Mapping the anatomy of placebo analgesia.

The identification of somatotopy in brainstem pain modulatory pathways could help treat chronic pain.

Reporting guidelines for music-based interventions checklist: Explanation and elaboration guide.

Background: Detailed intervention reporting is essential to interpretation, replication, and eventual translation of music-based interventions (MBIs) into practice. Despite availability of (RG-MBI, published 2011), multiple reviews reveal sustained problems with reporting quality and consistency. To address this, we convened an interdisciplinary expert panel to update and improve the utility and validity of the existing guidelines using a rigorous Delphi approach.

Prevalence and correlates of "undiagnosed pain"-Evidence from the US national Medical Expenditure Panel Survey.

There are no nationally representative studies examining both the frequency and correlates of "undiagnosed pain"-pain without a formal diagnosis. To identify the magnitude of this healthcare gap, we performed cross-sectional secondary analyses of the Medical Expenditure Panel Survey (MEPS), 2016-2019 data. The primary study outcome is "being undiagnosed": the absence of diagnoses for pain-related conditions among participants reporting pain-related interference (PRI).

Reporting guidelines for music-based interventions: An update and validation study.

Background: Detailed intervention reporting is essential to interpretation, replication, and translation of music-based interventions (MBIs). The 2011 were developed to improve transparency and reporting quality of published research; however, problems with reporting quality persist.

Methods: The purpose of this study was to update and validate the 2011 reporting guidelines using rigorous Delphi approach that involved an interdisciplinary group of MBI researchers; and to develop an explanation and elaboration guidance statement to support dissemination and usage.

Targeting and in C-fiber low threshold mechanoreceptor: limitation of -IRES-.

Peripheral somatosensory neurons in the dorsal root ganglia (DRG) transduce mechanical force in the skin and other organs into electrical signals using specialized mechanically activated (MA) ion channels that initiate neuronal activation in response to force. Increasing evidence highlights PIEZO2 as the primary transducer of low-threshold mechanical force in DRG neurons. However, in the absence of , mice and humans still respond to noxious painful stimuli like pinch, suggesting that additional MA channel(s) likely exist in DRG neurons.

Pain among US adults before, during, and after the COVID-19 pandemic: a study using the 2019 to 2023 National Health Interview Survey.

The unprecedented disruption of the COVID-19 pandemic raises crucial questions about its impact on chronic pain levels in the US population. We present a comprehensive analysis of chronic pain (CP), high-impact chronic pain (HICP), and site-specific pain prevalence before, during, and after the pandemic, and investigate key contributing factors. We analyze a nationally representative sample of 90,769 community-dwelling adults aged 18 years and older from 3 cross-sectional waves of the National Health Interview Survey (2019, 2021, and 2023).

Isolating Brain Mechanisms of Expectancy Effects on Pain: Cue-Based Stimulus Expectancies versus Placebo-Based Treatment Expectancies.

Clinical trials, laboratory experiments, and neuroimaging studies provide converging evidence that pain is highly sensitive to expectations, whether based on the psychosocial context surrounding treatment (e.g., placebo analgesia) or transient cues that provide information about painful events (e.

Intradental mechano-nociceptors serve as sentinels that prevent tooth damage.

The trigeminal sensory neurons that innervate the tooth's vital interior-intradental neurons-are expected to drive severe pain, yet their contribution to healthy tooth sensation has not been explored. Here, we uncover a role for myelinated high-threshold mechano-nociceptors (intradental HTMRs) in tooth protection using in vivo Ca imaging, opto-/chemogenetics, and the AI-driven behavioral analysis tool LabGym. Intradental HTMRs innervate the inner dentin through overlapping receptive fields and respond as the external structures of the tooth are damaged in the absence of either PIEZO2 or Na1.

Neuronal HDAC3 knockdown promotes propriospinal detour pathway formation and locomotor recovery in a mouse model of spinal cord injury.

Propriospinal detour pathways facilitate motor recovery after spinal cord injury (SCI). Here, through a screen of epigenetic modulators, we demonstrated that small interfering RNA (siRNA)-mediated knockdown of histone deacetylase 3, delivered by extracellular vesicles (EVsiHDAC3), promoted neurite outgrowth in murine spinal neurons and human induced pluripotent stem cell-derived sensory and motor neurons. To enhance in vivo efficacy, we developed a neurotrophic nanoparticle platform using gelatin methacryloyl microspheres conjugated with an optimized rabies glycoprotein-derived peptide.

Subjective salience ratings are a reliable proxy for physiological measures of arousal.

Pain is an inherently salient multidimensional experience that signals potential bodily threats and promotes nocifensive behaviours. Any stimulus can be salient depending on its features and context. This poses a challenge in delineating pain-specific processes in the brain, rather than salience-driven activity.

Reporting Guidelines for Music-based Interventions checklist: explanation and elaboration guide.

Background: Detailed intervention reporting is essential to interpretation, replication, and eventual translation of Music-based Interventions (MBIs) into practice. Despite availability of (RG-MBI, published 2011), multiple reviews reveal sustained problems with reporting quality and consistency. To address this, we convened an interdisciplinary expert panel to update and improve the utility and validity of the existing guidelines using a rigorous Delphi approach.

Acupoints in Acupuncture Research: Past, Present, and Future.

Background: Although acupuncture points (acupoints) have been used for thousands of years, their exact biological basis remains uncertain. This knowledge gap has hindered both acupuncture research and the integration of acupuncture into clinical care.

