Exploring therapeutic potential of Cannabis based therapy in autoimmune and rheumatic disorders.

The medical use of cannabis is expanding across many countries, with some legalizing its use outright and others implementing medical licensure systems to approve treatment for eligible patients. Despite this growing interest and utilization, there remains a lack of solid scientific evidence supporting its medical use, even though cannabis has been used therapeutically for thousands of years. The goal of the following communication is to present updated data on the potential roles of cannabis-based treatments in various autoimmune and rheumatic conditions.

Anxious-Ambivalent Attachment and Cybervictimization Among Young Adults: The Mediating Role of Problematic Internet Use.

Studies have shown anxious-ambivalent attachment commonly characterizes cyberbullying victims. Similarly, studies have shown an association between anxious-ambivalent attachment and problematic internet use (PIU). Previous studies have explained this asso-ciation by noting the high interpersonal needs of individuals with anxious-ambivalent attachment who are looking for social contact.

Tele-SPACE: group parent-based treatment for pediatric anxiety via telemedicine in a public health clinic.

Introduction: Supportive Parenting for Anxious Childhood Emotions (SPACE) is an evidence-based treatment for parents of children with anxiety disorders and/or obsessive-compulsive disorder (OCD). Given the many barriers to accessing such evidence-based treatments, we evaluated for the first time the application of group-based SPACE, delivered to parents via telemedicine within a public health outpatient setting.

Methods: In this single arm retrospective analysis of routine-care data participants, recruited from a hospital-based anxiety clinic, were mothers (N=50) of fifty children, ages 6.

Association Between Migraine and Hypertension in 2 Million Adolescents.

Background: An association between migraine and hypertension has long been suggested. However, previous studies yielded conflicting results, and only a few were conducted in adolescents. We aimed to investigate the association between migraine and hypertension in a large population-based study of adolescents.

Temporal satisfaction patterns in body image after aesthetic surgery: A systematic review and meta-analysis.

Background: Understanding how body image satisfaction evolves following aesthetic surgery is crucial for psychological adaptation and clinical practice. We systematically reviewed and meta-analyzed satisfaction trends over time following aesthetic surgery to elucidate the psychological adaptation process.

Methods: We searched PubMed, Web of Science, and PsycINFO (2010-2024) for studies reporting satisfaction at multiple post-operative time points.

The impact of shortening shifts of physicians during their residency on patients and physicians : A systematic review and meta-analysis.

Background: Prolonged shifts in residency contribute to physician fatigue, cognitive decline, and increased medical errors. This systematic review and meta-analysis evaluate how reducing shift length affects patient-physician safety, physician well-being, and residency training, addressing the ongoing challenge of balancing resident welfare, patient outcomes, and educational standards across varied implementation settings.

Methods: A comprehensive search of PubMed, EMBASE, The Cochrane Library, Google Scholar, and opengrey.

Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial.

Background And Aims: We explored whether changes in serum proteomic profiles differed between participants with distinct brain aging trajectories, and whether these changes were influenced by dietary intervention.

Methods: In this secondary analysis of the 18-month DIRECT PLUS trial, 294 participants were randomized to one of three arms: 1) Healthy dietary guidelines (HDG); 2) Mediterranean (MED) diet (+440 mg/day polyphenols from walnuts); or 3) low red/processed meat green-MED diet (+1240 mg/day polyphenols from walnuts, Mankai plant, and green tea). We measured 87 serum proteins (Olink-CVDII).

Pooled CRISPR screens identifies key regulators of bovine stem cell expansion for cultured meat.

Cultured meat presents a sustainable alternative to traditional meat production but faces significant challenges in scalability and cost efficiency. A key limitation is the restricted proliferation capacity of bovine mesenchymal stem cells (bMSCs), a widely used cell source in the field. Using a pooled, lentiviral CRISPR knockout screen, we interrogated 3000 CRISPR guides targeting 600 genes involved in stem cell regulation or proliferation.

Machine-learning based calculator for personalized risk assessment following ST-elevation myocardial infarction.

Background: Despite recent therapeutic advancements, a high-risk scenario for subsequent adverse events remains following ST-elevation myocardial infarction (STEMI). Risk scores provide important prognostication data following STEMI. However, the most established risk scores are not contemporary, their prognostic accuracy ranges across populations, and they cannot provide patient-centered recommendations.

Verbal Communication, Coordinated Effort, and Performance in Esports Teams: An Expert-Nonexpert Paradigm Study.

Verbal communication among expert and nonexpert esport team players during active gameplay of Counter-Strike: Global Offensive (CS:GO) was observed and analyzed. By analyzing 4,040 in-game statements comprising 22,490 words (15,727 made by experts and 6,763 by nonexperts) across eight matches, we examined communication characteristics, such as content, frequency, pace, and distribution. Expert teams communicated more frequently and effectively than nonexpert teams, using predominantly factual and action-related statements while maintaining a significantly faster communication pace.

Automated Platform for the Analysis of Multi-Plate Growth and Reporter Data.

Researchers traditionally calculate growth rates using the natural logarithm of optical density (OD), with existing script packages facilitating this process. Automatic plate readers, capable of simultaneously measuring OD across 384 cultures, significantly enhance data collection efficiency. Furthermore, these readers also measure luminescence and fluorescence, providing valuable insights into gene expression.

Euthyroid Sick Syndrome as an Index of Prognosis in Severe COVID-19 Disease.

: Euthyroid sick syndrome, or non-thyroidal illness syndrome, has been observed in severely ill patients and has been found to be an index of prognosis. It has been detected in patients with severe infectious diseases, e.g.

Youth Exposed to Armed Conflict: The Homeroom Teacher as a Protective Agent Promoting Student Resilience.

