The effect of exercise interventions on symptoms of anxiety in persons with multiple sclerosis: a systematic review and meta-analysis.

Introduction: Persons with multiple sclerosis (MS) frequently experience symptoms of anxiety. There is a large unmet need for effective and accessible interventions.

Objectives: To assess the effect of exercise on symptoms of anxiety in persons with MS, consider characteristics associated with effectiveness, and evaluate intervention design reporting.

Research Priorities for Nursing and Allied Health: A Priority-Setting Project Using a Partnership Approach.

Background: Research priorities guide research activities, funding and resources within health services. To ensure that research efforts are meaningful and impactful, it is vital that organisational research agendas reflect the priorities of both healthcare consumers and staff, alongside broader national and international research frameworks. This paper outlines a research priority-setting project conducted across two hospitals in Western Australia, aimed at identifying shared research priorities through a collaborative and inclusive approach.

Traces of phylogeny and ecology in hippocampal neuron numbers.

It is not known how selective pressures shape the numbers of interconnected neurons in defined neural circuits during the phylogeny of mammals. Consequently, models of function are without phylogenetic bounds, and species differences in neuronal makeup cannot be linked to ecological factors that generate selective pressures. Based on data from 65 species belonging to 11 orders, we here provide an analysis of five interconnected neuron populations in the circuitry of the hippocampus, the forebrain region encoding episodic memories.

Increased ATP production and P-glycoprotein activity underlie the marked changes in blood-brain barrier transport of drugs in a mouse model of amyotrophic lateral sclerosis.

Background And Purpose: Patients with amyotrophic lateral sclerosis (ALS) are prescribed many medications for symptomatic relief. However, how potential alterations to the blood-brain barrier (BBB) affect the brain exposure of drugs in ALS remains under-investigated.

Experimental Approach: We used high-dimensional proteomic analysis, cellular metabolism, and mitochondrial functional assays to characterise isolated brain microvascular endothelial cells (BMECs) from wildtype and SOD1 transgenic mice, a mouse model of familial ALS, at a late-symptomatic age (P115-120), together with a transcardiac brain perfusion technique to assess BBB function in situ.

Co-Design of a Weekly Meal Box for Neurological Conditions: Findings From Consumer and Healthcare Provider Collaborative Workshops.

Introduction: This study explores the collaborative co-design process for developing a weekly meal box tailored for individuals with neurological conditions. Recognising the critical role of nutrition for this community, the research addresses the challenges posed by cognitive and physical impairments in meal preparation.

Methods: Through two co-design workshops involving consumers, healthcare providers and industry experts, insights were gathered on dietary preferences, nutritional needs and practical challenges.

"": perspectives of people with neurological conditions on robot-assisted lower limb and gait neurorehabilitation.

Purpose: Explore perspectives of people living with neurological conditions in Western Australia (WA) on robot-assisted lower limb neurorehabilitation (RALLR), and implementation requirements.

Materials And Methods: This co-designed, qualitative descriptive study included people living with neurological conditions. In-person semi-structured focus groups (FGs) were facilitated by a person with lived experience of stroke.

Implementing modified constraint-induced movement therapy after stroke in an early-supported discharge rehabilitation service: a process evaluation using RE-AIM QuEST.

Background: Modified constraint-induced movement therapy (mCIMT) improves upper limb (UL) function after stroke. Despite extensive evidence supporting its efficacy and multiple clinical practice guidelines recommending its provision, very few eligible stroke survivors receive mCIMT internationally. A multi-modal behaviour change intervention, guided by the Theoretical Domains Framework (TDF) and Behaviour Change Wheel, was implemented across a large early-supported discharge (ESD) rehabilitation service in Perth, Australia, to increase delivery of mCIMT within existing resources.

Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice.