Objective: In response to a consensus in the scientific community about the need for an open-access database where researchers can deposit, share, and compare anatomical and physiological data associated with acupoints, the National Center for Complementary and Integrative Health has funded a project to develop such a database, the Topological Atlas and Repository for Acupoint Research (TARA).

Reporting Guidelines for Music-based Intervention: an update and validation study.

Background: Detailed intervention reporting is essential to interpretation, replication, and translation of music-based interventions (MBIs). The 2011 were developed to improve transparency and reporting quality of published research; however, problems with reporting quality persist. This represents a significant barrier to advances in MBI scientific research and translation of findings to practice.

Development of chronic pain and high-impact chronic pain across the US rural-urban continuum, 2019-2020.

Purpose: Rural health disadvantages are well documented in previous literature; however, research on rural-urban disparities in chronic pain outcomes is scarce. This paper fills this gap by examining pain prevalences and longitudinal transitions across the rural-urban continuum (i.e.

A distributed coding logic for thermosensation and inflammatory pain.

Somatosensory neurons encode detailed information about touch and temperature and are the peripheral drivers of pain. Here by combining functional imaging with multiplexed in situ hybridization, we determined how heat and mechanical stimuli are encoded across neuronal classes and how inflammation transforms this representation to induce heat hypersensitivity, mechanical allodynia and continuing pain. Our data revealed that trigeminal neurons innervating the cheek exhibited complete segregation of responses to gentle touch and heat.

Dynamic effects of psychiatric vulnerability, loneliness and isolation on distress during the first year of the COVID-19 pandemic.

The COVID-19 pandemic's impact on mental health is challenging to quantify because pre-existing risk, disease burden and public policy varied across individuals, time and regions. Longitudinal, within-person analyses can determine whether pandemic-related changes in social isolation impacted mental health. We analyzed time-varying associations between psychiatric vulnerability, loneliness, psychological distress and social distancing in a US-based study during the first year of the pandemic.

A pontine center in descending pain control.

Pain sensation changes according to expectation, context, and mood, illustrating how top-down circuits affect somatosensory processing. Here, we used an intersectional strategy to identify anatomical and molecular-spatial features of supraspinal descending neurons activated by distinct noxious stimulation. This approach captured known descending pain pathways as well as spinal projecting neurons that are anatomically mapped to Barrington's nucleus in the dorsal pontine tegmentum.

Pain persists in mice lacking both Substance P and CGRPα signaling.

The neuropeptides Substance P and CGRPα have long been thought important for pain sensation. Both peptides and their receptors are expressed at high levels in pain-responsive neurons from the periphery to the brain making them attractive therapeutic targets. However, drugs targeting these pathways individually did not relieve pain in clinical trials.

Subjective salience ratings are a reliable proxy for physiological measures of arousal.

Pain is an inherently salient multidimensional experience that signals potential bodily threats and promotes nocifensive behaviours. Any stimulus can be salient depending on its features and context. This poses a challenge in delineating pain-specific processes in the brain, rather than salience-driven activity.

Multivitamins After Myocardial Infarction in Patients With Diabetes: A Randomized Clinical Trial.

Importance: In 2013, the Trial to Assess Chelation Therapy (TACT) reported that in 1708 patients with stable coronary disease and prior myocardial infarction (MI), oral multivitamins and multiminerals (OMVMs), in a factorial design with edetate disodium (EDTA) chelation therapy, did not reduce cardiovascular events relative to placebo OMVMs, but active EDTA combined with active OMVMs was superior to placebo OMVM/placebo EDTA.

Objective: To compare OMVM vs placebo in terms of efficacy for reducing major adverse cardiovascular events in patients with diabetes and prior MI.

Design, Setting, And Participants: The TACT2 randomized, multicenter double-masked 2 × 2 factorial clinical trial took place across 88 sites in the US and Canada.

Epidural Steroids for Cervical and Lumbar Radicular Pain and Spinal Stenosis Systematic Review Summary: Report of the AAN Guidelines Subcommittee.

Background And Objectives: This review systematically evaluates and incorporates evidence for the use of epidural steroid injections (ESIs) in cervical and lumbar spinal stenosis and radiculopathies, assessing short-term (≤3 months) and long-term (≥6 months) improvements in pain and disability.

Methods: We searched databases for randomized controlled trials (RCTs) on the efficacy of ESIs published between January 2005 and January 2021. Data analysis was performed by American Academy of Neurology methodologists.

Addressing gaps in pain research from an integrated whole person perspective.

While our understanding of pain is rapidly growing, some areas of pain research are lagging behind. This article discusses two current and inter-related gaps in knowledge that are in need of addressing: first, the connections between "brain" and "body" components of pain; and second, the process of endogenous pain resolution. Historical reasons for these research gaps are discussed and solutions are outlined based on an integrative, whole person research approach.

Recommendations for monitoring adherence and fidelity in pragmatic trials based on experience in the Pain Management Collaboratory.

Objective: Most pragmatic trials follow the PRagmatic Explanatory Continuum Indicator Summary (PRECIS-2) criteria. The criteria specify unobtrusive measurement of participants' protocol adherence and practitioners' intervention fidelity but suggest no special monitoring strategies to assure trial integrity. We present experience with adherence/fidelity monitoring in the Pain Management Collaboratory (PMC) and provide recommendations for their monitoring in pragmatic trials to preserve inferences of treatment comparisons.