Psychological Vulnerability to Perinatal Depression: A Longitudinal Mediation Model.

Perinatal depression (PD) is a significant mental health concern affecting women during pregnancy (antenatal depression, AD) and postpartum (postpartum depression, PPD). The association between AD and PPD is well established, with AD serving as a risk factor for PPD. Additionally, a history of depression and neuroticism have been identified as key vulnerability factors.

Application of Prodigiosin Extracts in Textile Dyeing and Novel Printing Processes for Halochromic and Antimicrobial Wound Dressings.

The textile industry's reliance on synthetic dyes contributes significantly to pollution, highlighting the need for sustainable alternatives like biopigments. This study investigates the production and application of the biopigment prodigiosin, which was produced by with a yield of 1.85 g/L.

Outcomes After Reversible Cerebral Vasoconstriction Syndrome With Convexity Subarachnoid Hemorrhage: Individual Patient Data Analysis.

Background And Objectives: The most common cause of convexity subarachnoid hemorrhage (cSAH) in younger patients (younger than 60 years) is reversible cerebral vasoconstriction syndrome (RCVS). Evidence on the long-term outcomes of future vascular events and functional outcome after cSAH due to RCVS is limited. We aimed to assess the rates and baseline predictors of our primary outcomes (cSAH, intracerebral hemorrhage (ICH), and ischemic stroke), functional outcome, and mortality after cSAH attributed to RCVS.

Loss of REP-1 in retinal pigment epithelial cells leads to impaired phagosome processing and altered lysosomal pathway function.

Choroideremia (CHM) is a rare form of retinal degeneration caused by mutations in the ubiquitously expressed gene, encoding for Rab escort-protein-1 (REP-1). REP-1 is required for the prenylation of Rab GTPase proteins, regulators of intracellular membrane traffic, yet what specific cellular pathways are affected in CHM and how this contributes to disease progression remain unclear. Using both ARPE-19 and iPSC-derived retinal-pigmented epithelium (RPE) cells, where the gene was knocked-out using CRISPR/Cas9, we show that cells have an increased number of lysosomes.

Unraveling the Toxicity of a Non-Microcystin-Producing Strain (CCIBt3106) of : Ecotoxicological Effects on Aquatic Invertebrates.

Cyanobacterial blooms are becoming increasingly frequent and intense worldwide, often dominated by , a species capable of producing a wide array of bioactive metabolites beyond microcystins. This study evaluates the ecotoxicological potential of a non-microcystin-producing strain, CCIBt3106, using acute immobilization assays with three microcrustacean species: , , and . Biomass was extracted using solvents of varying polarity, and selected extracts (aqueous and 50% methanol) were further fractionated and analyzed via high-resolution liquid chromatography-tandem mass spectrometry (HR-LC-MS/MS).

Enhanced Mitochondrial Dynamics and Reactive Oxygen Species Levels with Reduced Antioxidant Defenses in Human Epicardial Adipose Tissue.

: Epicardial adipose tissue (EAT) is metabolically active and is in dynamic crosstalk with the surrounding cardiomyocytes, modulating their function and metabolism. Oxidative stress is a key contributor to cell death and cardiac remodeling, is a hallmark of diabetes (DM) and cardiovascular disease, such as coronary artery disease (CAD). However, little is known about these processes in EAT from patients undergoing cardiac surgery.

Juvenile dermatomyositis: a severe and atypical presentation.

Introduction: Juvenile dermatomyositis (JDM) is a rare immune-mediated disease, characterised by proximal muscle weakness and typical skin rashes1. We present a patient with severe JDM, to highlight the importance of a timely diagnosis and early initiation of treatment.

Case Description: A 9-year-old girl presented to the hospital due to asthenia, rash, generalized oedema, and inability to walk.

Anti-beta2-glycoprotein I IgG antibodies are associated with early-onset cryptogenic ischemic stroke.

Background: Previously undetected antiphospholipid antibodies (aPLs) potentially provide explanations for early-onset cryptogenic ischemic stroke (CIS). Prior association studies conducted over a decade ago were inconclusive and not focused on patients with CIS.

Methods: SECRETO is a multi-center case-control study enrolling patients aged 18-49 years with imaging-positive acute CIS and 1:1 matched stroke-free controls.

sp. nov., a Novel Species Isolated from a Drinking Water Fountain in a Rural Community.

