 rowers. PR1 rowers are classified based on the demonstration of impaired function of trunk swing.