Development and Validation of an Educational Tool on Hypodermoclysis for Palliative Care Professionals.

: Hypodermoclysis has gained increasing recognition as a safe, effective, and minimally invasive method for administering medication and fluids in palliative care. Despite its advantages, its adoption remains limited, primarily due to a lack of structured training resources for healthcare professionals. This study aimed to develop and validate an educational tool for training clinical nurses in hypodermoclysis administration in palliative care.

The Last Whistle: Unveiling the Relationship between the Career Path and Retirement Age in Professional Soccer.

This study explores the relationship between Career Indicators (CIs) and the retiring age of Portuguese soccer players, focusing on the impact of early career experiences and career discontinuation stages. Data were analyzed from retired Portuguese soccer players registered on a private digital platform, using specific CIs related to different stages of their athletic careers. The analysis involved a two-level mediation model incorporating various CIs.

Collaborative Practices in Mental Health Care: A Concept Analysis.

Collaboration in mental health care is essential for implementing a model oriented towards the psychosocial rehabilitation of people based on multifaceted interventions involving different actors and sectors of society to respond to demands. Despite the benefits presented by the scientific evidence, there are still many barriers to collaborative care, and professionals continue to struggle in reorienting their conduct. The current situation demands organization and the framing of well-founded action plans to overcome challenges, which in turn requires a detailed understanding of collaborative practices in mental health care and their conceptual boundaries.

Tell Me What You've Done, and I'll Predict What You'll Do: The Role of Motivation and Past Behavior in Exercise Adherence.

The main purpose of this study was to test a hierarchical model of motivation that integrates Achievement Goal Theory and Self-Determination Theory to explain and predict exercise adherence. In total, 2180 exercisers (1020 female, 1160 male) aged between 18 and 60 years, from different gyms and health clubs, completed several scales validated in exercise settings, regarding perceived motivational climate, basic psychological need satisfaction, behavioral regulation, and exercise adherence. For the last measure, weekly computer access to a control system over a 6-month period before and after data collection was consulted.

Spiritual Care Competence in Palliative Care: A Concept Analysis.

Care is a multidimensional concept that includes spirituality as a dynamic and integrative aspect of human experience. Integrating spirituality into clinical practice enables a more comprehensive response to the full spectrum of human needs, which is why spiritual care competence emerges as an aptitude that fits the profile and skills to be developed by those working on care provision. Regrettably, not enough attention has been paid to spiritual care competence largely due to the lack of knowledge of professionals and what this entails.

High-Resolution Computational Modeling of Transcranial Photobiomodulation: Light Propagation and Thermal Effects.

Background: Transcranial photobiomodulation (tPBM) is the noninvasive application of light to modulate underlying brain activity. There is increasing interest in evaluating tPBM as a therapeutic option. The typical technological questions are extent of light penetration and associated tissue temperature increases.

Student's Perception Towards Endodontic Training with Artificial Teeth: What Has Changed?

Objectives: This study assessed students' perceptions of artificial teeth (AT) after completing the Endodontics I, II, and III curricular units at the Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal. Additionally, the study aims to review existing literature on students' perceptions of three-dimensional (3D) printed models used in pre-clinical training, identifying current challenges and future needs for improvement.

Methods: A questionnaire was adapted, consisting of 24 questions, using a 5-point Likert scale, from 1 (Strongly Disagree) to 5 (Strongly Agree), in which students had to compare AT with natural teeth (NT) in various aspects of anatomy and endodontic procedures.

The Arabic Version of the Patient Health Questionnaire-2 (PHQ-2): Psychometric Evaluation Among Mothers of Children With Intellectual Disabilities.

Mothers of children with intellectual disabilities are particularly vulnerable to mental distress due to demanding and exhausting caregiving. However, in the Arab world, they are seldom screened for depression because of limited diagnostic resources. Addressing the urgent need for brief and reliable screening tools, this study evaluated the psychometric properties of the Arabic version of the Patient Health Questionnaire-2 (PHQ-2) among 85 Saudi mothers.

Spatial Distribution and Post-COVID-19 Health Complications in Older People: A Brazilian Cohort Study.

