[Modern view on the mechanism of traffic injury in collision of moving vehicle and pedestrian].

The article considers the main phases of traffic injury (TI) described by A.A. Solokhin in 1968 and their modern application in forensic medical and automotive examination.

[Mathematical programming in assessment of the postmortem interval under conditions of linearly varying external temperature].

Objective: To develop and implement a method for determining the postmortem interval and the marginal errors of its estimates under conditions of linearly varying external temperature in the format of an online application.

Material And Methods: A computer-assissted numerical search for the absolute minimum point of the objective function obtained from a system of nonlinear equations reflecting the results of double rectal or cranioencephalic thermometry of a corpse under conditions of linearly varying external temperature was carried out. The search algorithm was generalized to possible marginal errors in measuring the initial indicators of temperature and time.

[On the possibility of establishing postmortem interval of human by examining the electrical conductivity of the knee joints' synovial fluid].

Objective: To study the electrical conductivity of the knee joints' synovial fluid of human's corpse for assessment of the possibility of its application as criterion of forensic medical diagnosis of postmortem interval.

Material And Methods: The work was carried out on practical forensic medical material on the basis of the Bureau of Forensic Medical Expertise in the Republic of Bashkortostan. During the study, 103 corpses of both sexes, different ages who died from various causes were investigated.

[To determination of the causal relationship between the actions of medical professionals and the occurrence of adverse outcome in expertises on medical malpractice cases].

Two expert reports of medical malpractice cases, in one of which there was a conclusion about the presence of a direct causal relationship with the natural course of the disease, and the other - with the incorrect actions of the doctor, were analyzed. Methodological approaches to solving such issues are discussed. It is recommended to use the logical method of hypothetical elimination of incorrect actions of medical professionals in order to avoid errors.

[Forensic medical expertise in the cases of sexual crimes: dynamics of indicators and regional features].

Unlabelled: Crimes against the sexual integrity of the individual represent one of the most serious forms of violence.

Objective: To perform a retrospective epidemiological analysis with the systematization of analytical data on the performed forensic medical examinations (FMEs) of survivors of sexual abuse in order to increase the effectiveness of the system of preventive measures against such crimes.

Material And Methods: The data from the industry statistical report №42 were analyzed.

Mechanistic Insights Into Postprandial Insulin-Glucagon Interactions and Their Impact on Glucose Flux After Protein-Glucose Coingestion in Humans.

Unlabelled: Despite stimulating glucagon secretion, the mechanisms by which protein ingestion lowers glucose excursions remain unclear. We investigated this using the triple stable isotope glucose tracer technique to measure postprandial glucose fluxes. Eleven healthy adults completed three trials, ingesting 25 g glucose (25G; 100 kcal), 50 g glucose (50G; 200 kcal), or 25 g glucose plus 25 g whey protein (25WG; 200 kcal).

Toward Human-Centered Artificial Intelligence for Users' Digital Well-Being: Systematic Review, Synthesis, and Future Directions.

Background: As information and communication technologies and artificial intelligence (AI) become deeply integrated into daily life, the focus on users' digital well-being has grown across academic and industrial fields. However, fragmented perspectives and approaches to digital well-being in AI-powered systems hinder a holistic understanding, leaving researchers and practitioners struggling to design truly human-centered AI systems.

Objective: This paper aims to address the fragmentation by synthesizing diverse perspectives and approaches to digital well-being through a systematic literature review.

Diverse Attitudes and Experiences With Technology Use During the COVID-19 Pandemic Among Asian American and Pacific Islander Adults (the COMPASS Study): Survey Study.

Background: The COVID-19 pandemic forced the world to quarantine to slow the rate of transmission, causing communities to transition into virtual spaces. Asian American and Pacific Islander communities faced the additional challenge of discrimination that stemmed from racist and xenophobic rhetoric in the media. Limited data exist on technology use among Asian American and Pacific Islander adults during the height of the COVID-19 shelter-in-place period and its effect on their physical and mental health.

Development of an Instrument to Measure Resilience to Misinformation on Social Media: Measurement Properties and Validation.

Background: The spread of misinformation on social media poses significant risks to public health and individual decision-making. Despite growing recognition of these threats, instruments that assess resilience to misinformation on social media, particularly among families who are central to making decisions on behalf of children, remain scarce.

Objective: This study aimed to develop and evaluate the psychometric properties of a novel instrument that measures resilience to misinformation in the context of social media among parents of school-age children.

Participants' Perspectives on the iCareBreast Mobile-Based Perioperative Care Program for Women Undergoing Breast Cancer Surgery: Qualitative Process Evaluation.