Three isolates of a novel, rapidly growing, non-pigmented species were recovered from the water and runoff of a public fountain in a rural village in central Portugal, formerly used by the local population as a source of drinking water and not accessible to animals. High-quality draft genome sequencing, in silico DNA-DNA hybridization, and phylogenetic analyses confirmed that isolates 21AC1, 21AC14, and 21AC21 represent a previously undescribed species within the genus , forming a distinct phylogenetic lineage closely related to , and . MALDI-TOF MS analysis of the type strain 21AC1 revealed a unique spectral profile.

Benefits of a Multifunctional Sunscreen Formulation Containing Nanoencapsulated Antioxidants in the Skin Protection Against UV Radiation and Blue Light: Clinical and Preclinical Studies.

Background: The development of sunscreens with properties beyond photoprotection involves carefully optimizing the blend of ingredients and employing advanced systems to ensure effective delivery through the skin layers.

Aims: The aim of this study was to evaluate the efficacy of a multifunctional photoprotective formulation containing a blend of nanoencapsulated ingredients-ascorbyl palmitate, caffeine, and resveratrol-and the active ingredients niacinamide, hyaluronic acid, bisabolol, tocopherol, and carnosine in skin protection against UV and blue light radiations, by in vitro, ex vivo, and clinical studies.

Methods: A preclinical approach using human explants was performed to evaluate the protective effects of a sunscreen formulation against damage induced by UV and blue light radiation.

Maternal depressive symptomatology and mother-infant bonding difficulties: the mediating role of brooding rumination.

Background: While the association between maternal depressive symptomatology and mother-infant bonding (MIB) difficulties is well established, the mechanisms underlying this relationship remain unclear. This study innovatively investigates the mediating role of rumination (considering its two dimensions - brooding and reflection), a key cognitive process in depression that has been rarely explored in the postpartum period.

Aims: To compare rumination and MIB levels between mothers with and without depressive symptoms and assess whether maternal depressive symptomatology is associated with MIB difficulties, with rumination acting as a mediating factor.

Outcome of subtotal parathyroidectomy for surgical treatment of hyperparathyroidism after renal transplantation.

Objective: To evaluate the efficacy of STPX as a definitive treatment for Hyperparathyroidism after Renal Transplantation (HPT-RT) and determine whether there is a relationship between percentage intraoperative Parathyroid Hormone (ioPTH) decay levels and Parathyroid Hormone (PTH) values on the first postoperative day and surgical success.

Methods: This retrospective study analyzed the medical records of prospectively followed patients diagnosed with HPT-RT submitted to STPX in two tertiary hospitals (Brazilian Unified Health System ‒ SUS) for two years. Patients were allocated in two groups according to operative success (SG ‒ normalization of ionized Calcium [iCa] and PTH six months after surgery) or operative failure (FG ‒ persistence of high iCa and PTH).

European harmonization of asbestos exposure assessment: comparing PCM, SEM, and TEM to derive conversion factors.

After the European ban on the use of asbestos, exposure assessment of asbestos became imperative for ensuring compliance with safety standards. However, each European country has their own legislation and requirements, including measurement strategies, analytical techniques such as the microscope used as well as occupational exposure limits (OELs). The recent EU directive (EU) 2023/2668 significantly lowered the OEL for asbestos from 100,000 fibres/m³ 8-h time-weighted average to either 2,000 fibres/m³ when counting fibres between 0.

The endocannabinoid system in cancer biology: a mini-review of mechanisms and therapeutic potential.

The Endocannabinoid System (ECS) plays a critical role in maintaining physiological homeostasis, influencing a range of processes such as neuroprotection, inflammation, energy metabolism, and immune responses. Comprising cannabinoid receptors (CB1 and CB2), endogenous ligands (endocannabinoids), and the enzymes responsible for their synthesis and degradation, the ECS has attracted increasing attention in cancer research. Cannabinoid receptor activation has been associated with the regulation of cancer-related processes, including cell proliferation, apoptosis, and angiogenesis, suggesting that the ECS may have a role in tumor progression and cancer treatment.

Case Report: New insights about clinical manifestations of patients with genetic variants.