Degeneration of both upper motor neurons in the brain and lower motor neurons in the spinal cord defines amyotrophic lateral sclerosis (ALS), but how they are linked in ALS pathophysiology is unclear. Here, we uncover a cortical origin of neurodegeneration in ALS mediated by upper motor neuron hyperexcitability. Chronic hyperexcitability of upper motor neurons induced by excitatory chemogenetics in healthy adult mice induced progressive motor deficits, weakness and core pathological hallmarks of ALS, including upper motor neurons loss, synaptic pathology, corticospinal tract degeneration and reactive gliosis.

Comprehensive identification of pathogenic tandem repeat expansions in sporadic amyotrophic lateral sclerosis: advantages of long-read vs. short-read sequencing.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder presenting progressive weakness of the bulbar and extremity muscles, leading to a wide-ranging clinical phenotype. More than 30 genes have been associated to genetically inherited ALS yet, approximately 85%-90% of ALS cases are sporadic. Short tandem repeats expansions, have recently been found in clinically diagnosed ALS patients and are currently investigated as potential genetic biomarkers.

Skipping of Duplicated Dystrophin Exons: In Vitro Induction and Assessment.

Duplications of one or more dystrophin exons that disrupt the reading frame account for about 15% of all Duchenne cases, and like the more common genomic deletions, most pathogenic duplications of single or multiple dystrophin exons are also amenable to targeted exon skipping. However, additional considerations must be taken into account: (i) Skipping of all duplicated exons, and flanking exons as necessary, will frequently be required to restore the reading frame and generate an in-frame Becker muscular dystrophy-like mRNA, (ii) the phosphorodiamidate morpholino oligomer chemistry is more effective than the 2'-O-methyl modified oligonucleotides at inducing multiple exon skipping, and (iii) the apparent efficiency of exon skipping can be confounded by the choice of RT-PCR system. Standard RT-PCR systems can preferentially amplify the shorter amplicons, implying more efficient exon skipping than may actually be induced.

Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data.

Early prediction of disability progression in multiple sclerosis (MS) remains challenging despite its critical importance for therapeutic decision-making. We present the first systematic evaluation of personalized federated learning (PFL) for 2-year MS disability progression prediction, leveraging multi-center real-world data from over 26,000 patients. While conventional federated learning (FL) enables privacy-aware collaborative modeling, it remains vulnerable to institutional data heterogeneity.

COVID-19 Vaccine Boosters in People With Multiple Sclerosis: Improved SARS-CoV-2 Cross-Variant Antibody Response and Prediction of Protection.

Background And Objectives: Although disease-modifying therapies (DMTs) may suppress coronavirus disease 2019 (COVID-19) vaccine responses in people with multiple sclerosis (pwMS), limited data are available on the cumulative effect of additional boosters. Maturation of Spike immunoglobulin G (IgG) to target a greater diversity of SARS-CoV-2 variants, especially past the BA.1 variant, has not been reported.

Investigating the effects of age and conditioning stimulation intensity on SMA-M1 connectivity in younger, middle-aged, and older adults.

Purpose: This study aimed to investigate bilateral motor control and connectivity between supplementary motor area (SMA) and primary motor cortex (M1) in younger, middle-aged, and older healthy adults.

Methods: 32 younger (mean age 22.8 ± 5.

Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank.

Background: Osteoporosis and dementia are two common disorders mainly affecting ageing population, and heel estimated bone mineral density (eBMD) measured by quantitative ultrasound (QUS) has been demonstrated to be a reliable and non-invasive method for assessing skeletal health. The aim of this study is to determine the association between eBMD and incident dementia in older adults.

Methods: This retrospective cohort study employs UK Biobank data of 131,030 adults aged ≥ 60 years without dementia at baseline.

Four years on: Pregnancy and birth outcomes reported in the MSBase pregnancy, neonatal outcomes, and Women's Health Registry (2020-2024).

Background: Family planning is an important aspect of multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD) management. Knowledge gaps remain, including optimal perinatal management strategies, and fetal risks associated with disease-modifying therapy (DMT) exposure.

Objective: To describe perinatal DMT use, together with pregnancy and neonatal outcomes prospectively recorded in the International MSBase Pregnancy and Women's Health Registry.