In the aftermath of the COVID-19 pandemic, individuals infected with SARS-CoV-2 have progressively displayed a range of symptoms linked to protracted COVID during the post-acute phase of illness. Concurrently, in several nations globally, the phenomenon of population aging has been intensifying. In this scenario, the aged population has become both vulnerable and high-risk during the acute phase of COVID-19, and faces significant dangers associated with long-COVID.

The Practices of Portuguese Primary Health Care Professionals in Palliative Care Access and Referral: A Focus Group Study.

: The prevalence of people with incurable and progressive diseases in primary health care is high. Family doctors and nurses must be active agents in the early identification of palliative needs and the implementation of palliative approaches in cases of low to intermediate complexity. While there is a need for early referral of more complex palliative care (PC) cases to specialized teams, primary health care (PHC) professionals lack the confidence or skill to describe their role.

Burnout protective patterns among oncology nurses: a cross-sectional study using machine learning analysis.

Background: Oncology nurses face unique and intense demands due to the nature of their work, caring for patients with life-threatening illnesses. The emergence of professional burnout among these nurses is influenced by several factors, highlighting the importance of identifying protective and risk factors to mitigate its impact. This study aims to identify burnout profiles and protective socio-demographic and work-related patterns associated with reduced burnout among oncology nurses.

Loss and Grief Among Bereaved Family Members During COVID-19 in Brazil: A Grounded Theory Analysis.

The COVID-19 pandemic has resulted in countless losses around the world, profoundly affecting the lives of many people, especially those who faced the death of family members, bringing several negative repercussions to these families and constraining the experience of grief. This study aimed to understand the experience of loss and grief among bereaved individuals who lost family members during the COVID-19 pandemic. This qualitative study was guided by Charmaz's constructivist grounded theory as a methodological framework.

Marine Natural Products as Anticancer Agents 3.0.

Cancer represents a major global health challenge[...

Effectiveness of Nursing Interventions on Preventing the Risk of Infection in Adult Inpatients: Protocol for a Systematic Review.

Healthcare-associated infections (HAIs) are a major global public health concern, significantly impacting patient safety and healthcare quality. These infections are associated with high morbidity and mortality rates, prolonged hospital stays, and increased healthcare costs. Nurses play a critical role in infection prevention, implementing evidence-based interventions to reduce infection risks.

Psychometric evaluation of the Arabic version of the Eight-item Center for Epidemiological Studies Depression Scale (CESD-8): Specific cultural considerations for the assessment of depression.

Background: Despite extensive evaluations of the Center for Epidemiological Studies Depression Scale (CESD), its shortest version, the Eight-Item version (CESD-8), is less investigated, with absolute lack of information on its psychometric properties in the Arab world.

Methods: To fill the gap, data collected via an anonymous online survey from Saudi samples of students ( 979, 422) and employees ( 314), were analyzed through exploratory factor analysis, confirmatory factor analysis, and multigroup analysis to examine the structure and measurement invariance of the CESD-8. Convergent validity and internal consistency tests involved correlating the CESD-8 with its subscales, item analysis measures, and intra class correlations.

The needs of family caregivers providing palliative home care in Portugal: a multi-stage mixed methods study protocol.

Background: In palliative care (PC), family caregivers (FCs) play an important role in managing patient symptoms and addressing patient needs. In end-of-life (EoL), FCs frequently experience distress that exacerbates emotional strain and complicates grieving. Training FCs to care for palliative patients should be implemented urgently, enhancing their preparation, reducing their burden, and assuring Quality of Life (QoL) throughout illness progression.

PERI_DEP: A dataset of mother's mental health in Pakistan.

Perinatal depression (PND) represents a multifaceted mental health issue that impacts women throughout the perinatal period. Existing datasets have a class imbalance issue, resulting in biased outcomes. In Pakistan, we developed a novel dataset called PERI_DEP.

The effect of smoking on lung function changes during a 16-week combined exercise program in middle-aged workers: a latent growth curve analysis.

Purpose: To investigate the longitudinal changes in lung function of sedentary middle-aged workers over a 16-week combined exercise training program.