Armed conflict poses a significant threat to the mental health of youth worldwide. This study focused on the role of teachers as protective agents fostering resilience among their students. The study examined the moderating effects of teachers' personal well-being and their efficacy in the school on relations between their students' armed conflict exposure and student psychiatric symptoms.

Prediction of Aortic Stenosis Progression Using Artificial Intelligence: A Machine Learning Model.

Background: Current guidelines for monitoring aortic stenosis (AS) progression focus on serial echocardiographic assessment, which is resource-intensive and subject to variability. Artificial intelligence may offer an opportunity to enhance the early identification of patients at risk of developing severe AS.

Objectives: The objective of this study was to create an echo-based model that can predict whether a patient will deteriorate from mild/moderate AS to severe AS.

Invariant inter-subject relational structures in high order human visual cortex.

It is a fundamental of behavior that different individuals see the world in a largely similar manner. This is an essential basis for humans' ability to cooperate and communicate. However, what are the neural properties that underlie these inter-subject commonalities of our visual world? Finding out what aspects of neural coding remain invariant across individuals' brains will shed light not only on this fundamental question but will also point to the neural coding scheme at the basis of visual perception.

The effect of centrality bias on triage nurses in the emergency department.

Objective: To investigate whether centrality bias is one of the contributing factors for patient mistriage in the emergency department.

Methods: A randomized, controlled, single-blinded trial was conducted in an emergency department triage station between April 1 and November 3, 2021. Experienced triage nurses were divided into control and treatment groups.

Gamified Attention Bias Modification Training to Augment Cognitive-Behavioral Therapy for Youth Anxiety Disorders: A Randomized Controlled Trial.

Objective: Augmenting cognitive-behavioral therapy (CBT) with attention-bias modification training (ABMT) may maximize therapeutic benefit for anxiety through targeting different underlying processes. Yet, corresponding neural mechanisms are unclear. This pre-registered double-blind, randomized controlled trial assigned youth with anxiety disorders receiving CBT to active or sham gamified ABMT.

Advancing the human right to health in cancer care through drug repurposing strategies.

This perspective critically evaluates the global potential of drug repurposing strategies in oncology to advance health equity and sustainable innovation. Drug repurposing, especially with off-patent medications, offers significant advantages, including reduced costs, shortened timelines for clinical implementation, and enhanced approval success rates compared to new drug development. Herein, we advocate for leveraging of repurposing as a scientifically sound and ethically responsible strategy, while acknowledging the implementation barriers in low- and middle-income countries (LMICs) due to global systemic inequities.

To build a family: exploring preferred paths to parenthood among plurisexual individuals without children.

Aims/background: Limited research has examined family-building strategies among plurisexual individuals. Culture and gender are essential determinants of parenthood prospects among individuals with minoritized sexual identities. For plurisexual individuals, the partner's gender also seems to play a critical role.

Benzodiazepine Prescribing Patterns Following Mass Traumatic Events.

Importance: While clinical guidelines generally advise caution with benzodiazepine use following trauma, prescribing patterns during mass traumatic events reveal tensions between formal recommendations and frontline care delivery.

Objective: To assess changes in benzodiazepine prescribing patterns following the October 7, 2023, terrorist attacks in Israel and examine factors associated with prescribing decisions.

Design, Setting, And Participants: This population-based retrospective cohort study was conducted using the electronic database of Clalit Health Services in Israel, the country's largest health care service, covering approximately 54% of the population.

The Gendered Toy Choice (GTC): validating a behavioral measure of gendered parenting.

reflects parents' tendency to promote gender-typed behaviors of their children, shaping their everyday experiences and environments. Existing research primarily relies on self-report or observational methods, limiting behavioral insights. This study introduces the development and validation of the Gender Toy Choice (GTC) measure, an unobtrusive behavioral tool assessing parents' real-time product choices for their children.

Examining the impact of learning about a resolved conflict on attitudes in an ongoing conflict: Evidence from the Israeli-Palestinian context.

A popular intervention for increasing support for peace in violent intergroup conflicts is to describe the peaceful resolution of other conflicts. In four experiments, we tested the effectiveness of this approach in the context of the Israeli-Palestinian conflict by exposing Jewish-Israelis to information about the Northern Ireland conflict and peace process, or about tourism in Northern Ireland as a control. We found that learning about the historical peace process generally led participants to view conflicts as more malleable, their own conflict as less unique, and led to unfreezing of conflict-related beliefs.

Personality traits or emotional dysregulation: a multiple mediation analyses of adolescent depression.

Background: In a similar way to depression, the development of borderline personality traits seems closely linked to the experience of Stressful Life Events (SLEs). This study examined the extent to which emotion regulation and personality traits simultaneously mediate and significantly attenuate the direct path between SLEs and depressive symptoms.

Method: Parallel and serial multiple mediation models were employed to analyze a sample of 196 adolescents assessed twice over a 12-month period.

Professional and service-user perspectives regarding the future of mental healthcare in Israel.

Background: A recent call has been made in Israel to address the needs of citizens inflicted by multiple adversities such world pandemic, internal conflicts, events of mass trauma and ongoing war. Nonetheless, public's and mental health professional's view regarding these needs and their prioritization is not well understood. This study aims to bridge this gap in knowledge, by assessing mental health service users and professionals' views regarding the future of mental health in Israel.

Adolescent Body Mass Index, Weight Trajectories to Adulthood, and Osteoporosis Risk.

Importance: There are limited data regarding adolescent weight among healthy individuals and their trajectory through early adulthood with respect to bone health.

Objective: To assess the association between adolescent body mass index (BMI) and osteoporosis risk while accounting for BMI change during early adulthood.

Design, Setting, And Participants: A retrospective population-based cohort study from 1967 to 2019.