Development of an Instrument to Measure Resilience to Misinformation on Social Media: Measurement Properties and Validation.

Background: The spread of misinformation on social media poses significant risks to public health and individual decision-making. Despite growing recognition of these threats, instruments that assess resilience to misinformation on social media, particularly among families who are central to making decisions on behalf of children, remain scarce.

Objective: This study aimed to develop and evaluate the psychometric properties of a novel instrument that measures resilience to misinformation in the context of social media among parents of school-age children.

Fulminant myocarditis: outcome predictors in an international cohort study.

Background And Aims: Fulminant myocarditis (FM) is a complex clinical syndrome characterized by acute myocardial inflammation and cardiogenic shock. Evidence on long-term outcomes, mortality risk factors, and targeted treatment options remains limited.

Methods: This retrospective analysis included consecutive adult patients admitted for FM between January 2012 and November 2022 at 26 European tertiary centres.

The evolution of extreme sound frequencies in bird songs.

Bird songs differ widely among species and can show peculiar phenotypes, such as extreme or unusual sound frequencies for a species' body size. Although birds can modulate sound frequency, size-related limitations prevent vocalizing efficiently (i.e.

Photochemistry of 2-aminooxazole: a matrix-isolation and computational study of a putative key prebiotic molecule.

2-Aminooxazole 1 is a key intermediate in plausible prebiotic pathways to activated pyrimidine ribonucleotides. However, its photochemistry and underlying reaction mechanism remain unclear. Here, we present a combined matrix-isolation infrared spectroscopic and computational investigation of the UV-induced photochemistry of 1.

When is A Kidney Biopsy Indicated During the Treatment of Brain Cancer?

Introduction: Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) and is widely used in oncology for its anti-angiogenic properties. However, VEGF inhibition may result in significant nephrotoxicity, including thrombotic microangiopathy (TMA). While systemic TMA is well-described, isolated renal-limited TMA remains under recognised.

Severe Hypoalbuminaemia after Roux-En-Y Gastric Bypass: A Diagnosis of Exclusion.

Unlabelled: Bariatric surgery has emerged as a highly effective treatment option for individuals with obesity. Severe hypoalbuminaemia is a feared complication after a Roux-en-Y gastric bypass. It is characterised by a low serum albumin level of <25 g/l, neither explained by renal losses, protein-losing enteropathy nor by liver disfunction, and is associated with high morbidity and mortality.

Stroke risk following bee and wasp stings: a systematic review of ischemic and hemorrhagic events.

Background: Each year, approximately 100 million cases of bee and wasp stings are re-ported globally, with the majority resulting in mild reactions. However, in rarer instances, these stings can lead to severe and potentially fatal outcomes, including ischemic or hemorrhagic cerebral events. This article aims to synthesize and analyze the current evidence on the association between bee and wasp stings and the occurrence of ischemic and hemorrhagic strokes.

AI Algorithm for Lung Adenocarcinoma Pattern Quantification (PATQUANT): International Validation and Advanced Risk Stratification Superior to Conventional Grading.

The morphological patterns of lung adenocarcinoma (LUAD) are recognized for their prognostic significance, with ongoing debate regarding the optimal grading strategy. This study aimed to develop a clinical-grade, fully quantitative, and automated tool for pattern classification/quantification (PATQUANT), to evaluate existing grading strategies, and determine the optimal grading system. PATQUANT was trained on a high-quality dataset, manually annotated by expert pathologists.

Enhancing diagnostic precision: a multicentric study of endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in lymphoproliferative disorders.

Background: The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for the diagnosis of lymphoma has a low overall sensitivity. The lack of tissue architecture obtained by cytological needles decreases the diagnostic accuracy for diagnosis and subtyping of and relapsed mediastinal lymphomas. This study compares the sensitivity of EBUS-TBNA and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TMC) for both initial lymphoma diagnosis and recurrent cases, analyses safety, and evaluates the number of mediastinoscopies that could potentially be avoided due to this novel technique.

Case Report: Effective methotrexate removal by combined hemodialysis and polymeric resin hemoadsorption.

Background: High-dose methotrexate (HDMTX) is central to treating primary central nervous system lymphoma but carries a risk of acute kidney injury (AKI), which can delay methotrexate (MTX) clearance and increase toxicity. Glucarpidase is the treatment of choice for MTX toxicity, but limited access in many countries may necessitate alternatives. We present the first reported adult case of combined high-flux hemodialysis (HFHD) and HA230 hemoadsorption for MTX clearance.

First molecular detection of in captive tortoises in Portugal.

Introduction: is a well-recognized etiologic agent of upper respiratory tract disease in tortoises. Although frequently reported in both captive and wild populations across Europe, its occurrence in Portugal had not been previously documented. This study aimed to investigate the presence of in apparently healthy captive tortoises in mainland Portugal and to evaluate potential host- and management-related factors associated with infection.

The QGIS project: Spatial without compromise.

The QGIS project is a prominent open-source geographic information system (GIS) that has evolved over two decades, contributing significantly to the geospatial community. This paper presents the development, governance, and operational challenges faced by QGIS, providing an in-depth analysis of its growth from a hobby project to a global platform. We examine the project's organizational structure, release management, and infrastructure, alongside the financial model that sustains its development.