Influence of age on the association of vascular risk factors with acute stroke (INTERSTROKE): a case-control study.

Background: The absolute burden of stroke is increasing due to an ageing population, as well as an increased incidence of stroke in young adults. We aimed to determine whether age modifies the magnitude of association between vascular risk factors and stroke in the INTERSTROKE study.

Methods: INTERSTROKE is an international case-control study of risk factors for first acute stroke.

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics.

Mechanotransduction is essential for living cells to adapt to their extracellular environment. However, it is unclear how the biophysical adaptation of intracellular organelles responds to mechanical stress or how these adaptive changes affect cellular homeostasis. Here, using the tendon cell as a mechanosensitive cell type within a bioreactor, we show that the tension of the plasma membrane (PM) and the endoplasmic reticulum (ER) adaptively increases in response to repetitive external stimuli.

Expression and Site-Specific Biotinylation of Human Cytosolic 5'-Nucleotidase 1A in .

Autoantibodies targeting cytosolic 5'-nucleotidase 1A (cN1A) are found in several autoimmune diseases, including inclusion body myositis (IBM), Sjögren's syndrome, and systemic lupus erythematosus. While they have diagnostic relevance for IBM, little is known about the autoreactive B cells that produce these antibodies. To address this, we developed a robust protocol for the expression and site-specific biotinylation of recombinant human cN1A in .

Design, acceptability, and measured outcomes of music interventions for walking in persons with multiple sclerosis: A scoping review.

Background: Mobility impairments are common in persons with multiple sclerosis (MS), reducing independence and quality of life. Walking interventions can enhance mobility skills, with auditory-motor coupling (synchronising steps with auditory beats) serving as a promising method. Design and participants' characteristics may impact intervention effectiveness, but have not yet been compared across studies in persons with MS.

Retrotransposition-competent L1s are increased in the genomes of individuals with amyotrophic lateral sclerosis.

An individual's genetics contributes to their risk of developing amyotrophic lateral sclerosis (ALS); however, there is still a large proportion of the heritability of ALS to be understood. Part of this missing heritability may lie in complex variants, such as the long interspersed element 1 (L1) retrotransposon, which have yet to be evaluated. The majority of L1 insertions in the human genome are no longer able to retrotranspose, but to date 279 retrotransposition-competent (RC) L1s have been reported.

Therapeutic Potential of PSC-derived Cell Transplantation in Parkinson's Disease: A Systematic Review and Meta-analysis of Preclinical Studies.

Background: Parkinson's disease (PD) is a chronic progressive neurodegenerative disease with debilitating clinical presentations. Common therapeutic approaches for symptomatic improvement are often effective for a temporary period of time, after which patients often experience progressive disabilities. Cell replacement therapy is a potential therapeutic method that aims to replace depleted mesencephalic dopaminergic (DA) neurons, which may control symptoms and halt disease progression.

The landscape of non-reference SINE-VNTR-Alus in amyotrophic lateral sclerosis.

The fatal neurodegenerative disease, amyotrophic lateral sclerosis (ALS), leads to the degeneration of motor neurons in the brain and spinal cord. Many different genetic variants are known to increase the risk of developing ALS, however much of the disease heritability is still to be identified. To identify novel genetic factors, we characterised SINE-VNTR-Alu (SVA) presence/absence variation in 4403 genomes from the New York Genome Center (NYGC) ALS consortium.

Colchicine for preventing stroke in patients with and without intracranial atherosclerotic stenosis: a prespecified analysis of a randomized clinical trial.

Background: The effect of colchicine on subsequent stroke among patients with and without symptomatic intracranial artery stenosis (sICAS) and whether age modifies such effect are not known.

Methods: In this prespecified subgroup analysis of CHANCE-3, a randomized, double-blind, placebo-controlled clinical trial conducted at 244 centers in China between 11 August 2022 and 13 April 2023 (ClinicalTrials.gov number, NCT05439356), we included 7567 patients with ischemic stroke or transient ischemic attack and assessments of intracranial arteries at baseline.