Methods: Thirty-six sedentary workers (53.70 ± 6.

5'-Guanidino Xylofuranosyl Nucleosides as Novel Types of 5'-Functionalized Nucleosides with Biological Potential.

While various nucleoside and nucleotide analogs have been approved as anticancer and antiviral drugs, their limitations, including low bioavailability and chemotherapeutic resistance, encourage the development of novel structures. In this context, and motivated by our previous findings on bioactive 3'--substituted xylofuranosyl nucleosides and 5-guanidine xylofuranose derivatives, we present herein the synthesis and biological evaluation of 5'-guanidino furanosyl nucleosides comprising 6-chloropurine and uracil moieties and a 3--benzyl xylofuranosyl unit. The synthetic methodology was based on the glycosylation of a 5-azido 3--benzyl xylofuranosyl acetate donor with the silylated nucleobase and a subsequent one-pot sequential two-step protocol involving Staudinger reduction of the thus-obtained 5-azido uracil and N/N-linked purine nucleosides followed by guanidinylation with ,'-bis(-butoxycarbonyl)-''-triflylguanidine.

Perceptions and Practices of Interdisciplinary Action in an Intra-Hospital Support Team for Palliative Care: A Qualitative Study.

The quality of palliative care (PC) services is closely linked to the effectiveness of interdisciplinary collaboration. A coordinated approach among professionals from different fields fosters holistic, person-centered care, ensuring comprehensive support for patients with complex conditions and their families. In hospital settings, In-Hospital Palliative Care Support Teams (EIHSCPs) play a key role in delivering specialized care, enhancing interdepartmental communication, training other healthcare professionals, and optimizing resources.

Racial and Socioeconomic Disparity in Breast Cancer Mortality: A Systematic Review and Meta-Analysis.

: Breast cancer is one of the leading causes of female mortality worldwide, but significant racial and socioeconomic disparities persist in disease outcomes. This review aimed to analyze racial and socioeconomic inequalities in mortality and survival from breast cancer, identifying the impact of social risk factors on access to diagnosis and treatment. : A systematic literature review and meta-analysis was performed following PRISMA guidelines.

Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery.

The extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) have emerged as promising green alternatives to conventional organic solvents, offering advantages such as biodegradability, greater environmental and economic sustainability, low toxicity, and enhanced extraction selectivity.

Effects of a land and aquatic exercise-based program on pain, mobility and quality of life in patients with chronic low back pain: a study protocol for a randomized controlled trial.

Background: Chronic low back pain (CLBP) is a disease with significant functional, emotional and social impact. Several interventions are proposed for its management and exercise is one of main, land-based or water-based. This study describes a randomized controlled trial that will analyze the effect of a combined aquatic and land-based exercise program compared to an aquatic-based program on pain, functional incapacity and quality of life in adults with CLBP.

Informal Palliative Care at Home: A Focus Group Study Among Professionals Working in Palliative Care in Portugal.

Informal caregivers (ICs) are the backbone of home-based palliative care (PC) because they play a vital role in offering more seamless and timely support, preventing suffering and fostering comfort and dignity. Specialized home-based PC teams must recognize ICs' unmet needs in fulfilling daily responsibilities and enhance their preparedness for caring. In this vein, this study aimed to carry out the following: (a) explore how PC professionals perceive the preparedness of ICs to provide PC at home and (b) determine what barriers and enablers they consider essential for the delivery of high-quality PC at home.

Improved biosynthesis and characteristics of silver nanoparticles using marine endophytic fungi exposed to hypo-osmotic stress.

Silver nanoparticles (AgNPs) are valued for their unique properties and can be synthesized biologically, offering a greener alternative to traditional methods. This study assessed the potential of cell-free filtrates (CFFs) of seaweed-associated marine fungi to produce AgNPs. More specifically, Talaromyces pinophilus, Aspergillus fructus, Stemphylium gracilariae, Purpureocillium lilacinum, Microascus croci, Penicillium toxicarium, Exophiala mesophila, and Emericellopsis maritima, when cultured in media prepared with artificial seawater or distilled water (hypo-osmotic conditions) as a possible stress inducer.