GCK-MODY is a genetic condition characterized by alterations in the gene, which can include several types of inactivating genetic variants - ranging from missense and nonsense variants, and splice site variants, to small and large deletions and insertions in the gene. This disorder primarily affects glucose homeostasis and usually presents in heterozygous individuals. Although GCK-MODY is a well-studied condition, some variant carriers may manifest symptoms that deviate from the typical disease phenotype.

Light-Mediated 3D-Printed Wound Dressings Based on Natural Polymers with Improved Adhesion and Antioxidant Properties.

The lack of personalized wound dressings tailored to individual needs can significantly hinder wound healing. Hydrogels offer a promising solution, as they can be engineered to mimic the extracellular matrix (ECM), providing an optimal environment for wound repair. The integration of digital light processing (DLP), a high-resolution 3D printing process, allows precise customization of hydrogel-based wound dressings.

Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale.

Background: The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations of modifiable traditional, nontraditional, and female sex-specific risk factors with young-onset CIS, stratified by clinically relevant patent foramen ovale (PFO), defined by high-risk features of atrial septal aneurysm or large right-to-left shunt.

Methods: We enrolled consecutive patients aged 18 to 49 years with recent CIS and frequency-matched stroke-free controls of the same age and sex from 19 European sites.

Right Ventricular Dysfunction in Heart Failure Patients: Does Sex Matter?

Right ventricular dysfunction (RVD) predicts poor survival in chronic heart failure (HF). Sex differences in RVD have been suggested but are still unraveled. We studied the influence of sex in the prognostic impact of RVD in chronic HF.

Factors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection.

Background: Patients presenting with cervical artery dissection (CAD) are at risk for subsequent ischemic events. We aimed to identify characteristics that are associated with increased risk of ischemic stroke after initial presentation of CAD and to evaluate the differential impact of anticoagulant versus antiplatelet therapy in these high-risk individuals.

Methods: This was a preplanned secondary analysis of the STOP-CAD study (Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection), a multicenter international retrospective observational study (63 sites from 16 countries in North America, South America, Europe, Asia, and Africa) that included patients with CAD predominantly between January 2015 and June 2022.

Systolic blood pressure increase in chronic heart failure associates with survival advantage.

Background: The impact of systolic blood pressure (SBP) variation on chronic heart failure (HF) is largely unknown. We assessed the impact of SBP variation in patients with chronic HF.

Methods: This is a retrospective analysis of adult ambulatory patients with HF with left ventricular systolic dysfunction (LVSD).

Association Between Self-Perceived Stress and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.

Background And Objectives: Psychosocial stress is a potentially modifiable risk factor of early-onset ischemic stroke, with limited evidence suggesting a stronger association between stress and cryptogenic ischemic stroke (CIS) compared with strokes of known etiology. We aimed to explore the association between self-perceived stress and CIS, with subgroup analyses stratified by sex and age.

Methods: Young patients aged 18-49 years with a first-ever CIS and sex-matched and age-matched stroke-free controls from 19 European centers were included.

Early-stage immunoexpression of inflammatory, angiogenic, and survival markers in tongue epithelium of mice exposed to hookah smoke.

Objective: The objective was to evaluate the early-stage immunoexpression of markers (COX-2, NF-kB, VEGFR-1 and apoptotic index) related to inflammation, angiogenesis, and cell survival in the tongue dorsum epithelium of mice exposed to hookah smoke.

Materials And Methods: The sample consisted of Swiss mice (N = 20), female gender, aged 2 months, and approximately 25g each, four groups (n = 5) mice: group exposed to fresh air and groups exposed to hookah smoke for 7, 15, and 30 days. Tongues were embedded in paraffin.

Arabica coffee Intercropped with Improved Nutrient Uptake and Yield in the Brazilian Cerrado.

Coffee intercropped with modifies nutrient uptake, and consequently the yield and quality of coffee, by the greater release of nutrients and efficient nutrient cycling. There is little information about the increasing nutrient content in Arabica coffee plants intercropped with . The objective of this study was to evaluate the effect of intercropped with two coffee cultivars ( L.

All-cellulose resin for 3D printing hydrogels via digital light processing (DLP).

3D printing has emerged as a transformative technology in sustainable manufacturing, enabling rapid prototyping, minimizing material waste, and reducing the carbon footprint associated with traditional methods. However, their reliance on fossil-based materials limits their broad application. This study presents a novel approach for developing a single-component, fully cellulosic, natural-based resin for 3D printing hydrogels using digital light processing (DLP).