Identification of small compounds targeting ferroptosis in triple-negative breast cancer by using an integrated computational approach.

This study integrated bioinformatics and computational approaches to identify potential therapeutic compounds targeting ferroptosis in triple-negative breast cancer (TNBC) patients. Through analysis of TNBC transcriptomic data from the GEO and FerrDb databases, we identified 140 TNBC-associated ferroptosis genes. There were seven hub genes (KRAS, PKM, MAPK1, AR, AURKA, TFRC and ESR1), which emerged as potential diagnostic biomarkers.

Ultra-High-Performance Liquid Chromatography-High-Definition Mass Spectrometry-Based Metabolomics to Reveal the Potential Anti-Arthritic Effects of in Cultured Fibroblast-like Synoviocytes Derived from Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. The fruits of , which is a medicinal and edible resource, have been shown to have anti-inflammatory properties.

Methods: In this study, we investigated the effects of extracts (IVEs) on human RA fibroblasts-like synoviocytes (RA-FLS) by using a sensitive and selective ultra-high-performance liquid chromatography with high-definition mass spectrometry (UPLC-HDMS) method.

The petroleum ether extracts of Chloranthus fortunei(A. Gray) Solms-Laub.with bioactivities: A rising source in HCC drug treatment.

Ethnopharmacological Relevance: Hepatocellular Carcinoma (HCC) is an aggressive killer worldwide with high incidence and mortality. The herb Chloranthus fortunei (A. Gray) Solms-Laub is known as "Si Ji Feng" and is classified as a Feng-type medicine in classic Yao medicines.

Chemical composition and anti-inflammatory activity of flower essential oil from Nakai.

Nakai is an ornamental plant widely cultivated in East Asia. The essential oil of flowers (FEO) was extracted by hydrodistillation process and the volatile components were determined with gas chromatography coupled with mass spectrometry. The anti-inflammatory activity of FEO was investigated by using TPA-induced mouse ear inflammation model.