Background: Breast cancer treatment, particularly during the perioperative period, is often accompanied by significant psychological distress, including anxiety and uncertainty. Mobile health (mHealth) interventions have emerged as promising tools to provide timely psychosocial support through convenient, flexible, and personalized platforms. While research has explored the use of mHealth in breast cancer prevention, care management, and survivorship, few studies have examined patients' experiences with mobile interventions during the perioperative phase of breast cancer treatment.

Development and Validation of a Novel LC-MS/MS-Based Proteomics Method for Quantitation of Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR).

Retinol binding protein 4 (RBP4), the circulating carrier of retinol, complexes with transthyretin (TTR) and is a potential biomarker of cardiometabolic disease. However, RBP4 quantitation relies on immunoassays and Western blots without retinol and TTR measurement. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous absolute quantitation of circulating RBP4 and TTR is critical to establishing their biomarker potential.

Plasma glucose and HbA1c discrepancy may indicate hemoglobinopathy: a case series.

Introduction: Diabetes Mellitus is a chronic disease characterised by elevated plasma glucose (PG) levels. HbA1c has been widely utilized for diabetes diagnosis. However, certain conditions restrict its use.

Tuning the Electrical Property and Electronic Band Structures of Organic Semiconductors via Surface Tension.

Stress engineering is an effective way to tune the performance of semiconductors, which has been verified in the work of inorganic and organic single-crystal semiconductors. However, due to the limitations of the vapor-phase growth preparation conditions, the deposited polycrystalline organic semiconductors are more susceptible to residual stress. Therefore, it is of great research significance to develop a low-cost stress engineering applicable to vapor-deposited semiconductors.

The role and mechanism of abnormal lipid metabolism in colorectal cancer.

Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis.

Is a Response to Intraoperative Electrical Nerve Stimulation Associated With Recovery After Stretch Injury in the Rat Median Nerve?

Background: Peripheral nerve injury commonly results in pain and long-term disability for patients. Recovery after in-continuity stretch or crush injury remains inherently unpredictable. However, surgical intervention yields the most favorable outcomes when performed shortly after injury.

A real-world study on the safety and efficacy of therapeutic plasma exchange in patients with Alzheimer's disease.

BackgroundTherapeutic plasma exchange (TPE) with albumin replacement has emerged as a potential treatment for Alzheimer's disease (AD). The AMBAR trial showed that TPE could slow cognitive and functional decline, along with changes in core and inflammatory biomarkers in cerebrospinal fluid.ObjectiveTo evaluate the safety and effectiveness of TPE in a real-world setting in Argentina.

Approach to the Postmarket Evaluation of Consumer Wearable Technologies.

Importance: Consumer wearable technologies have wide applications, including some that have US Food and Drug Administration clearance for health-related notifications. While wearable technologies may have premarket testing, validation, and safety evaluation as part of a regulatory authorization process, information on their postmarket use remains limited. The Stanford Center for Digital Health organized 2 pan-stakeholder think tank meetings to develop an organizing concept for empirical research on the postmarket evaluation of consumer-facing wearables.

Recent Advances in Gene Therapy for Hemophilia.

Hemophilia, an X-linked monogenic disorder, arises from mutations in the or genes, which encode clotting factor VIII (FVIII) or clotting factor IX (FIX), respectively. As a prominent hereditary coagulation disorder, hemophilia is clinically manifested by spontaneous hemorrhagic episodes. Severe cases may progress to complications such as stroke and arthropathy, significantly compromising patients' quality of life.

A Risk Prediction Tool for Invasive Melanoma.

Importance: Increasingly, strategies to systematically detect melanomas invoke targeted approaches, whereby those at highest risk are prioritized for skin screening. Many tools exist to predict future melanoma risk, but most have limited accuracy and are potentially biased.

Objectives: To develop an improved melanoma risk prediction tool for invasive melanoma.

High-Intensity Exercise and Hippocampal Integrity in Adults With Cannabis Use Disorder: A Randomized Clinical Trial.

Importance: Cannabis is the most commonly used illicit drug, with 10% to 30% of regular users developing cannabis use disorder (CUD), a condition linked to altered hippocampal integrity. Evidence suggests high-intensity interval training (HIIT) enhances hippocampal structure and function, with this form of physical exercise potentially mitigating CUD-related cognitive and mental health impairments.

Objective: To determine the impact of a 12-week HIIT intervention on hippocampal integrity (ie, structure, connectivity, biochemistry) compared with 12 weeks of strength and resistance (SR) training in CUD.