A conversation with research software engineers at the International Brain Laboratory.

Open-source software is the lifeblood of many modern research projects, allowing researchers to push boundaries, build collaborations, and work transparently. The International Brain Laboratory (IBL), a group of more than twenty labs working together to understand the neuroscience of decision-making, uses open-source software and other open science practices extensively to advance its research. Here, we interview two of the IBL's research software engineers to learn more about their career paths and how they view open-source development.

Mapping Perceived Impact, Facilitators and Barriers of Cystic Fibrosis Management in Children and Adolescents: A Qualitative Study From the Parents' Perspective.

Background: Cystic fibrosis imposes a significant treatment burden on children and their informal caregivers, who have to change their routines to carefully adhere to medication and exercise as treatment regimes. Although informal caregivers are known to be key players in the daily management of these children, their own voice is scarcely explored, often hindering personalisation of care. The main objective of the study was to map the multifactorial impact of cystic fibrosis, as well as identify barriers and facilitators perceived by parental caregivers in managing the disease in the paediatric age.

Branched-Chain Amino Acids Exacerbate Colitis Progression by Lowering Colonic Fumarate Levels.

Background: Ulcerative colitis (UC) is a gastrointestinal inflammatory condition with an unclear etiology. Recent findings suggest that metabolites play a pivotal role in promoting intestinal health. We have previously observed a significant enrichment in colonic branched-chain amino acids (BCAAs) in resistant mice to colitis suggesting the potential role of these metabolites in UC development.

A Core-Shell Structured Microneedle Patch With Adjustable Release of Kinetically for the Treatment of Melasma.

Melasma is a facial hyperpigmentation disease that significantly impacts patients' quality of life. Clinical treatment is limited by the short half-lives and hydrophilicity of drugs, necessitating release curve optimization to maintain a stable therapeutic concentration for an extended period. This article utilizes natural biomaterials to design a core-shell structured microneedle, combining the "immediate release" and "delayed release" module to achieve programmed drug release.

Feasibility and acceptability of a postpartum mental health internet intervention in mothers of multiples.

Aims/background: Parents of multiples (twins, triplets+) have elevated postpartum mental health risks. About half of such parents desire postpartum mental health treatment, but only a minority receive care. We examined the feasibility and acceptability of - a self-guided web-based postpartum mental health intervention - in mothers of multiples (MoMs).

Advances on the Synthesis, Reactivity, and Biological Properties of 4H-Thiochromen-4-(thio)one Derivatives.

The aim of the present review is to provide a systematic survey on the recent advancements in the chemical synthesis of thiochromones, thiochromanones, the less explored thiochromene-4-thiones and some analogs. These compounds are used as versatile building blocks in the synthesis of other complex and polycyclic heterocyclic analogs. Highlights on biological and photophysical properties of these thio derivatives are also included and discussed.

The Key Role of Public Forests in Restoring Connectivity: an Application to Castilla y León Region, Spain.

Forests have been increasingly affected by natural disturbances and human activities. These impacts have caused habitat fragmentation and a loss of ecological connectivity. This study examines potential restoration pathways that reconnect the five largest forest cores in the Castilla y León region of Spain.

A literature review on the quantitative approaches to food waste: descriptive, predictive, and prescriptive analyses.

Food waste generated throughout the food supply chain raises several environmental, social, and economic issues. Quantitative methods can aid in managing food waste by describing current contexts, predicting future scenarios, and improving related operations. However, a literature review on the use of quantitative methods, specifically the descriptive, predictive, and prescriptive dimensions, to assess and prevent food waste is lacking.

Decoding the gene expression response of Cerastoderma edule to chronic trematode infection: A comparison among host tissues.

Parasites can induce gene expression changes in their hosts, either benefiting the parasite or the host. In particular, trematodes are not only one of the most ubiquitous groups of aquatic parasites, they also have huge impacts on individual hosts with significant ecological and economic repercussions. The trematode Bucephalus minimus infects Cerastoderma edule (the edible cockle), a socioeconomically and ecologically important bivalve, as its first intermediate host.

The role of Penicillium brevicompactum in bioprocessing plastic and metals from Printed Circuit Boards.

Printed circuit boards (PCB) present a complex recycling challenge due to their miniaturisation and different constituents (e.g., metals, plastics), highlighting the need for integrated bioprocessing approaches.

Pan-carcinoma sialyl-Tn-targeting expands CAR therapy to solid tumors.

Accurate identification of tumor-specific markers is vital for developing chimeric antigen receptor (CAR)-based therapies. While cell surface antigens are seldom cancer-restricted, their post-translational modifications (PTMs), particularly aberrant carbohydrate structures, offer attractive alternatives. Among these, the sialyl-Tn (STn) antigen stands out for its prevalent presence in various epithelial tumors.

Involuntary movements in patients with impaired awareness: A comparative study of phenomenology and neurophysiological evaluation.

Introduction: Subtle involuntary movements in patients with impaired awareness may suggest non-convulsive status epilepticus (NCSE), but their diagnostic accuracy is unclear. Since electroencephalography (EEG) is not always available, clinicians often rely on motor signs for early diagnosis. We aimed to characterize these movements and evaluate interrater agreement and diagnostic accuracy among specialists.